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Tendência e diferenciais socioeconômicos da mortalidade por câncer de colo de útero no Estado do Paraná (Brasil), 1980-2000; Socioeconomic trends and differentials in mortality due to cervical cancer in the State of Paraná (Brazil), 1980-2000

MÜLLER, Erildo Vicente; BIAZEVIC, Maria Gabriela Haye; ANTUNES, José Leopoldo Ferreira; CROSATO, Edgard Michel
Fonte: Associação Brasileira de Pós-Graduação em Saúde Coletiva Publicador: Associação Brasileira de Pós-Graduação em Saúde Coletiva
Tipo: Artigo de Revista Científica
POR
Relevância na Pesquisa
66.19%
O objetivo deste artigo é discutir a evolução da mortalidade por câncer de colo de útero no Estado do Paraná entre 1980 e 2000 e analisar seus diferenciais socioeconômicos em cada região. Taxas de mortalidade ajustadas por idade foram calculadas para as 22 regionais de saúde do Estado a cada ano. Análises comparativas avaliaram indicadores socioeconômicos associados com regiões que apresentaram tendência estacionária e crescente de mortalidade. A mortalidade por câncer de colo uterino cresceu no Estado como um todo a uma taxa de 1,68% (IC 1,20-2,17) ao ano. A maior parte das regiões apresentou tendência estacionária de mortalidade por câncer de colo de útero. As regionais com tendência de aumento na mortalidade apresentaram proporção significativamente mais elevada de analfabetismo (p<0,001) e de adultos (15 anos ou mais) com menos de 4 anos de estudo (p=0,001), e renda per capita (p=0,025) e IDH (p=0,023) inferiores. Houve tendência de aumento na mortalidade em todo o Estado; as regiões que contribuíram para o aumento experimentaram piores indicadores socioeconômicos.; The scope of this paper is to discuss the evolution of mortality due to cervical cancer in the State of Paraná, Brazil, between 1980 and 2000 and analyze the socioeconomic differentials in each region of the State. Mortality data were gathered from the System for Information on Mortality by age and town of residence. Age-adjusted death rates were calculated for 22 regions of the state in each year. Comparative analysis evaluated socioeconomic indicators associated with regions that showed either stationary or increasing mortality trends. Cervical cancer deaths increased in the state of Paraná...

Idade e prevalência da infecção genital por papilomavírus humano de alto risco em mulheres submetidas a rastreamento para câncer cervical; Age and prevalence of high risk human papilomavirus genital infection in women submitted to cervical cancer screening

Rama, Cristina Helena
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 06/07/2006 PT
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Introdução: A relação causal entre infecção genital por papilomavirus humano (HPV) de alto risco e o câncer do colo uterino está bem estabelecida; porém, há controvérsias em diferentes populações quanto à prevalência e distribuição da infecção em relação à idade. Objetivos: Caracterizar, pela Captura Híbrida II (CHII), a prevalência da infecção genital por HPV de alto risco e sua estratificação por idade. Verificar a associação da infecção com fatores de risco, resultados da citologia oncológica (CO), da colposcopia e da biópsia cervical. Casuística e Métodos: Em estudo transversal estudou-se 2300 mulheres (15-65 anos) que buscaram rastreamento para o câncer cervical. Aplicou-se questionário epidemiológico e foi feita a coleta da CO e da CHII, no caso de alteração em destes exames ou ambos indicou-se colposcopia e, nos casos anormais, procedeu-se à biópsia cervical. Resultados: A prevalência da infecção genital por HPV de alto risco em toda amostra foi de 17,8%: 27% (<25 anos), 21% (25-34 anos), 12% (35-54 anos) e de 14% (55-65 anos). Participantes com maior número de parceiros sexuais durante a vida apresentaram uma maior chance de infecção, relacionamento estável, idade entre 30 a 54 anos e ser ex-fumante foram fatores associados à proteção da infecção. Encontrou-se 204 (8...

Unidade móvel de prevenção na busca ativa do câncer do colo do útero nas zonas urbana e rural de Barretos; Mobile prevention unit for actively searching for uterine cervical cancer in the urban and rural zones of Barretos

Oliveira, Junea Caris de
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 25/02/2011 PT
Relevância na Pesquisa
66.21%
Introdução: O câncer do colo do útero é um problema de saúde publica, é uma importante causa de morbidade e mortalidade em mulheres de todo mundo. O rastreamento com a citologia de Papanicolaou, quando realizado periodicamente demonstrou ser eficaz na redução de incidência e mortalidade em países desenvolvidos. O rastreamento com unidade móvel de prevenção é uma estratégia para o diagnóstico precoce do câncer do colo do útero. Objetivo: Avaliar os resultados do programa de rastreamento com busca ativa e unidade móvel na detecção precoce do câncer do colo do útero na população das zonas urbana e rural de Barretos. Casuística e Métodos: Estudo retrospectivo, descritivo, com 16.849 mulheres na zona urbana e 1.055 na zona rural de Barretos. O projeto inclui visitas domiciliares repetidas de um profissional de saúde da unidade móvel do Hospital de Câncer de Barretos (HCB), entrevista e coleta de Papanicolaou. Mulheres com diagnóstico citológico de ASC-US, ASC-H, lesões intraepiteliais e carcinoma invasivo, foram convocadas para colposcopia e todas as mulheres com histopatológico de carcinoma foram tratadas e permanecem em seguimento no HCB. Os resultados deste programa foram comparados com dados do registro sobre câncer do colo do útero do Departamento Regional de Saúde V (DRS-V) e da Fundação Oncocentro de São Paulo (FOSP)...

Annual national direct and indirect cost estimates of the prevention and treatment of cervical cancer in Brazil

Novaes,Hillegonda Maria Dutilh; Itria,Alexander; Silva,Gulnar Azevedo e; Sartori,Ana Marli Christovam; Rama,Cristina Helena; Soárez,Patrícia Coelho de
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2015 EN
Relevância na Pesquisa
66.22%
OBJECTIVE: To estimate the annual direct and indirect costs of the prevention and treatment of cervical cancer in Brazil. METHODS: This cost description study used a "gross-costing" methodology and adopted the health system and societal perspectives. The estimates were grouped into sets of procedures performed in phases of cervical cancer care: the screening, diagnosis and treatment of precancerous lesions and the treatment of cervical cancer. The costs were estimated for the public and private health systems, using data from national health information systems, population surveys, and literature reviews. The cost estimates are presented in 2006 USD. RESULTS: From the societal perspective, the estimated total costs of the prevention and treatment of cervical cancer amounted to USD $1,321,683,034, which was categorized as follows: procedures (USD $213,199,490), visits (USD $325,509,842), transportation (USD $106,521,537) and productivity losses (USD $676,452,166). Indirect costs represented 51% of the total costs, followed by direct medical costs (visits and procedures) at 41% and direct non-medical costs (transportation) at 8%. The public system represented 46% of the total costs, and the private system represented 54%. CONCLUSION: Our national cost estimates of cervical cancer prevention and treatment...

Cervical cancer risk factors among HIV-infected Nigerian women

Ononogbu, Uzoma; Almujtaba, Maryam; Modibbo, Fatima; Lawal, Ishak; Offiong, Richard; Olaniyan, Olayinka; Dakum, Patrick; Spiegelman, Donna; Blattner, William; Adebamowo, Clement
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
EN_US
Relevância na Pesquisa
66.28%
Background: Cervical cancer is the third most common cancer among women worldwide, and in Nigeria it is the second most common female cancer. Cervical cancer is an AIDS-defining cancer; however, HIV only marginally increases the risk of cervical pre-cancer and cancer. In this study, we examine the risk factors for cervical pre-cancer and cancer among HIV-positive women screened for cervical cancer at two medical institutions in Abuja, Nigeria. Methods: A total of 2,501 HIV-positive women participating in the cervical cancer screen-and-treat program in Abuja, Nigeria consented to this study and provided socio-demographic and clinical information. Log-binomial models were used to calculate relative risk (RR) and 95% confidence intervals (95%CI) for the risk factors of cervical pre-cancer and cancer. Results: There was a 6% prevalence of cervical pre-cancer and cancer in the study population of HIV-positive women. The risk of screening positivity or invasive cancer diagnosis reduced with increasing age, with women aged 40 years and older having the lowest risk (RR=0.4; 95%CI=0.2–0.7). Women with a CD4 count of 650 per mm3 or more also had lower risk of screening positivity or invasive cancer diagnosis (RR=0.3, 95%CI=0.2–0.6). Other factors such as having had 5 or more abortions (RR=1.8...

Advancing Cervical Cancer Prevention in India

Krishnan, S; Madsen, E.; Porterfield, D.; Varghese, B.; Poehlman, J.; Taylor, O.
Fonte: World Bank, Washington, DC Publicador: World Bank, Washington, DC
Tipo: Brief
EN_US
Relevância na Pesquisa
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In 2010, nearly 74,000 new cases of cervical cancer were diagnosed among Indian women. This number is estimated to increase to as high as 225,000 cases by 2025. Cervical cancer is also the leading cause of cancer deaths in India, as most cases are not detected until they are in an advanced stage. In addition to the cost in lives, cervical cancer can have a significant social and economic impact on families and their communities, as it primarily affects women during their most productive years. Recognizing the challenge of cervical cancer, in 2013 the World Bank conducted a review of research studies on cervical cancer prevention and examined the implementation experiences of cervical cancer screening programs in India. A recently published report summarizes the current state of knowledge and practice, and offers recommendations for strengthening India s programmatic and policy responses to cervical cancer.

Promoting Quality of Cervical Cancer Screening and Treatment in India

Krishnan, S.; Madsen, E.; Porterfield, D.; Varghese, B.
Fonte: World Bank, Washington, DC Publicador: World Bank, Washington, DC
Tipo: Brief
EN_US
Relevância na Pesquisa
66.25%
Cervical cancer screening is highly cost effective, feasible, and culturally acceptable in higher and lower income settings across the world. According to the World Health Organization and the World Economic Forum, screening for cervical cancer is an evidence-based best buy prevention intervention (1). However, to be effective in reducing cervical cancer incidence and mortality, screening programs must be of high quality. Cervical cancer is the second most common cancer among women in India. In 2010, nearly 74,000 Indian women were newly diagnosed with the disease and 34,000 women died (2). Recognizing the challenge of cervical cancer in India, the World Bank published a review of research on cervical cancer prevention and implementation experiences of cervical cancer screening programs in the country (3). The review found that program effectiveness depends on the quality of screening interventions. Cervical cancer screening programs are effective when they achieve high coverage of the target population...

Lynch syndrome and cervical cancer

Antill, Y.C.; Dowty, J.G.; Ko Win, A.; Thompson, T.; Walsh, M.D.; Cummings, M.C.; Gallinger, S.; Lindor, N.M.; Le Marchand, L.; Hopper, J.L.; Newcomb, P.A.; Haile, R.W.; Church, J.; Tucker, K.M.; Buchanan, D.D.; Young, J.P.; Winship, I.M.; Jenkins, M.A.
Fonte: Wiley Publicador: Wiley
Tipo: Artigo de Revista Científica
Publicado em //2015 EN
Relevância na Pesquisa
66.18%
Carriers of germline mutations in DNA mismatch repair (MMR) genes are at increased risk of several cancers including colorectal and gynecologic cancers (Lynch syndrome). There is no substantial evidence that these mutations are associated with an increased risk of cervical cancer. A total of 369 families with at least one carrier of a mutation in a MMR gene (133 MLH1, 174 MSH2, 35 MSH6, and 27 PMS2) were ascertained via population cancer registries or via family cancer clinics in Australia, New Zealand, Canada, and USA. Personal and family histories of cancer were obtained from participant interviews. Modified segregation analysis was used to estimate the hazard ratio (incidence rates for carriers relative to those for the general population), and age-specific cumulative risks of cervical cancer for carriers. A total of 65 cases of cervical cancer were reported (including 10 verified by pathology reports). The estimated incidence was 5.6-fold (95% CI: 2.3-13.8; p=0.001) higher for carriers than for the general population with a corresponding cumulative risk to 80 years of 4.5% (95% CI: 1.9-10.7%) compared with 0.8% for the general population. The mean age at diagnosis was 43.1 years (95% CI: 40.0-46.2), 3.9 years younger than the reported USA population mean of 47.0 years (p=0.02). Women with MMR gene mutations were found to have an increased risk of cervical cancer. Due to limited pathology verification we cannot be certain that a proportion of these cases were not lower uterine segment endometrial cancers involving the endocervix...

Advancing Cervical Cancer Prevention in India : Insights from Research and Programs

Krishnan, Suneeta; Madson, Emily; Porterfield, Deborah; Varghese, Beena
Fonte: World Bank, Washington, DC Publicador: World Bank, Washington, DC
Tipo: Publications & Research :: Working Paper; Publications & Research
ENGLISH; EN_US
Relevância na Pesquisa
66.24%
Cervical cancer is the leading cause of cancer mortality in India, accounting for 17 percent of all cancer deaths among women age 30 to 69 years. At current incidence rates, the World Health Organization (WHO) estimates that the annual burden of new cases in India will increase to nearly 225,000 by 2025. Despite the considerable burden of cervical cancer morbidity and mortality in India, there are few large-scale, organized cervical cancer prevention programs in the country. We reviewed the research literature and conducted interviews with individuals engaged in research and public health program implementation to identify important elements of cervical cancer prevention efforts in India and implementation issues that merit further investigation. Although primary prevention through HPV vaccination has been endorsed by WHO, under certain conditions, in low- and middle-income countries (LMICs), its cost, partial efficacy and safety have been intensely debated in India. Further research and advocacy efforts are needed to determine the optimal strategies for its introduction and sustained use in the country. However...

DETERMINANTS OF CERVICAL CANCER SCREENING IN THE KILIMANJARO REGION OF TANZANIA

Skrastins, EMILY F E
Fonte: Quens University Publicador: Quens University
Tipo: Tese de Doutorado
EN; EN
Relevância na Pesquisa
66.19%
Background: Cervical cancer is a leading cause of death in Tanzanian women, with annual age-standardized mortality of 38 per 100,000. While organized screening programs have minimized cervical cancer rates in the developed world, a national prevention program has not yet been instituted in Tanzania. Though screening is available at clinics in the Kilimanjaro region, uptake of these services is reported to be low. The objectives of this thesis were: 1) to describe the knowledge, attitudes and practices of cervical cancer screening in rural and urban Kilimanjaro women, 2) to determine the main barriers preventing women from being screened, and 3) to identify important determinants of screening status and screening acceptability in the population. Methods: A cross-sectional survey was administered to 312 rural and 280 urban women in the region over June-July 2012. The sample was obtained through a multistage random sampling strategy. Descriptive statistics were performed to address Objectives 1 and 2, while multivariate logistic regression models were created using generalized estimating equations to address Objective 3. Results: Awareness of cervical cancer in the sample was high, but women had less knowledge of screening tests for the disease. The proportion of ever-screened women was significantly lower in the rural (4%) than in the urban (8%) sample. The most common barrier in never-screened women was not knowing that screening existed...

Estudo genético e epigenético no prognóstico do câncer cervical por meio da verificação de HPV de baixo e alto risco e da metilação e não metilação dos genes RARβ, TIMP3, CDH1 E MGMT; Study genetic and epigenetic on prognosis of cervical cancer by means of verification of HPV of low and high risk and methylation and unmethylation genes RARβ, TIMP3, CDH1 E MGMT

D'Alessandro, Aline Almeida Barbaresco
Fonte: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) Publicador: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Tipo: Tese de Doutorado Formato: application/pdf
POR
Relevância na Pesquisa
66.27%
The human papillomavirus (HPV) is a major etiologic factor in the development of cervical cancer, DNA virus primarily infects the epithelium and may induce benign and malignant lesions of the mucous membranes and skin. Carcinogenesis is a multistep process that involves both changes genetic and epigenetic. The two changes epigenetic most studied are DNA methylation and histone acetylation. DNA methylation may be related development to cancer, and their presence or absence can affect the prognosis. The objective of this study was to evaluate the prognosis of patients with cervical cancer in stages I and II through the verification of HPV high and low risk, and the presence and absence of genes methylated and unmethylated RARβ, TIMP3, CDH1 and MGMT. We analyzed 129 records and samples of paraffin embedded biopsies of patients with cervical cancer in stages I and II. Detection of HPV - DNA was performed by PCR for HPV DNA of low and high oncogenic risk and MSP-PCR to detect the genes methylated or not, RARβ, TIMP3, CDH1 and MGMT. The calculation of survival used the Kaplan-Meier method and the log-hank test to compare means of survival between the prognostic factors for cervical cancer. The overall survival at 60 months of patients with the presence of RARβ...

Social, demographic and healthcare factors associated with stage at diagnosis of cervical cancer: cross sectional study in a tertiary hospital in Northern Uganda

Mwaka, Amos Deogratius; Garimoi, Christopher Orach; Were, Edward Maloba; Roland, Martin; Wabinga, Henry; Lyratzopoulos, Georgios
Fonte: BMJ Group Publicador: BMJ Group
Tipo: Article; accepted version
EN
Relevância na Pesquisa
66.21%
This is the author accepted manuscript. It is currently under an indefinite embargo pending publication by the BMJ Group.; Objective: To examine patient and primary healthcare factors and stage at diagnosis in women with cervical cancer in Northern Uganda with the intention to identify factors that are associated with advanced stages in order to inform policies to improve survival from cervical cancer in the low- and middle-income countries. Design: Cross sectional hospital-based study Setting: Tertiary, not-for-profit private hospital in post-conflict region. Participants: Consecutive tissue-diagnosed symptomatic cervical cancer patients attending care. Of 166 patients, 149 were enrolled and analysed. Primary outcome: Cervical cancer stage at diagnosis. Results: Most women were diagnosed in stages III (45%) or IV (21%). After controlling for age, marital status, educational attainment and number of biological children, there was evidence for association between greater likelihood of advanced stage at diagnosis and pre-referral diagnosis of cancer by primary healthcare professionals (Adjusted OR (AOR)=13.04:95%CI; 3.59-47.3), financial difficulties precluding prompt help-seeking (AOR=5.5:95%CI; 1.58-20.64). After adjusting for age...

Screening for Cervical Cancer in HIV Positive Kenyan Women: the Role of HPV Genotyping

Dainty, Erin E.
Fonte: Universidade Duke Publicador: Universidade Duke
Tipo: Tese de Doutorado
Publicado em //2013
Relevância na Pesquisa
66.25%

Problem: Among HIV positive women in Kenya, cervical cancer has the highest incidence of any malignancy. In order to create effective screening strategies for both the primary and secondary prevention of cervical cancer in HIV-infected women, an understanding of the natural history of human papillomavirus (HPV) and HIV co infection is critical.

Objectives: To describe the prevalence of HPV genotypes in HIV infected women with mild dysplasia and those with biopsy-confirmed severe dysplasia and invasive cervical cancer in Eldoret, Kenya. To determine how CD4 count, as a marker of immunocompetence, relates to HPV genotype distribution in patients with compared to those with severe dysplasia and invasive cervical cancer.

Methodology: This was a cross-sectional study recruiting from two groups: women who have invasive cervical cancer and women who have mild dysplasia. Cervical swabs were collected for genotyping, along with a recent CD4 count and relevant sociodemographic and medical data. HPV genotyping for types 6, 11, 16, 18, 26, 31, 33, 35, 39, 43, 44, 45, 51, 52, 53, 54, 56, 58, 66, 68, 69, 70, 71, 73, 74, and 82 was performing using the INNO-LiPA HPV genotyping assay, SPF10 system version 1 (Innogenetics, Ghent...

Assessment of Current Cervical Cancer Screening Practice and Responses to a Novel Screening Device, Transvaginal Digital Colposcopy, Among Gynecologists in Hyderabad, India

Gorthala, Sisira
Fonte: Universidade Duke Publicador: Universidade Duke
Tipo: Tese de Doutorado
Publicado em //2015
Relevância na Pesquisa
66.24%

Background: India has the highest burden of cervical cancer mortality, globally, with 67,477 deaths in 2012. A novel device, the transvaginal digital colposcope (TVDC), or a small handheld colposcope, could potentially improve quality of care and address barriers to cervical cancer screening, by reducing patient discomfort and aiding practitioners in screening. Studies which validate India-WHO guidelines for cervical cancer screening report wide ranges of sensitivity and specificity for techniques currently used in low-resource settings, all of which are contingent on numerous factors from patient awareness to receptivity to user training, suggesting that the context is paramount to improving cervical cancer detection. To that end, assessment of the healthcare and physician environment in terms of practice and reaction to the new device is essential prior to device implementation in order to anticipate benefits or negative consequences of device use.

Methods: A survey was developed to explore experiences, practice, and approaches to cervical cancer screening based on a new technology, and administered to 15 gynecologists in various clinical settings in Hyderabad, India. First, participants answered questions about past and current practices for cervical cancer screening...

Cervical Cancer Detection and Prevention in Haiti: A Comparison of Pap Smear and Liquid-Based Cytology Detection Methods

Wolpert, Genevieve
Fonte: Universidade Duke Publicador: Universidade Duke
Tipo: Tese de Doutorado
Publicado em //2015
Relevância na Pesquisa
66.19%

Human Papillomavirus-induced cervical cancer represents one of the most significant causes of female morbidity and mortality from cancer worldwide. Detecting HPV-related cervical disease during the premalignant treatable stage of development is critical to reduce the burden of this disease. Cervical cytology has been the primary screening tool for cervical dysplasia in the United States for decades. However in Haiti, early attempts to identify cervical dysplasia were thwarted by a high incidence of obscuring inflammation on conventional Pap smears. This study seeks to determine if liquid-based cytology screening can increase the detection of cervical dysplasia over conventional Pap smears when obscuring inflammation is present. The study population was recruited in Haiti and women underwent both types of cervical dysplasia testing; those for whom it was indicated underwent follow-up cervical biopsy. The cervical dysplasia tests were compared to each other using kappa agreement statistics with cervical biopsy as the gold standard for diagnosis. Both tests showed comparable sensitivity for dysplasia with and without inflammation-containing samples. The Pap test showed superior specificity by greater agreement with the gold standard biopsy...

Design and methods of the evaluation of an HPV-based cervical cancer screening strategy in Mexico: the Morelos HPV study

Flores,Yvonne; Shah,Keerti; Lazcano,Eduardo; Hernández,Mauricio; Bishai,David; Ferris,Daron G; Lörincz,Attila; Hernández,Pilar; Salmerón,Jorge
Fonte: Instituto Nacional de Salud Pública Publicador: Instituto Nacional de Salud Pública
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/07/2002 EN
Relevância na Pesquisa
66.22%
Objective. The purpose of this paper is to describe the design and methodology of the Morelos HPV Study. The main objective of this study is to examine the use of two different methods for obtaining HPV DNA specimens, self-collected vaginal and clinician-collected cervical, to detect pre-invasive cervical lesions and cancer. Material and Methods. This study was conducted within the regular population-based framework of the Mexican Institute of Social Security (IMSS) cervical cancer screening program in Morelos. A total of 7,868 women were recruited between May and October 1999 and are representative of the population of women attending cervical cancer screening services at the 23 IMSS clinics in the state of Morelos in 1999. Women were provided with a detailed description of the study before signing an informed consent form. Basic data were obtained from all participants using a standard IMSS registration form. During the initial recruitment visit, a randomly selected subsample of 1 069 participants were interviewed to collect additional information about cervical cancer risk factors, acceptability of the HPV and Pap tests, as well as patient costs. Before the pelvic exam, participants were asked to provide a self-collected vaginal specimen for HPV testing. All participants underwent a pelvic examination that involved collecting a cervical sample for the Pap smear and a clinician-collected HPV specimen. Data were evaluated from 7 732 women with complete information for the three tests. The 1 147 women who received at least one positive result (Pap...

Epidemiology of cervical cancer in Colombia

Muñoz,Nubia; Bravo,Luis Eduardo
Fonte: Instituto Nacional de Salud Pública Publicador: Instituto Nacional de Salud Pública
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2014 EN
Relevância na Pesquisa
66.2%
Objective. To describe the incidence, mortality, time trends and prognostic factors for cervical cancer in Cali, Colombia, and to review the molecular epidemiological evidence showing that HPV is the major and necessary cause of cervical cancer and the implications of this discovery for primary and secondary prevention. Materials and methods. Incidence rates of cervical cancer during a 45-year period (1962-2007) were estimated based on the population-based cancer registry of Cali and the mortality statistics from the Municipal Health Secretariat of Cali. Prognostic factors were estimated based on relative survival. Review of the molecular epidemiological evidence linking HPV to cervical cancer was focused on the studies carried out in Cali and in other countries. Results. Incidence rates of squamous cell carcinoma (SCC) declined from 120.4 per 100 000 in 1962-1966 to 25.7 in 2003-2007 while those of adenocarcinoma increased from 4.2 to 5.8. Mortality rates for cervical cancer declined from 18.5 in 1984-1988 to 7.0 per 100 000 in 2009-2011. Survival was lower in women over 65 years of age and in clinical stages 3-4. Review of the molecular epidemiological evidence showed that certain types of HPV are the central and necessary cause of cervical cancer. Conclusions. A decline in the incidence and mortality of SCC and an increase in the incidence of adenocarcinoma during a 45-year period was documented in Cali...

Experiences of Batswana women diagnosed with both HIV/AIDS and cervical cancer

Molefe,T; Duma,SE
Fonte: Curationis Publicador: Curationis
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2009 EN
Relevância na Pesquisa
66.2%
The central phenomenon of interest to the authors was the experiences of Batswana women who have been diagnosed with both HIV/AIDS and cervical cancer. They wanted to know how these women and their families coped with the burden of the two 'fatal' diseases. This interest was brought about by the current surge in cervical cancer cases in the country, and the relationship between the two diseases. There is scant literature on the experiences of women with the dual diagnosis of HIV/AIDS and cervical cancer. The purpose of the study was to explore the experiences of Batswana women who are diagnosed with both HIV/AIDS and cervical cancer. The research question was 'What are the experiences of Batswana women diagnosed with both HIV/AIDS and cervical cancer?' A phenomenological descriptive qualitative research design was therefore appropriate to answer the research question. Semi-structured interviews and field notes were used to collect data. One-to-one interviews were conducted with six women diagnosed with the two diseases. Both convenience and purposive sampling techniques were used in selection of participants. The seven procedural steps proposed by Collaizi ( 1978) were utilized in data analysis as the study was based on the phenomenology approach. The findings revealed that HIV/AIDS and cervical cancer are chronic illnesses that can instill chronic emotional pain. Reactions to diagnosis with these diseases include pain...

Design and methods of the evaluation of an HPV-based cervical cancer screening strategy in Mexico: the Morelos HPV study

Flores,Yvonne; Shah,Keerti; Lazcano,Eduardo; Hernández,Mauricio; Bishai,David; Ferris,Daron G; Lörincz,Attila; Hernández,Pilar; Salmerón,Jorge
Fonte: Instituto Nacional de Salud Pública Publicador: Instituto Nacional de Salud Pública
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/07/2002 EN
Relevância na Pesquisa
66.22%
Objective. The purpose of this paper is to describe the design and methodology of the Morelos HPV Study. The main objective of this study is to examine the use of two different methods for obtaining HPV DNA specimens, self-collected vaginal and clinician-collected cervical, to detect pre-invasive cervical lesions and cancer. Material and Methods. This study was conducted within the regular population-based framework of the Mexican Institute of Social Security (IMSS) cervical cancer screening program in Morelos. A total of 7,868 women were recruited between May and October 1999 and are representative of the population of women attending cervical cancer screening services at the 23 IMSS clinics in the state of Morelos in 1999. Women were provided with a detailed description of the study before signing an informed consent form. Basic data were obtained from all participants using a standard IMSS registration form. During the initial recruitment visit, a randomly selected subsample of 1 069 participants were interviewed to collect additional information about cervical cancer risk factors, acceptability of the HPV and Pap tests, as well as patient costs. Before the pelvic exam, participants were asked to provide a self-collected vaginal specimen for HPV testing. All participants underwent a pelvic examination that involved collecting a cervical sample for the Pap smear and a clinician-collected HPV specimen. Data were evaluated from 7 732 women with complete information for the three tests. The 1 147 women who received at least one positive result (Pap...

Epidemiology of cervical cancer in Colombia

Muñoz,Nubia; Bravo,Luis Eduardo
Fonte: Instituto Nacional de Salud Pública Publicador: Instituto Nacional de Salud Pública
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2014 EN
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Objective. To describe the incidence, mortality, time trends and prognostic factors for cervical cancer in Cali, Colombia, and to review the molecular epidemiological evidence showing that HPV is the major and necessary cause of cervical cancer and the implications of this discovery for primary and secondary prevention. Materials and methods. Incidence rates of cervical cancer during a 45-year period (1962-2007) were estimated based on the population-based cancer registry of Cali and the mortality statistics from the Municipal Health Secretariat of Cali. Prognostic factors were estimated based on relative survival. Review of the molecular epidemiological evidence linking HPV to cervical cancer was focused on the studies carried out in Cali and in other countries. Results. Incidence rates of squamous cell carcinoma (SCC) declined from 120.4 per 100 000 in 1962-1966 to 25.7 in 2003-2007 while those of adenocarcinoma increased from 4.2 to 5.8. Mortality rates for cervical cancer declined from 18.5 in 1984-1988 to 7.0 per 100 000 in 2009-2011. Survival was lower in women over 65 years of age and in clinical stages 3-4. Review of the molecular epidemiological evidence showed that certain types of HPV are the central and necessary cause of cervical cancer. Conclusions. A decline in the incidence and mortality of SCC and an increase in the incidence of adenocarcinoma during a 45-year period was documented in Cali...