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Diagnosis and treatment of cervical cancer during pregnancy; Diagnóstico e tratamento do câncer do colo uterino durante a gestação

GONÇALVES, Carla Vitola; DUARTE, Geraldo; COSTA, Juvenal Soares Dias da; MARCOLIN, Alessandra Cristina; BIANCHI, Mônia Steigleder; DIAS, Daison; LIMA, Luis Cláudio de Velleca e
Fonte: Associação Paulista de Medicina - APM Publicador: Associação Paulista de Medicina - APM
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
36.32%
CONTEXT AND OBJECTIVE: One third of all cervical carcinomas occur during the reproductive period. Cervical carcinoma is the second greatest cause of death due to cancer during this phase. The estimated frequency of cervical cancer during pregnancy is one case for every 1,000 to 5,000 pregnancies. The aim here was to provide information about the difficulties in diagnosing and managing cervical neoplasia during pregnancy. MATERIALS: A systematic review of the literature was undertaken through the PubMed, Cochrane, Excerpta Medica (Embase), Literatura Latino Americana e do Caribe em Ciências da Saúde (Lilacs) and Scientific Electronic Library Online (SciELO) databases, using the following words: pregnancy, cervical cancer, diagnosis and management. RESULTS: There was a consensus in the literature regarding diagnosis of cervical carcinoma and management of preneoplastic lesions during pregnancy. However, for management of invasive carcinoma, there was great divergence regarding the gestational age taken as the limit for observation rather than immediate treatment. CONCLUSION: All patients with cytological abnormalities should undergo colposcopy, which will indicate and guide biopsy. Conization is reserved for patients with suspected invasion. High-grade lesions should be monitored during pregnancy and reevaluated after delivery. In cases of invasive carcinoma detected up to the 12th week of pregnancy...

Avaliação cefalométrica do crescimento craniofacial em crianças leucodermas brasileiras, com má oclusão de Classe II durante as fases de crescimento determinadas pela maturação das vértebras cervicais; Cephalometric evaluation of craniofacial growth in Class II malocclusion and Normal Occlusion Brazilian children during stages of growth determined by maturation of cervical vertebrae

Silva, Fabiane Louly Baptista Santos
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 30/06/2010 PT
Relevância na Pesquisa
36.15%
As características do crescimento craniofacial dos indivíduos portadores de má oclusão de Classe II na fase de crescimento, são de intenso interesse dos ortodontistas por esta má oclusão representar uma alta porcentagem dos casos em tratamento nos consultórios. Esta investigação objetivou estudar cefalométrica e comparativamente o crescimento craniofacial em crianças leucodermas portadoras de má oclusão de Classe II e de Oclusão Normal. Foram utilizadas 148 telerradiografias em norma lateral de 78 meninos e 70 meninas, faixa etária dos 7 aos 12 anos, portadores de má oclusão de Classe II, e 60 telerradiografias em norma lateral de 30 meninas e 30 meninos com Oclusão Normal. As amostras foram divididas considerando-se o estágio da maturação das vértebras cervicais pelo método de Hassel e Farman(HASSEL; FARMAN 1995), estando os grupos nos níveis Iniciação(I), Aceleração (A) e Transição (T) do desenvolvimento esquelético. Foram utilizadas as grandezas SNA, A-Nperp e Co-A para avaliar o componente maxilar; SNB, P-Nperp, Co-Gn, Co-Go e Go-Gn para o componente mandibular; ANB representou a relação maxilomandibular; SN.GoGn, FMA, NS.Gn, BaN.PtGn e ENA-Me para o componente vertical, e o ângulo da base do crânio representado por NS.Ba. O teste t independente foi aplicado: entre os grupos para verificar a precocidade dos índices entre os gêneros; em cada grupo e índice nos gêneros feminino e no masculino; na comparação entre os grupos em cada índice nos gêneros feminino e no masculino; na comparação entre os grupos na fase IT (Iniciação Transição) em cada gênero. Os resultados mostraram: precocidade do índice A (aceleração) no gênero feminino do grupo de Classe II. Na comparação entre os gêneros do grupo de Classe II no nível I...

Avaliação da coordenação sucção/deglutição/respiração através da ausculta cervical digital em recém-nascidos pré-termo e a termo

Silva, Caroline Silveira da
Fonte: Universidade Federal do Rio Grande do Sul Publicador: Universidade Federal do Rio Grande do Sul
Tipo: Dissertação Formato: application/pdf
POR
Relevância na Pesquisa
36.25%
Introdução: Recém- nascidos a termo nascem com a habilidade de coordenar as funções de sucção- deglutição- respiração. Recém-nascidos pré-termo não apresentam essa habilidade, consequentemente, necessitam de alimentação por sonda e podem apresentar dificuldade na transição da alimentação por sonda para via oral. O objetivo desse estudo foi comparar o padrão de coordenação sucção-deglutição-respiração de recém-nascidos a termo em aleitamento materno exclusivo e recém-nascidos pré-termo na transição da alimentação por sonda para a via oral com mamadeira. Métodos: Foram avaliados 64 recém-nascidos (32 recém-nascidos pré-termo e 32 recém-nascidos a termo) internados na UTI Neonatal e Alojamento Conjunto do Hospital Fêmina de Porto Alegre. Os recém-nascidos a termo foram avaliados durante as primeiras 48horas de vida e os recém-nascidos pré-termo foram avaliados no início da alimentação por via oral após período de alimentação por sonda orogástrica. O equipamento utilizado na ausculta cervical digital era composto por um detector acústico e por um pré-amplificador com filtro conectados a um computador Coreo 2 Duo. O microfone foi fixado com fita adesiva no pescoço do recém-nascido para captar os sinais da sucção/deglutição durante a alimentação. Três sinais de 30 segundos foram obtidos de cada RN e uma média foi obtida para os seguintes parâmetros: total de “suck-swallow signal” (SSS); duração total dos SSS; total de pausas para respirar >2...

Long-term effectiveness and treatment timing for bionator therapy

Faltin, K.; Faltin, R. M.; Baccetti, T.; Franchi, L.; Ghiozzi, B.; McNamara, J. A.
Fonte: E H Angle Education Research Foundation, Inc Publicador: E H Angle Education Research Foundation, Inc
Tipo: Artigo de Revista Científica Formato: 221-230
ENG
Relevância na Pesquisa
26.15%
The aim of the present investigation was to provide information about the long-term effects and optimal timing for class-II treatment with the Bionator appliance. Lateral cephalograms of 23 class-II patients treated with the Bionator were analyzed at three time periods: T1, start of treatment; T2, end of Bionator therapy; and T3, long-term observation (after completion of growth). T3 includes a phase with fixed appliances. The treated sample was divided into two groups according to their skeletal maturity as evaluated by the cervical vertebral maturation (CVM) method. The early-treated group (13 subjects) initiated treatment before the peak in mandibular growth, which occurred after completion of Bionator therapy. The late-treated group (10 subjects) received Bionator treatment during the peak. The T1-T2, T2-T3, and T1-T3 changes in the treated groups were compared with changes in control groups of untreated class-II subjects by nonparametric statistics (P < .05). The findings of the present study on Bionator therapy followed by fixed appliances indicate that this treatment protocol is more effective and stable when it is performed during the pubertal growth spurt. Optimal timing to start treatment with the Bionator is when a concavity appears at the lower borders of the second and the third cervical vertebrae (CVMS 11). In the long term...

Avaliação longitudinal do crescimento craniofacial de indivíduos classe II tratados e não tratados

Gonçalves, Renata de Cassia
Fonte: Universidade Estadual Paulista (UNESP) Publicador: Universidade Estadual Paulista (UNESP)
Tipo: Tese de Doutorado Formato: 166 f. : il. color. + anexo
POR
Relevância na Pesquisa
16.61%
Pós-graduação em Ciências Odontológicas - FOAR; This research was developed in three studies. The aim of the 1st study was to evaluate the sexual dimorphism and the growth pattern of the hand-wrist bones and the cervical vertebrae, to compare the skeletal maturation determined by hand-wrist and vertebral evaluations and to develop a quantitative indicator of the vertebral skeletal maturity in Class II Brazilian subjects (n=32 children, 17F and 15M, from 7 to 9 years old). The Eklöf & Ringertz Method and the Fishman Maturation Prediction Method were used to assess the hand-wrist maturity and the Santos-Pinto Method was used to evaluate the vertebral maturity. The findings showed the girls develop earlier than boys, but the skeletal changes are larger in boys. There was a high correlation between carpal method and quantitative indicator of the 3rd cervical vertebra skeletal maturity. It was concluded that there are sexual dimorphism between boys and girls with early maturation in girls and larger growth changes in boys. The skeletal maturity can be quantitatively determined both by the hand-wrist method as cervical vertebral methods. The 2nd and 3rd studies was to evaluate the sagittal, vertical and transverse radiographic changes of the treatment in two phases of patients with Class II division 1 malocclusion taking into account the skeletal maturity through analysis of Lateral and Posteroanterior cephalometric radiographies. The sample of two groups was composed by 64 children with Class II division 1 malocclusion in mixed dentition phase...

Diagnosis and treatment of cervical cancer during pregnancy

Gonçalves,Carla Vitola; Duarte,Geraldo; Costa,Juvenal Soares Dias da; Marcolin,Alessandra Cristina; Bianchi,Mônia Steigleder; Dias,Daison; Lima,Luis Cláudio de Velleca e
Fonte: Associação Paulista de Medicina - APM Publicador: Associação Paulista de Medicina - APM
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/11/2009 EN
Relevância na Pesquisa
36.3%
CONTEXT AND OBJECTIVE: One third of all cervical carcinomas occur during the reproductive period. Cervical carcinoma is the second greatest cause of death due to cancer during this phase. The estimated frequency of cervical cancer during pregnancy is one case for every 1,000 to 5,000 pregnancies. The aim here was to provide information about the difficulties in diagnosing and managing cervical neoplasia during pregnancy. MATERIALS: A systematic review of the literature was undertaken through the PubMed, Cochrane, Excerpta Medica (Embase), Literatura Latino Americana e do Caribe em Ciências da Saúde (Lilacs) and Scientific Electronic Library Online (SciELO) databases, using the following words: pregnancy, cervical cancer, diagnosis and management. RESULTS: There was a consensus in the literature regarding diagnosis of cervical carcinoma and management of preneoplastic lesions during pregnancy. However, for management of invasive carcinoma, there was great divergence regarding the gestational age taken as the limit for observation rather than immediate treatment. CONCLUSION: All patients with cytological abnormalities should undergo colposcopy, which will indicate and guide biopsy. Conization is reserved for patients with suspected invasion. High-grade lesions should be monitored during pregnancy and reevaluated after delivery. In cases of invasive carcinoma detected up to the 12th week of pregnancy...

The selective innervation of guinea-pig superior cervical ganglion cells by sprouts from intact preganglionic axons.

Henningsen, I; Liestøl, K; Maehlen, J; Nja, A
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /01/1985 EN
Relevância na Pesquisa
26.15%
If the guinea-pig superior cervical ganglion is partially denervated in a way which spares some preganglionic axons arising from each of the spinal cord segments which normally innervate this ganglion (C8-T7), sprouting of the intact preganglionic axons occurs without a loss of selective end-organ responses to stimulation of individual ventral roots (Maehlen & Njå, 1981). In the present work we examine the selective innervation of individual ganglion cells by ventral roots after sprouting and compare it to that in normal ganglia. After sprouting the pattern of ganglion cell innervation by the intact preganglionic axons shows some of the features typical of normal ganglia. Thus each ganglion cell is strongly innervated by one or two neighbouring spinal cord segments, with the adjacent segments contributing a synaptic influence which diminishes with distance from the dominant one. Acutely after the partial denervation there is a tendency for the rostral segments to innervate ganglion cells more strongly than do caudal segments, compared to the situation in normal ganglia. The same is true following sprouting. The pattern of ganglion cell innervation observed after sprouting can be explained if the affinities of ganglion cells for innervation from particular spinal levels are assumed to be unchanged and the shift in the relative availability of different preganglionic axons...

The chemical morphology of age-related changes in human intervertebral disc glycosaminoglycans from cervical, thoracic and lumbar nucleus pulposus and annulus fibrosus.

Scott, J E; Bosworth, T R; Cribb, A M; Taylor, J R
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /02/1994 EN
Relevância na Pesquisa
26.58%
Hyaluronan (HA), chondroitin and keratan sulphates (CS, KS), collagen and dry weights were measured in the annulus fibrosus and nucleus pulposus of human cervical, thoracic and lumbar intervertebral discs aged 36-79 y. Alcian blue-critical electrolyte concentration (CEC) staining of sections extended the results. The collagen, total polyanion, HA, CS and KS contents of the nucleus pulposus and annulus fibrosus were plotted for all 3 regions against age. Regional differences and age-related trends were found. For regional differences, the collagen content of the nucleus pulposus was highest in cervical discs and lowest in lumbar discs. In contrast, the total polyanion content of the nucleus pulposus was highest in lumbar discs and lowest in cervical discs. These differences were seen in fetal and adult discs. With respect to age-related trends, the collagen content of the annulus fibrosus was higher in adults and children than in neonates and infants. The collagen content of the nucleus pulposus increased with age in thoracic and lumbar discs, but it was consistently high in cervical discs. There was generally a downward trend of total polyanion and CS with increase in age. This was quite consistent for the annulus fibrosus in all regions and there were dramatic decreases in the lumbar nucleus pulposus in all adults compared with infants and children. These trends were least evident in the cervical nucleus pulposus where infant values were low. CS changes correlated with water content. HA and KS increased in all discs with increasing maturity. Oversulphated KS...

The effect of age on dendrites in the rat superior cervical ganglion.

Andrews, T J; Li, D; Halliwell, J; Cowen, T
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /02/1994 EN
Relevância na Pesquisa
26.06%
Intracellular injection of a biotinylated probe in fixed superior cervical ganglia followed by confocal microscopy was used to investigate the effects of age on the dendritic arborisation of sympathetic neurons in rats aged 6 wk (young adult), 7 months (fully grown adult) and 24 months (aged). In accordance with other studies considerable dendritic growth was observed during postnatal development. However, in old age dendritic growth did not continue, and significant atrophy was observed. Quantitation of neuronal morphology showed significant reductions in soma size, total dendritic length, number of branch points and total area of dendritic arborisation in old age. Unexpectedly, significant reductions in the numbers of primary dendrites were observed in maturity and in old age. Concomitant with this atrophy there was an increase in age-related morphological abnormalities. The similarities between the atrophy and dendritic abnormalities shown by our aged neurons and those seen in other studies of young adult sympathetic neurons following axotomy or trophic factor deprivation are discussed.

The CNS-PNS transitional zone of rat cervical dorsal roots during development and at maturity. A morphological and morphometric study.

Fraher, J P; Sheehan, M M
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /06/1987 EN
Relevância na Pesquisa
26.06%
Each seventh cervical dorsal nerve root is attached to the spinal cord surface by four to eight rootlets. A tapering outgrowth of central nervous tissue, the central tissue projection, extends distally into the proximal part of each rootlet in the immediate postnatal period. The central ends of the most proximal peripheral internodes surround this projection. Thus a length of rootlet contains both CNS and PNS tissue. This is termed the transitional zone. Material was processed by standard preparative techniques for electron microscopy. Serial semithin and ultrathin sections were made over the entire extent of several transitional zones at ages ranging from 2 to 300 days postnatum. Central tissue projections were reconstructed in three dimensions and analysed morphometrically. The morphology of the central tissue projection varies during development. At first, it forms an irregular projection into the anterior portion of the rootlet. It than elongates and takes the form of a dorsoventrally flattened, distally tapering wedge. By 20 days postnatum it has attained its definitive form. This consists of three segments: a proximal wedge-shaped portion, similar to that described above; continuous with this is a distally tapering, dorsoventrally flattened...

Effects of nerve growth factors from mouse salivary glands and snake venom on the sympathetic ganglia of neonatal and developing mice.

Banks, B E; Charlwood, K A; Edwards, D C; Vernon, C A; Walter, S J
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /05/1975 EN
Relevância na Pesquisa
16.19%
1. Quantitative histological analysis has been made of the effects of nerve growth factor (NGF) from mouse submaxillary gland and from the venom of Vipera russelli on superior cervical ganglia of neonatal mice. 2. The hypertrophic and hyperplastic effects reported by other workers have been confirmed. 3. The hypertrophic effect arises from an increase in the rate at which the sympathetic neurones attain their mature size. The size at maturity is never exceeded. 4. The hyperplastic effect arises from an increase in the rate of production of neurones from less differentiated cells. In the developmental period, the number of neurones can exceed that found at maturity. If injection of NGF is discontinued the excess neurones disappear. 5. If injection of NGF is continued to maturity, the excess number of neurones is maintained.

Morphology of the cervical vertebrae in the fetal-neonatal human skeleton

CASTELLANA, C. ; KÓSA, F.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /01/1999 EN
Relevância na Pesquisa
26.15%
The gross anatomical features of human cervical vertebrae during the fetal-neonatal period were investigated in order to develop morphological standards for the individual ossification centres for use in forensic and anthropological osteology. It was found that the morphology of the cervical vertebral arches and the centra cannot be used for the determination of fetal age although the dens of the axis displays some developmental differences which may be useful for the determination of fetal maturity.

Quantitative Evaluation of Collagen Crosslinks and Corresponding Tensile Mechanical Properties in Mouse Cervical Tissue during Normal Pregnancy

Yoshida, Kyoko; Jiang, Hongfeng; Kim, MiJung; Vink, Joy; Cremers, Serge; Paik, David; Wapner, Ronald; Mahendroo, Mala; Myers, Kristin
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 14/11/2014 EN
Relevância na Pesquisa
26.2%
The changes in the mechanical integrity of the cervix during pregnancy have implications for a successful delivery. Cervical collagens are known to remodel extensively in mice with progressing gestation leading to a soft cervix at term. During this process, mature crosslinked collagens are hypothesized to be replaced with immature less crosslinked collagens to facilitate cervical softening and ripening. To determine the mechanical role of collagen crosslinks during normal mouse cervical remodeling, tensile load-to-break tests were conducted for the following time points: nonpregnant (NP), gestation day (d) 6, 12, 15, 18 and 24 hr postpartum (PP) of the 19-day gestation period. Immature crosslinks (HLNL and DHLNL) and mature crosslinks (DPD and PYD) were measured using ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS). There were no significant changes in the total immature crosslink density (HLNL+DHLNL mol per collagen mol) throughout normal mouse gestation (range: 0.31–0.49). Total mature crosslink density (PYD+DPD mol per collagen mol) decreased significantly in early softening from d6 to d15 (d6: 0.17, d12: 0.097, d15: 0.026) and did not decrease with further gestation. The maturity ratio (total mature to total immature crosslinks) significantly decreased in early softening from d6 to d15 (d6: 0.2...

Neoadjuvant and postoperative chemotherapy with paclitaxel plus cisplatin for the treatment of FIGO stage IB cervical cancer in pregnancy

Kong, Tae-Wook; Lee, Eun Ju; Lee, Yonghee; Chang, Suk-Joon; Son, Joo Hyuk; Ryu, Hee-Sug
Fonte: Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society Publicador: Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
26.2%
Cervical cancer is one of the most common malignancy diagnosed during pregnancy. The experience of the use of neoadjuvant chemotherapy (NACT) with paclitaxel plus cisplatin during pregnancy is limited. Three pregnant women with International Federation of Gynecology and Obstetrics (FIGO) stage IB cervical cancer received NACT with paclitaxel plus cisplatin until fetal lung maturity, and then underwent cesarean delivery and radical hysterectomy. Two of our patients had intermediate pathologic risk factors, and received adjuvant chemotherapy with the same regimen used in NACT. All patients did not have any evidence of disease recurrence for follow-up of 3, 4, and 8 years, respectively. NACT with paclitaxel plus cisplatin followed by radical hysterectomy and adjuvant chemotherapy could be considered as one of feasible alternatives to primary radical surgery or concurrent chemoradiation therapy with the termination of pregnancy in pregnant women with FIGO stage IB cervical cancer who have two or more intermediate pathologic-risk factors.

The diagnostic performance of dental maturity for identification of the circumpubertal growth phases: a meta-analysis

Perinetti, Giuseppe; Westphalen, Graziela H; Biasotto, Matteo; Salgarello, Stefano; Contardo, Luca
Fonte: Springer-Verlag Publicador: Springer-Verlag
Tipo: Artigo de Revista Científica
Publicado em 23/05/2013 EN
Relevância na Pesquisa
26.09%
The present meta-analysis initially evaluates the reliability of dental maturation in the identification of the circumpubertal growth phases, essentially for determining treatment timing in orthodontics. A literature survey was performed using the Medline, LILACS and SciELO databases, and the Cochrane Library (2000 to 2011). Studies of the correlation between dental and cervical vertebral maturation methods were considered. The mandibular canine, the first and second premolars, and the second molar were investigated. After the selection, six articles qualified for the final analysis. The overall correlation coefficients were all significant, ranging from 0.57 to 0.73. Five of these studies suggested the use of dental maturation as an indicator of the growth phase. However, the diagnostic performance analysis uncovered limited reliability only for the identification of the pre-pubertal growth phase. The determination of dental maturity for the assessment of treatment timing in orthodontics is not recommended.

Enhancement of Early Cervical Cancer Diagnosis with Epithelial Layer Analysis of Fluorescence Lifetime Images

Gu, Jun; Fu, Chit Yaw; Ng, Beng Koon; Liu, Lin Bo; Lim-Tan, Soo Kim; Lee, Caroline Guat Lay
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 12/05/2015 EN
Relevância na Pesquisa
26.27%
This work reports the use of layer analysis to aid the fluorescence lifetime diagnosis of cervical intraepithelial neoplasia (CIN) from H&E stained cervical tissue sections. The mean and standard deviation of lifetimes in single region of interest (ROI) of cervical epithelium were previously shown to correlate to the gold standard histopathological classification of early cervical cancer. These previously defined single ROIs were evenly divided into layers for analysis. A 10-layer model revealed a steady increase in fluorescence lifetime from the inner to the outer epithelial layers of healthy tissue sections, suggesting a close association with cellular maturity. The shorter lifetime and minimal lifetime increase towards the epithelial surface of CIN-affected regions are in good agreement with the absence of cellular maturation in CIN. Mean layer lifetimes in the top-half cervical epithelium were used as feature vectors for extreme learning machine (ELM) classifier discriminations. It was found that the proposed layer analysis technique greatly improves the sensitivity and specificity to 94.6% and 84.3%, respectively, which can better supplement the traditional gold standard cervical histopathological examinations.

Diagnosis and treatment of cervical cancer during pregnancy

Gon??alves, Carla Vitola; Duarte, Geraldo; Costa, Juvenal Soares Dias da; Marcolin, Alessandra Cristina; Bianchi, M??nia Steigleder; Dias, Daison Nelson Ferreira; Lima, Luis Cl??udio de Velleca e
Fonte: Universidade Federal do Rio Grande Publicador: Universidade Federal do Rio Grande
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
36.32%
CONTEXT AND OBJECTIVE: One third of all cervical carcinomas occur during the reproductive period. Cervical carcinoma is the second greatest cause of death due to cancer during this phase. The estimated frequency of cervical cancer during pregnancy is one case for every 1,000 to 5,000 pregnancies. The aim here was to provide information about the difficulties in diagnosing and managing cervical neoplasia during pregnancy. MATERIALS: A systematic review of the literature was undertaken through the PubMed, Cochrane, Excerpta Medica (Embase), Literatura Latino Americana e do Caribe em Ci??ncias da Sa??de (Lilacs) and Scientific Electronic Library Online (SciELO) databases, using the following words: pregnancy, cervical cancer, diagnosis and management. RESULTS: There was a consensus in the literature regarding diagnosis of cervical carcinoma and management of preneoplastic lesions during pregnancy. However, for management of invasive carcinoma, there was great divergence regarding the gestational age taken as the limit for observation rather than immediate treatment. CONCLUSION: All patients with cytological abnormalities should undergo colposcopy, which will indicate and guide biopsy. Conization is reserved for patients with suspected invasion. High-grade lesions should be monitored during pregnancy and reevaluated after delivery. In cases of invasive carcinoma detected up to the 12th week of pregnancy...

Who remains undelivered more than seven days after a single course of prenatal corticosteroids and gives birth at less than 34 weeks?

McLaughlin, K.; Crowther, C.; Vigneswaran, P.; Hancock, E.; Willson, K.
Fonte: Blackwell Publishing Asia Publicador: Blackwell Publishing Asia
Tipo: Artigo de Revista Científica
Publicado em //2002 EN
Relevância na Pesquisa
25.91%
Minimal information exists as to how women who give birth more than seven days after initial corticosteroid treatment, who may benefit from repeat prenatal corticosteroids, differ from women who give birth within seven days, at < 34 weeks gestation. Objectives: To examine the differences, if any, between women who received a single course of prenatal corticosteroids and remained undelivered more than seven days later and women who gave birth within seven days of treatment, at < 34 weeks gestation. Design: Retrospective cohort. Setting: Women's and Children's Hospital, Adelaide. Population: Women who gave birth at < 34 weeks gestation from 1 January 1994 to 31 December 1996. Methods: Data were extracted from medical records and retrieved from the hospital's database. Main potential predictors collected: Prenatal corticosteroid exposure, reason for risk of preterm birth, maternal demographics and previous and current obstetric history. Results: Of the 506 women, 122 (24%) remained undelivered more than seven days following prenatal corticosteroid therapy. Initial corticosteroid treatment was given on average 1.6 weeks earlier to women who remained undelivered more than seven days after treatment. Women who were given prenatal corticosteroids for placenta praevia (RR 6.03...

Histological and immunohistological study of the developing and involuting superficial cervical thymus in the koala (Phascolarctos cinereus).

Canfield, P; Hemsley, S; Connolly, J
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /08/1996 EN
Relevância na Pesquisa
25.91%
The thymuses of 44 koalas, ranging from less than 30 d to more than 14 y of age, were examined histologically and immunohistologically. The thymuses from 17 of these koalas dying acutely through trauma were regarded as not being significantly affected by disease and formed the basis for study of the normal thymus. Most other koalas had chronic illness and, consequently, disease affected (involuted) thymuses. Histologically, thymuses showed obvious corticomedullary differentiation with small Hassall's corpuscles visible in koalas more than 8 mo of age. Most cortical and medullary lymphocytes stained for CD3 and CD5 (T lymphocyte markers) while some cells (predominantly medullary) stained for CD79b (B lymphocytes and plasma cells), IgG (plasma cells) or MHC class II (reticular epithelium, macrophages and possibly lymphocytes). Adults of up to 5-6 y of age which had died through trauma had little evidence of involution and had prominent Hassall's corpuscles and medullary epithelial thymocytes. Thymic eosinopoiesis was an inconsistent finding. In traumatised animals over this age, involution was obvious with fibrous replacement of lobules, loss of Hassall's corpuscles and the development of dilated ducts lined by nonciliated epithelium. However...

Early cephalometric characteristics in Class III malocclusion

Farias,Vanessa Costa; Tesch,Ricardo de Souza; Denardin,Odilon Victor Porto; Ursi,Weber
Fonte: Dental Press International Publicador: Dental Press International
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2012 EN
Relevância na Pesquisa
36.33%
OBJECTIVE: Early identification of craniofacial morphological characteristics allows orthopedic segmented interventions to attenuate dentoskeletal discrepancies, which may be partially disguised by natural dental compensation. To investigate the morphological characteristics of Brazilian children with Class III malocclusion, in stages I and II of cervical vertebrae maturation and compare them with the characteristics of Class I control patients. METHODS: Pre-orthodontic treatment records of 20 patients with Class III malocclusion and 20 control Class I patients, matched by the same skeletal maturity index and sex, were selected. The craniofacial structures and their relationships were divided into different categories for analysis. Angular and linear measures were adopted from the analyses previously described by Downs, Jarabak, Jacobson and McNamara. The differences found between the groups of Class III patients and Class I control group, both subdivided according to the stage of cervical vertebrae maturation (I or II), were assessed by analysis of variance (ANOVA), complemented by Bonferroni's multiple mean comparisons test. RESULTS: The analysis of variance showed statistically significant differences in the different studied groups...