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Situação epidemiológica da filariose linfática bancroftiana no município de Maceió, estado de Alagoas.; The epidemiological situation of bancroftian lymphatic filariasis in the municipality of Maceió, state of Alagoas.

Leite, Anderson Brandão
Fonte: Universidade Federal de Alagoas; BR; Biologia; Programa de Pós-Graduação em Ciências da Saúde; UFAL Publicador: Universidade Federal de Alagoas; BR; Biologia; Programa de Pós-Graduação em Ciências da Saúde; UFAL
Tipo: Dissertação Formato: application/pdf
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Bancroftian lymphatic filariasis is a neglected parasitic illness, known popularly as elephantiasis, because it is one of its chronic clinical manifestations. It is an anthroponotic disease caused by a nematode helminth of the species Wuchereria bancrofti (Cobbold, 1877) (Spirurida: Onchocercidae). Bancroftian filariasis occurs in 83 countries localized in tropical and subtropical regions and is considered by the World Health Organization as the second leading cause, worldwide, of work disability. With the objective to ascertain the current distribution of lymphatic filariasis in Maceio, based upon previous studies, hemoscopic and entomological surveys were conducted in the city. The hemoscopic surveys were performed using a thick blood smear (TBS) in a random sample of 20,025 students of night schools, enrolled in the 143 public schools that cover the 50 districts of the city, a sample of 1418 employees of the same public night schools and of 546 soldiers of the Brazilian Army s 59th Motorized Infantry Battalion. Also evaluated by TBS was the family of the sole microfilaremic person found, composed of four individuals and 239 families of current and former neighbors of this patient, with a total of 943 individuals. The entomological survey...

Efeito de um extrato de chrysobalanus icaco na marcação de constituíntes sanguíneos com tecnécio-99m, na morfologia de hemácias, na topologia plasmidial e na ação do cloreto estanoso no dna plasmidial

Presta, Giuseppe Antônio
Fonte: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde Publicador: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde
Tipo: Tese de Doutorado Formato: application/pdf
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The use of radionuclides has contributed for advances in Health Sciences, to research or to the diagnosis and/or treatment of diseases. These advances have been possible with the utilization of radiopharmaceuticals labeled with technetium-99m (99mTc). Stannous chloride (SnCl2) has the main reducing agent utilized to obtain radiopharmaceuticals labeled with technetium-99m. It has been reported that several natural or synthetic drugs are capable to alter the labeling of blood constituents with 99mTc, as well as the red blood cells morphology. The aim of this study was to evaluate possible alterations of Chrysobalanus icaco extract on the labeling of blood constituents with 99mTc, on the morphology of RBC of blood of Wistar rats, on the breakage of plasmid DNA and on the effects of stannous chloride on plasmid DNA. The results showed significant (P<0.05) alteration of the labeling of blood constituents with 99mTc, as well as, modification of the morphology and morphometry (perimeter/area ratio) of the RBC in presence of the extract. These data suggest that this abajeru extract could alter the labeling of blood constituents with 99mTc by its chelating/antioxidant action and/or effects on membrane structures. Moreover C. icaco extract altered the electrophoretic profile and decreased significantly (p<0.05) the effect of SnCl2 on plasmid DNA. The results obtained in this work could indicate a dose-dependent protective action against the SnCl2 and a genotoxic effect of C. icaco extract on plasmid DNA; O uso de radionuclídeos tem contribuído para avanços relevantes em Ciências da Saúde...

Efeito de preparações de produtos naturais (cravo da índia e tomate) e de um produto sintético na marcação de constituintes sangüineos com tecnécio-99m e na morfologia de hemácias isoladas de sangue de ratos wistar

Paoli, Severo de
Fonte: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde Publicador: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde
Tipo: Tese de Doutorado Formato: application/pdf
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There are strong interests in the evaluation of the biological effects of natural and synthetic products. Blood constituents labeled with technetium-99m (99mTc) are used in nuclear medicine. The aim of this work was to study the effects of Clove (Caryophyllus aromaticas L.) and OZE (preparation used in the Health Sciences) on the labeling blood constituents with 99mTc and on the morphologic red blood cells (RBC) and the action of an extract of tomato (TO) on the labeling of blood constituents Blood samples were incubated with clove or OZE or TO, stannous chloride and 99mTc. Plasma (P), blood cells (BC), insoluble fractions (IF) of plasma and blood cells were separated. The radioactivity was counted and percentage of radioactivity (%ATI) to each blood fraction was calculated. The shape and morphometric parameter (perimeter/area ratio) were evaluated in the studies with clove and OZE. Clove extract and OZE altered significantly (p<0.05) the %ATI of blood constituents and the shape of red blood cells. However, clove extract not altered the red blood cells perimeter/area ratio. The tomato extract used at the highest concentrations reduced significantly (p<0.05) the %ATI in IF-P, although this extract did not modify the radiolabeling on BC...

Efeitos de um extrato aquoso de buzhong yi qi wan (fórmula magistral chinesa) na marcação de constituintes sanguíneos com tecnécio-99m, na morfologia e na fragilidade osmótica de hemácias de ratos Wistar

Giani, Tânia Santos
Fonte: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde Publicador: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde
Tipo: Tese de Doutorado Formato: application/pdf
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Technetium-99m (99mTc) has been used to obtain several radiobiocomplexes utilized to aid in the diagnosis of diseases. Blood constituents, as red blood cells (RBC) and plasma proteins, have been labeled with 99mTc. Natural and synthetic drugs can alter the labeling of these constituents. The aim of this work was to investigate the possibility of a Buzhong YiQi Wan extract to alter (i) the labeling of blood constituents with 99mTc, (ii) the RBC morphology, and (iii) osmotic fragility of RBC withdrawn from Wistar rats. The data showed that the BYQW extract (i) could affect labeling of blood constituintes with 99mTc, (ii) could affect the membrane integrity decreasing the osmotic resistance and (iii) could not alter the shape of RBC. Probably, these findings would be associated with properties of the substances present in the aqueous extract of BYQW. This study has multiple disciplinary aspects in knowledge areas: Radiobiology, Botanic, Phytotherapy and Haematology; A pesquisa em Ciências da Saúde, assim como as avaliações clínicas têm sido favorecidas pelo uso de isótopos radioativos, sendo que o tecnécio-99m (99mTc) tem sido o mais utilizado para obtenção de radiobiocomplexos com finalidade de diagnóstico. Diversas drogas naturais ou sintéticas são capazes de interferir na marcação de estruturas sanguíneas com 99mTc...

Excesso de peso em região do nordeste brasileiro: contraste entre escolares de rede pública e privada de ensino

Brasil, Lana do Monte Paula
Fonte: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde Publicador: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde
Tipo: Dissertação Formato: application/pdf
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The prevalence of obesity has been increased in the last three decades. It is already considered as epidemic by the World Health Organization and reaches around 300 million people worldwide. The weight gain in all ages is related to a sedentary way of life and hyper caloric food ingestion at the modern society. Obesity is a chronic disease and leads to high blood pressure, diabetes, cardiovascular diseases and cancer. The aim of this study was to evaluate the prevalence of weight excess among student in Natal schools and to analyze its association with age, gender, school category and geographic localization in city zones. This was a transversal study which enrolled 1927 children. 1084 of these were between 6 and 8 years-old (group 1) and 843 were 9 to 10 years-old (group 2). 895 of the total children studied in private schools and 1032 studied in public schools. 33,6% of the students had body mass index equal or above the 85th percentile and were considered as having weight excess. There was no statistical difference in this prevalence considering neither gender nor age. The weight excess prevalence in private schools was 54,5% and in public ones was 15,6% (p<0,01; OR=6,49). Weight excess was also more prevalent in the south and east city zones (41...

Seleção de categorias da Classificação Internacional de Funcionalidade, Incapacidade e Saúde para avaliação do paciente com acidente vascular cerebral em reabilitação

Silva, Diana Lídice Araújo da
Fonte: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde Publicador: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde
Tipo: Dissertação Formato: application/pdf
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Stroke represents the first cause of disabilities among adults. Although different professions work together in treatment of stroke patients, all they use different terminologies for the description of the patients problems and it can constitute an impediment in the communication between the staff members. Thus, the multidisciplinary and interdisciplinary work would be facilitated if using a reference common tool, as the new International Classification of Functioning, Disability and Health (ICF). However, the ICF is very extensive and complex and due to its complexity, it has been evidenced the necessity to select its categories to become it more practical. The aim of the study was to investigate which categories of the ICF are more suitable to evaluate and to describe the stroke patient in the view of teachers and municipal public health professionals. It was a descriptive research, which involved 5 professors and 11 professionals of Physiotherapy that have worked at the health public area in Natal / RN. It was used the Delphi Technique in 3 rounds and the Likert Scale to select the categories among the ICF components. As result, from the 362 IFC categories, 94 were selected. The selected categories correspond to rehabilitative characteristics of Stroke patients in the universe of the Physiotherapy performance. The methodology applied was suitable to the studied object emphasizing the necessity of future studies for validation of the chosen categories; O acidente vascular cerebral representa a primeira causa de incapacidade entre adultos. Embora diferentes profissões trabalhem juntas no tratamento dos pacientes com AVC...

Avaliação do potencial de mutagenicidade e toxidade da lectina hipoglicemiante de folha de Bauhinia monandra (pata-de-vaca)

Sisenando, Herbert Ary Arzabe Antezamana Costa Nóbrega
Fonte: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde Publicador: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde
Tipo: Dissertação Formato: application/pdf
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Medicinal plants have been used since antiquity to treat various human diseases. The leaves of Bauhinia monandra are widely used in Brazil as herbal remedies in the treatment of Diabetes Mellitus. From the leaves of B. monandra was purified a galactose-specific lectin, called BmoLL, which also showed a significant hypoglycemic capacity. Following the proposed rules by decree No 116 of 1996/08/08 of the Ministry of Health of Brazil, the study aimed to evaluate the potential for toxicity and mutagenicity of BmoLL from the use of tests with Escherichia coli strain CC104 (Forward mutagenesis assay) with Salmonella typhimurium strain TA (Kado test), with plasmid pBCKS (Break occurrences in plasmid DNA) and enzyme exonuclease III (Search of abasic sites). The results demonstrated that the lectin was unable to increase the frequency of reverse mutation of strains of S. typhimurium, with and without metabolic activity. However, a significant decrease in the frequency of spontaneous mutation was observed in strains of E. coli, especially in poor repair (CC104mutMmutY), indicating an antioxidant potential of the lectin. BmoLL is unable to generate genotoxic and cytotoxic damage, based on the concentrations and the tests performed; As plantas medicinais têm sido usadas desde a antiguidade no tratamento de diversas enfermidades humanas. As folhas de Bauhinia monandra são amplamente utilizadas no Brasil como fitoterápico no tratamento do Diabetes Mellitus. A partir das folhas de B. monandra...

Marcadores genéticos associados com a resposta inflamatória na meningite bacteriana

Fontes, Fabrícia Lima
Fonte: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde Publicador: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde
Tipo: Dissertação Formato: application/pdf
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; A meningite bacteriana (MB) é uma doença infecto-contagiosa que apresenta altas taxas de mortalidade e morbidade, constituindo-se assim um grave problema de saúde pública. É caracterizada por uma intensa inflamação granulocítica que leva a injúria neuronal e consequentemente surgimento de sequelas neurológicas. A resposta inflamatória determina tanto a susceptibilidade à MB como sua consequência clínica. Essa resposta depende não só do tipo e da intensidade do estímulo, mas também de fatores genéticos do hospedeiro, tais como polimorfismos localizados em regiões codificantes ou regulatórias de genes importantes durante a infecção, dentre os mais frequentes os polimorfismos de um único nucleotídeo (SNPs). O objetivo desse estudo foi investigar a associação entre os polimorfismos em TNF -308G/A, TNF -857C/T, IL-8 -251A/T, AADAT+401C/T, que codificam proteínas importantes durante a resposta inflamatória e APEX1 Asn148Glu, OGG1 Ser326Cys e PARP-1 Val762Ala, que codificam enzimas de reparo de DNA, com a ocorrência da MB. O estudo foi realizado com um grupo de 54 pacientes, admitidos no Hospital Giselda Trigueiro, Natal-RN, Brasil, o qual é referência para doenças infecciosas no estado...

Investigação da acalásia do esfíncter anal interno por meio da eletromanometria de pacientes chagásicos obstipados com e sem megacolo (Goiânia-Goiás-Brasil); Investigation of the internal anal sphincter achalasia by electromanometry of constipated patients with Chagas disease with and without megacolon (Goiania, Goias, Brazil)

ALMEIDA, Arminda Caetano de
Fonte: Universidade Federal de Goiás; BR; UFG; Doutorado em Ciencias da Saude; Ciencias da Saude Publicador: Universidade Federal de Goiás; BR; UFG; Doutorado em Ciencias da Saude; Ciencias da Saude
Tipo: Tese de Doutorado Formato: application/pdf
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Chagas disease remains as an important public health challenge in South America. The Chagas colopathy is considered the second clinical digestive manifestation most common of the disease and constipation chronic, its main symptom. The general objective was to investigate the presence of achalasia, through electromanometry of the internal anal sphincter, in constipated chagasic patients with and without megacolon. This study evaluated clinical and electromanometry parameters of 64 patients with symptoms of constipation, attended on the service of coloproctologya on a university hospital in Brazil, central region. The achalasia was present in 91.3% (IC95% 74.13 to 98.52) of patients with megacolon and/or megarecto (Group 1), in 47.29% (IC95% 27.29 to 68.57) without megacolon and/or megarecto (Group2), and was not present in patients of the control group (Group 3). The rectal capacity was 309.1, 159.2 and 150.1 ml in the groups 1, 2 and 3 respectively. In conclusion the electromanometry detects achalasia of the internal anal sphincter in almost totality of patients with megacolon and/or megarecto. The megacolon presence in constipated patients with Chagas Disease alert to the possibility of occurrence of achalasia on the internal anal sphincter. In chronically constipated patients with positive serology for Chagas Disease...

Análise clínica e microbiológica de úlceras venosas de pacientes atendidos em Unidades Básicas de Saúde de Goiânia; Clinical and microbiological analysis of the venous ulcers of patients treated at Basic Health Centers of Goiânia

SANTOS, Silvana de Lima Vieira dos
Fonte: Universidade Federal de Goiás; BR; UFG; Doutorado em Ciencias da Saude; Ciencias da Saude Publicador: Universidade Federal de Goiás; BR; UFG; Doutorado em Ciencias da Saude; Ciencias da Saude
Tipo: Tese de Doutorado Formato: application/pdf
POR
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This cross-sectional study was performed in the dressing rooms of the primary healthcare network of Goiânia, Goiás, Brasil, with the following objectives: to identify the prevalence of Gram-negative bacteria (GNB) in venous ulcers (VU) with clinical signs of infection; analyze the susceptibility profile of the isolates; detect the production of AmpC β-lactamases and metallo-beta-lactamases, and extended spectrum beta-lactamase (ESBL); describe the clinical signs and symptoms of infection in VU; evaluate the wounds clinical stage of infection and its relationship with the presence of GNB. The data were analyzed by means of descriptive statistics procedures, proportion and Chi-square tests (p<0.05). All ethical aspects were followed. The participants were 69 patients with venous ulcers, with or without arterial complication, totaling 98 wounds. It was verified that 74.5% of the wounds showed GNB growth, particularly enterobacteria (53.8%) and non-fermenting gram-negative bacteria (46.2%). The prevalent species among the enterobacteria was Escherichia coli (24.5%), followed by Enterobacter aerogenes, Pantoea agglomerans and Proteus mirabilis (12.2% each). Regarding the non-fermenting gram-negative bacteria, the prevalent genre was Pseudomonas (66.6%)...

Perfil Neuropsicológico das Alterações de Linguagem nas Demências Subcorticais da Substância Branca e Cinzenta; Neuropsychological Profile of Language Changes in Dementia subcortical white matter and Grey

LACERDA, Maria Carolina Cabral de
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina
Tipo: Dissertação Formato: application/pdf
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In the twentieth century, it was believed that the injury cortical was the substrate of cerebral dysfunction neuropathological. Studies of dementia were primarily focused on disorders of the cerebral cortex and sub cortical gray region, which originated the concepts of cortical and subcortical dementia respectively. The report of dementia mainly involving the white brain received less attention. The aim of this study was to achieve a profile of changes in language and cognitive processes involved in changes in the white sub cortical dementia (DSB) and dementia sub cortical gray (DSC) and then compared with the control group and among themselves. Thus 15 patients were evaluated with DSB, 8 with DSC and 14 control subjects. We applied the following tests: Boston for Diagnostic of Aphasia Examination (BDAE), the Boston Naming Test (BNT), Token Test, Verbal fluency - semantic category and board Theft of biscuits. The results showed that the subcortical group showed worse performance with the control group, showing significant differences in the Boston Naming Test and on the evidence of comprehension and oral production and graphics for the Boston Diagnostic Test of Aphasia. The DSB group showed more significant changes when compared with the control group than in the comparison between DSC X control group. Despite the language is related to cortical involvement...

Prevenção do Câncer do Colo do Útero na Estratégia Saúde da Família: contribuições para a capacitação do Agente Comunitário de Saúde; Prevention of Uterine Cervical Cancer in The Family Health Program: contributions to the empowerment of the Community Health Agent.

Ferreira, Tatyana Xavier Almeida Matteucci
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina
Tipo: Dissertação Formato: application/pdf
POR
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Introduction: Uterine cervical cancer (UCC) is the second most common malignancy among women in Brazil, the main strategy for early detection of premalignant lesions is the cytopathology. Despite the existence of the screening program there was no reduction in the incidence and mortality rate of UCC in Brazil. The Family Health Strategy has the potential to work in the organization of UCC screening and in this context, one should consider that the Community Health Agents (CHA) play a central role. Objective: Contribute to the training of CHA in preventing UCC. Methodology: Intervention study conducted with the CHA from Goiânia-GO. The training of CHA on the prevention of UCC was conducted. During the training structured questionnaires were used to collect data. For statistical analysis, all variables were evaluated descriptively by calculating the absolute and relative frequencies. Knowledge of CHA on UCC preventing practices before and after training was compared by the McNemar test, adopting a 5% error. Results: There was a lack of knowledge of CHA about the prevention of UCC before the training. We observed the improvement of knowledge after the training, especially in relation to the purpose of cytopathology, the proper preparation of women for their achievement...

Implantação de uma Unidade Sentinela Centro de Referência em Medicina Internacional e de Viagem no Hospital das Clínicas da Universidade Federal de Goiás (HC / UFG); Introduction of Sentinel Unit Reference Center in International and Travel Medicine in General Hospital at Federal University of Goiás.

AIRES, Leticia Mara Conceição
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina
Tipo: Dissertação Formato: application/pdf
POR
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Introduction: The number of domestic and international travel has increased in past years. This way, Travel Medicine, has become an important subject, with the emergence of services that provide health care to travelers. Objective: To evaluate strategies used in deploying Sentinel Unit Reference Center for International and Travel Medicine at the HC / UFG. Methods: First approach: Systematic Review of Literature using the keywords: "Travel and medicine", "Travel and prevention", "Travel and Disease and Medicine" and "Traveler and medicine . Then were selected articles in English, Spanish and Portuguese, from 2004 to 2008. Second approach: a descriptive, qualitative and quantitative, with evaluation of actions taken during the period preceding the implementation of the Unit. Results: In the literature review were found 1,301 articles, and 72 included for analysis, we observed that malaria is the most studied disease, the main preventive measures discussed are chemoprophylaxis for malaria and vaccination. Health professionals working in Travel Medicine are general practitioners, pharmacists and nurses in various parts of the world, and among the obstacles we stress the lack of information in travelers, the lack of professional preparation and last-minute travelers. In a qualitative and quantitative research was performed a retrospective study in which differences were observed between physicians at the General Hospital and the tropical Diseases Hospital...

Análise do padrão do uso de medicamentos em idosos no município de Goiânia, Goiás; Analysis of the pattern of drugs use in the elderly in Goiânia, Goiás

SANTOS, Thalyta Renata Araújo
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina
Tipo: Dissertação Formato: application/pdf
POR
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Introduction: The fact of elderly people live in a greater amount with chronic diseases, make the elderly a great consumer of health services and, probably, the most medicated group in the society. In this context serious problems arise, such as the use of multiple medications simultaneously (polypharmacy) that can lead to serious consequences to the elderly health. Another problem is the self-medication, which may exacerbate the associated risks with prescript drugs, delaying a diagnosis and masking a disease. There is, still, the use of drugs considered inappropriate for elderly, either by reducing the therapeutic efficacy or an increased risk of adverse effects that increase the advantages in elderly usage. Objective: Analyzing the pattern of use of medications in aged people in the city of Goiânia-GO, and associate it with socioeconomic aspects and with the self-rated health. Methods: A population-based study and cross-section, that evaluated the health of elderly in the city of Goiânia-GO. The data collection was carried out in December/2009 to April/2010 from 934 elderly. The questionnaire had questions about medications, in addition to information about self-rated health and socioeconomic profile. The drugs groups were classified according to the Anatomical Therapeutic Chemical and Classification-ATC. The inappropriate drugs for elderly were identified according to Beers Criteria. Used Mann Whitney (U) and Chi-square test...

Avaliação da eficácia e segurança do uso de radioterapia intraocular com estrôncio 90 e bevacizumabe no tratamento de pacientes portadores de degeneração macular relacionada à idade, forma exsudativa; Three-year safety and visual acuity results of epimacular straontium-90*ytrium90 brachytherapy with bevacizumab for the treatment of sobfoveal chorodoidal neovascularization secondary to agerelated macular degerenation

BIANCHI, Lívia Carla de Souza Nassar
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina
Tipo: Dissertação Formato: application/pdf
POR
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Purpose: To evaluate the efficacy and safety of strontium-90 epimacular brachytherapy combined with intravitreal bevacizumab for treating subfoveal choroidal neovascularization secondary to exudative age-related macular degeneration. Its effects on visual acuity and macular thickness at 36 months of follow up were also studied. Methods: Sixteen patients with predominantly classic, minimally classic and occult choroidal neovascularization were treated with a single 24 Gy dose of radiation during pars plana vitrectomy, associated to two injections of bevacizumab at baseline and one injection at the one-month visit. The patients underwent a complete ophthalmologic examination, which included fluorescein angiography and optical coherence tomography, at the initial visit, every three months during the first year, and every six months during the second and third years of follow up. Results: Of the 16 cases, 2 patients (12.5%) lost more than 15 letters at the end of 36 months, and 3 (18.75%) lost fewer than 15 letters. Among the patients with improved visual acuity, 3 (18.75%) gained less than 15 letters and 8 (50%) gained more than 15 letters at the end of treatment. The mean best corrected visual acuity showed a gain of 16.0 letters at 12 months. After 36 months (n = 16)...

Avaliação da composição corporal e qualidade de vida em pacientes submetidos ao esvaziamento cervical supraomohióideo; Evaluation of body composition and quality of life in patients sunmitted to supraomohyoid neck dissection

PAULA JÚNIOR, Célio Antônio de
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina
Tipo: Dissertação Formato: application/pdf
POR
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Supraomohyoid neck dissection is an important procedure in the treatment of patients with malignancy in the oral cavity and oropharynx, however there are common side effects in the post operative period. Results of an elaborate review of literature in electronic databases to investigate the effect of a resistance exercise protocol in this population showed significant improvement in the quality of life of patients trained, however studies which deal with the issue are limited. To quantify the damage caused by post-operative supraomohyoid neck dissection, and thus develop a secure protocol of exercises for this population, this study evaluated changes in body composition, body mass index, range of motion and quality of life in patients undergoing unilateral or bilateral supraomohyoid neck dissection pre and post-operatively (30 and 90 days). In the post-operative period, the 28 patients observed showed a significant reduction in body weight, muscle weight, and fat percentage. In terms of range of motion, a reduction of flexion, extension, abduction, medial rotation and lateral rotation was detected in the post-operative period (30 and 90 days). Decreased range of motion of flexion and abduction post-operatively had a negative correlation with quality of life...

Infecção pelo Trypanosoma cruzi em doadores de sangue: Revisão Sistemática da Literatura e Estudo de Prevalência no Hemocentro de Goiás; Trypanosoma cruzi infection in blood donors: Systematic Review of Literature and Prevalence Study at Hemocentro de Goiás

SANTOS, Cristiane Araújo Tuma
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina
Tipo: Dissertação Formato: application/pdf
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Relevância na Pesquisa
145.8%
Introduction: Chagas disease or American trypanosomiasis is one of several infectious diseases that can be transmitted via blood, justifying the rigorous screening of blood donors. The transfusion transmission of trypanosomiasis has been reduced in Brazil with the implementation of programs to control the quality of blood products. Objectives: a) To do Systematic Review addressing the issue of transfusion transmission of Chagas disease and b) determine the prevalence of Chagas' infection in blood donors attending the Coordinator Blood Bank of Goiás, regional blood centers of Catalão, Rio Verde and Jataí and mobile units that collect blood in 62 cities in Goiás, in the years 2005 to 2009. Methods: 1) Systematic Review using the keywords "Chagas' disease," "blood donor", "Trypanosoma cruzi" and "blood transfusion" and the qualifier "epidemiology" in databases: MEDLINE, LILACS PAHO and WHOLIS. 2) Cross-sectional study to determine the seroprevalence for Trypanosoma cruzi, using data from computerized laboratory files whose serological technique was immunosorbent assay (ELISA). The positive donors were characterized by sex, age, nationality and origin, through records of attendance. Confidence Intervals were calculated at 95%. To reach statistical significance was considered p <0.05. Results: There were 314 articles in different databases...

Correlação entre parâmetros ecocardiográficos e sobrevida na insuficiência cardíaca de etiologia chagásica; Correlation between echocardiographic parameters and survival in heart failure due to Chagas disease

FROTA, Daniela do Carmo Rassi
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina
Tipo: Dissertação Formato: application/pdf
POR
Relevância na Pesquisa
135.87%
Introduction: Chagas disease is still considered a serious health and economics problem even one hundred years after its discovery in Latin American countries. In chronic phase the cardiac involvement is the most frequent and severe manifestation. The two-dimensional echocardiography provides important data for diagnosis and prognosis of this disease, mainly by evaluating the degree of ventricular impairment. Objectives: To correlate echocardiographic parameters with cardiovascular mortality (primary end-point) in a population of chagasic patients with severe ventricular dysfunction (ejection fraction <35%). Also establish the correlation between E / Em ratio, end-diastolic pressure of left ventricle (LVEDP) and plasma level of BNP in order to estimate filling pressures. Methods: This study is a retrospective analysis of a cohort of 60 patients included in Randomized Multicenter Study of Cardiac Cell Therapy in Chagas' heart disease - from February 2006 to February 2009. Echocardiographic parameters analyzed were left ventricle end diastolic and end systolic diameter (LVDD and LVSD), left ventricle diastolic and systolic volume (LVDV and LVSV), ejection fraction estimated by Simpson's method (EF), diameter of left atrium (LA), left atrial volume and left atrial volume indexed (LAV and LAV / m²)...

Subdiagnóstico da doença pulmonar obstrutiva crônica na atenção primária; Underdiagnosis of chronic obstructive pulmonary disease in primary care

QUEIROZ, Maria Conceição de Castro Antonelli Monteiro de
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina
Tipo: Dissertação Formato: application/pdf
POR
Relevância na Pesquisa
145.81%
The chronic obstructive pulmonary disease (COPD) is a disease with systemic manifestations, mainly caused by smoking and is characterized by progressive bronchial obstruction irreversible or partially reversible. Respiratory symptoms include dyspnea, wheezing, coughing and expectoration. The characteristics include systemic skeletal muscle dysfunction, weight loss, anxiety, depression, osteoporosis, increased risk of cardiovascular disease. Is mainly related to smoking and exposure to biomass. The spirometry in high-risk populations is a simple and effective method for the detection of COPD. The diagnosis at the initial stage of the disease allows the application of preventive measures in relation to smoking and the workplace. In Brazil, the underdiagnosis of COPD is due, among other factors, the underutilization of spirometry, the low rate of medical diagnosis in primary care units and the lack of knowledge about the patient's disease risk. The objective of this study is to investigate the underdiagnosis of Chronic Obstructive Pulmonary Disease (COPD) in primary care units and the factors associated with them, to identify individuals with clinical and functional criteria of COPD, to detect cases of underdiagnosis in subjects with COPD and assess the degree use of spirometry as a diagnostic method for COPD in the primary network. We recruited individuals aged 40 years or older and who had a smoking history of at least 20 pack / years. Participants answered a questionnaire on demographics...

Características epidemiológics e clínicas dos pacientes com insuficiência cardíaca atendidos no Hospital das Clínicas da Universidade Federal de Goiás; Epidemiological and clinical characteristics of patients with heart failure treated at the Hospital das Clínicas, Federal University fo Goias

NOGUEIRA, Patrícia Resende
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina
Tipo: Dissertação Formato: application/pdf
POR
Relevância na Pesquisa
145.8%
Heart failure (HF) is a complex syndrome in which several risk factors are involved in its genesis, making it difficult to its prevention and management. Objectives: To identify the etiology and risk factors associated with HF frequently found in patients treated in a referential clinic in the state of Goiás, to compare the clinical and demographic characteristics of these patients, to analyze the treatment used is in accordance with the established guidelines for the management of HF in Brazil. Methods: A retrospective, descriptive and observational study of medical records of patients with heart failure treated in 2008 at the Hospital das Clínicas da Universidade Federal de Goiás. The analysis through means the Chi-square test (χ2) and Fisher's exact test was used to compare demographic and clinical characteristics of patients and forms of treatment according to the main etiology of HF. The One-way analysis of variance (ANOVA) and the Kruskal-Wallis test were used for quantitative variables. Results: 144 medical records of patients were analyzed, with a mean age 61 ± 15 years, 54.2% were male. Chagas cardiomyopathy was the main cause of HF (41%). Hypertension (48.6%), anemia (22.9%), coronary artery disease (19.4%), dyslipidemia (17.3%) and diabetes mellitus (16.6%) were the most frequent risk factors. There was no significance between patients of different etiologies as the ejection fraction...