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Intellectual functioning in children with epilepsy: Frontal lobe epilepsy, childhood absence epilepsy and benign epilepsy with centro-temporal spikes

Lopes, Ana Filipa; Simões, Mário Rodrigues; Monteiro, José Paulo; Fonseca, Maria José; Martins, Cristina; Ventosa, Lurdes; Lourenço, Laura; Robalo, Conceição
Fonte: Elsevier Publicador: Elsevier
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
36.98%
Purpose The purpose of our study is to describe intellectual functioning in three common childhood epilepsy syndromes – frontal lobe epilepsy (FLE), childhood absence epilepsy (CAE) and benign epilepsy with centro-temporal spikes (BECTS). And also to determine the influence of epilepsy related variables, type of epilepsy, age at epilepsy onset, duration and frequency of epilepsy, and treatment on the scores. Methods Intellectual functioning was examined in a group of 90 children with epilepsy (30 FLE, 30 CAE, 30 BECTS), aged 6–15 years, and compared with a control group (30). All subjects obtained a Full Scale IQ ≥ 70 and they were receiving no more than two antiepileptic medications. Participants completed the Wechsler Intelligence Scale for Children – Third Edition. The impact of epilepsy related variables (type of epilepsy, age at epilepsy onset, duration of epilepsy, seizure frequency and anti-epileptic drugs) on intellectual functioning was examined. Results Children with FLE scored significantly worse than controls on WISC-III Verbal IQ, Full Scale IQ and Processing Speed Index. There was a trend for children with FLE to have lower intelligence scores than CAE and BECTS groups. Linear regression analysis showed no effect for age at onset...

Estudo de neurotransmissores relacionados à depressão e psicose em amostras de cérebro humano de pacientes submetidos à cirurgia por epilepsia de lobo temporal; Neurotransmitters related to depression and psychosis in human brain samples of patients submitted to surgery for temporal lobe epilepsy study.

Scherer, Edson Arthur
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 09/05/2008 PT
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36.92%
A epilepsia é um transtorno do funcionamento cerebral caracterizado por crises epilépticas recorrentes que acomete cerca de 1 a 2% da população mundial. A epilepsia do lobo temporal (ELT) é o subtipo mais prevalente. A refratariedade aos medicamentos é comum e cerca de 40 % destes pacientes apresentam transtornos psiquiátricos. Neste trabalho utilizamos o método de TacMan real time PCR para quantificar o mRNA de subtipos dos receptores de noradrenalina, dopamina, serotonina e substância P em hipocampos cirurgicamente removidos de pacientes com ELT para conhecer o papel destes na ELT com ou sem comorbidade psiquiátrica (depressão ou psicose). Nossa amostra foi de 48 pacientes com ELT sem (Epilepsia - 24) ou com comorbidade psicótica (Psicose - 10) ou depressiva (Depressão - 14) e 8 Controles (necrópsias). O receptor adrenérgico-α2A (AD2A) apresentou diferença entre os grupos (p = 0,0059) com significância para a variável Antiepiléptico (p = 0,0374) e pós-teste significante de maior expressão do mRNA de AD2A no grupo Epilepsia comparado com Controle e com Psicose. A ativação dos receptores α2A no hipocampo pelos antiepilépticos pode explicar nossos achados do grupo Epilepsia comparado ao Controle, corroborando a literatura acerca do AD2A na epilepsia e em relação aos antiepilépticos. O AD2C mostrou diferença entre os grupos (p = 0...

Epilepsia : prevalencia, caracteristicas epidemiologicas e lacuna de tratamento farmacologico; Epilepsy: prevalence, epidemiologic characteristics and pharmacological treatment gap

Ana Lucia Andrade Noronha Kanashiro
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 30/06/2006 PT
Relevância na Pesquisa
36.93%
A prevalência de epilepsia ao redor do mundo é estimada em 10/1.000 pessoas; no entanto, o acesso ao tratamento é muito variável. Muitas pessoas não são tratadas, principalmente nos países com desenvolvimento não equilibrado entre as diversas áreas. No Brasil, os estudos epidemiológicos realizados até o momento não haviam abordado o assunto da lacuna de tratamento farmacológico, sendo que este nunca houvera sido medido e suas causas não haviam ainda sido estudadas. Este trabalho teve como objetivo: 1) definir a prevalência da epilepsia em duas áreas urbanas do sudeste do Brasil; 2) definir a lacuna de tratamento farmacológico em pessoas com epilepsia ativa identificadas nessas regiões e 3) extrapolar os dados epidemiológicos encontrados para o Brasil. Foi realizada uma estimativa da lacuna de tratamento da epilepsia, de forma indireta, que nos motivou a investigar melhor a epidemiologia da condição. Posteriormente, nós realizamos um levantamento epidemiológico, utilizando um questionário de rastreamento (sensibilidade 95,8%, especificidade 97,8%) e um questionário validado para classificação sócio-econômica, para determinar a prevalência e a lacuna de tratamento da epilepsia e a influência do fator sócio-econômico sobre elas...

Avaliação neuropsicológica de crianças com epilepsia rolândica : funções executivas; Neuropsychological assessment of children with rolandic epilepsy : executive functions

Marina Liberalesso Neri
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 16/02/2012 PT
Relevância na Pesquisa
36.93%
A epilepsia benigna da infância com pontas centrotemporais (EBIPCT) ou rolândica (ER) é a forma mais freqüente de epilepsia na infância e é classificada como sendo focal, genética e de evolução benigna. Apesar de não haver déficit intelectual, essas crianças podem apresentar alterações cognitivas específicas. O presente estudo teve como objetivos: identificar e descrever alterações de funções executivas em crianças com ER e verificar a influência de variáveis clínicas da epilepsia nas funções executivas. Os participantes foram submetidos à aplicação de testes de funções executivas. Foram incluídas crianças com diagnóstico clínico e eletroencefalográfico de ER. A maioria dos pacientes estava controlada e muitos deles encontravam-se sem medicação. Os resultados obtidos foram comparados com os de um grupo de crianças de um grupo-controle (GC) constituído de indivíduos normais, com idade e nível sócio-educacional semelhantes ao das crianças com epilepsia. Os dados coletados nos dois grupos foram analisados e comparados através dos testes estatísticos: Mann-Whitney, teste Qui-quadrado e teste Exato de Fisher. Os resultados mostraram que quanto aos dados numéricos crianças com ER obtiveram pior desempenho em cinco das seis categorias consideradas do Wisconsin Card Sorting Test (WCST): nº de erros...

Epilepsy in children with cerebral palsy

Bruck,Isac; Antoniuk,Sérgio Antônio; Spessatto,Adriane; Bem,Ricardo Schmitt de; Hausberger,Romeu; Pacheco,Carlos Gustavo
Fonte: Academia Brasileira de Neurologia - ABNEURO Publicador: Academia Brasileira de Neurologia - ABNEURO
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2001 EN
Relevância na Pesquisa
36.92%
OBJECTIVE: To describe the prevalence and characteristics of epilepsy in patients with cerebral palsy in a tertiary center. METHODS: a total of 100 consecutive patients with cerebral palsy were retrospectively studied. Criteria for inclusion were follow-up period for at least 2 years. Types and incidence of epilepsy were correlated with the different forms of cerebral palsy. Other factors associated with epilepsy such as age of first seizure, neonatal seizures and family history of epilepsy were also analysed. RESULTS: follow-up ranged between 24 and 151 months (mean 57 months). The overall prevalence of epilepsy was 62%. Incidence of epilepsy was predominant in patients with hemiplegic and tetraplegic palsies: 70.6% and 66.1%, respectively. First seizure occurred during the first year of life in 74.2% of patients with epilepsy. Generalized and partial were the predominant types of epilepsy (61.3% and 27.4%, respectively). Thirty-three (53.2%) of 62 patients were seizure free for at least 1 year. Neonatal seizures and family history of epilepsy were associated with a higher incidence of epilepsy. CONCLUSIONS: epilepsy in cerebral palsy can be predicted if seizures occur in the first year of life, in neonatal period and if there is family history of epilepsy.

Teachers perception about epilepsy

Fernandes,Paula T.; Noronha,Ana L.A.; Araújo,Ulisses; Cabral,Paula; Pataro,Ricardo; de Boer,Hanneke M.; Prilipko,Leonid; Sander,Josemir W.; Li,Li M.
Fonte: Academia Brasileira de Neurologia - ABNEURO Publicador: Academia Brasileira de Neurologia - ABNEURO
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2007 EN
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36.93%
PURPOSE: To identify in a town of Brazil the knowledge, attitude and perception of epilepsy in teachers of elementary schools and to compare these before and after a training exercise. METHODS: Teachers of nine public schools of Barão Geraldo, Campinas, Brazil completed a questionnaire. Two researchers had meetings with teachers, presenting the Global Campaign "Epilepsy out of the shadows", when the questionnaire was first completed by all attendees. Twenty teachers of these schools were motivated to attend a training course entitled "Epilepsy and Health" as part of their continuous education programme. Two years later the same questionnaire was again completed (post-test) by these 20 teachers. RESULTS: 100 teachers originally completed the questionnaire (97 women, mean age 42 years, 64 married). Forty-three percent of teachers said that they had enough knowledge regarding epilepsy and 20% said that they had poor knowledge about the condition. Regarding the IQ of children with epilepsy, 45% of teachers believed that they had average IQ, 18% above average, six percent under average and 29% did not know. Teachers believed that children with epilepsy have a higher possibility of acquiring mental disease in the future (51%); that epilepsy is a disease (68%); that epilepsy is contagious (1%); epilepsy is treatable (90%). After the course...

Patterns of depressive symptoms in epilepsy

Triantafyllou,Nikolaos I.; Gatzonis,Stergios; Kararizou,Evangelia; Papageorgiou,Charalampos C.
Fonte: Academia Brasileira de Neurologia - ABNEURO Publicador: Academia Brasileira de Neurologia - ABNEURO
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2013 EN
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36.93%
Objective: The purpose of this study was to determine the nature and extent of depressive symptoms among patients with epilepsy. Methods: Ninety patients were investigated over a three-month period: 42 were suffering from generalized epilepsy, 29 from focal epilepsy and 19 from undetermined epilepsy. All completed the Zung self-rating scale for assessment of the depressive symptoms. Results: Sixty-seven patients felt stigmatized because of epilepsy (67%): 73.6% in the undetermined epilepsy group, 55.1% in the focal epilepsy group and 88% in the generalized epilepsy group. Moreover, among the 90 epileptic patients studied, symptoms of irritability, indecisiveness, personal devaluation and emptiness showed a constant increasing trend for their presence from the undetermined epilepsy group through the generalized epilepsy group to the focal epilepsy group. Conclusions: These findings indicate that although the focal epilepsy patients felt less stigmatized, they did not differ greatly in terms of depressive symptoms, in relation to the undetermined epilepsy and generalized epilepsy patients.

Genetics of Epilepsy in Clinical Practice

Berkovic, Samuel F.
Fonte: American Epilepsy Society Publicador: American Epilepsy Society
Tipo: Artigo de Revista Científica
Publicado em //2015 EN
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46.68%
Genetics should now be part of everyday clinical epilepsy practice. Good data exist to provide empiric risks based on epilepsy syndrome diagnosis. Investigation of the molecular basis of some epilepsies is now a practical clinical task and is of clear value to the patient and family. In some cases, specific therapeutic decisions can now be made based on genetic findings, and this scenario of precision therapy is likely to increase in the coming years.

Clinical Genetic Testing in Epilepsy

Mefford, Heather C.
Fonte: American Epilepsy Society Publicador: American Epilepsy Society
Tipo: Artigo de Revista Científica
Publicado em //2015 EN
Relevância na Pesquisa
46.6%
New technologies for mutation detection in the human genome have greatly increased our understanding of epilepsy genetics. Application of genomic technologies in the clinical setting allows for more efficient genetic diagnosis in some patients; therefore, it is important to understand the types of tests available and the types of mutations that can be detected. Making a genetic diagnosis improves overall patient care by enhancing prognosis and recurrence risk counseling and informing treatment decisions.

Autism and Cognition Within Epilepsy: Social Matters

Tuchman, Roberto
Fonte: American Epilepsy Society Publicador: American Epilepsy Society
Tipo: Artigo de Revista Científica
Publicado em //2015 EN
Relevância na Pesquisa
46.89%
The association of epilepsy, autism spectrum disorders (ASD), and intellectual disability (ID) is well recognized. There is a wide range of social-cognitive deficits that can be identified in epilepsy over the life-span, from ASD in infants with an epileptic encephalopathy, to social-cognitive impairments affecting social interaction and comprehension in those with normal nonsocial cognitive function. Identifying ASD and social-cognitive deficits is an important aspect of comprehensive epilepsy care. There are behavioral and educational interventions that exist to treat ASD and social-cognitive deficits. These behavioral, communication, and educational interventions, in conjunction with medications to treat the seizures, should be considered an integral part of the comprehensive management of epilepsy throughout the life-span. The following are the key points of this review: Autism spectrum disorders and social-cognitive deficits are associated with epilepsy throughout the life-span, and identification of these deficits is an important part of epilepsy care.Children with an epileptic encephalopathy such as infantile spasms are at high risk for developing ASD, and the social-cognitive deficits that precede ASD may be recognized in the first year of life.In epilepsy...

Autism and Epilepsy: Exploring the Relationship Using Experimental Models

Stafstrom, Carl E.; Benke, Tim A.
Fonte: American Epilepsy Society Publicador: American Epilepsy Society
Tipo: Artigo de Revista Científica
Publicado em //2015 EN
Relevância na Pesquisa
46.73%
The common co-occurrence of autism and epilepsy suggests that certain neurobiological mechanisms are shared between these disorders. In particular, the profusion of novel genetic mutations being discovered in autism and epilepsy points to abnormalities in synapse formation and function that alter the balance between neuronal excitation and inhibition. Animal models can be informative in sorting out the medical and behavioral complexities in autism and epilepsy and the relationship between them. As mechanistic information accrues, it is anticipated that mutation- and pathway-specific targeted treatments can be developed.

Accounting for Comorbidity in Assessing the Burden of Epilepsy Among US Adults: Results from the National Comorbidity Survey Replication (NCS-R)

Lane, Michael C.; Stang, Paul E.; Kessler, Ronald; Shahly, Vicki
Fonte: Nature Publishing Group Publicador: Nature Publishing Group
Tipo: Artigo de Revista Científica
EN_US
Relevância na Pesquisa
36.92%
Although epilepsy is associated with substantial role impairment, it is also highly comorbid with other physical and mental disorders, making unclear the extent to which impairments associated with epilepsy are actually due to comorbidities. This issue was explored in the National Comorbidity Survey Replication (NCS-R), a nationally representative household survey of 5,692 US adults. Medically-recognized epilepsy was ascertained with self-report, comorbid physical disorders with a chronic conditions checklist, and comorbid DSM-IV mental disorders with the Composite International Diagnostic Interview (CIDI). Lifetime epilepsy prevalence was estimated at 1.8%. Epilepsy was comorbid with numerous neurological and general medical conditions and with a sporadic cluster of mental comorbidities (panic, PTSD, conduct disorder, and substance use disorders). Although comorbid disorders explain part of the significant gross associations of epilepsy with impairment, epilepsy remains significantly associated with work disability, cognitive impairment, and days of role impairment after controlling comorbidities. The net association of epilepsy with days of role impairment after controlling for comorbidities is equivalent to an annualized 89.4 million excess role impairment days among US adults with epilepsy...

Clinical Characteristics of Children with Autism Spectrum Disorder and Co-Occurring Epilepsy

Viscidi, Emma W.; Triche, Elizabeth W.; Pescosolido, Matthew F.; McLean, Rebecca L.; Joseph, Robert M.; Spence, Sarah J.; Morrow, Eric M.
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
EN_US
Relevância na Pesquisa
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Objectives: To estimate the prevalence of epilepsy in children with Autism Spectrum Disorder (ASD) and to determine the demographic and clinical characteristics of children with ASD and epilepsy in a large patient population. Methods: Cross-sectional study using four samples of children with ASD for a total of 5,815 participants with ASD. The prevalence of epilepsy was estimated from a population-based sample. Children with and without epilepsy were compared on demographic and clinical characteristics. Multivariate logistic regression was used to examine the association between demographic and clinical characteristics and epilepsy. Results: The average prevalence of epilepsy in children with ASD 2–17 years was 12.5%; among children aged 13 years and older, 26% had epilepsy. Epilepsy was associated with older age, lower cognitive ability, poorer adaptive and language functioning, a history of developmental regression and more severe ASD symptoms. The association between epilepsy and the majority of these characteristics appears to be driven by the lower IQ of participants with epilepsy. In a multivariate regression model, only age and cognitive ability were independently associated with epilepsy. Children age 10 or older had 2.35 times the odds of being diagnosed with epilepsy (p<.001) and for a one standard deviation increase in IQ...

Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A

Kasperavičiute, D.; Catarino, C.B.; Matarin, M.; Leu, C.; Novy, J.; Tostevin, A.; Leal, B.; Hessel, E.V.S.; Hallmann, K.; Hildebrand, M.S.; Dahl, H-H.M.; Ryten, M.; Trabzuni, D.; Ramasamy, A.; Alhusaini, S.; Doherty, C.P.; Dorn, T.; Hansen, J.; Krämer,
Fonte: Oxford University Press (OUP) Publicador: Oxford University Press (OUP)
Tipo: Artigo de Revista Científica
Publicado em 06/09/2013 ENG
Relevância na Pesquisa
36.93%
Epilepsy comprises several syndromes, amongst the most common being mesial temporal lobe epilepsy with hippocampal sclerosis. Seizures in mesial temporal lobe epilepsy with hippocampal sclerosis are typically drug-resistant, and mesial temporal lobe epilepsy with hippocampal sclerosis is frequently associated with important co-morbidities, mandating the search for better understanding and treatment. The cause of mesial temporal lobe epilepsy with hippocampal sclerosis is unknown, but there is an association with childhood febrile seizures. Several rarer epilepsies featuring febrile seizures are caused by mutations in SCN1A, which encodes a brain-expressed sodium channel subunit targeted by many anti-epileptic drugs. We undertook a genome-wide association study in 1018 people with mesial temporal lobe epilepsy with hippocampal sclerosis and 7552 control subjects, with validation in an independent sample set comprising 959 people with mesial temporal lobe epilepsy with hippocampal sclerosis and 3591 control subjects. To dissect out variants related to a history of febrile seizures, we tested cases with mesial temporal lobe epilepsy with hippocampal sclerosis with (overall n = 757) and without (overall n = 803) a history of febrile seizures. Meta-analysis revealed a genome-wide significant association for mesial temporal lobe epilepsy with hippocampal sclerosis with febrile seizures at the sodium channel gene cluster on chromosome 2q24.3 [rs7587026...

Avaliando a autoestima de adolescentes com epilepsia; Evaluating the self esteem of adolescents with epilepsy

Nathália Ferreira Siqueira
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 15/07/2010 PT
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36.93%
A epilepsia passa a significar perdas em diferentes áreas: física, saúde, emprego, relações sociais e familiares. Autoestima e autoconfiança também são afetadas. O presente trabalho teve como principal objetivo avaliar e comparar a autoestima dos adolescentes com epilepsia e sem epilepsia. Também objetivou-se avaliar e relacionar a qualidade de vida com a autoestima no adolescente com epilepsia. Variáveis clinicas e demográficas e aspectos relacionados a representação da doença foram considerados. Esse estudo avaliou 67 adolescentes, de ambos os sexos, na faixa etária de 11 a 18 anos, 37 pacientes assistidos no ambulatório de Neurologia/ HC da Unicamp com diagnostico de epilepsia e 30 adolescentes sem este diagnostico que frequentavam escolas publicas na região de Campinas-SP. O critério de inclusão do estudo foi: ter diagnostico de epilepsia há mais de dois anos para o grupo com epilepsia e não ter epilepsia para o grupo sem epilepsia e habilidade para responder questões por eles mesmos. O critério de exclusão para os dois grupos foi: não ser portador de outras doenças neurológicas progressivas ou doenças psiquiátricas evidentes, não terem se submetido a cirurgia no cérebro, não fazerem uso de medicações que pudessem afetar o sistema nervoso central...

Morte e epilepsia : estudo dos registros de óbito de pessoas com epilepsia; Death and epilepsy : study of death records of people with epilepsy

Priscila Moraes de Paula Toledo Porto
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 16/12/2010 PT
Relevância na Pesquisa
36.95%
A epilepsia é considerada como um sério problema de saúde pública com um risco de mortalidade precoce 2 ou 3 vezes superior à população. Historicamente, a mortalidade por epilepsia, c uma questão negligenciada e as mortes relacionadas com a epilepsia não são bem compreendidas. Esse processo social de desconhecimento resulta na subestimação da morte sem considerar que, em sua grande maioria é um evento que pode ser evitado e prevenido, o que dificulta ainda mais a adoção de medidas adequadas de controle e manejo que previnam essa morte. A hipótese que se sugere é que o problema de subregistro que tem sido evidenciada em outros estudos de mortalidade esteja acontecendo principalmente em relação ã epilepsia nas estatísticas oficiais. Apesar de o Brasil estar entre um dos poucos países emergentes que disponibiliza grande quantidade de informações de saúde, as fontes de dados geradas pelos diferentes sistemas de informação não se relacionam, tornando as informações vitais dispersas e desarticuladas entre os sistemas. Entre algumas estratégias utilizadas por países que apresentam estatísticas de qualidade discutível, cita-se o relacionamento de bancos de dados que visa agregar várias informações provenientes de diversas fontes relacionadas ao indivíduo e o estudo de causas múltiplas de morte que considera todas as condições que contribuíram para a morte levando em conta todas as causas mencionadas na declaração de óbito. É objetivo deste estudo analisar conjuntamente todas as causas declaradas na declaração de óbito...

Epilepsy and physical exercise

Pimentel, J; Tojal, R; Morgado, J
Fonte: British Epilepsy Association Publicador: British Epilepsy Association
Tipo: Artigo de Revista Científica
Publicado em //2015 ENG
Relevância na Pesquisa
46.81%
Epilepsy is one of the commonest neurologic diseases and has always been associated with stigma. In the interest of safety, the activities of persons with epilepsy (PWE) are often restricted. In keeping with this, physical exercise has often been discouraged. The precise nature of a person's seizures (or whether seizures were provoked or unprovoked) may not have been considered. Although there has been a change in attitude over the last few decades, the exact role of exercise in inducing seizures or aggravating epilepsy still remains a matter of discussion among experts in the field. Based mainly on retrospective, but also on prospective, population and animal-based research, the hypothesis that physical exercise is prejudicial has been slowly replaced by the realization that physical exercise might actually be beneficial for PWE. The benefits are related to improvement of physical and mental health parameters and social integration and reduction in markers of stress, epileptiform activity and the number of seizures. Nowadays, the general consensus is that there should be no restrictions to the practice of physical exercise in people with controlled epilepsy, except for scuba diving, skydiving and other sports at heights. Whilst broader restrictions apply for patients with uncontrolled epilepsy...

Taking Sides: Physician's Perceptions on the Use of the Wada Test in Epilepsy Surgery—Q-PULSE Survey Commentary

Quigg, Mark
Fonte: American Epilepsy Society Publicador: American Epilepsy Society
Tipo: Artigo de Revista Científica
Publicado em //2015 EN
Relevância na Pesquisa
46.68%
The recent Q-PULSE Survey compiled by Chad Carlson asked members to place the Wada test (bilateral intracarotid amobarbital test) in the context of the current practice of epilepsy surgery. Historically, the Wada test has three purposes: to lateralize language, to assess the risk of memory loss after epilepsy surgery, and to help provide predictive data in localization of the epileptic focus.

Evidence-Based Guideline Update: Vagus Nerve Stimulation for the Treatment of Epilepsy: Report of the Guideline Development Subcommittee of the American Academy of Neurology

Morris, George L.; Gloss, David; Buchhalter, Jeffrey; Mack, Kenneth J.; Nickels, Katherine; Harden, Cynthia
Fonte: American Epilepsy Society Publicador: American Epilepsy Society
Tipo: Artigo de Revista Científica
Publicado em //2013 EN
Relevância na Pesquisa
46.81%
OBJECTIVE: To evaluate the evidence since the 1999 assessment regarding efficacy and safety of vagus nerve stimulation (VNS) for epilepsy, currently approved as adjunctive therapy for partial-onset seizures in patients >12 years. METHODS: We reviewed the literature and identified relevant published studies. We classified these studies according to the American Academy of Neurology evidence-based methodology. RESULTS: VNS is associated with a >50% seizure reduction in 55% (95% confidence interval [CI] 50%–59%) of 470 children with partial or generalized epilepsy (13 Class III studies). VNS is associated with a >50% seizure reduction in 55% (95% CI 46%–64%) of 113 patients with Lennox-Gastaut syndrome (LGS) (4 Class III studies). VNS is associated with an increase in ≥50% seizure frequency reduction rates of ~7% from 1 to 5 years postim-plantation (2 Class III studies). VNS is associated with a significant improvement in standard mood scales in 31 adults with epilepsy (2 Class III studies). Infection risk at the VNS implantation site in children is increased relative to that in adults (odds ratio 3.4, 95% CI 1.0–11.2). VNS is possibly effective for seizures (both partial and generalized) in children, for LGS-associated seizures...

Epilepsy and work: when the epilepsy should be considered incapacitating?; Epilepsia e trabalho: quando a epilepsia deve ser considerada incapacitante?

Miziara, Carmen Silvia Molleis Galego; Miziara, Ivan Dieb; Muñoz, Daniel Romero
Fonte: Universidade de São Paulo. Faculdade de Medicina Publicador: Universidade de São Paulo. Faculdade de Medicina
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ART.; Formato: application/pdf
Publicado em 07/12/2011 POR
Relevância na Pesquisa
36.93%
Epilepsy is a brain disorder characterized predominantly by the disruption of normal brain function, recurrent and unpredictable, called the seizure. It is a variety of disorders reflecting the basic brain dysfunction, which may result from different etiologias 1. It is one of the most common causes of brain disorders, affecting 50 million people around the world 2, and represents a personal and social burden. The possibility of physical injuries due seizures, social exclusion, stigma, and psychological disorders are some factors that also contribute to the compromised employment position of person with epilepsy; and their effects may be felt particularly hard in areas or times of high employment. A Brazilian study indicates that 36% of individuals with epilepsy are out of work due to illness or retired 4. But epilepsy is not always a condition of incapacity to work. Epilepsy is considered incapacitating when one or more life activity is substantially limited, among them the job. The objective of this study was to analyze the main factors of work absenteeism of people with epilepsy. The methodology applied was the literature review, in the main databases- “PUBMED” and “BIREME,” with access to other bases “LILACS”, “IBECS”...