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Manifestações extra-intestinais em doença de Crohn e retocolite ulcerativa: prevalência e correlação com o diagnóstico, extensão, atividade, tempo de evolução da doença; Extra-intestinal manifestations in Crohn disease and ulcerative rectocolitis: prevalence and correlation with diagnosis, extension, activity, disease evolution time

Mota, Erodilho Sande
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 09/01/2008 PT
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INTRODUÇÃO: As doenças inflamatórias intestinais têm chamado a atenção da comunidade científica pela multiplicidade de manifestações no trato digestivo, manifestações extra-intestinais e pela sua incidência em ascensão. Existe uma grande prevalência de manifestações extra-intestinais em portadores de doença de Crohn e de retocolite ulcerativa, variando na literatura de 24 a 65%. Estas alterações podem surgir antes dos sintomas intestinais, concomitante ou ulteriormente, podendo ou não ter relação com a atividade da doença intestinal. O conhecimento destas manifestações extra-intestinais assim como seu quadro clínico, evolução e tratamento é importante, devido ao aumento da morbidade e mortalidade desencadeada por elas. OBJETIVO: Objetivou-se neste trabalho determinar a prevalência de manifestações extra-intestinais em retocolite ulcerativa e doença de Crohn, correlacionando com diagnóstico do tipo de doença inflamatória intestinal, extensão, tempo de evolução e aparecimento dos sintomas, sexo e atividade da doença. MÉTODOS: Os pacientes que participaram do estudo estão cadastrados no Ambulatório de Doenças Inflamatórias do Serviço de Cirurgia do Cólon, Reto e Ânus do Departamento de Gastroenterologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo de setembro de 1984 até setembro de 2004. Os dados para a pesquisa foram colhidos retrospectivamente de mil protocolos que foram preenchidos em caráter prospectivo na primeira consulta do doente e atualizados em consultas subsequentes. Foram estudadas as manifestações articulares...

Fatores associados à doença renal crônica em pacientes internados em um hospital universitário na cidade de São Paulo; Factors associated with chronic kidney disease among hospitalized patients in a university hospital in the city of São Paulo

Pinho, Natália Alencar de
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 14/06/2013 PT
Relevância na Pesquisa
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Introdução: a doença renal crônica constitui importante problema de saúde pública mundial. Contudo, pouco se sabe sobre suas características em nosso meio. Objetivo: identificar os fatores associados à doença renal crônica em pacientes internados em um hospital universitário. Método: foram selecionados, aleatoriamente, 386 pacientes que constituíram dois grupos: com e sem doença renal crônica. A doença renal crônica foi definida pela presença de diagnóstico médico ou antecedente pessoal. Os dados foram obtidos do prontuário do paciente. Foram comparados os grupos com e sem doença renal crônica e os hipertensos com e sem doença renal crônica, mediante as variáveis de estudo. Estimou-se a taxa de filtração glomerular (eTFG) dos pacientes sem doença renal a partir das equações Modification of Diet in Renal Disease abreviada (MDRD4) e Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). Verificou-se a associação da eTFG <90 mL/min/1,73m², pela MDRD4, com dados biossociais e comorbidades. O nível de significância foi de p<0,05. Resultados: a amostra foi 50,5% homens, 64,4% brancos, 50,7% com companheiro e idade de 58,2±18,6 anos. Os pacientes com doença renal crônica se distinguiram daqueles sem a doença (p<0...

Survey for Foot-and-mouth Disease in the Endangered Marsh Deer (Blastocerus dichotomus) from Marshlands of the Parana River Basin, Brazil

Pessoa Araujo, Joao; Nogueira, Marcia F.; Duarte, Jose M. B.
Fonte: Wildlife Disease Assoc, Inc Publicador: Wildlife Disease Assoc, Inc
Tipo: Artigo de Revista Científica Formato: 939-943
ENG
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Habitat fragmentation and diseases have resulted in a decline of the marsh deer (Blastocerus (dichotomus) throughout its South American range. Our objectives were to determine whether marsh deer intended for translocation from a region of the Rio Parana Basin had been infected previously by foot-and-mouth disease virus (FMDV) and whether they were carrying virus We captured marsh deer from June to October 1998 and collected blood from 108 animals and esophageal-pharyngeal fluid from 53 Serum was tested for antibodies against three FMDV serotypes (O, A, and C) by liquid-phase-blocking sandwich enzyme-linked immunosorbent assay (ELISA) Esophageal-pharyngeal fluid was tested for FMDV RNA by reverse transcription polymerase chain reaction (RT-PCR) and inoculation into three successive baby hamster kidney (BHK-21) cell subcultures, followed by RT-PCR of cultures We detected low log(10) titers (range 1 0-1 5) to FM DV subtype A(24) Cruzeiro in 19 of 108 sampled marsh deer, but failed to isolate FMDV or detect FMDV RNA in any samples we conclude that marsh deer from our study site were unlikely to carry FMDV, however, as a preventive measure, the 19 animals with titers for FMDV were not sent to FMDV-free Brazilian states

Pine wilt disease: global issues, trade and economic impact

Webster, Jonh; MOTA, Manuel
Fonte: Springer Publicador: Springer
Tipo: Parte de Livro
ENG
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Pine wilt disease (PWD) is perhaps the most serious threat to pine forests worldwide. Since it´s discovery in the early XXth century by Japanese forest researchers, and the relationship with its causative agent, the pinewood nematode (PWN) Bursaphelenchus xylophilus, in the 1970s, PWD has wreaked havoc wherever it appears. Firstly in the Far East (Japan, China and Korea) and now, more recently in 1999, in the EU (Portugal). The forest sector in Portugal plays a major role in the Portuguese economy with a 12% contribution to the industrial gross domestic product, 3.2% of the gross domestic product, 10% of foreign trade and 5% of national employment. Maritime pine (Pinus pinaster) is one of the most important pine productions, and industrial activity, such as the production of wood and resin, as well as coastal protection associated with sand dunes. Also, stone pine (Pinus pinea) plays an important role in the economy with a share derived from the exports of high-quality pineon seed. Thus, the tremendous economical and ecological impact of the introduction of a pest and pathogen such as the PWN, although as far as is known, the only species susceptible to the nematode is maritime pine. Immediately following detection, the research team involved (Univ. Évora...

The diagnostic value of circulating microRNAs for middle-aged (40–60-year-old) coronary artery disease patients

Sayed,Ali Sheikh Md; Xia,Ke; Li,Fei; Deng,Xu; Salma,Umme; Li,Tingbo; Deng,Hai; Yang,Dafeng; Haoyang,Zhou; Yang,TianLun; Peng,Jun
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2015 EN
Relevância na Pesquisa
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OBJECTIVE: Circulating microRNAs have been recognized as promising biomarkers for various diseases. The present study aimed to explore the potential roles of circulating miR-149, miR-424 and miR-765 as non-invasive biomarkers for the diagnosis of coronary artery disease in middle-aged (40–60-year-old) patients. METHODS: Sixty-five stable coronary artery disease patients (49–57 years old), 30 unstable coronary artery disease patients (49–58 years old), and 32 non-coronary artery disease patients (49–-57 years old) who were matched for age, sex, smoking habits, hypertension and diabetes were enrolled in this study. Total RNA was isolated from plasma with TRIzol reagent. Circulating miRNA levels were measured by quantitative real-time polymerase chain reaction. RESULTS: Circulating miR-149 levels were decreased 4.49-fold in stable coronary artery disease patients (1.18 ± 0.84) and 5.09-fold in unstable coronary artery disease patients (1.04 ± 0.65) compared with non-coronary artery disease patients (5.30 ± 2.57) (p<0.001). Circulating miR-424 levels were reduced 3.6-fold in stable coronary artery disease patients (1.18 ± 0.60) and 5-fold in unstable coronary artery disease patients (0.86 ± 0.54) compared with non-coronary artery disease patients (4.35 ± 2.20) (p<0.001). In contrast...

The association between primary biliary cirrhosis and coeliac disease: a study of relative prevalences

Kingham, J; Parker, D
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /01/1998 EN
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Background—Coexistent primary biliary cirrhosis (PBC) and coeliac disease has been recorded but the association has not been systematically studied. 
Aims—To determine relative prevalences of PBC and coeliac disease in a defined population over a 12 year period. 
Patients and methods—All patients with PBC or coeliac disease in a stable population of 250 000 in South Wales were identified from a clinical register and laboratory records. 
Results—Sixty seven patients with PBC and 143 patients with coeliac disease have been diagnosed and followed over a median of 86 (4-135) months; point prevalences in 1996 were 20 per 100 000 for PBC and 54 per 100 000 for coeliac disease. PBC in patients with coeliac disease was sought by investigating abnormal liver function tests. Ten (7%) had persistent abnormalities and three had PBC. Coeliac disease in patients with PBC was sought by investigating malabsorption, haematinic deficiency, positive antigliadin antibody, or coeliac disease family history. Eleven patients underwent duodenal biopsy revealing one further coeliac disease case. Four patients (three women) have both conditions giving a point prevalence for patients with both conditions of 1.6 per 100 000 (95% confidence limits 0.44 to 4.1 per 100 000). Prevalence of PBC in patients with coeliac disease was 3% and of coeliac disease in patients with PBC was 6%. 
Conclusion—A 12 year study of a stable 250 000 population revealed a relative prevalence of PBC in 3% of 143 patients with coeliac disease and of coeliac disease in 6% of 67 patients with PBC. PBC and coeliac disease are therefore associated. Screening for PBC in patients with coeliac disease using antimitochondrial antibody testing and screening for coeliac disease in patients with PBC with antigliadin antibody testing or duodenal biopsy are recommended. 



The Association of Meningococcal Disease with Influenza in the United States, 1989–2009

Jacobs, Jessica Hartman; Viboud, Cécile; Tchetgen, Eric Tchetgen; Schwartz, Joel; Steiner, Claudia; Simonsen, Lone; Lipsitch, Marc
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
EN_US
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Importance and Objective Prior influenza infection is a risk factor for invasive meningococcal disease. Quantifying the fraction of meningococcal disease attributable to influenza could improve understanding of viral-bacterial interaction and indicate additional health benefits to influenza immunization. Design, Setting and Participants A time series analysis of the association of influenza and meningococcal disease using hospitalizations in 9 states from 1989–2009 included in the State Inpatient Databases from the Agency for Healthcare Research and Quality and the proportion of positive influenza tests by subtype reported to the Centers for Disease Control. The model accounts for the autocorrelation of meningococcal disease and influenza between weeks, temporal trends, co-circulating respiratory syncytial virus, and seasonality. The influenza-subtype-attributable fraction was estimated using the model coefficients. We analyzed the synchrony of seasonal peaks in hospitalizations for influenza, respiratory syncytial virus, and meningococcal disease. Results and Conclusions In 19 of 20 seasons, influenza peaked≤2 weeks before meningococcal disease, and peaks were highly correlated in time (ρ = 0.95; P <.001). H3N2 and H1N1 peaks were highly synchronized with meningococcal disease while pandemic H1N1...

The diagnostic value of circulating microRNAs for middle-aged (40–60-year-old) coronary artery disease patients

Md Sayed, Ali Sheikh; Xia, Ke; Li, Fei; Deng, Xu; Salma, Umme; Li, Tingbo; Deng, Hai; Yang, Dafeng; Haoyang, Zhou; Yang, TianLun; Peng, Jun
Fonte: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo Publicador: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Tipo: Artigo de Revista Científica
EN_US
Relevância na Pesquisa
35.89%
OBJECTIVE: Circulating microRNAs have been recognized as promising biomarkers for various diseases. The present study aimed to explore the potential roles of circulating miR-149, miR-424 and miR-765 as non-invasive biomarkers for the diagnosis of coronary artery disease in middle-aged (40–60-year-old) patients. METHODS: Sixty-five stable coronary artery disease patients (49–57 years old), 30 unstable coronary artery disease patients (49–58 years old), and 32 non-coronary artery disease patients (49–-57 years old) who were matched for age, sex, smoking habits, hypertension and diabetes were enrolled in this study. Total RNA was isolated from plasma with TRIzol reagent. Circulating miRNA levels were measured by quantitative real-time polymerase chain reaction. RESULTS: Circulating miR-149 levels were decreased 4.49-fold in stable coronary artery disease patients (1.18 ± 0.84) and 5.09-fold in unstable coronary artery disease patients (1.04 ± 0.65) compared with non-coronary artery disease patients (5.30 ± 2.57) (p<0.001). Circulating miR-424 levels were reduced 3.6-fold in stable coronary artery disease patients (1.18 ± 0.60) and 5-fold in unstable coronary artery disease patients (0.86 ± 0.54) compared with non-coronary artery disease patients (4.35 ± 2.20) (p<0.001). In contrast...

Reducing Climate-Sensitive Disease Risks

World Bank
Fonte: Washington, DC Publicador: Washington, DC
EN_US
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Disease risks to humans, animals, and plants are determined by interconnected environmental variables that affect incidence, transmission, and outbreak. Climate change affects many of the environmental variables that lead to disease. Regardless of the species involved, the impacts can ultimately affect the health, livelihood, and economic security of humans. The objective of this World Bank economic and sector work is to build on scientific and operational knowledge of early action tools to help practitioners reduce the risks of key climate-sensitive infectious diseases by strengthening risk management systems for disease outbreaks. The report includes an assessment of known interventions such as the establishment of surveillance systems, the development of region and nation-specific disease outlooks, the creation of climate-sensitive disease risk maps, and the construction and implementation of early warning advisory systems. This research highlights the need for better understanding of the evolving interactions between the environment and emerging and reemerging disease pathogens. It also points to the inseparable interactions between animal health and human health...

Smoking and Periodontal Disease in Vietnamese Middle-Aged Population

Do, Loc Giang
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado Formato: 140305 bytes; 60976 bytes; 215788 bytes; 411575 bytes; 297797 bytes; 85356 bytes; 168652 bytes; 226108 bytes; 106439 bytes; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/
Publicado em //2001 EN
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Current understanding of periodontal disease derives from studies mostly conducted in developed countries. However, the disease process among those studied populations may be confounded by the professional dental care. There have been few attempts to investigate factors related to the disease among populations of developing countries where the natural history of the disease is minimally confounded by care. This imbalance is evident in risk assessment research on the associations between periodontal disease and smoking-one of the most significant risk factors for the disease. Also, most studies on smoking used convenience or purposive samples, which may bias the findings. Therefore, there is a need for research conducted among a representative sample of a developing country. The present study aimed to describe the prevalence, extent and severity of chronic adult periodontitis among representative Vietnamese middle-aged adults. Also, it aimed to investigate smoking, which is highly prevalent in Vietnam, as a risk indicator for periodontal disease in a population with minimal access to dental care. The study was designed as a cross-sectional population-based study with a multistage, stratified random sample with probability of selection proportional to population size. The US National Institute of Dental Research (NIDR) protocol was used to assess loss of periodontal attachment among 575 dentate subjects in two randomly selected provinces. Assessment was made at mesial and buccal sites of every present tooth...

Perception, knowledge & awareness of coronary heart disease among rural Australian women 25 to 65 years of age – a descriptive study.

Crouch, Rosanne
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado
Publicado em //2008
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Context:Heart disease is the leading cause of morbidity and mortality in Australian women. Traditionally, heart disease has been perceived as a man’s disease, where as women’s health issues have historically focused on menopause and breast cancer, leading women to believe that coronary heart disease is not an important health issue for them. Many Australian women fear cancer, although heart disease kills four times more women then breast cancer. The major risk factors for developing heart disease are the same for both men and women. These include hypertension, cigarette smoking, hyperlipidemia, diabetes, obesity, sedentary lifestyle, stress, age, heredity and race. Purpose: The purpose of this study was to: a. Assess rural women’s current level of awareness of heart disease as the leading cause of death in Australian women. b. Describe rural women’s current knowledge and perception of cardiovascular disease as well as actual risk of cardiovascular disease, and c. Evaluate whether heightened awareness and increased knowledge is associated with increased action to lower risk of heart disease. Method: A questionnaire combining questions from three existing questionnaires used in numerous other studies was developed to collect data on perception...

NK, T and NK T-cells in ageing, coeliac disease and inflammatory bowel disease.

Grose, Randall Hilton
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado
Publicado em //2008
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This thesis investigated the number and function of natural killer T-cells (NK T-cells) as a function of age, in coeliac disease, Crohn’s disease and ulcerative colitis. NK T-cells are a newly appreciated class of immune cells that are able to regulate the activity of the broader T-cell population. NK T-cells have been implicated in animal models of autoimmune disease and in human autoimmune disease. A subset of NK cells express the T-cell receptor (TCR) and are termed NK T-cells. In humans a further small subset of NK T-cells express an invariant TCR α chain (Vα24Jα18) and contain the immunoregulatory cell population that is distinguished from classical T-cells by promptly producing interleukin-4 (IL-4). Invariant NK T-cells (iNK T-cells) have the surface phenotype of Vα24+ Vβ11+ T-cells and express CD161+ NK markers. They are CD4+ (single positive; SP) or CD4- (double negative; DN), CD1d restricted and are α-galactosylceramide (α-GalCer) reactive. NKT cells have been implicated in numerous autoimmune disorders. Early work showed a major deficiency of NKT cell numbers in nonobese diabetic (NOD) mice, a well-established model of spontaneous, autoimmune T-cell mediated insulin-dependent diabetes. Both the number of NKT cells and function...

Public health management of increased incidence of meningococcal disease in the Australian Capital Territory: 2003 to 2004

Isaac-Toua, Geethanjali; Guest, Charles; Hiam, Rona; Passaris, Irene
Fonte: National Centre for Disease Control Publicador: National Centre for Disease Control
Tipo: Artigo de Revista Científica
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This paper describes a sudden increase of meningococcal notifications in the Australian Capital Territory within a 3 month period, and the public health strategies used to manage it. There were 15 cases of meningococcal disease notified to the Communicabl

Selective Disruption of the Cerebral Neocortex in Alzheimer's Disease

Desikan, Rahul S.; Schmansky, Nicholas J.; Cabral, Howard J.; Hess, Christopher P.; Weiner, Michael W.; Kemper, Thomas L.; Dale, Anders M.; Sabuncu, Mert R; the Alzheimer’s Disease Neuroimaging Initiative; Reuter, Martin; Biffi, Alessandro; Anderson, Ch
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
EN_US
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Background: Alzheimer's disease (AD) and its transitional state mild cognitive impairment (MCI) are characterized by amyloid plaque and tau neurofibrillary tangle (NFT) deposition within the cerebral neocortex and neuronal loss within the hippocampal formation. However, the precise relationship between pathologic changes in neocortical regions and hippocampal atrophy is largely unknown. Methodology/Principal Findings: In this study, combining structural MRI scans and automated image analysis tools with reduced cerebrospinal fluid (CSF) Aß levels, a surrogate for intra-cranial amyloid plaques and elevated CSF phosphorylated tau (p-tau) levels, a surrogate for neocortical NFTs, we examined the relationship between the presence of Alzheimer's pathology, gray matter thickness of select neocortical regions, and hippocampal volume in cognitively normal older participants and individuals with MCI and AD (n = 724). Amongst all 3 groups, only select heteromodal cortical regions significantly correlated with hippocampal volume. Amongst MCI and AD individuals, gray matter thickness of the entorhinal cortex and inferior temporal gyrus significantly predicted longitudinal hippocampal volume loss in both amyloid positive and p-tau positive individuals. Amongst cognitively normal older adults...

Automated MRI Measures Identify Individuals with Mild Cognitive Impairment and Alzheimer's Disease

Desikan, Rahul S.; Cabral, Howard J.; Hess, Christopher P.; Dillon, William P.; Glastonbury, Christine M.; Weiner, Michael W.; Schmansky, Nicholas J.; Salat, David H.; Greve, Douglas N.; Buckner, Randy Lee; Fischl, Bruce R.; Alzheimer’s Disease Neuroima
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
EN_US
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Mild cognitive impairment can represent a transitional state between normal ageing and Alzheimer's disease. Non-invasive diagnostic methods are needed to identify mild cognitive impairment individuals for early therapeutic interventions. Our objective was to determine whether automated magnetic resonance imaging-based measures could identify mild cognitive impairment individuals with a high degree of accuracy. Baseline volumetric T1-weighted magnetic resonance imaging scans of 313 individuals from two independent cohorts were examined using automated software tools to identify the volume and mean thickness of 34 neuroanatomic regions. The first cohort included 49 older controls and 48 individuals with mild cognitive impairment, while the second cohort included 94 older controls and 57 mild cognitive impairment individuals. Sixty-five patients with probable Alzheimer's disease were also included for comparison. For the discrimination of mild cognitive impairment, entorhinal cortex thickness, hippocampal volume and supramarginal gyrus thickness demonstrated an area under the curve of 0.91 (specificity 94%, sensitivity 74%, positive likelihood ratio 12.12, negative likelihood ratio 0.29) for the first cohort and an area under the curve of 0.95 (specificity 91%...

First epizootic of rabbit hemorrhagic disease in free living populations of Oryctolagus cuniculus at Doñana National Park, Spain

Villafuerte, Rafael; Calvete, C.; Gortázar, Christian; Moreno, Sacramento
Fonte: Wildlife Disease Association Publicador: Wildlife Disease Association
Tipo: Artículo Formato: 543485 bytes; application/pdf
ENG
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4 pages.-- PMID: 8028101 [PubMed].; The first known epizootic of rabbit hemorrhagic disease (RHD) occurred in two free-living wild rabbit (Oryctolagus cuniculus) populations at Donana National Park, Spain. Rabbit population density was not correlated to RHD mortality. Only adult animals were affected; males and females had similar mortality rates.; This paper is a contribution of the Convenio de Cooperación ICONA-CSIC, 1990-92.; Peer reviewed

Baseline and longitudinal grey matter changes in newly diagnosed Parkinson's disease: ICICLE-PD study

Mak, Elijah; Su, Li; Williams, Guy B.; Firbank, Michael J.; Lawson, Rachel A.; Yarnall, Alison J.; Duncan, Gordon W.; Owen, Adrian M.; Khoo, Tien K.; Brooks, David J.; Rowe, James B.; Barker, Roger; Burn, David J.; O'Brien, John T.
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Article; published version
EN
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This is the final version of the article. It first appeared from Oxford University Press via http://dx.doi.org/10.1093/brain/awv211; Mild cognitive impairment in Parkinson?s disease is associated with progression to dementia (Parkinson?s disease dementia) in a majority of patients. Determining structural imaging biomarkers associated with prodromal Parkinson?s disease dementia may allow for the earlier identification of those at risk, and allow for targeted disease modifying therapies. One hundred and five non-demented subjects with newly diagnosed idiopathic Parkinson?s disease and 37 healthy matched controls had serial 3 T structural magnetic resonance imaging scans with clinical and neuropsychological assessments at baseline, which were repeated after 18 months. The Movement Disorder Society Task Force criteria were used to classify the Parkinson?s disease subjects into Parkinson?s disease with mild cognitive impairment (n = 39) and Parkinson?s disease with no cognitive impairment (n = 66). Freesurfer image processing software was used to measure cortical thickness and subcortical volumes at baseline and follow-up. We compared regional percentage change of cortical thinning and subcortical atrophy over 18 months. At baseline, cases with Parkinson?s disease with mild cognitive impairment demonstrated widespread cortical thinning relative to controls and atrophy of the nucleus accumbens compared to both controls and subjects with Parkinson?s disease with no cognitive impairment. Regional cortical thickness at baseline was correlated with global cognition in the combined Parkinson?s disease cohort. Over 18 months...

The role of tau in the pathological process and clinical expression of Huntington?s disease

Vuono, Romina; Winder-Rhodes, Sophie; de Silva, Rohan; Cisbani, Giulia; Drouin-Ouellet, Janelle; REGISTRY Investigators of the European Huntington?s Disease Network; Spillantini, Maria G.; Cicchetti, Francesca; Barker, Roger A.
Fonte: OUP Publicador: OUP
Tipo: Article; published version
EN
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This is the final version of the article. It was first available from Oxford University Press viahttp://dx.doi.org/10.1093/brain/awv107; Huntington's disease is a neurodegenerative disorder caused by an abnormal CAG repeat expansion within exon 1 of the huntingtin gene HTT. While several genetic modifiers, distinct from the Huntington's disease locus itself, have been identified as being linked to the clinical expression and progression of Huntington's disease, the exact molecular mechanisms driving its pathogenic cascade and clinical features, especially the dementia, are not fully understood. Recently the microtubule associated protein tau, MAPT, which is associated with several neurodegenerative disorders, has been implicated in Huntington's disease. We explored this association in more detail at the neuropathological, genetic and clinical level. We first investigated tau pathology by looking for the presence of hyperphosphorylated tau aggregates, co-localization of tau with mutant HTT and its oligomeric intermediates in post-mortem brain samples from patients with Huntington's disease (n = 16) compared to cases with a known tauopathy and healthy controls. Next, we undertook a genotype-phenotype analysis of a large cohort of patients with Huntington's disease (n = 960) with a particular focus on cognitive decline. We report not only on the tau pathology in the Huntington's disease brain but also the association between genetic variation in tau gene and the clinical expression and progression of the disease. We found extensive pathological inclusions containing abnormally phosphorylated tau protein that co-localized in some instances with mutant HTT. We confirmed this related to the disease process rather than age...

Evaluation of Australia's National Notifiable Disease Surveillance System

Miller, Megge; Roche, Paul W; Spencer, Jenean; Deeble, Mary
Fonte: National Centre for Disease Control Publicador: National Centre for Disease Control
Tipo: Artigo de Revista Científica
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The Australian National Notifiable Diseases Surveillance System (NNDSS) is a passive surveillance system that collects information on communicable diseases. The Australian Government manages NNDSS under the auspices of the Communicable Diseases Network Australia (CDNA). Data collected by each state and territory are collated, analysed and disseminated by the Australian Government Department of Health and Ageing. We report the first evaluation of NNDSS since it was established in 1991. Three primary stakeholder groups were surveyed: (a) CDNA members, (b) the National Surveillance Committee and (c) the readership of Communicable Diseases Intelligence, the primary means of data dissemination from NNDSS. The evaluation revealed that the system was acceptable, structurally simple, and that the data collected were actively used by stakeholders. However, the lack of clearly documented aims and objectives for NNDSS, inflexibility to changing needs, lack of timeliness and complexity in processes were seen as problematic. The results of this evaluation, supported by recent federal funding to enhance national biosecurity, will provide the framework for enhancing NNDSS to meet national communicable disease surveillance requirements in Australia.

Higher prevalence of periodontal disease among patients with predialytic renal disease; Higher prevalence of periodontal disease among patients with predialytic renal disease

Joseph, Rosamma; Krishnan, Rajaratnam; Narayan, Vivek
Fonte: UNICAMP/FOP Publicador: UNICAMP/FOP
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; Formato: application/pdf
Publicado em 17/12/2015 ENG
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Aim: Periodontal diseases can have a significant effect on the systemic health. Chronic systemic diseases such as renal disease may also influence progression of periodontal disease. The present study assessed the prevalence of periodontal disease among a group of patients with renal disease and compared their periodontal status to that of healthy controls. Methods: 77 patients with different forms of renal disease and 77 healthy controls were examined for oral hygiene status, gingival inflammation, probing pocket depth and clinical attachment loss. The subjects were grouped into three as no/mild, moderate and severe periodontitis. Results: All periodontal parameters were significantly elevated in the case group as compared to controls (p < 0.001). The prevalence and severity of periodontal disease was also significantly higher in the case group (p < 0.001). Conclusions: This study provides evidence for a greater prevalence and severity of periodontal disease among patients with renal disease. The periodontal health of all patients with renal disease needs to be carefully monitored.; Aim: Periodontal diseases can have a significant effect on the systemic health. Chronic systemic diseases such as renal disease may also influence progression of periodontal disease. The present study assessed the prevalence of periodontal disease among a group of patients with renal disease and compared their periodontal status to that of healthy controls. Methods: 77 patients with different forms of renal disease and 77 healthy controls were examined for oral hygiene status...