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- Instituto Politécnico de Leiria
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- Elsevier
- MDPI - Multidisciplinary Digital Publishing Institute
- Universidade de Aveiro
- American Society of Plant Physiologists
- Molecular Diversity Preservation International
- American Society for Microbiology
- Baishideng Publishing Group Co., Limited
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- Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Bioquímica; Bioquímica; Biologia Molecular
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- Springer Berlin Heidelberg
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Resultados filtrados por Publicador: MDPI - Multidisciplinary Digital Publishing Institute
Inhibition of Bladder Tumor Growth by Chitooligosaccharides in an Experimental Carcinogenesis Model
Fonte: MDPI - Multidisciplinary Digital Publishing Institute
Publicador: MDPI - Multidisciplinary Digital Publishing Institute
Tipo: Artigo de Revista Científica
Publicado em //2012
ENG
Relevância na Pesquisa
37.77%
Urinary bladder cancer is one of the most common cancers worldwide, with the
highest incidence in industrialized countries. Patients with cancer commonly use
unconventional and complementary therapy including nutraceuticals. In this study we
evaluated the efficacy of chitooligosaccharides (in orange juice) in rat bladder cancer
chemoprevention and as therapeutic agent, on a rat model of urinary bladder
carcinogenesis induced with N-butyl-N-(4-hydroxybutyl) nitrosamine. Results indicate that
chitooligosaccharides may have a preventive effect on bladder cancer development and a
curative effect upon established bladder tumors, dependent on the concentration ingested
500 mg/kg b.w., every three days, showed capacity to inhibit and prevent the proliferation
of bladder cancer; however, this was associated with secondary effects such as
hypercholesterolemia and hypertriglyceridemia. The use of lower doses (50 and 250 mg/kg
b.w.) showed only therapeutic effects. It is further suggested that this antitumor effect might be due to its expected anti-inflammatory action, as well as by mechanisms not directly
dependent of COX-2 inhibition, such as cellular proliferation control and improvement in
antioxidant profile.
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