Página 1 dos resultados de 39 itens digitais encontrados em 0.275 segundos

A sociedade civil organizada no enfrentamento da AIDS no município de São Paulo; Organised civil society in fighting aids in São Paulo

Pereira, Adriana Jimenez
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 15/06/2010 PT
Relevância na Pesquisa
45.42%
Este estudo teve como objetivo analisar a organização da sociedade civil no município de São Paulo na luta contra a aids, com destaque para os processos histórico e políticos condicionantes da atuação dos movimentos sociais e das organizações não governamentais. No campo da Saúde Coletiva, nota-se que é escassa a análise de movimentos sociais e organizações não governamentais na área da saúde, embora seja de fundamental importância para o efetivo controle social e expressão das demandas populares na construção das políticas públicas de saúde. Considerando os conceitos de sociedade civil formada por classes, que procuram exercer uma hegemonia, e do Estado como espaço dialético da luta de classes e da luta social, este estudo compreende as formas organizadas da sociedade como potenciais para a transformação social ao intervir no Estado. Assim, para a apreensão do objeto de estudo, desenvolveu-se a pesquisa utilizando o método qualitativo, de caráter descritivo-exploratório. Foram realizadas entrevistas com 14 sujeitos sociais inseridos em diferentes espaços políticos da luta contra a aids, com predomínio na participação em organizações não governamentais (ONGs), localizadas na cidade de São Paulo. Os procedimentos de análise seguiram as recomendações da análise de discurso. A história da aids foi determinada pela pressão da sociedade civil organizada...

Efeitos da suplementação crônica de L-arginina sobre a expressão de proteínas envolvidas na regulação da síntese proteica muscular em ratos treinados em exercícios de alta intensidade; Effects of chronic supplementation of L-arginine on the expression of proteins involved in the regulation of muscle protein synthesis in muscle of trained rats in high-intense Exercise.

Gomes, Mariana de Rezende
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 12/04/2013 PT
Relevância na Pesquisa
45.51%
A arginina é um aminoácido condicionalmente essencial que participa de inúmeras reações metabólicas no organismo como, por exemplo, o ciclo da uréia, a síntese de creatina e a geração de óxido nítrico (NO). Além dessas funções a arginina é associada, com a sensibilidade à insulina, a secreção de GH e mais recentemente com a síntese protéica muscular. O objetivo deste trabalho foi investigar o efeito da suplementação via oral crônica de L-arginina sobre a síntese protéica muscular, pela via da mTOR, a fim de contribuir com as novas discussões científicas acerca deste aminoácido de ampla atuação. Métodos: Foram utilizados ratos wistar machos adultos com cerca de 200g de peso corporal divididos em quatro grupos de quatorze animais denominados na seguinte forma: Arginina Treinado (AT), Arginina Sedentário (AS), Dieta-Controle Treinado (CT) e Dieta-Controle Sedentário (CS). Ambas as dietas foram elaboradas com base das recomendações da AIN-93, sendo que a dieta enriquecida com arginina recebeu acréscimo de 2% deste aminoácido e a dieta controle recebeu um mix de aminoácidos não essenciais para garantir que ambas fossem isonitrogenadas e isocalóricas e as proporções de aminoácidos presente nas rações foi conferida por aminograma. O treinamento dos animais consistiu em exercício anaeróbio com sessões que eram compostas de 4 séries de 10 saltos com um minuto de descanso entre estas em tanque de água. Os saltos eram desempenhados com carga de 50% do peso corporal acoplado ao tórax dos animais na freqüência de 5 dias por semana por 6 semanas. A evolução da massa corporal dos animais bem como o consumo de ração foram avaliadas três vezes por semana e estimada uma média semanal. Foram realizados testes de tolerância oral à glicose (OGTT) e tolerância à insulina (ITT) no início e ao final do experimento em todos os animais para avaliar alterações na sensibilidade à insulina. Após 72hs da última sessão de treinamento os animais foram anestesiados para infusão de insulina...

Solving fluid dynamics problems with Matlab

Pereira, Rui M. S.; Gajjar, Jitesh S. B.
Fonte: INTECH - Open Access Publisher Publicador: INTECH - Open Access Publisher
Tipo: Parte de Livro
Publicado em /10/2011 ENG
Relevância na Pesquisa
45.42%
MATLAB (short for Matrix Laboratory) was created by Cleve Moler and Jack Little in the 1970’s. It is a programming language for technical computing. Its environment is easy to work with, the syntax is very simple and intuitive, it has powerful toolboxes to treat many different problems in engineering, and it allows us to produce fantastic graphics as the programme runs. It also allows us to create a graphical interface (via graphical user interfaces - GUIs) that gives our programme a look that is very close to professional software. Because of many of the mentioned features, a MATLAB code can be very compact, allowing anyone to have "the big picture" of any code without have to look at all its details. Another great advantage of Matlab is that, if the code is written in a vectorized form, the code can run much faster than if it was written in the traditional form (’a la C/fortran’). The fact that MATLAB allows us to use a powerful toolbox for sparse matrices, is also a great advantage since, many traditional linear algebra operations can be highly improved, allowing the codes to run much faster than it would run with the traditional linear algebra functions. In our work we have made extensive use of MATLAB to do ’proof of concept’ studies...

O desenvolvimento profissional docente: a função supervisiva do coordenador de ano do 1º ciclo

Pinto, Maria Teresa Neves Ribeiro Albuquerque
Fonte: Instituto Politécnico de Lisboa Publicador: Instituto Politécnico de Lisboa
Tipo: Dissertação de Mestrado
Publicado em /10/2010 POR
Relevância na Pesquisa
45.43%
Dissertação apresentada à Escola Superior de Educação de Lisboa para obtenção de grau de mestre em Ciências da Educação, especialidade de Supervisão em Educação; O presente estudo tem como objectivo principal saber como é perspectivada a função supervisiva do Coordenador de Ano do 1º Ciclo, procurando compreender as concepções dos intervenientes sobre as finalidades e modos de funcionamento deste órgão, de criação relativamente recente e que não existe em todos os Agrupamentos e escolas do 1º Ciclo. Neste sentido, estudámos o caso das Coordenações de Ano numa Escola do 1º Ciclo, inserida num Agrupamento Vertical de Escolas da região da Grande Lisboa. Utilizámos a entrevista semi-directiva para sabermos as concepções da Adjunta da Directora, dos quatro Coordenadores de Ano da Escola e de quatro Professores Titulares de Turma sobre as características e funções deste órgão. Realizámos ainda a análise das actas das reuniões de ano em dois momentos distintos: no final de um ano lectivo e no início do seguinte (fim do 1º período), para a identificar os objectivos e formas de organização de reuniões de coordenação de ano no 1º CEB e os eixos de acção dos seus coordenadores...

The Riia Gene of Bacteriophage T4. II. Regulation of Its Messenger RNA Synthesis

Daegelen, P.; Brody, E.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /06/1990 EN
Relevância na Pesquisa
35.4%
When the rII genes are first introduced into cells which had been previously infected by T4 phage deleted for these genes, the kinetics of synthesis of rIIA and rIIB RNA are rapid and identical. We show that this rapid synthesis depends on a functional motA gene for rIIB, but not for rIIA, RNA synthesis. By primer-extension mapping of T4 messenger RNA, we find three promoters close to the rIIA gene. One of them is an early promoter just before the rIIA.1 gene; it is used under all conditions tested. Another is in the coding portion of the rIIA.1 gene; it is weak, primarily because of a 19-bp spacing between the -10 and -35 elements, and its use is stimulated by T4 functions. The third is a motA-dependent (middle) promoter which has an unusual CCCGCTT box at -33. We present results which suggest that none of these promoters is likely to be the site at which the motB and motC gene products exercise their major influence on rIIA RNA synthesis.

Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy

Ojima, Koichi; Kawabata, Yukiko; Nakao, Harumi; Nakao, Kazuki; Doi, Naoko; Kitamura, Fujiko; Ono, Yasuko; Hata, Shoji; Suzuki, Hidenori; Kawahara, Hiroyuki; Bogomolovas, Julius; Witt, Christian; Ottenheijm, Coen; Labeit, Siegfried; Granzier, Henk; Toyama-
Fonte: American Society for Clinical Investigation Publicador: American Society for Clinical Investigation
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
35.47%
Limb-girdle muscular dystrophy type 2A (LGMD2A) is a genetic disease that is caused by mutations in the calpain 3 gene (CAPN3), which encodes the skeletal muscle–specific calpain, calpain 3 (also known as p94). However, the precise mechanism by which p94 functions in the pathogenesis of this disease remains unclear. Here, using p94 knockin mice (termed herein p94KI mice) in which endogenous p94 was replaced with a proteolytically inactive but structurally intact p94:C129S mutant protein, we have demonstrated that stretch-dependent p94 distribution in sarcomeres plays a crucial role in the pathogenesis of LGMD2A. The p94KI mice developed a progressive muscular dystrophy, which was exacerbated by exercise. The exercise-induced muscle degeneration in p94KI mice was associated with an inefficient redistribution of p94:C129S in stretched sarcomeres. Furthermore, the p94KI mice showed impaired adaptation to physical stress, which was accompanied by compromised upregulation of muscle ankyrin-repeat protein-2 and hsp upon exercise. These findings indicate that the stretch-induced dynamic redistribution of p94 is dependent on its protease activity and essential to protect muscle from degeneration, particularly under conditions of physical stress. Furthermore...

Epigenetic Changes in Response to Tai Chi Practice: A Pilot Investigation of DNA Methylation Marks

Ren, Hua; Collins, Veronica; Clarke, Sandy J.; Han, Jin-Song; Lam, Paul; Clay, Fiona; Williamson, Lara M.; Andy Choo, K. H.
Fonte: Hindawi Publishing Corporation Publicador: Hindawi Publishing Corporation
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
45.38%
Tai chi exercise has been shown to improve physiological and psychosocial functions, well-being, quality of life, and disease conditions. The biological mechanisms by which tai chi exerts its holistic effects remain unknown. We investigated whether tai chi practice results in positive epigenetic changes at the molecular level. Design. The DNA methylation profiles of sixty CpG-dinucleotide marks in female tai chi practitioners (N = 237; 45–88 years old) who have been practising tai chi for three or more years were compared with those of age-matched control females (N = 263) who have never practised tai chi. Results. Six CpG marks originating from three different chromosomes reveal a significant difference (P < 0.05) between the two cohorts. Four marks show losses while two marks show gains in DNA methylation with age in the controls. In the tai chi cohort all six marks demonstrate significant slowing (by 5–70%) of the age-related methylation losses or gains observed in the controls, suggesting that tai chi practice may be associated with measurable beneficial epigenetic changes. Conclusions. The results implicate the potential use of DNA methylation as an epigenetic biomarker to better understand the biological mechanisms and the health and therapeutic efficacies of tai chi.

ATP binding and cross-bridge detachment steps during full Ca2+ activation: comparison of myofibril and muscle fibre mechanics by sinusoidal analysis

Iorga, Bogdan; Wang, Li; Stehle, Robert; Pfitzer, Gabriele; Kawai, Masataka
Fonte: Blackwell Science Inc Publicador: Blackwell Science Inc
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
45.38%
Single myofibrils 50–60 μm in length and 2–3 μm in diameter were isolated from rabbit psoas muscle fibres, and cross-bridge kinetics were studied by small perturbations of the length (∼0.2%) over a range of 15 frequencies (1–250 Hz). The experiments were performed at 15°C in the presence of 0.05–10 mm MgATP, 8 mm phosphate (Pi), 200 mm ionic strength with KAc (acetate), pCa 4.35–4.65, and pH 7.0. Two exponential processes, B and C, were resolved in tension transients. Their apparent rate constants (2πb and 2πc) increased as the [MgATP] was raised from 0.05 mm to 1 mm, and then reached saturation at [MgATP] ≥ 1. Given that these rate constants were similar (c/b∼1.7) at [Pi]≥ 4 mm, they were combined to achieve an accurate estimate of the kinetic constants: their sum and product were analysed as functions of [MgATP]. These analyses yielded K1= 2.91 ± 0.31 mm−1, k2= 288 ± 36 s−1, and k−2= 10 ± 21 s−1 (±95% confidence limit, n= 13 preparations), based on the cross-bridge model: AM+ATP ↔ (step 1) AM.ATP ↔ (step 2) A+M.ATP, where K1 is the ATP association constant (step 1), k2 is the rate constant of the cross-bridge detachment (step 2), and k−2 is the rate constant of its reversal step. These kinetic constants are respectively comparable to those observed in single fibres from rabbit psoas (K1= 2.35 ± 0.31 mm−1...

Educação Inclusiva ou Educação para todos? Contribuições da teoria histórico-cultural para uma análise crítica da realidade escolar; Inclusive education or Education for all? Contributions from cultural-historical theory to a critical analysis of school reality

Batistão, Sandra Paula da Silva
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 03/07/2013 PT
Relevância na Pesquisa
45.49%
Esta pesquisa tem como objetivo analisar os limites e as possibilidades da educação inclusiva a partir da gestão de política pública para o exercício da ação pedagógica do professor e do professor assessor frente à proposta de um contexto educacional com a finalidade de identificar caminhos que possam compor para o processo de superação do que está instituído no cotidiano escolar. Durante o movimento de investigação os conceitos de Estado, Educação, Educação Inclusiva e Necessidades Educacionais Especiais são tratados a partir dos pressupostos da pedagogia histórico-crítica e da psicologia histórico-cultual estabelecendo relações entre a ação pedagógica de todos os sujeitos da educação e o exercício de suas funções. A unidade de análise na pesquisa é a relação entre a gestão de política de Estado no campo da Educação e todos os envolvidos na construção do processo educacional inclusivo, destacando a função social do professor, do professor assessor e da equipe escolar quando estes, no cotidiano da escola, deparam-se com alunos com diagnóstico de dificuldades de aprendizagem e ou deficiência. Sabe-se que muito tem sido discutido sobre a escola inclusiva como sendo aquela que matricula alunos com deficiência na sala regular de ensino...

Toward a universal theory of the human group: sociological systems framework applied to the comparative analysis of groups and organizations

Burns, Tom R.; Machado, Nora; Corte, Ugo
Fonte: CIES-IUL Publicador: CIES-IUL
Tipo: Trabalho em Andamento
Publicado em //2014 ENG
Relevância na Pesquisa
45.53%
Drawing on a sociological multi-level, dynamic systems approach – actor-system-dynamics (ASD) -- which has been developed and applied in institutional, organizational, and societal analyses, we formulate a general model for the comparative analysis of social groups and organizations. This social systems approach has not been previously applied in the group area. We claim that the approach can be systematically and fruitfully applied to small as well as large groups and organizations as a methodology to understand and analyze their structure, functioning and dynamics. A group is considered a system with three universal subsystems on which any human social organization, including small groups, depends and which motivate, shape and regulate group activities and productions. The subsystems are bases or group requisites – necessary for group “functioning” and performance in more or less orderly or coherent ways; on this basis a group may be able to realize its purposes or goals(as well as possibly some members’ personal goals) and maintain and reproduce the group. The group bases consist of: first, a rule regime (collective culture)defining group identity and purpose, shaping and regulating roles and role relationships...

A universal theory of social groups: the actor-system-dynamics approach to agents, rule regimes, and interaction processes

Burns, Tom R.; Corte, Ugo; Machado, Nora
Fonte: CIES-IUL Publicador: CIES-IUL
Tipo: Trabalho em Andamento
Publicado em //2014 ENG
Relevância na Pesquisa
35.51%
Drawing on multi-level, dynamic systems theory in sociology which has been developed and applied in institutional, organizational, and societal analyses, we formulate a general theory of social groups. This social systems approach has not been previously applied in the group area. We claim that this particular systems approach can be systematically and fruitfully applied to small as well as large groups to understand and analyze their functioning and dynamics. In this article, we refer to a group as an aggregation of persons/social agents that is characterized by (1) shared group identity, (2) a shared rule regime (collective culture) shaping and regulating their roles and role relationships and group behavioral outputs (3) its bases of membership and adherence or commitment to the group, its identity and rule regime, (4) its technologies and material resources used in group interactions, 2 performances, and productions (5) it shared places (situations for interaction), and (6) its times for gathering and interacting. The theory identifies three universal bases on which any human group or social organization, including small groups, depends and which motivate, shape and regulate group activities and productions (Section II). The bases are group requisites – necessary for group “functioning” and interacting in more or less orderly or coherent ways...

The Commonwealth Government's industrial relations reforms: a valid use of the corporations power?

Swann, Emma
Fonte: Universidade Nacional da Austrália Publicador: Universidade Nacional da Austrália
Tipo: Relatório
Relevância na Pesquisa
55.41%
The Commonwealth Government intends to introduce major reforms to Australia's industrial relations system. Public debate has centred on the effect of some of the proposed reforms on working conditions. However, the intention of the Commonwealth to remove the power of the States over industrial relations and create a single industrial relations system is perhaps the most fundamental reform that has been proposed. The Government plans to implement these reforms by re-drafting the entire Workplace Relations Act (1996) (which predominately relies on the conciliation and arbitration power in the Constitution) in order to base the Act on the corporations power in the Constitution. The States have argued that the Commonwealth cannot use the corporations power to create a unitary industrial relations system and have indicated that they will challenge the validity of this legislation in the High Court. It is not entirely clear if the Commonwealth can use the corporations power to regulate employment activities. The High Court has been divided over the question 'which activities of a coiporation can be regulated under the power?' Some Justices have taken a narrow approach to the power, claiming (for example) that only activities that are related to the trading function of trading corporations can be regulated. Other Justices have taken a broader interpretation...

Le leadership interstitiel, le champ d'action des Amérindiens ou le pouvoir dans la marge : l'exemple de la communauté algonquine de Kitigan Zibi (Québec)

Morissette, Anny
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Thèse ou Mémoire numérique / Electronic Thesis or Dissertation
FR
Relevância na Pesquisa
35.41%
Quel est le champ d’action des Amérindiens dans le contexte politique canadien? Malgré les tentatives de l’État canadien de briser la structure politique traditionnelle des Autochtones en introduisant le système électif et politique du conseil de bande, ceux-ci sont loin d'avoir été des victimes passives. L'étude du leadership interstitiel est la ligne directrice de cette thèse car il est la clé d’une pratique politique « in the cracks » qui confère un pouvoir marginal aux Amérindiens. En s'intéressant aux conditions historiques et sociales de déploiement de l’arène politique en milieu de réserve, il est possible de comprendre la quotidienneté et la contemporanéité de l’exercice du pouvoir au sein d’une population minoritaire fortement politisée. La recherche ethnographique porte sur la politique locale de la communauté algonquine de Kitigan Zibi (Québec). L’analyse des acteurs anishnabeg a montré une variabilité du leadership politique chez les Algonquins et l’existence de différents types de leader malgré l’imposition d’une fonction de chef par la Loi sur les Indiens. Le contrôle des affaires politiques officielles d’une bande par les agents coloniaux, c'est-à-dire les missionnaires et les agents indiens...

Educar (para) o pensar : desenvolvimento de competências reflexíveis em professores e alunos do 1º CEB : contributos da "Filosofia para Crianças"

Machado, Celeste Maria Marçal Vieira
Fonte: Universidade de Aveiro Publicador: Universidade de Aveiro
Tipo: Tese de Doutorado
POR
Relevância na Pesquisa
65.44%
O presente estudo inscreve-se na área científica da Formação de Professores, incidindo, particularmente, na compreensão do processo de desenvolvimento das competências reflexivas percebidas como factor de promoção do seu próprio desenvolvimento profissional e pessoal, do desenvolvimento da capacidade de pensar dos seus alunos, da revalorização dos processos curriculares de ensino-aprendizagem e de inovação dos contextos educacionais. Num contexto de complexidade, incerteza e mudança, importa repensar estratégias de formação de professores e de alunos para que possam constituir-se como fatores potenciadores do desenvolvimento da competência reflexiva. Estratégias que convocam, quer o professor, quer o aluno, para um tipo de questionamento de maior exigência reflexiva e consideradas potenciadoras do pensamento crítico, criativo e de cuidado com o outro, numa perspetiva educativa centrada no cuidar, que valoriza a dimensão humana, a atuação responsável, ética e solidária, em todos os planos da vida. Neste estudo propomo-nos retomar algumas das estratégias de formação já configuradas no movimento Filosofia para Crianças e que se constituíram como um programa de formação em contexto, no qual se procurou aprofundar e compreender as múltiplas dimensões e modos como interatuam os diferentes participantes da relação educativa em práticas curriculares reconfiguradas à luz dos pressupostos que sustentam este estudo. Do ponto de vista metodológico...

Dissecando o GEN

Piza Jor.,S. de Toledo
Fonte: Universidade de São Paulo; Escola Superior de Agricultura Publicador: Universidade de São Paulo; Escola Superior de Agricultura
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/1947 PT
Relevância na Pesquisa
75.64%
In thee present paper the classical concept of the corpuscular gene is dissected out in order to show the inconsistency of some genetical and cytological explanations based on it. The author begins by asking how do the genes perform their specific functions. Genetists say that colour in plants is sometimes due to the presence in the cytoplam of epidermal cells of an organic complex belonging to the anthocyanins and that this complex is produced by genes. The author then asks how can a gene produce an anthocyanin ? In accordance to Haldane's view the first product of a gene may be a free copy of the gene itself which is abandoned to the nucleus and then to the cytoplasm where it enters into reaction with other gene products. If, thus, the different substances which react in the cell for preparing the characters of the organism are copies of the genes then the chromosome must be very extravagant a thing : chain of the most diverse and heterogeneous substances (the genes) like agglutinins, precipitins, antibodies, hormones, erzyms, coenzyms, proteins, hydrocarbons, acids, bases, salts, water soluble and insoluble substances ! It would be very extrange that so a lot of chemical genes should not react with each other. remaining on the contrary...

RNA Sequencing of the Exercise Transcriptome in Equine Athletes

Capomaccio, Stefano; Vitulo, Nicola; Verini-Supplizi, Andrea; Barcaccia, Gianni; Albiero, Alessandro; D'Angelo, Michela; Campagna, Davide; Valle, Giorgio; Felicetti, Michela; Silvestrelli, Maurizio; Cappelli, Katia
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 31/12/2013 EN
Relevância na Pesquisa
45.56%
The horse is an optimal model organism for studying the genomic response to exercise-induced stress, due to its natural aptitude for athletic performance and the relative homogeneity of its genetic and environmental backgrounds. Here, we applied RNA-sequencing analysis through the use of SOLiD technology in an experimental framework centered on exercise-induced stress during endurance races in equine athletes. We monitored the transcriptional landscape by comparing gene expression levels between animals at rest and after competition. Overall, we observed a shift from coding to non-coding regions, suggesting that the stress response involves the differential expression of not annotated regions. Notably, we observed significant post-race increases of reads that correspond to repeats, especially the intergenic and intronic L1 and L2 transposable elements. We also observed increased expression of the antisense strands compared to the sense strands in intronic and regulatory regions (1 kb up- and downstream) of the genes, suggesting that antisense transcription could be one of the main mechanisms for transposon regulation in the horse under stress conditions. We identified a large number of transcripts corresponding to intergenic and intronic regions putatively associated with new transcriptional elements. Gene expression and pathway analysis allowed us to identify several biological processes and molecular functions that may be involved with exercise-induced stress. Ontology clustering reflected mechanisms that are already known to be stress activated (e.g....

HDL-S1P: cardiovascular functions, disease-associated alterations, and therapeutic applications

Levkau, Bodo
Fonte: Frontiers Media S.A. Publicador: Frontiers Media S.A.
Tipo: Artigo de Revista Científica
Publicado em 20/10/2015 EN
Relevância na Pesquisa
35.51%
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid contained in High-density lipoproteins (HDL) and has drawn considerable attention in the lipoprotein field as numerous studies have demonstrated its contribution to several functions inherent to HDL. Some of them are partly and some entirely due to the S1P contained in HDL (HDL-S1P). Despite the presence of over 1000 different lipids in HDL, S1P stands out as it possesses its own cell surface receptors through which it exercises key physiological functions. Most of the S1P in human plasma is associated with HDL, and the amount of HDL-S1P influences the quality and quantity of HDL-dependent functions. The main binding partner of S1P in HDL is apolipoprotein M but others may also exist particularly under conditions of acute S1P elevations. HDL not only exercise functions through their S1P content but have also an impact on genuine S1P signaling by influencing S1P bioactivity and receptor presentation. HDL-S1P content is altered in human diseases such as atherosclerosis, coronary artery disease, myocardial infarction, renal insufficiency and diabetes mellitus. Low HDL-S1P has also been linked to impaired HDL functions associated with these disorders. Although the pathophysiological and molecular reasons for such disease-associated shifts in HDL-S1P are little understood...

On functions whose symmetric part of gradient agree and a generalization of Reshetnyak's compactness theorem

Lorent, Andrew
Fonte: Universidade Cornell Publicador: Universidade Cornell
Tipo: Artigo de Revista Científica
Relevância na Pesquisa
45.38%
We consider the following question: Given a connected open domain $\Omega\subset R^n$, suppose $u,v:\Omega\rightarrow R^n$ with $\det(\nabla u)>0$, $\det(\nabla v)>0$ a.e. are such that $\nabla u^T(x)\nabla u(x)=\nabla v(x)^T \nabla v(x)$ a.e. does this imply a global relation of the form $\nabla v(x)= R\nabla u(x)$ a.e. in $\Omega$ where $R\in SO(n)$? If $u,v$ are $C^1$ it is an exercise to see this true, if $u,v\in W^{1,1}$ we show this is false. We prove this question has a positive answer if $v\in W^{1,1}$ and $u\in W^{1,n}$ is a mapping of $L^p$ integrable dilatation for $p>n-1$. These conditions are sharp in two dimensions and this result represents a generalization of the corollary to Liouville's theorem that states that the differential inclusion $\nabla u\in SO(n)$ can only be satisfied by an affine mapping. Liouville's corollary for rotations has been generalized by Reshetnyak who proved convergence of gradients to a fixed rotation for any weakly converging sequence $v_k\in W^{1,1}$ for which $$ \int_{\Omega} \mathrm{dist}(\nabla v_k,SO(n)) dz\rightarrow 0 \text{as} k\rightarrow \infty. $$ Let $S(\cdot)$ denote the (multiplicative) symmetric part of a matrix. In Theorem 3 we prove an analogous for any pair of weakly converging sequences $v_k\in W^{1...

Fundamento de las críticas al Tribunal Europeo de Derechos Humanos en el asunto Del Río Prada c. España; Basis for the criticism to the European Court of Human Rights in the case Del Rio Prada v. Spain

Cacho Sánchez, Yaelle
Fonte: Centro de Estudios Políticos y Constitucionales Publicador: Centro de Estudios Políticos y Constitucionales
Tipo: info:eu-repo/semantics/article; publishedVersion
SPA
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55.55%
RESUMEN: Las afirmaciones y críticas vertidas en torno a la sentencia del TEDH de 21 de octubre de 2013 en el asunto Del Río Prada c. España a través de los medios de comunicación trascendieron los argumentos de la Gran Sala, para plantear cuestiones como el papel desempeñado por el juez español, o la desobediencia a Estrasburgo. Todas estas críticas se traducen en importantes cuestiones jurídicas de fondo relativas al TEDH como mecanismo de garantía de los derechos humanos, a las condiciones de ejercicio de sus funciones por los jueces, o a la naturaleza y ejecución de las sentencias. Más allá del propio fallo del Tribunal y de los hechos y argumentos en los que se apoya, el presente trabajo se centra en el análisis de todas estas cuestiones en la búsqueda de los fundamentos jurídicos que sustentan las críticas contra la condena de España en el asunto Del Río Prada.; ABSTRACT: The statements and criticisms regarding the judgment of the European Court of Human Rights on October 21 2013 in Del Rio Prada v. Spain through the media went beyond the arguments of Grand Chamber, to raise issues such as the role played by the Spanish judge or even the disobedience to Strasbourg. All these reviews result in significant legal questions regarding the role of the European Court of Human Rights as an international mechanism for the protection of human rights...

The significance of the European Union for the evolution of citizenship and immigration policies: The cases of the United Kingdom and Italy.

Dell'Olio, Fiorella
Fonte: London School of Economics and Political Science Thesis Publicador: London School of Economics and Political Science Thesis
Tipo: Thesis; NonPeerReviewed Formato: application/pdf
Publicado em //2001 EN
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This thesis analyses the link that the establishment of European citizenship creates between citizenship, nationality, and immigration policies. To be a European citizen, one needs to be a national of a member state. According to this criterion, nationality and citizenship are bound to each other. There is no possibility of access for those who do not have the status of national citizenship. European citizenship legitimised a privileged position to which not all individuals are entitled, and conditions of access are under the jurisdiction of each member state. It is argued that normatively European citizenship reinforces the ideology of nationality while empirically it has been used to forge a sort of European identity. In other words, the underlying argument is that European citizenship functions to define European identity and nationality functions towards the establishment of national immigration policies. This process leads to the formation of a binary typology of 'us and them', strengthened by legislation and political debates. The formation of the category of 'us' as Europeans does not find a response at the empirical level as the public does not fully identify with the Euro-polity. What emerges instead is that the public regards 'compatibility' between a European and national identity as more optimal. The principal benefit of Euro-citizenship is to re-prioritise the means of citizenship from political rights to social and economic rights. This 'opportunity structure'...