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Trypanosoma cruzi alkaline 2-DE : optimization and application to comparative proteome analysis of flagellate life stages

Magalhães, Adriana Dias; Charneau, Sébastien Olivier; Paba, Jaime; Guércio, Rafael Augusto Pontes; Teixeira, Antonio Raimundo Lima Cruz; Santana, Jaime Martins de; Sousa, Marcelo Valle de; Ricart, Carlos André Ornelas
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
ENG
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Background Trypanosoma cruzi, a flagellate protozoan, is the etiological agent of Chagas disease, a chronic illness that causes irreversible damage to heart and digestive tract in humans. Previous 2-DE analyses of T. cruzi proteome have not focused on basic proteins, possibly because of inherent difficulties for optimizing 2-DE in the alkaline pH range. However, T. cruzi wide pH range 2-DE gels have shown few visible spots in the alkaline region, indicating that the parasite either did not have an appreciable amount of alkaline proteins or that these proteins were underrepresented in the 2-DE gels. Results Different IEF conditions using 6–11 pH gradient strips were tested for separation of T. cruzi alkaline proteins. The optimized methodology described here was performed using anodic "paper bridge" sample loading supplemented by increased concentration of DTT and Triton X-100 on Multiphor II (GE Healthcare) equipment and an electrode pad embedded in DTT- containing solution near the cathode in order to avoid depletion of reducing agent during IEF. Landmark proteins were identified by peptide mass fingerprinting allowing the production of an epimastigote 2-DE map. Most identified proteins corresponded to metabolic enzymes, especially those related to amino acid metabolism. The optimized 2-DE protocol was applied in combination with the "two-in-one gel" method to verify the relative expression of the identified proteins between samples from epimastigote and trypomastigote life stages. Conclusion High resolution 2-DE gels of T. cruzi life forms were achieved using the optimized methodology and a partial epimastigote alkaline 2-DE map was built. Among 700 protein spots detected...

Bleomycin-induced flagellate hyperpigmentation

Resende, C; Araújo, C; Gomes, J; Brito, C
Fonte: BMJ Publicador: BMJ
Tipo: Artigo de Revista Científica
Publicado em //2013 ENG
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27.24%
Bleomycin is a chemotherapeutic agent used in the treatment of different tumours. It has several side effects, including flagellate hyperpigmentation, which is a unique and a well-documented side effect of bleomycin therapy. We report a case of a 23-year-old woman with a personal history of ovarian dysgerminoma, who developed flagellate hyperpigmentation on trunk after bleomycin therapy.

The role of limnological variables and habitat complexity in impacted tropical streams as regulatory factors on the flagellate protozoa community

Camargo,Janielly Carvalho; Vieira,Ludgero Cardoso Galli; Velho,Luiz Felipe Machado
Fonte: Associação Brasileira de Limnologia Publicador: Associação Brasileira de Limnologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2012 EN
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OBJECTIVE: To contribute to the knowledge of patterns of spatial and seasonal distribution of composition and species richness of flagellate protozoa in tropical impacted streams and to identify which variables (physical and chemical or descriptor variables of habitat complexity) control these attributes in these environments. METHODS: Samplings were performed in 10 tropical streams (5 urban and 5 rural) in two periods (summer and winter). Limnological variables were determined on the field (except for the concentration of nutrients), the habitat macrostructure was visually estimated in situ, using a quadrat and the species identification was performed in vivo, under optical microscope. RESULTS: In total, 106 taxa were identified, the order Euglenida was that contributed most to the species richness, probably due to the high tolerance to environmental changes. Multivariate analyses (ANOSIM and MDS) evidenced significant spatial and seasonal differences both for composition and species richness. The Bioenv and Mantel Test indicated that the patterns of composition and richness were controlled by physical and chemical variables indicative of water quality (pH, electrical conductivity, and concentration of nutrients). However, the species richness was also influenced by the habitat structural complexity and by its stability...

Flagellate green algae from four water bodies in the state of Rio de Janeiro, Southeast Brazil

Menezes,Mariângela; Bicudo,Carlos Eduardo de Mattos
Fonte: Instituto de Botânica Publicador: Instituto de Botânica
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2008 EN
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Floristic survey of flagellate green algae (Chlorophyceae and Prasinophyceae) from four water bodies in the state of Rio de Janeiro, southeast Brazil. Samples were collected bimonthly from September 1988 to August 1991. Thirty-five taxa of which 31 in Chlorophyceae (24 Chlamydomonadales and seven Volvocales) and four in Prasinophyceae (Polyblepharidales) were identified. Twenty-three taxa are new records for Brazil and 31 are registered for the first time for Rio de Janeiro State. On basis of cell shape, location of the nucleus and degree of longitudinal striations on the chloroplast surface a new combination, Vitreochlamys lefevrei (Bourr.) Menezes & C. Bicudo, is proposed. Integrating studies among morphological analysis on natural/cultured material and characterizing of reproduction/life cycle as well the correlating between the occurrence of the species and environmental conditions are needed in order to better knowledge the degree of phenotypic plasticity within the members of the flagellate green algae in the country.

Bacterial Filament Formation, a Defense Mechanism against Flagellate Grazing, Is Growth Rate Controlled in Bacteria of Different Phyla

Hahn, Martin W.; Moore, Edward R. B.; Höfle, Manfred G.
Fonte: American Society for Microbiology Publicador: American Society for Microbiology
Tipo: Artigo de Revista Científica
Publicado em /01/1999 EN
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A facultatively filamentous bacterium was isolated from eutrophic lake water and was identified as Flectobacillus sp. strain MWH38 (a member of the Cytophaga-Flavobacterium-Bacteroides phylum) by comparative 16S rRNA gene sequence analysis. Filament formation by Flectobacillus sp. strain MWH38 and filament formation by Flectobacillus major, the closest known relative of strain MWH38, were studied in chemostat cultures under grazing pressure by the bacterivorous flagellate Ochromonas sp. strain DS and without predation at several growth rates. The results clearly demonstrated that filament formation by the two flectobacilli is growth rate controlled and thus independent of the presence of a predator. However, flagellate grazing positively influenced bacterial growth rates by decreasing bacterial biomass and thus indirectly stimulated filament formation. The results of investigations of cell elongation and filament formation by Comamonas acidovorans PX54 (a member of the β subclass of the class Proteobacteria) supported the recent proposal that in this species the mechanism of filament formation is growth rate controlled. The finding that the grazing defense mechanism consisting of filament formation is growth rate controlled in the flectobacilli investigated and C. acidovorans PX54 (i.e....

Flagellate Predation on a Bacterial Model Community: Interplay of Size-Selective Grazing, Specific Bacterial Cell Size, and Bacterial Community Composition

Hahn, Martin W.; Höfle, Manfred G.
Fonte: American Society for Microbiology Publicador: American Society for Microbiology
Tipo: Artigo de Revista Científica
Publicado em /11/1999 EN
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The influence of grazing by the bacterivorous nanoflagellate Ochromonas sp. strain DS on the taxonomic and morphological structures of a complex bacterial community was studied in one-stage chemostat experiments. A bacterial community, consisting of at least 30 different strains, was fed with a complex carbon source under conditions of low growth rate (0.5 day−1 when nongrazed) and low substrate concentration (9 mg liter−1). Before and after the introduction of the predator, the bacterial community composition was studied by in situ techniques (immunofluorescence microscopy and fluorescent in situ hybridization), as well as by cultivation on agar media. The cell sizes of nonspecifically stained and immunofluorescently labeled bacteria were measured by image analysis. Grazing by the flagellate caused a bidirectional change in the morphological structure of the community. Medium-size bacterial cells, which dominated the nongrazed community, were largely replaced by smaller cells, as well as by cells contained in large multicellular flocs. Cell morphological changes were combined with community taxonomic changes. After introduction of the flagellate, the dominating strains with medium-size cells were largely replaced by single-celled strains with smaller cells on the one hand and...

Grazing Pressure by a Bacterivorous Flagellate Reverses the Relative Abundance of Comamonas acidovorans PX54 and Vibrio Strain CB5 in Chemostat Cocultures

Hahn, Martin W.; Höfle, Manfred G.
Fonte: American Society for Microbiology Publicador: American Society for Microbiology
Tipo: Artigo de Revista Científica
Publicado em /05/1998 EN
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27.62%
The response of the bacterial strains Comamonas acidovorans PX54 (β subclass of the class Proteobacteria) and Vibrio strain CB5 (γ subclass of the class Proteobacteria) to grazing by the bacterivorous flagellate Ochromonas sp. was examined in one-stage chemostat experiments under conditions of low growth rates with a complex carbon source. The two bacterial strains were cultured together; they were cultured without flagellates in the first phase of the experiments and in the presence of the flagellates in the second phase. Monoclonal and polyclonal antibodies were used to determine the numbers and sizes of C. acidovorans PX54 and Vibrio strain CB5 cells. The flagellates caused strong changes in total bacterial cell numbers, in the relative abundances of the individual bacterial strains, and in bacterial cell size distribution. Vibrio strain CB5 dominated the total bacterial cell numbers during the flagellate-free phase of the experiments with a relative abundance of 93%, but this declined to 33% after inoculation with the flagellate. In contrast to Vibrio strain CB5, C. acidovorans PX54 responded to grazing with a strong expansion of cell length distribution toward large, filamentous cells. These changes in cell morphology resulted in a high percentage of inedible cells in the C. acidovorans PX54 population but not in the Vibrio strain CB5 population...

Comparison of Rates of Flagellate Bacterivory and Bacterial Production in a Marine Coastal System

Barcina, Isabel; Ayo, Begoña; Unanue, Marian; Egea, Luis; Iriberri, Juan
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /12/1992 EN
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Protozoan predation on bacteria and bacterioplankton secondary production were simultaneously determined in La Salvaje Beach water during 1990. Protozoan grazing on bacterioplankton was measured from fluorescently labeled bacterium uptake rates; estimates of bacterial secondary production were obtained from [3H]thymidine incorporation rates. Two different conversion factors were used to transform thymidine incorporation rates into bacterial production rates; both of them were specific for La Salvaje Beach and were calculated by using empirical and semitheoretical approaches. The average flagellate predation rate was 14.0 bacteria flagellate-1 h-1; the average population predation rate was 7.35 x 106 bacteria liter-1 h-1. The estimates of bacterial production differed greatly depending on the conversion factor used, and so did the percentages of bacterial production consumed by flagellated protozoa (4.6% when the empirical conversion factor for La Salvaje Beach was used and 113% when the semitheoretical conversion factor specific for this system was used). The ecological implications of each of these values are discussed.

Colloidal and Dissolved Organic Matter Excreted by a Mixotrophic Flagellate during Bacterivory and Autotrophy

Tranvik, Lars
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /06/1994 EN
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Excretion of dissolved and colloidal organic carbon by a mixotrophic flagellate, the chrysophyte Poterioochromonas malhamensis, was studied. Flagellates were incubated either with 14C-labeled bacteria or with inorganic 14C, in order to compare organic exudates originating from primary production with exudates originating from ingested bacteria. Colloids of >0.02 μm constituted a larger fraction of the exudates originating from ingested bacteria, compared with exudates derived from primary production. Flagellate feeding on bacteria specifically labeled in different cell components was compared. Cell wall components gave rise to less colloidal organic carbon than did other cell constituents. To investigate the degradability of flagellate 14C-exudates, they were added to lake water and mineralization to 14CO2 was monitored. Bacterially derived exudates were more recalcitrant than exudates originating from photosynthesis. The results support the hypothesis that bacterial utilization of labile organic compounds, followed by flagellate bacterivory and exudation, results in a transformation of labile organic matter into more recalcitrant forms.

Successful Predation of Filamentous Bacteria by a Nanoflagellate Challenges Current Models of Flagellate Bacterivory

Wu, Qinglong L.; Boenigk, Jens; Hahn, Martin W.
Fonte: American Society for Microbiology Publicador: American Society for Microbiology
Tipo: Artigo de Revista Científica
Publicado em /01/2004 EN
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27.24%
Current models suggest that (i) filamentous bacteria are protected against predation by nanoflagellates, (ii) prey size is positively correlated with prey-predator contact probability, and (iii) contact probability is mainly responsible for size-selective predation by interception-feeding flagellates. We used five strains of filamentous bacteria and one bacterivorous nanoflagellate, Ochromonas sp. strain DS, to test these assumptions. The five strains, including one spirochete and four Betaproteobacteria strains, were isolated by the filtration-acclimatization method. All five strains possess flexible cells, but they differ in average cell length, which ranged from 4.5 to 13.7 μm. High-resolution video microscopy was used to measure contact, capture, and ingestion rates, as well as selectivity of the flagellate feeding. Growth and feeding experiments with satiating and nonsatiating food conditions, as well as experiments including alternative well-edible prey, were performed. In contrast to predictions by current models, the flagellate successfully consumed all the tested filamentous strains. The ingestion rate was negatively correlated with bacterial length. On the other hand, the lengths of the filamentous bacteria were not positively correlated to the contact rate and capture rate but were negatively correlated to ingestion efficiency. In experiments including alternative nonfilamentous prey...

Contrasting Bacterial Strategies To Coexist with a Flagellate Predator in an Experimental Microbial Assemblage

Pernthaler, J.; Posch, T.; Simek, K.; Vrba, J.; Amann, R.; Psenner, R.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /02/1997 EN
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27.62%
We studied predator-induced changes within a slowly growing mixed microbial assemblage that was sustained by algal exudates in a continuous cultivation system. In situ hybridization with fluorescent monolabeled oligonucleotide probes was used for a tentative community analysis. This method also allowed us to quantify the proportions of predators with ingested bacteria of different taxonomic groups. In addition, we determined grazing rates on bacteria with fluorescently labelled prey. Bacteria belonging to the alpha and beta subdivisions of the phylum Proteobacteria ((alpha)- and (beta)-Proteobacteria, respectively) showed very different responses to the addition of a bacterivorous flagellate, Bodo saltans. Within one day, filamentous protist-inedible bacteria developed; these belonged to the (beta)-Proteobacteria and constituted between 8.7 and 34% of bacteria from this subgroup. Total abundance of (beta)-Proteobacteria decreased from 3.05 x 10(sup6) to 0.23 x 10(sup6) cells ml(sup-1), and estimated cell division rates were low. Other morphologically inconspicuous protist-edible bacteria belonging to the (alpha)-Proteobacteria were found to respond to predation by an increase in growth rate. Although these bacteria were heavily grazed upon...

THE AMEBA-TO-FLAGELLATE TRANSFORMATION IN TETRAMITUS ROSTRATUS : II. Microtubular Morphogenesis

Outka, Darryll E.; Kluss, Byron C.
Fonte: The Rockefeller University Press Publicador: The Rockefeller University Press
Tipo: Artigo de Revista Científica
Publicado em 01/11/1967 EN
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27.24%
Tetramitus exhibits independent ameboid and flagellate stages of remarkable morphological dichotomy. Transformation of the ameba involves the formation of four kinetosomes and their flagella. The arrangement of these kinetosomes and associated whorls of microtubules extending under the pellicle establishes the asymmetric flagellate form. While no recognizable kinetosomal precursors have been seen in amebae, and there is no suggestion of self-replication in dividing flagellates, developmental stages of kinetosomes have been identified. These are occasionally seen in association with the nucleus or with dense bodies which lie either inside of or close to the proximal end of the prokinetosome. Outgrowth of flagella involves formation of an axoneme and a membrane. From the distal tip of the kinetosome microtubules grow into a short bud, which soon forms an expanded balloon containing a reticulum of finely beaded filaments. The free ends of the microtubules appear unraveled; they are seen first as single elements, then as doublets, and finally are arranged into a cylinder. Growth in length is accompanied by a reduction in the diameter of the balloon. The concept that the formation of the kinetic apparatus might involve a nuclear contribution...

Bleomycin-induced flagellate hyperpigmentation

Resende, Cristina; Araújo, Catarina; Gomes, Joana; Brito, Celeste
Fonte: BMJ Publishing Group Publicador: BMJ Publishing Group
Tipo: Artigo de Revista Científica
Publicado em 05/06/2013 EN
Relevância na Pesquisa
27.24%
Bleomycin is a chemotherapeutic agent used in the treatment of different tumours. It has several side effects, including flagellate hyperpigmentation, which is a unique and a well-documented side effect of bleomycin therapy. We report a case of a 23-year-old woman with a personal history of ovarian dysgerminoma, who developed flagellate hyperpigmentation on trunk after bleomycin therapy.

Character of Cellulase Activity in the Guts of Flagellate-Free Termites with Different Feeding Habits

Li, Zhi-Qiang; Liu, Bing-Rong; Zeng, Wen-Hui; Xiao, Wei-Liang; Li, Qiu-Jian; Zhong, Jun-Hong
Fonte: University of Wisconsin Library Publicador: University of Wisconsin Library
Tipo: Artigo de Revista Científica
Publicado em 21/04/2013 EN
Relevância na Pesquisa
27.24%
Cellulose digestion in termites (Isoptera) is highly important for ecological reasons and applications in biofuel conversion. The speciose Termitidae family has lost flagellates in the hindgut and developed diverse feeding habits. To address the response of cellulase activity to the differentiation of feeding habits, a comparative study of the activity and distribution of composite cellulases, endo-β-1, 4-glucanase, and β-glucosidase was performed in seven common flagellate-free termites with three feeding habits: the humus-feeding termites Sinocapritermes mushae (Oshima et Maki), Malaysiocapritermes zhangfengensis Zhu, Yang et Huang and Pericapritermes jiangtsekiangensis (Kemner); the fungus-growing termites Macrotermes barneyi Light and Odontotermes formosanus (Shiraki); and the wood-feeding termites Nasutitermes parvonasutus (Shiraki) and Havilanditermes orthonasus (Tsai et Chen). The results showed that in diverse feeding groups, the wood-feeding group had the highest total composite cellulase and endo-β-1, 4-glucanase activities, while the fungus-growing group had the highest β-glucosidase activity. In terms of the distribution of cellulase activity in the alimentary canals, the cellulase activities in wood-feeding termites were concentrated in the midgut...

Bleomycin-induced flagellate erythema: A case report and review of the literature

LEE, HUI-YOUNG; LIM, KYU-HYOUNG; RYU, YOUNGJOON; SONG, SEO-YOUNG
Fonte: D.A. Spandidos Publicador: D.A. Spandidos
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
27.24%
Bleomycin has been used most commonly in the treatment of Hodgkin’s lymphoma, certain germ cell tumors (GCT) and for the sclerosis of recurrent pleural effusions. Bleomycin toxicity predominantly affects the skin and lungs. Skin toxicity includes Raynaud’s phenomenon, hyperkeratosis, nail-bed changes and palmoplantar desquamation. Flagellate erythema is an unusual rash occurring specifically during bleomycin use. In the present study, we report a case of bleomycin-induced flagellate erythema in a patient with GCT. A 42-year-old male was diagnosed with stage IIIB testicular cancer and treated with bleomycin, etoposide and cisplatin chemotherapy. After 10 days from the initiation of treatment, the patient subsequently developed a generalized pruritus and erythematous linear rash that was most prominent on the trunk, and upper and lower extremities. The patient was commenced on a short course of low-dose oral prednisolone, 20 mg daily, and antihistamine. Consequently, bleomycin was withheld from the patient’s treatment regimen. The present study describes the case, along with a review of the associated literature.

Flagellate dermatitis after consumption of Shiitake mushrooms

Czarnecka, Agnieszka B.; Kreft, Burkhard; Marsch, Wolfgang Ch.
Fonte: Termedia Publishing House Publicador: Termedia Publishing House
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
27.24%
Flagellate dermatitis occurs in patients who have eaten Shiitake mushrooms. We are reporting on a 55-year-old man, who developed whiplash-striped, severely itching efflorescences on the trunk 3 days after eating Lentinula edodes. Flagellate dermatitis is also known as a cutaneous side effect of bleomycin therapy.

Character of cellulase activity in the guts of flagellate-free termites with different feeding habits

Li, Zhi-Qiang; Liu, Bing-Rong; Zeng, Wen-Hui; Xiao, Wei-Liang; Li, Qiu-Jian; Zhong, Jun-Hong
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica Formato: text/html
EN
Relevância na Pesquisa
27.24%
Cellulose digestion in termites (Isoptera) is highly important for ecological reasons and applica-tions in biofuel conversion. The speciose Termitidae family has lost flagellates in the hindgut and developed diverse feeding habits. To address the response of cellulase activity to the differentia-tion of feeding habits, a comparative study of the activity and distribution of composite cellulases, endo-β-1,4-glucanase, and β-glucosidase was performed in seven common flagellate-free termites with three feeding habits: the humus-feeding termitesSinocapritermes mushae (Oshima et Maki), Malaysiocapritermes zhangfengensis Zhu, Yang et Huang andPericapriter-mes jiangtsekiangensis (Kemner); the fungus-growing termitesMacrotermes barneyi Light andOdontotermes formosanus (Shiraki); and the wood-feeding termitesNasutitermes parvonasutus (Shiraki) andHavilanditermes orthonasus (Tsai et Chen). The results showed that in diverse feeding groups, the wood-feeding group had the highest total composite cellulase and endo-β-1,4-glucanase activities, while the fungus-growing group had the highest β-glucosidase activity. In terms of the distribution of cellulase activity in the alimentary canals...

Flagellate dermatitis following consumption of shiitake mushroom

Loo, Hui Voon; Oon, Hazel H.
Fonte: PAGEPress Publications Publicador: PAGEPress Publications
Tipo: Artigo de Revista Científica
Publicado em 05/10/2011 EN
Relevância na Pesquisa
27.24%
Japanese dermatologists were the first to describe the very characteristic flagellate dermatitis following consumption of undercooked or raw shiitake mushroom (Lentinus edodes). These similar eruptions were also reported in patients treated with bleomycin, in dermatomyositis and adult onset Still's disease. We report a case where a 40 year old chinese female developed flagellate dermatitis following ingestion of a bun containing shiitake mushroom.

Crash of a population of the marine heterotrophic flagellate Cafeteria roenbergensis by viral infection

Massana, Ramon; Campo, Javier del; Dinter, Christian; Sommaruga, Rubén
Fonte: Society for Applied Microbiology; Blackwell Publishing Publicador: Society for Applied Microbiology; Blackwell Publishing
Tipo: Artículo Formato: 180710 bytes; application/pdf
ENG
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10 pages, 6 figures.-- Printed version published Dec 2007.-- Full-text version available Open Access at: http://www.icm.csic.es/bio/projects/icmicrobis/pdf/%20Massana07.pdf; Viruses are known as important mortality agents of marine microorganisms. Most studies focus on bacterial and algal viruses, and few reports exist on viruses infecting marine heterotrophic protists. Here we show results from several incubations initiated with a microbial assemblage from the central Indian Ocean and amended with different amounts of organic matter. Heterotrophic flagellates developed up to 30 000 cells ml−1 in the most enriched incubation. A 18S rDNA clone library and fluorescent in situ hybridization counts with newly designed probes indicated that the peak was formed by Cafeteria roenbergensis and Caecitellus paraparvulus (90% and 10% of the cells respectively). Both taxa were below detection in the original sample, indicating a strong positive selective bias during the enrichment. During the peak, C. roenbergensis cells were observed with virus-like particles in the cytoplasm, and 4 days later this taxa could not be detected. Transmission electron microscopy confirmed the viral nature of these particles, which were large (280 nm), had double-stranded DNA...

DERMATITIS FLAGELADA INDUCIDA POR BLEOMICINA: RELATO DE CASO; BLEOMYCIN-INDUCED FLAGELLATE DERMATITIS: A CASE REPORT; DERMATITE FLAGELADA INDUZIDA POR BLEOMICINA: RELATO DE CASO

Bispo Junior, Walfrido; Universidade Federal de Alagoas; Barros de Oliveira, Silvana Maria; Hospital Universitário Prof. Alberto Antunes/Universidade Federal de Alagoas; Soares Oliveira, Rosane; Hospital Universitário Prof. Alberto Antunes/Universidade
Fonte: Universidade Federal do Paraná Publicador: Universidade Federal do Paraná
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; ; Formato: application/pdf; application/pdf
Publicado em 28/06/2015 POR; ENG
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La dermatitis flagelada consiste en una hiperpigmentación cutánea de aspecto flagelado y su causa específica es la bleomicina. La bleomicina es un agente quimioterápico usado en el tratamiento de diferentes neoplasias. El objetivo de este relato fue describir el caso de una paciente de 31 años de edad, en tratamiento de Linfoma de Hodgkin con protocolo de Quimioterapia Antineoplásica compuesto por cuatro drogas, entre las cuales la bleomicina, ocasionada con desarrollo de Dermatitis Flagelada. El caso ocurrió en un hospital universitario del nordeste del Brasil en 2014. La terapia utilizada como tratamiento fue uso de cor ticoide, lo que proporcionó la remisión de las lesiones del tipo flagelo y permitió la continuidad del tratamiento sin necesidad de cambio del protocolo quimioterápico. El papel del estudio es abrir discusión acerca de los aspectos que involucran el manejo de esa hipersensibilidad, para garantizar la continuidad del tratamiento antineoplásico.; Flagellate Dermatitis consists of cutaneous hyperpigmentation with a flagellate appearance, one specific cause of which is bleomycin. Bleomycin is a chemotherapy agent used in the treatment of different neoplasias. This report’s objective is to describe the case of a 31-year-old patient receiving treatment for Hodgkin Lymphoma with a protocol of Antineoplastic Chemotherapy made up of four drugs...