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Teste de sangue oculto nas fezes e retossigmoidoscopia flexível : ferramentas para o rastreamento de neoplasias colorretais em pacientes assintomáticos.; Fecal occult bloodtesting and flexiblerectosigmoidoscopy : tools for screening for colorectal neoplasias in asymptomatic patients.

Assunção, Paulo Roberto Torres
Fonte: Universidade Federal de Alagoas; BR; Biologia; Programa de Pós-Graduação em Ciências da Saúde; UFAL Publicador: Universidade Federal de Alagoas; BR; Biologia; Programa de Pós-Graduação em Ciências da Saúde; UFAL
Tipo: Dissertação Formato: application/pdf
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The colorectal cancer (CRC) is the third most common cancer in the world and the second leading cause of mortality in the United States. In Brazil, the CRC is the fourth place of incidence among men and the third place among women. Objective Evaluate the factibility and the efficacy of fecal occult blood testing (FOBT) and of flexible rectosigmoidoscopy (RS), as tools used in the CRC screening, in asymptomatic patients. Methods - The study is a transversal one and presents a sample of 102 individuals from 50 years old on. The FOBT used was the guaiac, FECA-CULT® method, performed only once in faeces collected from a complete bowel movement. The individuals, who presented the positive FOBT, were sent to complementary colonoscopy, although it is not a method of this study. The whole individuals were undertaken to RS, after bowel preparation using monobasic sodium phosphate monohydrate and dibasic sodium phosphate heptahydrate solution. Results - The subjects presented minimum age of 50 years old and maximum of 82 years old, average of 61,6 years old and standard deviation of + 8,1. Among 102 subjects, 42 (41%) are male and 60 (58,8%) are female. The FOBT presented 10 positive cases (9,8%) (CI 95%: 4,8%-17,3%) and 92 negative cases (90...

Situação epidemiológica da filariose linfática bancroftiana no município de Maceió, estado de Alagoas.; The epidemiological situation of bancroftian lymphatic filariasis in the municipality of Maceió, state of Alagoas.

Leite, Anderson Brandão
Fonte: Universidade Federal de Alagoas; BR; Biologia; Programa de Pós-Graduação em Ciências da Saúde; UFAL Publicador: Universidade Federal de Alagoas; BR; Biologia; Programa de Pós-Graduação em Ciências da Saúde; UFAL
Tipo: Dissertação Formato: application/pdf
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Bancroftian lymphatic filariasis is a neglected parasitic illness, known popularly as elephantiasis, because it is one of its chronic clinical manifestations. It is an anthroponotic disease caused by a nematode helminth of the species Wuchereria bancrofti (Cobbold, 1877) (Spirurida: Onchocercidae). Bancroftian filariasis occurs in 83 countries localized in tropical and subtropical regions and is considered by the World Health Organization as the second leading cause, worldwide, of work disability. With the objective to ascertain the current distribution of lymphatic filariasis in Maceio, based upon previous studies, hemoscopic and entomological surveys were conducted in the city. The hemoscopic surveys were performed using a thick blood smear (TBS) in a random sample of 20,025 students of night schools, enrolled in the 143 public schools that cover the 50 districts of the city, a sample of 1418 employees of the same public night schools and of 546 soldiers of the Brazilian Army s 59th Motorized Infantry Battalion. Also evaluated by TBS was the family of the sole microfilaremic person found, composed of four individuals and 239 families of current and former neighbors of this patient, with a total of 943 individuals. The entomological survey...

Antígenos da forma amastigota de Leishmania chagasi identificados por dupla varredura da biblioteca de cDNA

Salha, Daniella Regina Arantes Martins
Fonte: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde Publicador: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde
Tipo: Tese de Doutorado Formato: application/pdf
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Control of human visceral leishmaniasis in endemic regions is hampered in part by the lack of knowledge with respect of the role reservoirs and vector. In addition, there is not yet an understanding of how non-symptomatic subclinical infection might influence the maintenance of infection in a particular locality. Of worrisome is the limited accessibility to medical care in places with emerging drug resistance. There is still no available protective vaccine either for humans or other reservoirs. Leishmania species are protozoa that express multiple antigens which are recognized by the vertebrate immune system. Since there is not one immunodominant epitope recognized by most hosts, strategies must be developed to optimize selection of antigens for prevention and immunodiagnosis. For this reason, we generated a cDNA library from the intracellular amastigote form of Leishmania chagasi, the causative agent of South American visceral leishmaniasis. We employed a two-step expression screen of the library to systematically identify T and T-dependent B cell antigens. The first step was aimed at identifying the largest possible number of clones producing an epitope-containing polypeptide with a pool of sera from Brazilians with documented visceral leishmaniasis. After removal of clones encoding heat shock proteins...

Exercício físico, saúde e qualidade de vida em pessoas com HIV/AIDS em Natal/Rio Grande do Norte

Guerra, Luís Marcos de Medeiros
Fonte: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde Publicador: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde
Tipo: Dissertação Formato: application/pdf
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A sobrevida das pessoas com AIDS tem aumentado com o uso das terapias com antiretrovirais (TARV), esses, entretanto, possuem efeitos colaterais que interferem no padrão morfofuncional e hematológico, o que pode levar a alterações na qualidade de vida (QV). Este estudo quase-experimental objetivou avaliar parâmetros antropométricos, funcionais, hematológicos e de QV em pessoas com HIV/AIDS submetidas a um programa de exercícios de 16 semanas. Os participantes tinham idade entre 35 e 51 anos (n=15), eram registrados no Núcleo de atendimento do Hospital Giselda Trigueiro em Natal/Rio Grande do Norte e apresentaram CD4350cel/mm3, lipodistrofia e estavam em TARV. Foram avaliados o índice de massa corpórea (IMC), a relação cintura-quadril (RCQ), o percentual de gordura (%G), a força escapular e manual, a contagem de CD4, carga viral e QV, antes e após a intervenção. Essa foi realizada com exercícios de aquecimento e utilizou como base os exercícios resistidos, realizados 3x/semana, com 1h e intensidade de 60 a 75% de 1RM. Observaram-se modificações significativas no %G (p=0,031), força escapular (p=0,007) e preensão manual (p=0,039). Houve aumento no CD4 e a carga viral manteve-se indetectável. Nos domínios da QV...

Marcadores genéticos associados com a resposta inflamatória na meningite bacteriana

Fontes, Fabrícia Lima
Fonte: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde Publicador: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde
Tipo: Dissertação Formato: application/pdf
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; A meningite bacteriana (MB) é uma doença infecto-contagiosa que apresenta altas taxas de mortalidade e morbidade, constituindo-se assim um grave problema de saúde pública. É caracterizada por uma intensa inflamação granulocítica que leva a injúria neuronal e consequentemente surgimento de sequelas neurológicas. A resposta inflamatória determina tanto a susceptibilidade à MB como sua consequência clínica. Essa resposta depende não só do tipo e da intensidade do estímulo, mas também de fatores genéticos do hospedeiro, tais como polimorfismos localizados em regiões codificantes ou regulatórias de genes importantes durante a infecção, dentre os mais frequentes os polimorfismos de um único nucleotídeo (SNPs). O objetivo desse estudo foi investigar a associação entre os polimorfismos em TNF -308G/A, TNF -857C/T, IL-8 -251A/T, AADAT+401C/T, que codificam proteínas importantes durante a resposta inflamatória e APEX1 Asn148Glu, OGG1 Ser326Cys e PARP-1 Val762Ala, que codificam enzimas de reparo de DNA, com a ocorrência da MB. O estudo foi realizado com um grupo de 54 pacientes, admitidos no Hospital Giselda Trigueiro, Natal-RN, Brasil, o qual é referência para doenças infecciosas no estado...

Candidíase vulvovaginal: sintomatologia, fatores de risco e colonização anal concomitante

Holanda, Antônio Arildo Reginaldo de
Fonte: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde Publicador: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde
Tipo: Dissertação Formato: application/pdf
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Post-menarche patients with clinical signs of vulvovaginitis were analyzed in this study, whose aims were the following: identify the frequency of C. albicans and non C. albicans species and negative results, correlate the vaginal culture for yeast with risk factors and symptomatology; compare positive and negative results for yeast in the vaginal and anal cultures; compare the positive results for C. albicans with other results found in the vaginal and anal cultures; and compare concomitant positivity for C. albicans and non C. albicans in the vaginal and anal cultures. Sample selection occurred between May, 2003 and May, 2005, and included 99 patients from Natal, Brazil. The laboratory methods used consisted of CHROMagar Candida culture medium, thermotolerance test at 42-45°C and hypertonic NaCL, in addition to the classic methods of carbohydrate assimilation and fermentation. We used absolute numbers, percentages, means of central tendency, chi-squared test (χ2) with Yates correction, Fisher s exact test and odds ratio for statistical analysis. The most frequent species was C. albicans in 69% of the cases. The positivity for Candida spp showed an association with the use of tight-fitting intimate clothing and/or synthetics...

Detecção de vírus gastroentéricos em mulheres em Goiânia-GO; Gastroenteric viruses detection in fecal samples from women in Goiânia-GO, Brazil

FERREIRA, Rui Gilberto
Fonte: Universidade Federal de Goiás; BR; UFG; Doutorado em Medicina Tropical; Ciências da Saúde Publicador: Universidade Federal de Goiás; BR; UFG; Doutorado em Medicina Tropical; Ciências da Saúde
Tipo: Tese de Doutorado Formato: application/pdf
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The gastroenteric viruses are important etiological agents of gastroenteritis in individuals of all ages. It is believed that individuals with deficits in the immune system (humoral and/or cellular), among them pregnant women and human immune deficiency virus (HIV)-seropositive women, are more susceptible to these viral infections. The rotaviruses, adenoviruses, astroviruses, and caliciviruses constitute are among the main causes of acute gastroenteritis in the world, and are accounted for high morbi-mortality rates, especially among children under five years of age. It is believed that, by the age of three, approximately 90% of all children in developing countries have antibodies to one or more of these agents. Neonatal infection does not exclude the possibility of re-infection, with different viral serotypes, however it protects the individual against severe disease. This study aimed at the detection of rotavirus, adenovirus, astrovirus e calicivirus in women seeing at the Hospital das Clínicas da Universidade Federal de Goiás (HC-UFG) and at the investigation of as association between the positivity to this viruses and the low immune status, characteristic in pregnant women and/or HIV-seropositive women. This was a prospective follow-up study of women seeing at the Gynecology and obstetrics (OB-GYN) sector of the HC-UFG aiming at the detection of gastroenteric viruses (rotavirus...

Implantação de uma Unidade Sentinela Centro de Referência em Medicina Internacional e de Viagem no Hospital das Clínicas da Universidade Federal de Goiás (HC / UFG); Introduction of Sentinel Unit Reference Center in International and Travel Medicine in General Hospital at Federal University of Goiás.

AIRES, Leticia Mara Conceição
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina
Tipo: Dissertação Formato: application/pdf
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Introduction: The number of domestic and international travel has increased in past years. This way, Travel Medicine, has become an important subject, with the emergence of services that provide health care to travelers. Objective: To evaluate strategies used in deploying Sentinel Unit Reference Center for International and Travel Medicine at the HC / UFG. Methods: First approach: Systematic Review of Literature using the keywords: "Travel and medicine", "Travel and prevention", "Travel and Disease and Medicine" and "Traveler and medicine . Then were selected articles in English, Spanish and Portuguese, from 2004 to 2008. Second approach: a descriptive, qualitative and quantitative, with evaluation of actions taken during the period preceding the implementation of the Unit. Results: In the literature review were found 1,301 articles, and 72 included for analysis, we observed that malaria is the most studied disease, the main preventive measures discussed are chemoprophylaxis for malaria and vaccination. Health professionals working in Travel Medicine are general practitioners, pharmacists and nurses in various parts of the world, and among the obstacles we stress the lack of information in travelers, the lack of professional preparation and last-minute travelers. In a qualitative and quantitative research was performed a retrospective study in which differences were observed between physicians at the General Hospital and the tropical Diseases Hospital...

Fatores de risco sócio-ambientais para o binômio teníase-cisticercose em um bairro da periferia de Goiânia, Goiás-Brasil

SILVA, Delson José da
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina
Tipo: Dissertação Formato: application/pdf
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The taeniasis-cysticercosis complex imposes a serious problem to the public health system especially in developing and poor countries In a cross-sectional exploratory descriptive study it was attempted to investigate environmental and epidemiologic factors associated with disease transmission in an outskirts` poor district of the city of Goiânia - Brazil where potential risk factors for this disease have been detected The sample was made up of 12.895 subjects (75% of the local population) who voluntarily answered a questionnaire containing information concerning demographics hygienic and alimentary habits swine raising technique place of human stool disposal and seizure history The investigating team was composed of volunteers and health sciences professionals and students Statistical analysis showed the following statistically significant results: 588 of the subjects with seizure history 11,2% presented cysticercosis; taeniasis was more prevalent in female subjects with age ranging from 40 to 49 years (7%; p=0.00); the diagnosis of taeniasis was established in 4.02% (p=0.00) of the subjects who consumed pork (80.41%) in 100% (p=0.00) of those who consumed raw meat in 5.93% (p=0.00) of the subjects who consumed meat more than once a week in 7.44% (p=0.00) of those who drank water from the well in 6.7% (p=0.03) of the subjects who currently raise swine in 15.6% (p=0.00) of those who raise swine in the surroundings of their home and in 25% (p=0.00) of the subjects with outdoor defecation habit Our findings strongly suggest that the detection of the various factors involved in the acquisition and maintenance of the taeniasis-cysticercosis complex are of utmost importance for the adoption of appropriate measures aiming to interrupt the life cycle of this parasitosis which is a consequence of the relationships between humans environment and swine; O complexo teníase-cisticercose representa sério problema de saúde pública especialmente nos países em desenvolvimento e de baixas condições sócio-econômicas Em estudo descritivo exploratório de corte transversal buscou-se investigar fatores sócio-ambientais associados ao relato da doença em moradores do bairro Finsocial no município de Goiânia localizado na periferia da cidade A equipe de entrevistadores foi constituída de voluntários profissionais e estudantes da área de saúde A amostra foi composta por 12.895 indivíduos (75% da população) residentes neste bairro que voluntariamente responderam ao questionário padronizado sobre quesitos que envolveram dados demográficos (nome idade sexo) hábitos de higiene (lavar as mãos) hábitos alimentares (ingestão e forma de consumo de carne suína e/ou verduras/legumes) sistema de criação de suínos local de deposição de fezes humana e antecedentes de convulsão assim como relato de diagnóstico médico prévio de neurocisticercose Para o diagnóstico de teníase foi considerado o relato de eliminação de solitária ou gomos do parasito A análise mostrou resultados com significância estatística para teníase: quanto ao sexo feminino na faixa etária entre 40 e 49 anos (7...

Prevalência da infecção por Neisseria gonorrhoeae em adolescentes do sexo feminino no município de Goiânia, Goiás; Prevalence of Neisseria gonorrhoeae genital infection among female sexually active adolescents in Distrito Sanitário Noroeste from Goiânia, Brazil

DUARTE, Jannaína Karlla de Queiroz
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina
Tipo: Dissertação Formato: application/pdf
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BACKGROUND: Adolescents are at great risk for genital Neisseria gonorrhoeae infection. Although most infections are asymptomatic it can cause severe reproductive sequels to women. Few studies exist about prevalence of these infection in Brazil and fewer in adolescent population. OBJECTIVES: To determine the prevalence of Neisseria gonorrhoeae genital infection among female sexually active adolescents, in Distrito Sanitário Noroeste from Goiânia, Brazil and to identify demographic and behavioral profiles associated to gonococcal infection. METHODS: We performed a cross-sectional study among 427 sexually active female adolescents (15-19 years), random selected at Distrito Sanitário Noroeste and served by the Health Family Program. It were excluded pregnant adolescents, pos-partum, using antibiotics or on period. The gonococcal infection was determined by using polimerase chain reaction (PCR) of Amplicor Roche kit for N. gonorrhoeae and C. trachomatis applied to endocervical swab specimens. Sociodemographic and behavioral data were assessed by face-to-face questionnaire. RESULTS: The mean age of 427 random selected adolescents was 17.2 ± 1.3 years, most female were single (67.9%). The mean age of menarch was 12.4 years and at first sexual intercourse was 15 years. 35...

Tuberculose latente em pacientes com artrite reumatoide. Avaliação da resposta celular e novas estratégias diagnósticas.; Latent tuberculosis in rheumatoid arthritis patients. Evaluation of cellular response and new diagnostic strategies

SILVA, Daniela Graner Schuwartz Tannus
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina
Tipo: Dissertação Formato: application/pdf
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The diagnosis of latent tuberculosis (TBIL) in patients with rheumatoid arthritis (RA) has got special importance with the advent of anti tumor necrosis factor (anti-TNF-α) and the arise of cases of active tuberculosis in these patients. The tuberculin skin test (TST) is a test used for more than a century on the diagnosis of TBIL but has limited value in patients with RA. New tests that are based on the production and release of interferon-gamma (IFN-γ) have been studied but its role has not yet been well established in this group of patients. This paper shows a review about the use of anti-TNF-α and its role on the development of tuberculosis, the use of the TST for the diagnosis of TBIL in patients with RA and new tests for diagnosis of TBIL. The review is illustrated with a case of a patient who developed tuberculosis after starting the use of anti-TNF-α. In the sequence, a study comparing the diagnostic TBIL in a group of RA patients by cellular immune response, compared to TST, T.SPOT-TB and measurement of IFN-γ by flow cytometry after stimulation with Hspx and through computed tomography changes consistent with TBIL. It was observed that the response to TST was lower in RA patients (13.5%) than the expected response to the general population. We also observed that the T.SPOT-TB identified a greater number of patients with TBIL compared to PT (36.8%). The IFN-γ in response to Hspx was not statistically different among the groups considered TBIL (TST and / or T.SPOT-TB positives) or NO TBIL (TST and T.SPOT-TB negatives). Finally...

Avaliação moluscicida das plantas Pterodon emarginatus Vogel 1837, Magonia pubescens St. Hil, e Croton urucurana Baill 1864, sobre Biomphalaria glabrata (Say, 1818) e cercaricida sobre Schistosoma mansoni (Sambon, 1907)

CORRÊA, Marinês Conceição Rieth
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina
Tipo: Dissertação Formato: application/pdf
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The molluscicide and cercaricide action of the Pterodon emarginatus plants Magonia pubescens and Croton urucurana found in the Brazilian scrubland center-west region and in other Brazilian regions where the schistosomose is endemic was evaluated separately in laboratories The brute etanolic extracto obtained after the dilution in water were tested over the Biomphalaria glabrata snails intermediary host of Schistosoma mansoni The evaluation of the bioactivity was done from the initial concentration of 100ppm over adult snails and those ones which died in the adult phase had their concentrations reduced at 50 25 and 12.5ppm successively The molluscicide effect was evaluated over the snails development phasis over the laying of eggs and over the ovigery masses hatching The extracts that did not show bioactivity on 100ppm did not have their concentrations decreased The P emarginatus extract did not demonstrate bioactivity over the snails the laying of eggs the ovigery masses hatching and the liberation of cercaries Showing the cercaricide effect five hours after the start of the experiment whereas the controlling group survived for 36 hours over the same conditions The M pubescens extract demonstrated 100% of bioactivity on the four concentrations utilized and in all the snails development phasis with the exception of the ovigery masses hatching The cercaricide effect was 100% on the 100 and 50ppm concentrations within fifteen minutes 100% on 25ppm within 30 minutes and 100% on 12.5ppm within two hours whereas the controlling group survived for 36 hours at the same conditions With the C urucurana extract the bioactivity was of 26.6% on the 100ppm concentration within 24 hours of an exposition over adult snails On the 50 25 and 12.5ppm concentrations it was not showed bioactivity over the adult and young snails the laying of eggs and the ovigery masses hatching It was presented bioactivity with newly-developed snails on the three concentrations tested after 24 hours of exposition With the cercaries the deaths were observed from the fifteen minutes on the 100 and 50ppm concentrations two hours on 25ppm and five hours on 12.5ppm...

Potencial prognóstico da expressão de COX-2 e VEGF-C no adenocarcinoma colorretal de pacientes de um Hospital de referência do SUS no tratamento oncológico; Role of VEGF-C; COX-2; Colorectal; adenocarcinoma

MOTA, Eliane Duarte
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina
Tipo: Dissertação Formato: application/pdf
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BACKGROUND: Colorectal adenocarcinoma (CRA) is a worldwide distributed pathology, and lymph node metastasis is associated with a poor prognostic outcome. Angiogenesis and lymphangiogenesis are correlated with metastasis. Vascular endothelial growth factor C (VEGF-C) and Cyclooxygenase 2 (COX-2) are molecules directly involved in those processes. We investigated the possible association of the expression of VEGF-C and COX-2 with clinical/pathology features and five year survival rate. MATERIALS AND METHODS: One hundred and thirty four cases of CRA from a Cancer Reference Hospital were randomly selected. The expression of VEGF-C and COX-2 was detected by immunohistochemistry and a univariate analysis was applied to evaluate the association between their expression and clinical stages, metastasis, and/or survival. RESULTS: COX-2 expression was observed in 98.67% of the adenocarcinoma cases while VEGF-C was found in 54.48% of the cases. COX-2 was highly expressed by all clinical stages of CRA, but its expression was not associated with LN metastasis, tumor infiltration or five years survival. A correlation was observed between LN metastasis and VEGF-C positivity (p=0.02) and clinical stages of the disease. The range of VEGF-C expressions was from 34.6% to 88.9% in stages 1 through 4...

Prevalência e estudo neuropsicológico de transtornos cognitivos e demências decorrentes de neuroinfecções em hospital de referência; Prevalence and neuropsychological study of disorders cognitive and dementia resulting from neuroinfecções in referral hospital

REIMER, Cláudio Henrique Ribeiro
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina
Tipo: Dissertação Formato: application/pdf
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Several infectious and parasitic diseases have been described as possible causes of cognitive loss, especially the neuroinfections that the location in the CNS, may evolve into frank dementia table (although subject to reversal). The vast possibilities as a result has large etiological heterogeneity of neuropsychiatric symptoms, which may hinder the clinical evaluation, but if using neuropsychological testing, it increases the chances of detection of cognitive and behavioral symptoms and therefore the diagnostic accuracy. The objective of the study is to estimate the prevalence of dementia and cognitive changes in neuroinfections, and characterize the co-morbid psychiatric symptoms. The sample comprised 60 patients with infection of the CNS in order to identify possible changes in performance in Mini-Mental State Examination (MMSE) and a questionnaire on activities of daily living for Pfeffer, and conduct behavioral assessment by questionnaire BEHAV - AD. By applying the MMSE and the Pfeffer questionnaire found that 20 patients (33.3% of the sample) had cognitive disorders without dementia and 23 patients were diagnosed as dementia, which is the framework neuropsychological most prevalent (38.3% of patients). If we include patients with cognitive disorders without dementia and those with dementia in one group...

Infec????o por HPV e polimorfismos nos genes TP53 e MDM2 em mulheres HIV positivas e negativas; Infec????o por HPV e polimorfismos nos genes TP53 e MDM2 em mulheres HIV positivas e negativas

ENTIAUSPE, Ludmila Gon??alves
Fonte: Universidade Federal de Pelotas; Biotecnologia; Programa de P??s-Gradua????o em Biotecnologia; UFPel; BR Publicador: Universidade Federal de Pelotas; Biotecnologia; Programa de P??s-Gradua????o em Biotecnologia; UFPel; BR
Tipo: Tese de Doutorado Formato: application/pdf
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Estimates show that approximately 80% of sexually active women will be infected by the Human Papillomavirus (HPV) in some point of their life course, and HPV DNA has been found in 99,7% of cervical cancer (CC) cases. Thus, several factors may contribute to CC development, including co-infections with Human Immunodeficiency Virus (HIV), as well as genetic factors, including TP53 and MDM2 polymorphisms. Some authors have associated CC development risk, among women infected with oncogenic HPV strains, with the Arg72Pro TP53 SNP. The MDM2 protein plays an important role in p53 protein regulation and, thus, a MDM2 SNP referred as SNP309 may also be implicated in CC risk in association with high-risk HPV genotypes. The present work aimed at determining the frequencies of HPV infection and identification of its genotypes, as well as the frequencies of the SNPs Arg72Pro and SNP309 and their associations with CC risk in female HIV-positive and negative populations in the city of Pelotas. It has been observed a prevalence of HPV infection of 30% among HIV-negative women, and 68% in the positive group. The HPV-16 genotype was the most prevalent in the HIV-negative group, and HPV-6 in the positive group. Among HPV-positive women, the TP53 Arg/Arg genotype was the most prevalent in both HIV groups...

Part??culas magn??ticas: s??ntese e aplica????es em ensaios de 3 imunosepara????o; Magnetic particles: synthesis and applications of 3 immunoseparation assays

MONTE, Leonardo Garcia
Fonte: Universidade Federal de Pelotas; Biotecnologia; Programa de P??s-Gradua????o em Biotecnologia; UFPel; BR Publicador: Universidade Federal de Pelotas; Biotecnologia; Programa de P??s-Gradua????o em Biotecnologia; UFPel; BR
Tipo: Tese de Doutorado Formato: application/pdf
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The development of reagents for infectious disease diagnosis and prevention is strategic for the scientific and technological advance of the country. Promising results have been obtained with the use of magnetic nanocomposites (MNC) in health for several purposes as separation, purification and detection of cells or biomolecules. In this work, an immunomagnetic separation (IMS) method using carbon and cobalt-based (MNCc), synthesized, and other polystyrene and iron-based (MNCp) commercially available was applied, for the isolation and detection of pathogenic leptospires. The MNCc were synthesized through polymeric precursor method and characterized by scanning electron microscopy/transmission (SEM/TEM), X-ray diffractometry (XRD), infrared spectrometry (FTIR), and immunofluorescence (IF). The MNCc surface was functionalized with carboxylic groups through the incorporation of acrylic acid. MNCc, adsorbed with monoclonal antibodies (MAbs) against pathogenic leptospires, were used in the IMS assays followed by PCR and cell culture was able to detect and isolate the organism. MNCp were used for detecting Leptospira spp. in biological fluids from dogs artificially contaminated with leptospires, and clinical samples from dogs positive for leptospirosis. The introduction of IMS...

Características epidemiológics e clínicas dos pacientes com insuficiência cardíaca atendidos no Hospital das Clínicas da Universidade Federal de Goiás; Epidemiological and clinical characteristics of patients with heart failure treated at the Hospital das Clínicas, Federal University fo Goias

NOGUEIRA, Patrícia Resende
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina
Tipo: Dissertação Formato: application/pdf
POR
Relevância na Pesquisa
185.83%
Heart failure (HF) is a complex syndrome in which several risk factors are involved in its genesis, making it difficult to its prevention and management. Objectives: To identify the etiology and risk factors associated with HF frequently found in patients treated in a referential clinic in the state of Goiás, to compare the clinical and demographic characteristics of these patients, to analyze the treatment used is in accordance with the established guidelines for the management of HF in Brazil. Methods: A retrospective, descriptive and observational study of medical records of patients with heart failure treated in 2008 at the Hospital das Clínicas da Universidade Federal de Goiás. The analysis through means the Chi-square test (χ2) and Fisher's exact test was used to compare demographic and clinical characteristics of patients and forms of treatment according to the main etiology of HF. The One-way analysis of variance (ANOVA) and the Kruskal-Wallis test were used for quantitative variables. Results: 144 medical records of patients were analyzed, with a mean age 61 ± 15 years, 54.2% were male. Chagas cardiomyopathy was the main cause of HF (41%). Hypertension (48.6%), anemia (22.9%), coronary artery disease (19.4%), dyslipidemia (17.3%) and diabetes mellitus (16.6%) were the most frequent risk factors. There was no significance between patients of different etiologies as the ejection fraction...

Análise dos resultados sorológico, anatomopatológico e parasitológico de material abortivo para infecções com risco de transmissão vertical com ênfase na toxoplasmose; Analysis of the results serological, pathological and parasitological of material abortive for infections with a risk of vertical transmission with emphasis on toxoplasmosis

BARBARESCO, Aline Almeida
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina
Tipo: Dissertação Formato: application/pdf
POR
Relevância na Pesquisa
165.83%
The infection caused by Toxoplasma gondii, Trypanosoma cruzi, Rubella virus, Cytomegalovirus (CMV) and Treponema pallidum, can reach the fetus via the placenta or transamniótica may cause different damage. The severity of the infection or even abortion, depend on the virulence of the strain of microorganism, the immune response of the mother and the period. The aim of this study was to analyze the results of serological, pathological and parasitological material for abortive infections with risk of vertical transmission, with emphasis on toxoplasmosis. They were invited to participate in the study, women who miscarried and complete or incomplete, attended at two public hospitals in Goiânia, Goiás, between the period June 2008 to June 2009. Were interviewed through a questionnaire and collected blood samples and abortive material. There were immunologic tests for toxoplasmosis, Chagas disease, rubella, cytomegalovirus and syphilis and pathology in cytogenetic. 55% of women were aged 20 to 30 years of age. The majority (68%) had gestational ages ranging from 7-14th weeks. 54.3% of women had completed high school or incomplete. Regarding the number of abortions, most women (69%) had only one abortion and minority (2.9%) were already in the fourth or fifth abortion. For the analysis of serology...