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Análise da sobrevida de pacientes com carcinoma hepatocelular pequeno; Survival analysis of patients with small hepatocellular carcinoma

Kikuchi, Luciana Oba Onishi
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 21/11/2007 PT
Relevância na Pesquisa
46.45%
Introdução: O carcinoma hepatocelular (CHC) é o câncer primário de fígado mais comum. A cirrose hepática é o principal fator de risco para esse tumor. O rastreamento para o CHC em pacientes com cirrose tem sido recomendado há anos. Acredita-se que a detecção e o tratamento precoce do CHC melhorem a sobrevida dos pacientes. O objetivo deste estudo foi analisar a sobrevida dos pacientes cirróticos com CHC pequeno e identificar fatores preditivos de sobrevida no Brasil. Casuística e Métodos: Entre janeiro de 1998 e dezembro de 2003, 74 pacientes cirróticos com CHC foram avaliados. Eles preenchiam os seguintes critérios: CHC com até três nódulos e no máximo 30 mm de diâmetro cada. Os fatores preditores de sobrevida foram identificados através do método de Kaplan-Meier e o modelo de Cox. Resultados: A média de idade foi de 58 anos (32-77); 71% dos pacientes eram do sexo masculino; 64% tinham hepatite C; 60% eram Child-Pugh A, o valor mediano da pontuação de MELD foi de 11; 79% tinham hipertensão portal. No momento do diagnóstico, 71% tinham uma única lesão; o tamanho do principal tumor era menor que 20 mm em 47%; o valor médio de AFP foi de 131 ng/ml. Três pacientes tinham trombose de veia porta, sugestiva de invasão vascular. Cinqüenta pacientes (67...

Carcinoma hepatocelular de pequeno tamanho e cirrose hepática pelo vírus da hepatite C: estudo caso-controle de variáveis clínicas e laboratoriais; Small hepatocellular carcinoma and hepatitis C liver cirrhosis. A case-control study based on clinical and laboratorial data

Matielo, Celso Eduardo Lourenço
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 11/08/2005 PT
Relevância na Pesquisa
46.37%
O carcinoma hepatocelular (CHC) é a quinta neoplasia maligna mais frequente no mundo, sendo que, em mais de 80% dos casos, seu aparecimento está relacionado à presença de cirrose hepática (CH). A infecção crônica pelo vírus da hepatite C (VHC) é uma das principais causas de cirrose hepática no mundo e, consequentemente, de CHC. Este estudo caso-controle foi baseado na análise de variáveis clínicas, bioquímicas e sorológicas de 31 pacientes cirróticos pelo VHC com CHC de pequeno tamanho (<= 3 cm, tamanho médio = 22 mm) comparando-os com grupo controle de 62 pacientes cirróticos pelo VHC sem CHC, pareados por idade e sexo. Os principais objetivos foram identificar marcadores auxiliares ao diagnóstico de CHC e desenvolver um modelo linear para o diagnóstico presuntivo de CHC de pequeno tamanho. Os dados levantados foram submetidos à análise univariada. Demonstramos diferenças significantes entre os dois grupos com relação à presença de marcadores de infecção pregressa pelo vírus da hepatite B; às dosagens séricas de aspartato aminotransferase, de alanina aminotransferase, de gamaglutamil transpeptidase; à contagem de plaquetas, fibrinogênio plasmático, alfafetoproteína e resposta virológica sustentada ao tratamento com interferon. As variáveis significantes foram submetidas à análise multivariada com procedimento de regressão logística "stepwise" para ajustar o modelo linear. Esta análise multivariada selecionou duas variáveis preditoras para o diagnóstico de CHC...

Hepatocellular carcinoma in patients undergoing orthotopic liver transplantation : radiological findings with anatomopathological correlation in Brazil; Carcinoma hepatocelular em pacientes submetidos a transplante hepático : achados radiológicos com correlação anatomopatológica no Brasil

Maciel, Antonio Carlos; Moreira, Roger Klein; Cerski, Carlos Thadeu Schmidt; Resende, Vinícius Labrea; Zanotelli, Maria Lucia; Matiotti, Simone B.
Fonte: Universidade Federal do Rio Grande do Sul Publicador: Universidade Federal do Rio Grande do Sul
Tipo: Artigo de Revista Científica Formato: application/pdf
POR
Relevância na Pesquisa
36.65%
Racional - O carcinoma hepatocelular é um dos tumores malignos mais comuns em todo o mundo. Exames de imagens, especialmente tomografia computadorizada e ultra-sonografia, estão entre as principais técnicas diagnósticas, embora a acurácia destes métodos possa apresentar significativa variabilidade. Objetivos - Determinar a prevalência de carcinoma hepatocelular em pacientes cirróticos submetidos a transplante hepático na Santa Casa de Misericórdia de Porto Alegre, RS; estimar a sensibilidade da tomografia computadorizada e da ultra-sonografia na detecção pré-transplante de carcinoma hepatocelular nesse grupo de pacientes; correlacionar características radiológicas com achados anatomopatológicos. Materiais e métodos - Estudo de prevalência retrospectivo. População: pacientes adultos, cirróticos, submetidos a transplante hepático de janeiro de 1990 a julho de 2003. Entre os 292 pacientes transplantados, foi diagnosticado 31 casos de carcinoma hepatocelular, dos quais 29 foram incluídos no estudo. As características tomográficas e ecográficas dos tumores diagnosticados pré-transplante foram comparadas com as observadas em exame anatomopatológico. Resultados - A prevalência da infecção pelo vírus da hepatite C nos pacientes com diagnóstico de carcinoma hepatocelular foi de 93...

Avaliação da angiogenese em transplantes hepaticos atraves do CD34 e CD105 : comparação entre carcinoma hepatocelular, nodulos displasicos e nodulos regenerativos; Evaluation of angiogenesis in liver explants by CD34 and CD105 : comparative study between hepatocellular Carcinoma, dysplastic nodules and regerative cirrhotic nodules

Vanderlei Segatelli
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 22/02/2010 PT
Relevância na Pesquisa
46.43%
O carcinoma hepatocelular (CHC) destaca-se como uma das formas mais comuns de câncer no mundo, correspondendo a aproximadamente 90% das neoplasias primárias do fígado, sendo a cirrose seu mais importante fator de risco. A sua progressão, no entanto, depende de inúmeros fatores e, entre estes, a angiogênese assume papel fundamental, principalmente por ser o CHC um tumor altamente vascularizado. É sabido que tumores sólidos, ao atingirem volume de 1 a 2mm3, passam a ter seu crescimento dependente de neovascularização e no fígado esta se faz através de capilarização sinusoidal, processo pelo qual ocorrem alterações morfológicas nos sinusóides hepáticos, com perda das fenestrações e deposição de membrana basal. Neste estudo retrospectivo avaliamos a angiogênese, através dos marcadores imuno-histoquímicos CD34 e CD105 (Endoglina), com determinação da densidade microvascular (DMV) em 44 produtos de hepatectomia total, compreendendo 44 nódulos neoplásicos (CHC), 44 nódulos regenerativos (NR) e 15 nódulos com características microscópicas de lesões pré-malignas (ou Nódulos Displásicos - ND), sendo 8 de baixo grau e 7 de alto grau. A avaliação compreendeu a determinação da DMV no centro e na periferia de todos os nódulos. Para análise estatística foi utilizada análise descritiva com apresentação de medidas de posição e dispersão para variáveis contínuas; para a comparação dos grupos foi utilizada a ANOVA...

Brain metastasis of hepatocellular carcinoma detected after liver transplantation

França,Alex Vianey Callado; Martinelli,Ana; Silva Jr.,Orlando Castro e
Fonte: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED Publicador: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/2004 EN
Relevância na Pesquisa
46.5%
AIM: We report the case of a patient with hepatocellular carcinoma submitted to liver transplantation, who subsequently manifested tumor recurrence initially as brain metastasis. CASE DESCRIPTION: A 48-year-old male cirrhotic patient with hepatitis C infection, and two focal hepatic lesions, had a cytologic and histologic diagnosis of hepatocellular carcinoma. Before transplant, he was submitted to adjuvant treatment with a combination of arterial embolization and intratumoral ethanol injection. In the 3rd month post-liver transplantation, the patient developed headache, nausea and vomiting, without any neurological impairment. Brain computed tomography and magnetic resonance imaging identified an expansive hypervascular lesion with internal bleeding. Evaluation of the surgical explant revealed macroscopic invasion of portal vessels. CONCLUSION: Brain metastasis of a hepatocellular carcinoma after liver transplantation may occur. This metastasis may have occurred before or soon after the transplant. Patients with hepatocellular carcinoma, awaiting liver transplant, should be screened for cerebral metastasis. Vascular invasion may indicate hematogenic dissemination of the tumor.

Hepatocellular carcinoma in patients undergoing orthotopic liver transplantation: radiological findings with anatomopathological correlation in Brazil

Maciel,Antônio Carlos; Cerski,Carlos Thadeu; Moreira,Roger Klein; Resende,Vinicius Labrea; Zanotelli,Maria Lúcia; Matiotti,Simone Berwig
Fonte: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED Publicador: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2006 EN
Relevância na Pesquisa
36.6%
BACKGROUND: Hepatocellular carcinoma is one of the most common malignant tumors worldwide. Imaging techniques, specially computed tomography and ultrasound, are among the most useful diagnostic tools, although the accuracy of these methods may have a significant variability. AIMS: To determine the prevalence of hepatocellular carcinoma in cirrhotic patients undergoing orthotopic liver transplantation at "Santa Casa de Misericórdia" of Porto Alegre, RS, Brazil; to estimate the sensitivity of computed tomography and ultrasound in pretransplantation detection of hepatocellular carcinoma in this population; to correlate the radiological characteristics with anatomopathological findings. MATERIALS AND METHODS: Retrospective prevalence study. Population: adult, cirrhotic patients undergoing orthotopic liver transplantation from January 1990 to July 2003. Among the 292 transplanted patients, 31 cases of hepatocellular carcinoma were diagnosed, of which 29 were included in the study. Tumor characteristics in both ultrasound and computed tomography were compared to those observed in anatomopathological examination. RESULTS: Prevalence of hepatitis C virus infection among patients with diagnosis of hepatocellular carcinoma was 93.5%, and the prevalence of hepatocellular carcinoma among transplanted patients was 10.6%. The overall sensitivity of the imaging techniques was 70.3% for computed tomography and 72% for ultrasound. CONCLUSION: The prevalence of hepatocellular carcinoma at our institution...

Occult hepatitis B virus infection in patients with chronic liver disease due to hepatitis C virus and hepatocellular carcinoma in Brazil

Branco,Fernanda; Mattos,Angelo Alves de; Coral,Gabriela Perdomo; Vanderborght,Bart; Santos,Diogo Edele; França,Paulo; Alexander,Cláudio
Fonte: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED Publicador: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2007 EN
Relevância na Pesquisa
46.5%
BACKGROUND: The prevalence and consequences of occult HBV infection in patients with chronic liver disease by HCV remain unknown. AIMS: To evaluate the prevalence of occult HBV infection in a population of HCV-infected patients with hepatocellular carcinoma. METHODS: The serum samples were tested for HBV DNA by nested PCR and liver tissue analysis was carried out using the immunohistochemical technique of 66 HBsAg-negative patients: 26 patients with chronic hepatitis by HCV (group 1), 20 with hepatocellular carcinoma related to chronic infection by HCV (group 2) and 20 with negative viral markers for hepatitis B and C (control group). RESULTS: Occult HBV infection was diagnosed in the liver tissue of 9/46 (19.5%) HCV-infected patients. Prevalence of occult B infection was evaluated in the HCV-infected patients with and without hepatocellular carcinoma, and there were seven (77.7%) of whom from group 2, conferring a 35% prevalence of this group. No serum sample was positive for HBV DNA in the three groups. CONCLUSION: Occult infection B is frequently detected in liver tissue of HCV-infected patients, especially in cases of hepatocellular carcinoma. However large studies are needed to confirm that co-infection could determine a worse progress of chronic liver disease in this population.

Non-cancerous prognostic factors of hepatocellular carcinoma after liver transplantation

Batista,Thales Paulo; Miranda,Luiz Eduardo Correia; Sabat,Bernardo David; Melo,Paulo Sérgio Vieira de; Fonseca Neto,Olival Cirilo Lucena da; Amorim,Américo Gusmão; Lacerda,Cláudio Moura
Fonte: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia Publicador: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2012 EN
Relevância na Pesquisa
46.38%
PURPOSE: To explore non-cancerous factors that may be related with medium-term survival (24 months) after liver transplantation (LT) in this data from northeast Brazil. METHODS: A cross-sectional study was carried out in patients who underwent deceased-donor orthotopic LT because hepatocellular carcinoma (HCC) at the University of Pernambuco, Brazil. Non-cancerous factors (i.e.: donor-, receptor-, surgery- and center-related variables) were explored as prognostic factors of medium-term survival using univariate and multivariate approachs. RESULTS: Sixty-one patients were included for analysis. Their three, six, 12 and 24-month overall cumulative survivals were 88.5%, 80.3%, 73.8% and 65.6%, respectively. Our univariate analysis identified red blood cell transfusion (Exp[b]=1.26; p<0.01) and hepato-venous reconstruction technique (84.6% vs. 51.4%, p<0.01; respectively for piggyback and conventional approaches) as significantly related to post-LT survival. The multivariate analysis confirmed the hepato-venous reconstruction technique was an independent prognostic factor. CONCLUSION: The piggyback technique was related to improved medium-term survival of hepatocellular carcinoma patients after liver transplantation in this northeast Brazilian sample.

Hepatocellular carcinoma may display elevated nestin expression in endothelial cells: experimental study

Nogueira,Adriano Barreto; Nogueira,Ariel Barreto; Costa,Anderson Lino; Lima,Fabiana Roberto; Siqueira,Sheila Aparecida; Teixeira,Manoel Jacobsen
Fonte: Associação Paulista de Medicina - APM Publicador: Associação Paulista de Medicina - APM
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2015 EN
Relevância na Pesquisa
46.52%
CONTEXT AND OBJECTIVE: Nestin, a class VI intermediate filament protein, is highly expressed in the portal mesenchyme and sinusoidal endothelium of the human fetal liver, but scarcely expressed in adult portal vessel endothelium. During experimental liver regeneration, an increased number of nestin-positive parenchymal cells have been observed in the zone adjacent to the Hering canals. These parenchymal cells are regarded as hepatic stem cells or hepatoblasts, which may be involved in hepatocellular carcinogenesis. In the light of recent reports describing nestin-positive parenchymal cells in hepatocellular carcinoma, we aimed to use this tumor type as a positive control for immunohistochemical detection of nestin. DESIGN AND SETTING: Experimental study conducted at a university hospital. METHODS: Hepatocellular carcinoma sections from one case were analyzed for nestin expression by immunohistochemistry using confocal microscopy. RESULTS: Surprisingly, a conspicuous pattern resembling liver sinusoid-like cytoarchitecture was observed upon nestin staining of endothelial cells. CONCLUSIONS: This pattern has not been previously described. The preliminary results shown here suggest that nestin-positive endothelial cells are located in niches of immature or proliferative cells. Moreover...

Clinical and pathological evaluation of fibrolamellar hepatocellular carcinoma: a single center study of 21 cases

Chagas,Aline Lopes; Kikuchi,Luciana; Herman,Paulo; Alencar,Regiane S.S.M.; Tani,Claudia M.; Diniz,Márcio Augusto; Pugliese,Vincenzo; Rocha,Manoel de Souza; D′Albuquerque,Luiz Augusto Carneiro; Carrilho,Flair Jose; Alves,Venancio A.F.
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2015 EN
Relevância na Pesquisa
36.65%
OBJECTIVES: Fibrolamellar hepatocellular carcinoma is a rare primary malignant liver tumor that differs from conventional hepatocellular carcinoma in several aspects. The aim of this study was to describe the clinical, surgical and histopathological features of fibrolamellar hepatocellular carcinoma and to analyze the factors associated with survival. METHODS: We identified 21 patients with histopathologically diagnosed fibrolamellar hepatocellular carcinoma over a 22-year period. Clinical information was collected from medical records and biopsies, and surgical specimens were reviewed. RESULTS: The median age at diagnosis was 20 years. Most patients were female (67%) and did not have associated chronic liver disease. Most patients had a single nodule, and the median tumor size was 120 mm. Vascular invasion was present in 31% of patients, and extra-hepatic metastases were present in 53%. Fourteen patients underwent surgery as the first-line therapy, three received chemotherapy, and four received palliative care. Eighteen patients had “pure fibrolamellar hepatocellular carcinoma,” whereas three had a distinct area of conventional hepatocellular carcinoma and were classified as having “mixed fibrolamellar hepatocellular carcinoma.” The median overall survival was 36 months. The presence of “mixed fibrolamellar hepatocellular carcinoma” and macrovascular invasion were predictors of poor survival. Vascular invasion was associated with an increased risk of recurrence in patients who underwent surgery. CONCLUSION: Fibrolamellar hepatocellular carcinoma was more common in young female patients without chronic liver disease. Surgery was the first therapeutic option to achieve disease control...

Hepatocellular carcinoma following neonatal hepatitis

Moore, L.; Bourne, A.; Moore, D.; Preston, H.; Byard, R.
Fonte: TAYLOR & FRANCIS Publicador: TAYLOR & FRANCIS
Tipo: Artigo de Revista Científica
Publicado em //1997 EN
Relevância na Pesquisa
46.48%
Hepatocellular carcinoma is an uncommon malignancy in young children associated with a variety of congenital and acquired conditions. It has been generally held that idiopathic neonatal hepatitis is not an antecedent of hepatocellular neoplasia in childhood. We report a 28-month-old girl in whom a diagnosis of neonatal giant cell hepatitis was confirmed by liver biopsy at 4 months of age who was followed up with serial liver biopsies. Hepatitis B and C virus infection and metabolic abnormalities had been excluded by appropriate testing. There was no history of parenteral nutrition. The morphologic criteria for a diagnosis of cirrhosis were satisfied in a liver biopsy undertaken at 23 months of age. At 28 months a laparotomy was performed because of continuing jaundice and the development of an abdominal mass. Biopsy of the mass revealed a hepatocellular carcinoma. Ploidy studies showed an aneuploid tumor and a hyperdiploid karyotype was confirmed by chromosomal analysis. This case demonstrates by sequential biopsy the progression from neonatal hepatitis to cirrhosis and hepatocellular carcinoma in a young child.; Lynette Moore; Anthony J. Bourne; BS David J. Moore; BS Henry Preston; BS Roger W. Byard

Case Report: A hepatocellular carcinoma metastasis in the distal pancreas

Texler, M.; Pierides, J.; Maddern, G.
Fonte: Blackwell Publishing Publicador: Blackwell Publishing
Tipo: Artigo de Revista Científica
Publicado em //1998 EN
Relevância na Pesquisa
46.5%
Hepatocellular carcinoma is a highly malignant neoplasm. Extrahepatic metastases are found in 64% of patients with hepatocellular carcinoma. The lungs, regional lymph nodes, kidney, bone marrow and adrenals are common sites of metastases. Pancreatic metastases are not common (<5%). A case report of a hepatocellular carcinoma with a metastasis in the distal pancreas is presented. A resection of the primary tumour and metastasis was carried out with the patient still alive 16 months after resection. This case illustrates that hepatic resection for hepatocellular carcinoma with a single local metastasis can be reasonably considered although a cure has not been established.

Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency

Knisely, A.; Strautnieks, S.; Meier, Y.; Stieger, B.; Byrne, J.; Portmann, B.; Bull, L.; Pawlikowska, L.; Bilezikci, B.; Ozcay, F.; Laszlo, A.; Tiszlavicz, L.; Moore, L.; Raftos, J.; Arnell, H.; Fischler, B.; Nemeth, A.; Papadogiannakis, N.; Cielecka-Kusz
Fonte: John Wiley & Sons Inc Publicador: John Wiley & Sons Inc
Tipo: Artigo de Revista Científica
Publicado em //2006 EN
Relevância na Pesquisa
46.28%
Hepatocellular carcinoma (HCC) is rare in young children. We attempted to see if immunohistochemical and mutational-analysis studies could demonstrate that deficiency of the canalicular bile acid transporter bile salt export pump (BSEP) and mutation in ABCB11, encoding BSEP, underlay progressive familial intrahepatic cholestasis (PFIC)--or "neonatal hepatitis" suggesting PFIC--that was associated with HCC in young children. We studied 11 cases of pediatric HCC in the setting of PFIC or "neonatal hepatitis" suggesting PFIC. Archival liver were retrieved and immunostained for BSEP. Mutational analysis of ABCB11 was performed in leukocyte DNA from available patients and parents. Among the 11 nonrelated children studied aged 13-52 months at diagnosis of HCC, 9 (and a full sibling, with neonatal hepatitis suggesting PFIC, of a tenth from whom liver was not available) had immunohistochemical evidence of BSEP deficiency; the eleventh child did not. Mutations in ABCB11 were demonstrated in all patients with BSEP deficiency in whom leukocyte DNA could be studied (n = 7). These mutations were confirmed in the parents (n = 14). With respect to the other 3 children with BSEP deficiency, mutations in ABCB11 were demonstrated in all 5 parents in whom leukocyte DNA could be studied. Thirteen different mutations were found. In conclusion...

Osteopontin increases hepatocellular carcinoma cell growth in a CD44 dependant manner

Phillips, R.; Helbig, K.; Van Der Hoek, K.; Seth, D.; Beard, M.
Fonte: W J G Press Publicador: W J G Press
Tipo: Artigo de Revista Científica
Publicado em //2012 EN
Relevância na Pesquisa
46.28%
AIM: To investigate the role of osteopontin (OPN) and its splice variants in the proliferation of hepatocellular carcinoma (HCC). METHODS: The expression of OPN variants in HCC cell lines as well as HCC tissue samples and non-tumour tissue was studied using polymerase chain reaction. OPN variant cDNAs were cloned into a mammalian expression vector allowing both transient expression and the production of stable OPN expressing cell lines. OPN expression was studied in these cells using Western blotting, immunofluoresnce and enzyme linked immunosorbent assay. A CD44 blocking antibody and siRNA targeting of CD44 were used to examine the role of this receptor in the OPN stimulated cell growth observed in culture. Huh-7 cells stably expressing either OPN-A, -B or -C were injected subcutaneously into the flanks of nude mice to observe in vivo tumour growth. Expression of OPN mRNA and protein in these tumours was examined using reverse transcription-polymerase chain reaction and immunohistochemistry. RESULTS: OPN is expressed in HCC in 3 forms, the full length OPN-A and 2 splice variants OPN-B and -C. OPN variant expression was noted in HCC tissue as well as cognate surrounding cirrhotic liver tissue. Expression of these OPN variants in the HCC derived cell line Huh-7 resulted in secretion of OPN into the culture medium. Transfer of OPN conditioned media to naïve Huh-7 and HepG2 cells resulted in significant cell growth suggesting that all OPN variants can modulate cell proliferation in a paracrine manner. Furthermore the OPN mediated increase in cellular proliferation was dependent on CD44 as only CD44 positive cell lines responded to OPN conditioned media while siRNA knockdown of CD44 blocked the proliferative effect. OPN expression also increased the proliferation of Huh-7 cells in a subcutaneous nude mouse tumour model...

Pathologic diagnosis of early hepatocellular carcinoma: a report of the international consensus group for hepatocellular neoplasia

Burt, A.
Fonte: John Wiley & Sons Inc Publicador: John Wiley & Sons Inc
Tipo: Artigo de Revista Científica
Publicado em //2009 EN
Relevância na Pesquisa
46.36%
International Consensus Group for Hepatocellular Neoplasia; International Consensus Group for Hepatocellular Neoplasia Contributor: Alastair D. Burt for the University of Adelaide

Systematic review and meta-analysis of survival and disease recurrence after radiofrequency ablation for hepatocellular carcinoma

Tiong, L.; Maddern, G.
Fonte: John Wiley & Sons Ltd Publicador: John Wiley & Sons Ltd
Tipo: Artigo de Revista Científica
Publicado em //2011 EN
Relevância na Pesquisa
46.21%
BACKGROUND: Despite being one of the commonest causes of cancer-related death around the world, only 20 per cent of hepatocellular carcinomas (HCCs) are amenable to curative treatment (surgical resection or liver transplantation). Radiofrequency ablation (RFA) has emerged as a popular therapy for unresectable HCC. There is evidence that the disparity in survival after curative RFA and surgery for HCC, especially tumours smaller than 3 cm in diameter, is narrowing. This review examined the survival and disease recurrence rates after RFA for HCC over the past decade. METHODS: A systematic review was conducted using MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Methodology Register and the Database of Abstracts of Reviews of Effects from January 2000 until November 2010. Papers reporting on patients with HCC who were treated with RFA, either in comparison or in combination with other interventions, such as surgery or percutaneous ethanol injection (PEI), were eligible for inclusion. Outcome data collected were overall survival, disease-free survival and disease recurrence rates. Only randomized controlled trials (RCTs), quasi-RCTs and non-randomized comparative studies with more than 12 months' follow-up were included. RESULTS: Forty-three articles...

Doença de Madelung e Carcinoma Hepatocelular: Relato de Caso; Madelung’s disease and hepatocellular carcinoma: case report

Alcântara, Cid C. S.; Nobre, Christiane A.; Monteiro, Mirella M. B.; Freitas, Lara R. S.
Fonte: Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto Publicador: Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; Formato: application/pdf
Publicado em 30/12/2013 POR
Relevância na Pesquisa
46.37%
A doença de Madelung, lipomatose cervical benigna simétrica, é afecção rara, de etiologia desconhecida caracterizada por acúmulo de volumosas massas de gordura não encapsuladas. Existem poucos estudos sobre a doença de Madelung e associação com neoplasias. Descrevemos um caso de doença de Madelung associada a carcinoma hepatocelular.; The Madelung’s disease, known as benign symmetric cervical lipomatosis is a rare condition of unknown etiology characterized by massive accumulation of fat mass. There are few studies on Madelung’s disease and association with neoplasia. We describe a case of Madelung’s disease associated with hepatocellular carcinoma.

Aflatoxins in foodstuffs: current concepts on mechanisms of toxicity and its involvement in the etiology of hepatocellular carcinoma; Aflatoxinas: conceitos sobre mecanismos de toxicidade e seu envolvimento na etiologia do câncer hepático celular

Oliveira, Carlos Augusto Fernandes de; Germano, Pedro Manuel Leal
Fonte: Universidade de São Paulo. Faculdade de Saúde Pública Publicador: Universidade de São Paulo. Faculdade de Saúde Pública
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; ; Formato: application/pdf
Publicado em 01/08/1997 POR
Relevância na Pesquisa
46.35%
Foram revistos os conceitos de maior relevância sobre mecanismos de toxicidade e evidências do envolvimento das aflatoxinas na etiologia do câncer hepático humano. A aflatoxina B1 (AFB1), principal metabólito produzido por fungos do gênero Aspergillus, manifesta seus efeitos tóxicos após conversão hepática em AFB1-epóxido, o qual reage com macromoléculas celulares, incluindo proteínas, RNA (ácido ribonucléico) e DNA (ácido desoxirribonucléico). A reação com o DNA ocorre através da ligação com guaninas, ao nível do códon 249, do gene supressor de tumores p53. Em seres humanos, estudos de biomonitoramento individual de derivados AFB1-N7-guanina tem demonstrado que as aflatoxinas constituem importantes fatores de risco, com uma provável interação sinergística com o vírus da hepatite B, para o desenvolvimento do carcinoma hepatocelular em populações expostas. Considerando-se a ocorrência freqüente das aflatoxinas em produtos alimentícios, no Brasil, ressalta-se a necessidade de estudos que avaliem criteriosamente o impacto dos níveis de exposição a estas toxinas sobre a saúde humana.; Current concepts derived from intensive research over the last decade, on biotransformation, mechanisms of toxicity and evidences for the involvement of aflatoxins in the etiolgy of human liver cancer are summarily presented. Aflatoxin B1(AFB1)...

HEPATOCELLULAR CARCINOMA – A LITERATURE REVIEW; CARCINOMA HEPATOCELULAR – UMA REVISÃO BIBLIOGRÁFICA

Vianna, Bruno Leal; Hospital de Clínicas da Universidade Federal do Paraná; Muncinelli, João Felipe Galbiatti; Hospital de Clínicas da Universidade Federal do Paraná; Garcia, Rafael Eduardo; Hospital de Clínicas da Universidade Federal do Paraná; T
Fonte: Setor de Ciência da Saúde - Universidade Federal do Paraná Publicador: Setor de Ciência da Saúde - Universidade Federal do Paraná
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ;
Publicado em 09/12/2015 EN
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46.5%
Introdução: globalmente, são diagnosticados mais de meio milhão de casos de carcinoma hepatocelular (CHC) ao ano. É o terceiro câncer em mortalidade e o sexto em incidência. Os fatores de risco são bastante conhecidos e descritos na literatura - a cirrose, o principal deles, é encontrada em 90% dos casos. Em termos globais, a etiologia mais comum é o vírus da hepatite B (HBV), seguido do vírus da hepatite C (HCV). Material e métodos: realizada uma busca na base de dados do Medline a partir da ferramente MeSH do site Pubmed no dia 11 de março de 2014. Foram usadas como palavras-chave: “carcinoma hepatocellular/epidemiology”. Restringindo a revisões sistemáticas ou revisões publicadas nos últimos 5 anos, foram encontrados 154 artigos. A partir da leitura do título e abstract, o número foi reduzido a 52. Adicionalmente, incluímos artigos referenciados nos trabalhos selecionados. Resultados e Discussão: a distribuição do CHC no mundo é bastante heterogênea e dinâmica. Oitenta e dois por cento dos novos casos concentram-se em países em desenvolvimento, com a China contemplando sozinha 55%. Localidades de alta incidência de CHC normalmente são endêmicas para o HBV. Já em regiões de baixa incidência para o câncer...

Carcinoma hepatocelular variedad fibrolamelar metastásico en menores de 20 años: Reporte de 2 casos tratados con intención curativa y revisión de la literatura

Butte,Jean M; Waugh,Enrique; Meneses,Manuel; Pruzzo,Rossana; Carvallo,Cristian; Redondo,Francisca; Suárez,Claudio; Parada,Hugo; Amaral,Horacio; de La Fuente,Hernán
Fonte: Sociedad Médica de Santiago Publicador: Sociedad Médica de Santiago
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2009 ES
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46.33%
Fibrolamellar hepatocellular carcinoma (FLC) is a rare histologic variant of hepatocellular carcinoma that appears most commonly in teenagers andyoung adults. The diagnosis is often made incidentally and surgical resection is the only curative treatment. Here we report two cases of incidental FLC involving a 19 year-old male, initially diagnosed with screening abdominal ultrasound, and a 14 year-old female that presented with abdominalpain. Diagnostic workup consisted of abdominal PET/CT and MR1Imaging studies and tissue diagnosis was confirmed with percutaneous liver biopsy. Both patients were treated with radical liver resection/tumor excision. However, tumor recurrence was observed in both during short-term follow-up. The male patient was treated successfully with surgical treatment however the female patient succumbed top regression of disease.