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Teste de sangue oculto nas fezes e retossigmoidoscopia flexível : ferramentas para o rastreamento de neoplasias colorretais em pacientes assintomáticos.; Fecal occult bloodtesting and flexiblerectosigmoidoscopy : tools for screening for colorectal neoplasias in asymptomatic patients.

Assunção, Paulo Roberto Torres
Fonte: Universidade Federal de Alagoas; BR; Biologia; Programa de Pós-Graduação em Ciências da Saúde; UFAL Publicador: Universidade Federal de Alagoas; BR; Biologia; Programa de Pós-Graduação em Ciências da Saúde; UFAL
Tipo: Dissertação Formato: application/pdf
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The colorectal cancer (CRC) is the third most common cancer in the world and the second leading cause of mortality in the United States. In Brazil, the CRC is the fourth place of incidence among men and the third place among women. Objective Evaluate the factibility and the efficacy of fecal occult blood testing (FOBT) and of flexible rectosigmoidoscopy (RS), as tools used in the CRC screening, in asymptomatic patients. Methods - The study is a transversal one and presents a sample of 102 individuals from 50 years old on. The FOBT used was the guaiac, FECA-CULT® method, performed only once in faeces collected from a complete bowel movement. The individuals, who presented the positive FOBT, were sent to complementary colonoscopy, although it is not a method of this study. The whole individuals were undertaken to RS, after bowel preparation using monobasic sodium phosphate monohydrate and dibasic sodium phosphate heptahydrate solution. Results - The subjects presented minimum age of 50 years old and maximum of 82 years old, average of 61,6 years old and standard deviation of + 8,1. Among 102 subjects, 42 (41%) are male and 60 (58,8%) are female. The FOBT presented 10 positive cases (9,8%) (CI 95%: 4,8%-17,3%) and 92 negative cases (90...

Exercício físico, saúde e qualidade de vida em pessoas com HIV/AIDS em Natal/Rio Grande do Norte

Guerra, Luís Marcos de Medeiros
Fonte: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde Publicador: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde
Tipo: Dissertação Formato: application/pdf
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A sobrevida das pessoas com AIDS tem aumentado com o uso das terapias com antiretrovirais (TARV), esses, entretanto, possuem efeitos colaterais que interferem no padrão morfofuncional e hematológico, o que pode levar a alterações na qualidade de vida (QV). Este estudo quase-experimental objetivou avaliar parâmetros antropométricos, funcionais, hematológicos e de QV em pessoas com HIV/AIDS submetidas a um programa de exercícios de 16 semanas. Os participantes tinham idade entre 35 e 51 anos (n=15), eram registrados no Núcleo de atendimento do Hospital Giselda Trigueiro em Natal/Rio Grande do Norte e apresentaram CD4350cel/mm3, lipodistrofia e estavam em TARV. Foram avaliados o índice de massa corpórea (IMC), a relação cintura-quadril (RCQ), o percentual de gordura (%G), a força escapular e manual, a contagem de CD4, carga viral e QV, antes e após a intervenção. Essa foi realizada com exercícios de aquecimento e utilizou como base os exercícios resistidos, realizados 3x/semana, com 1h e intensidade de 60 a 75% de 1RM. Observaram-se modificações significativas no %G (p=0,031), força escapular (p=0,007) e preensão manual (p=0,039). Houve aumento no CD4 e a carga viral manteve-se indetectável. Nos domínios da QV...

Marcadores genéticos associados com a resposta inflamatória na meningite bacteriana

Fontes, Fabrícia Lima
Fonte: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde Publicador: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde
Tipo: Dissertação Formato: application/pdf
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; A meningite bacteriana (MB) é uma doença infecto-contagiosa que apresenta altas taxas de mortalidade e morbidade, constituindo-se assim um grave problema de saúde pública. É caracterizada por uma intensa inflamação granulocítica que leva a injúria neuronal e consequentemente surgimento de sequelas neurológicas. A resposta inflamatória determina tanto a susceptibilidade à MB como sua consequência clínica. Essa resposta depende não só do tipo e da intensidade do estímulo, mas também de fatores genéticos do hospedeiro, tais como polimorfismos localizados em regiões codificantes ou regulatórias de genes importantes durante a infecção, dentre os mais frequentes os polimorfismos de um único nucleotídeo (SNPs). O objetivo desse estudo foi investigar a associação entre os polimorfismos em TNF -308G/A, TNF -857C/T, IL-8 -251A/T, AADAT+401C/T, que codificam proteínas importantes durante a resposta inflamatória e APEX1 Asn148Glu, OGG1 Ser326Cys e PARP-1 Val762Ala, que codificam enzimas de reparo de DNA, com a ocorrência da MB. O estudo foi realizado com um grupo de 54 pacientes, admitidos no Hospital Giselda Trigueiro, Natal-RN, Brasil, o qual é referência para doenças infecciosas no estado...

Candidíase vulvovaginal: sintomatologia, fatores de risco e colonização anal concomitante

Holanda, Antônio Arildo Reginaldo de
Fonte: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde Publicador: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Ciências da Saúde; Ciências da Saúde
Tipo: Dissertação Formato: application/pdf
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Post-menarche patients with clinical signs of vulvovaginitis were analyzed in this study, whose aims were the following: identify the frequency of C. albicans and non C. albicans species and negative results, correlate the vaginal culture for yeast with risk factors and symptomatology; compare positive and negative results for yeast in the vaginal and anal cultures; compare the positive results for C. albicans with other results found in the vaginal and anal cultures; and compare concomitant positivity for C. albicans and non C. albicans in the vaginal and anal cultures. Sample selection occurred between May, 2003 and May, 2005, and included 99 patients from Natal, Brazil. The laboratory methods used consisted of CHROMagar Candida culture medium, thermotolerance test at 42-45°C and hypertonic NaCL, in addition to the classic methods of carbohydrate assimilation and fermentation. We used absolute numbers, percentages, means of central tendency, chi-squared test (χ2) with Yates correction, Fisher s exact test and odds ratio for statistical analysis. The most frequent species was C. albicans in 69% of the cases. The positivity for Candida spp showed an association with the use of tight-fitting intimate clothing and/or synthetics...

Implantação de uma Unidade Sentinela Centro de Referência em Medicina Internacional e de Viagem no Hospital das Clínicas da Universidade Federal de Goiás (HC / UFG); Introduction of Sentinel Unit Reference Center in International and Travel Medicine in General Hospital at Federal University of Goiás.

AIRES, Leticia Mara Conceição
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Ciências da Saúde; Ciências da Saúde - Medicina
Tipo: Dissertação Formato: application/pdf
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Introduction: The number of domestic and international travel has increased in past years. This way, Travel Medicine, has become an important subject, with the emergence of services that provide health care to travelers. Objective: To evaluate strategies used in deploying Sentinel Unit Reference Center for International and Travel Medicine at the HC / UFG. Methods: First approach: Systematic Review of Literature using the keywords: "Travel and medicine", "Travel and prevention", "Travel and Disease and Medicine" and "Traveler and medicine . Then were selected articles in English, Spanish and Portuguese, from 2004 to 2008. Second approach: a descriptive, qualitative and quantitative, with evaluation of actions taken during the period preceding the implementation of the Unit. Results: In the literature review were found 1,301 articles, and 72 included for analysis, we observed that malaria is the most studied disease, the main preventive measures discussed are chemoprophylaxis for malaria and vaccination. Health professionals working in Travel Medicine are general practitioners, pharmacists and nurses in various parts of the world, and among the obstacles we stress the lack of information in travelers, the lack of professional preparation and last-minute travelers. In a qualitative and quantitative research was performed a retrospective study in which differences were observed between physicians at the General Hospital and the tropical Diseases Hospital...

Tuberculose latente em pacientes com artrite reumatoide. Avaliação da resposta celular e novas estratégias diagnósticas.; Latent tuberculosis in rheumatoid arthritis patients. Evaluation of cellular response and new diagnostic strategies

SILVA, Daniela Graner Schuwartz Tannus
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina
Tipo: Dissertação Formato: application/pdf
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The diagnosis of latent tuberculosis (TBIL) in patients with rheumatoid arthritis (RA) has got special importance with the advent of anti tumor necrosis factor (anti-TNF-α) and the arise of cases of active tuberculosis in these patients. The tuberculin skin test (TST) is a test used for more than a century on the diagnosis of TBIL but has limited value in patients with RA. New tests that are based on the production and release of interferon-gamma (IFN-γ) have been studied but its role has not yet been well established in this group of patients. This paper shows a review about the use of anti-TNF-α and its role on the development of tuberculosis, the use of the TST for the diagnosis of TBIL in patients with RA and new tests for diagnosis of TBIL. The review is illustrated with a case of a patient who developed tuberculosis after starting the use of anti-TNF-α. In the sequence, a study comparing the diagnostic TBIL in a group of RA patients by cellular immune response, compared to TST, T.SPOT-TB and measurement of IFN-γ by flow cytometry after stimulation with Hspx and through computed tomography changes consistent with TBIL. It was observed that the response to TST was lower in RA patients (13.5%) than the expected response to the general population. We also observed that the T.SPOT-TB identified a greater number of patients with TBIL compared to PT (36.8%). The IFN-γ in response to Hspx was not statistically different among the groups considered TBIL (TST and / or T.SPOT-TB positives) or NO TBIL (TST and T.SPOT-TB negatives). Finally...

Avaliação moluscicida das plantas Pterodon emarginatus Vogel 1837, Magonia pubescens St. Hil, e Croton urucurana Baill 1864, sobre Biomphalaria glabrata (Say, 1818) e cercaricida sobre Schistosoma mansoni (Sambon, 1907)

CORRÊA, Marinês Conceição Rieth
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina
Tipo: Dissertação Formato: application/pdf
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The molluscicide and cercaricide action of the Pterodon emarginatus plants Magonia pubescens and Croton urucurana found in the Brazilian scrubland center-west region and in other Brazilian regions where the schistosomose is endemic was evaluated separately in laboratories The brute etanolic extracto obtained after the dilution in water were tested over the Biomphalaria glabrata snails intermediary host of Schistosoma mansoni The evaluation of the bioactivity was done from the initial concentration of 100ppm over adult snails and those ones which died in the adult phase had their concentrations reduced at 50 25 and 12.5ppm successively The molluscicide effect was evaluated over the snails development phasis over the laying of eggs and over the ovigery masses hatching The extracts that did not show bioactivity on 100ppm did not have their concentrations decreased The P emarginatus extract did not demonstrate bioactivity over the snails the laying of eggs the ovigery masses hatching and the liberation of cercaries Showing the cercaricide effect five hours after the start of the experiment whereas the controlling group survived for 36 hours over the same conditions The M pubescens extract demonstrated 100% of bioactivity on the four concentrations utilized and in all the snails development phasis with the exception of the ovigery masses hatching The cercaricide effect was 100% on the 100 and 50ppm concentrations within fifteen minutes 100% on 25ppm within 30 minutes and 100% on 12.5ppm within two hours whereas the controlling group survived for 36 hours at the same conditions With the C urucurana extract the bioactivity was of 26.6% on the 100ppm concentration within 24 hours of an exposition over adult snails On the 50 25 and 12.5ppm concentrations it was not showed bioactivity over the adult and young snails the laying of eggs and the ovigery masses hatching It was presented bioactivity with newly-developed snails on the three concentrations tested after 24 hours of exposition With the cercaries the deaths were observed from the fifteen minutes on the 100 and 50ppm concentrations two hours on 25ppm and five hours on 12.5ppm...

Prevalência e estudo neuropsicológico de transtornos cognitivos e demências decorrentes de neuroinfecções em hospital de referência; Prevalence and neuropsychological study of disorders cognitive and dementia resulting from neuroinfecções in referral hospital

REIMER, Cláudio Henrique Ribeiro
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina
Tipo: Dissertação Formato: application/pdf
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Several infectious and parasitic diseases have been described as possible causes of cognitive loss, especially the neuroinfections that the location in the CNS, may evolve into frank dementia table (although subject to reversal). The vast possibilities as a result has large etiological heterogeneity of neuropsychiatric symptoms, which may hinder the clinical evaluation, but if using neuropsychological testing, it increases the chances of detection of cognitive and behavioral symptoms and therefore the diagnostic accuracy. The objective of the study is to estimate the prevalence of dementia and cognitive changes in neuroinfections, and characterize the co-morbid psychiatric symptoms. The sample comprised 60 patients with infection of the CNS in order to identify possible changes in performance in Mini-Mental State Examination (MMSE) and a questionnaire on activities of daily living for Pfeffer, and conduct behavioral assessment by questionnaire BEHAV - AD. By applying the MMSE and the Pfeffer questionnaire found that 20 patients (33.3% of the sample) had cognitive disorders without dementia and 23 patients were diagnosed as dementia, which is the framework neuropsychological most prevalent (38.3% of patients). If we include patients with cognitive disorders without dementia and those with dementia in one group...

Tipos de HPV e câncer do colo uterino: impacto no prognóstico das pacientes com tumores nos estádios iniciais; Human papillomavirus types 16 and 18 and the prognosis of patients with stage I cervical cancer

Zampronha, Rossana de Araújo Catão
Fonte: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) Publicador: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Tipo: Dissertação Formato: application/pdf
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INTRODUCTION: The cervical cancer is the third most frequent malignant neoplasia among women in Brazil and it is responsible for the fourth cause of death for cancer. It is related among other causes to persistent infection by human papillomavirus. Doubts persist if HPV type could influence the tumor prognosis. OBJECTIVE: To study the prevalence of HPV 18 and HPV 16 in women presenting cervical cancer in clinic stage Ib, treated by radical hysterectomy with linfadenectomy, establishing prognostic correlation. METHODS: A retrospective cohort study, including 86 pacients with cervical cancer Ec I, submitted to radical hysterectomy, in a single center, in which were analysed the known prognostic factors and the positivity to HPV by PCR. Univariate analysis was performed, with Kaplan-Meir curves, for survival estimative. RESULTS: The prevalence of HPV 16 infection was 65.3% and HPV 18 prevalence was 33.3%. To both virus the prevalence was 26.9%. The overall survival for women presenting HPV 18 infection, in sixty months, was 91% and those women without HPV 18 infection, the overall survival was 96%. The overall survival for women with and without HPV16 infection was 94% and 96%, respectively. The disease free survival was not influenced by the presence of either virus. CONCLUSION: In the present study...

Perfil epidemiológico e clínico das meningites infecciosas em idosos, no Hospital de Doenças Tropicais – HDT/AA Goiânia, Goiás, Brasil, 2000 - 2006; Epidemiological and clinical profile of the infectious meningitis in the elderly: a study of cases series in a reference hospital

Alvarenga, José Alberto
Fonte: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) Publicador: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Tipo: Dissertação Formato: application/pdf
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It is estimated that until the year 2020, in Brazil, 13 % of the population will be constituted by the elderly (population who are above 60 years old), counting 30 million people. The frequency and the gravity of the infectious diseases spread with age. Among these days, infectious diseases are the third cause of death after the sixty’s. The physical changes and the lack of immunological response in the elderly worsen day after day, favoring the infections’ gravity. Moreover, chronic diseases treated with immunosuppressor drugs and other, repeated hospitalizations and nutritional deficiency are addictive factors which explain this kind of diseases to grow worse in this specific population. This dissertation is about a retrospective essay with a descriptive analysis raising medical documents from patients with infectious meningitis in the Hospital de Doenças Tropicais (HDT), State of Goiás, Brazil, and aimed to evaluate the epidemiologic and clinical profile of the infectious meningitis in the elderly, the level of clinical suspicion and confirmation in health services in our State. About 110 cases of meningitis in elderly were notified between the years 2000 and 2006. From all cases, 64 (58,71%) were confirmed, 64...

Infecções por Acinetobacter baumannii em adultos admitidos em unidades de terapia intensiva (UTIs) de Goiânia e Aparecida de Goiânia; Acinetobacter baumannii infections in adults admitted to intensive care units in the Goiânia and Aparecida de Goiânia city of Brazil

Godoy, Cássia Silva de Miranda
Fonte: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) Publicador: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Tipo: Dissertação Formato: application/pdf
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Acinetobacter baumannii (Ab), has an important role in healthcare-associated infections, present a rapid global and emerging multidrug-resistant (MDR) strains, affecting many countries. In Brazil, Ab is responsible for outbreaks infections in intensive care units (ICUs) since 1996, with high rates of antimicrobial resistance. This was a descriptive cohort study of adult infected with Ab during the period of June to December of 2010, that evaluated the clinical and epidemiological profile of infections caused by Ab and analyzed genetically, by pulsed field gel electrophoresis (PFGE), clinical isolates from patients admitted in five ICUs of the Municipality of Goiania. We identified 64 cases of patient infected or colonized with Ab during the study period, 84 samples culture positive for Ab with a global infection rate of 4.8%. Infection incidence at each hospital was as follows: 10 % in ICU-1, 4.3% in ICU-2, 7.8% in ICU-3, 1.3% in ICU-4, and 7.5 % in ICU-5. The mean age of patients was 53.2 years (sd=19) and 59.4% (38) were male. Symptomatic infections occurred in 90.6% of the cases. The most frequent site of infection was pulmonary (53.1%), followed by surgical site (10.9%), and urinary tract (7.8%). The most common underlying diseases were neoplasia (34.4%) and AIDS (17.2%). Most of the patients infected with Ab (98.4%) had received antimicrobial therapy previously. The most frequently used drugs were cephalosporins (71.4%)...

Valor do teste de avidez da IgG como marcador de doença aguda ou crônica e de transmissão vertical na toxoplasmose; The value of specific IgG – avidity test to date infeccion and its relationship with vertical transmission in toxoplasmosis

Alvarenga, Fernanda Rassi
Fonte: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Medicina Tropical e Saúde Pública (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) Publicador: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Medicina Tropical e Saúde Pública (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Tipo: Dissertação Formato: application/pdf
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Toxoplasmosis is a parasitic disease widespread around the world caused by Toxoplasma gondii. Infection acquired during pregnancy may cause intrauterine damage and sequelae in the newborn. Serological testing for IgG/IgM anti-Toxoplasma antibodies may fail to differentiate between recent and past infection. Despite that, rapid diagnosis of acute infection during pregnancy allows rapid treatment and prevents or attenuates congenital toxoplasmosis. PURPOSE: to establish the frequency of acute toxoplasmosis in pregnant women, the vertical transmission rate and the value of specific IgG-avidity test to date infection in pregnancy; to evaluate the relationship between IgG-avidity and congenital toxoplasmosis. MATERIAL AND METHODS: this report summarizes a retrospective study performed on 235,993 pregnant women attended by “The Pregnancy Protection Program” – public health system (SUS) of the State of Goiás – Brazil, from January 2004 to December 2007. ELISA (IgG / IgM) and IgG-avidity test were performed for maternal screening of toxoplasmosis. Fetal and newborn investigation of the infection was performed by “The Toxoplasmosis Vertical Transmission Control Program” protocols. The association between data was statistically analyzed by the x2 test (p < 0...

Análises das comparações bioquímicas no soro e exsudato peritoneal de camundongos BALB/c inoculados com cepa cistogênica e não cistogênica de Toxoplasma gondii

Sylvio, Mirian de
Fonte: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Medicina Tropical e Saúde Pública (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) Publicador: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Medicina Tropical e Saúde Pública (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Tipo: Dissertação Formato: application/pdf
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Infection with Toxoplasma gondii occurs throughout the globe, with a prevalence of up to 90% in the population. The physiological changes caused by this parasite are well studied in immunocompromised individuals and in cases of congenital transmission. In immunocompetent individuals the infection is usually asymptomatic and little explored by researchers. Experimental studies follow the pattern of human studies, and there fow mention about the biochemical changes (liver and kidney metabolisms) in the host infected by T. gondii. This study aimed the quantification of hepatic and kidney alterations caused by acute infections by T. gondii (non cystogenic strain – RH) and by chronic infections (cystogenic strain – ME-49). The control group was formed by mice without infection, only submitted to saline stress. Several enzymes were measured in serum and peritoneal exudate of mice infected and control such as: aspartate aminotransferase (AST), alanine aminotransferase (ALT), glutamyltransferase (GGT), alkaline phosphatase (ALP), urea, creatinine and lactate dehydrogenase, using an automated methodology. AST and ALT presented a significative difference in the serum of mice infected with RH strain when compared to controls indicating a destruction of liver cells. The peritoneal exudates did not present significative changes in relation to controls nor did the urea and creatinine levels. The séric lactate dehydrogenase showed gradual changes in all days of the infection in mice peritoneal exudates as early as this change was evident only in the fifth day of infection. All samples of the group infected with ME-49 strain showed changes in serum and peritoneal exudate during all days of analysis. Only ALT peritoneal exudates showed no change during all days of analysis. An increase in urea at all doses was observed...

Infecção pelo vírus da hepatite B em pacientes com tuberculose em hospital de referência em Goiânia-GO

Aires, Rodrigo Sebba
Fonte: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Medicina Tropical e Saúde Pública (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) Publicador: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Medicina Tropical e Saúde Pública (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Tipo: Tese de Doutorado Formato: application/pdf
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Hepatitis B and tuberculosis (TB) are important public health problems. This study aimed to investigate the epidemiological and molecular profile of the hepatitis B virus (HBV) infection among patients with TB who were attended at the reference hospital for infectious diseases in Goiânia, Goiás. A total of 402 patients were interviewed for socio-demographic characteristics, risk factors for HBV infection and previous hepatitis B vaccination. Blood samples were collected and sera were tested for HBsAg, anti-HBc, and anti-HBs markers by an enzyme-linked immunosorbent assay (ELISA). HBsAg reactive samples were tested for HBeAg e anti-HBe markers by ELISA. HBV DNA was detected in HBsAg and anti-HBc reactive samples by polymerase chain reaction (PCR). HBV DNA positive samples were genotyped by restriction fragment length polymorphism (RFLP) and sequencing of the Pre-S/S region. The overall HBV prevalence infection was 25.6% (95% CI: 21.5-30.2). Age higher or equal 50 years old and injecting or non-injecting drug use were risk factors associated with HBV infection. HBV DNA was detected in ten (76.9%) HBsAg reactive samples. Of these, eight were genotyped as genotypes A (n = 7) and D (n=1). HBV occult infection rate of 14.4% was found among anti-HBc reactive patients. Only 10.9% had serological evidence of previous HBV vaccination. The high prevalence and risk factors such as injecting or non-injecting drug use...

Leishmaniose Tegumentar Americana na região Centro-Oeste: avaliação de dados clínicos, epidemiológicos, laboratoriais e moleculares; Cutaneous Leishmaniasis in the Midwest region: review of clinical, epidemiological, laboratory and molecular data

Balian, Rosana Pereira Morais
Fonte: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Biologia das Interações PH (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) Publicador: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Biologia das Interações PH (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Tipo: Dissertação Formato: application/pdf
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Protozoa of the genus Leishmania, which affects the skin and/or mucous membranes, cause American Cutaneous Leishmaniasis (ACL). It is an endemic zoonosis whose numbers of cases in the Brazil Midwest region are growing. In the Goiás state, 2798 ACL cases were been reported between 2007 and 2013. In the present study, our proposal was to investigate the epidemiological and molecular characteristics of ACL patients attended at the ambulatory of the Hospital Anuar Auad in the period 2000 at 2006 and identify the species of Leishmania sp. The study included 152 patients with ACL, 124 were from of the state of Goiás and 28 at Mato Grosso, aged between 6-79 years, and center and thirteen these individuals were male. For diagnosis, clinical, epidemiological and laboratory data were collected, such as direct examination (ED), histopathology (AH), Montenegro skin test (MST), indirect immunofluorescence (IIF). ELISA using crude extract of L. (Viannia) braziliensis was performing. Characterization of Leishmania species was carried out by polymerase chain reaction (PCR). The positivity of ED, AH, MST, IIF and ELISA was 70.6%, 80.9%, 68.9%, 44.2% and 73.0%, respectively. Specific IgG to L. (V.) braziliensis were detecting in 84.7% of patients with mucosal leishmaniasis (ML)...

Detecção do DNA de Chlamydia trachomatis em espondiloartopatias e artrite reumatóide; Detection of Chlamydia trachomatis in spondyloarthropathies and rheumatoid arthritis

Fernandez, Rafael Navarrete
Fonte: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) Publicador: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Tipo: Dissertação Formato: application/pdf
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Introduction: Chlamydia trachomatis is the bacteria responsible for the most prevalent sexually transmitted disease worldwide. Most of the infections in men and women is asymptomatic and when undiagnosed and untreated may reach the joints causing not only arthritis, but also other acknowledged complications related to the female reproductive system. Objective: To investigate C. trachomatis DNA in the urine and synovial fluid from patients with spondyloarthropathies (SpA) and rheumatoid arthritis (RA) and evaluate serum anti-C. trachomatisIgG and IgM antibodies. Methods: The population consisted of 15 patients with spondyloarthropathies, being nine with undifferentiated spondyloarthropathy (US) and six with reactive arthritis (ReA) (group I), and 15 patients with rheumatoid arthritis (RA) (group II). The chlamydial DNA was assessed in synovial fluid and urine samples of all patients by Amplicor PCR. The anti-chlamydial IgG and IgM antibodies were quantified through indirect imunofluorescence (IIF), while 15 patients of group I were typed for HLA-B27 by the use of flow citometry. Social demographical data and all information on sexual behavior and presence of symptoms were collected through a (questionnaire in the form of) an interview. Results: C. trachomatis DNA was found in only one synovial fluid sample from patient with ReA (6...

Part??culas magn??ticas: s??ntese e aplica????es em ensaios de 3 imunosepara????o; Magnetic particles: synthesis and applications of 3 immunoseparation assays

MONTE, Leonardo Garcia
Fonte: Universidade Federal de Pelotas; Biotecnologia; Programa de P??s-Gradua????o em Biotecnologia; UFPel; BR Publicador: Universidade Federal de Pelotas; Biotecnologia; Programa de P??s-Gradua????o em Biotecnologia; UFPel; BR
Tipo: Tese de Doutorado Formato: application/pdf
POR
Relevância na Pesquisa
85.91%
The development of reagents for infectious disease diagnosis and prevention is strategic for the scientific and technological advance of the country. Promising results have been obtained with the use of magnetic nanocomposites (MNC) in health for several purposes as separation, purification and detection of cells or biomolecules. In this work, an immunomagnetic separation (IMS) method using carbon and cobalt-based (MNCc), synthesized, and other polystyrene and iron-based (MNCp) commercially available was applied, for the isolation and detection of pathogenic leptospires. The MNCc were synthesized through polymeric precursor method and characterized by scanning electron microscopy/transmission (SEM/TEM), X-ray diffractometry (XRD), infrared spectrometry (FTIR), and immunofluorescence (IF). The MNCc surface was functionalized with carboxylic groups through the incorporation of acrylic acid. MNCc, adsorbed with monoclonal antibodies (MAbs) against pathogenic leptospires, were used in the IMS assays followed by PCR and cell culture was able to detect and isolate the organism. MNCp were used for detecting Leptospira spp. in biological fluids from dogs artificially contaminated with leptospires, and clinical samples from dogs positive for leptospirosis. The introduction of IMS...

Avaliação neuropsicológica no diagnóstico diferencial das demências infecto parasitárias e degenerativas; Neuropsychological assessment and differential diagnosis of infectious parasitic and degenerative dementias

Soares, Vânia Lúcia Dias
Fonte: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) Publicador: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Tipo: Dissertação Formato: application/pdf
POR
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96.1%
Neuropsychological assessment and differential diagnosis between infective and degenerative dementias.. There are no studies comparing the neuropsychological profile of patients with parasitic infectious dementia (DIP) and other forms of primarily degenerative dementia. The objectives were to compare the neuropsychological deficits present in three groups of patients with dementia and a normal control group in relation to the DIP group. For this purpose, we prospectively evaluated 130 individuals with dementia from Dementia Unit, Hospital das Clinicas, Federal University of Goias and from the Tropical Diseases Hospital, Goiânia, aged above 18 years, divided in the following groups: infectious dementia (DIP), Alzheimer's disease (AD) , frontotemporal lobar degeneration(DLFT) , parkinsonism plus (PP) and normal controls. All underwent extensive neuropsychological assessment, addressing all cognitive domains (verbal and visual memory, attention, executive functions, gnosis, praxis, visuospatial skills, language). The productions were transcribed into tables and quantified by specific tests (Stroop, Trail Making A / B, Cancelation Test, Maze, Digit Span, Rey Figure, RAVLT, Logical Memory, Verbal Fluency, Hooper and Proverbs from WAIS). The DIP group generally presented with severe neuropsychological deficits present in multiple cognitive domains...

Análise dos resultados sorológico, anatomopatológico e parasitológico de material abortivo para infecções com risco de transmissão vertical com ênfase na toxoplasmose; Analysis of the results serological, pathological and parasitological of material abortive for infections with a risk of vertical transmission with emphasis on toxoplasmosis

BARBARESCO, Aline Almeida
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Medicina Tropical; Medicina
Tipo: Dissertação Formato: application/pdf
POR
Relevância na Pesquisa
85.89%
The infection caused by Toxoplasma gondii, Trypanosoma cruzi, Rubella virus, Cytomegalovirus (CMV) and Treponema pallidum, can reach the fetus via the placenta or transamniótica may cause different damage. The severity of the infection or even abortion, depend on the virulence of the strain of microorganism, the immune response of the mother and the period. The aim of this study was to analyze the results of serological, pathological and parasitological material for abortive infections with risk of vertical transmission, with emphasis on toxoplasmosis. They were invited to participate in the study, women who miscarried and complete or incomplete, attended at two public hospitals in Goiânia, Goiás, between the period June 2008 to June 2009. Were interviewed through a questionnaire and collected blood samples and abortive material. There were immunologic tests for toxoplasmosis, Chagas disease, rubella, cytomegalovirus and syphilis and pathology in cytogenetic. 55% of women were aged 20 to 30 years of age. The majority (68%) had gestational ages ranging from 7-14th weeks. 54.3% of women had completed high school or incomplete. Regarding the number of abortions, most women (69%) had only one abortion and minority (2.9%) were already in the fourth or fifth abortion. For the analysis of serology...

Estudo genético e epigenético no prognóstico do câncer cervical por meio da verificação de HPV de baixo e alto risco e da metilação e não metilação dos genes RARβ, TIMP3, CDH1 E MGMT; Study genetic and epigenetic on prognosis of cervical cancer by means of verification of HPV of low and high risk and methylation and unmethylation genes RARβ, TIMP3, CDH1 E MGMT

D'Alessandro, Aline Almeida Barbaresco
Fonte: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) Publicador: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP); Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Tipo: Tese de Doutorado Formato: application/pdf
POR
Relevância na Pesquisa
95.84%
The human papillomavirus (HPV) is a major etiologic factor in the development of cervical cancer, DNA virus primarily infects the epithelium and may induce benign and malignant lesions of the mucous membranes and skin. Carcinogenesis is a multistep process that involves both changes genetic and epigenetic. The two changes epigenetic most studied are DNA methylation and histone acetylation. DNA methylation may be related development to cancer, and their presence or absence can affect the prognosis. The objective of this study was to evaluate the prognosis of patients with cervical cancer in stages I and II through the verification of HPV high and low risk, and the presence and absence of genes methylated and unmethylated RARβ, TIMP3, CDH1 and MGMT. We analyzed 129 records and samples of paraffin embedded biopsies of patients with cervical cancer in stages I and II. Detection of HPV - DNA was performed by PCR for HPV DNA of low and high oncogenic risk and MSP-PCR to detect the genes methylated or not, RARβ, TIMP3, CDH1 and MGMT. The calculation of survival used the Kaplan-Meier method and the log-hank test to compare means of survival between the prognostic factors for cervical cancer. The overall survival at 60 months of patients with the presence of RARβ...