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Parâmetros bioquímicos de alterações do citoesqueleto no modelo experimental da doença do Xarope do Bordo

Funchal, Cláudia da Silva
Fonte: Universidade Federal do Rio Grande do Sul Publicador: Universidade Federal do Rio Grande do Sul
Tipo: Tese de Doutorado Formato: application/pdf
POR
Relevância na Pesquisa
18.58%
A Doença do Xarope do Bordo (DXB) é um erro inato do metabolismo causado pela deficiência na atividade do complexo desidrogenase dos cetoácidos de cadeia ramificada, levando ao acúmulo de concentrações milimolares dos seguintes α-cetoácidos de cadeia ramificada (CACR): ácidos α-cetoisocapróico (CIC), α-ceto-β-metilvalérico (CMV), α-cetoisovalérico (CIV) e dos seus aminoácidos precursores, leucina, isoleucina e valina em tecidos de pacientes afetados. Essa doença é caracterizada por severos sintomas neurológicos que incluem edema e atrofia cerebral, entretanto, os mecanismos envolvidos na neuropatologia da DXB ainda não são bem estabelecidos. Neste trabalho utilizamos um modelo experimental de DXB com o objetivo de verificar os efeitos dos CACR que se acumulam nessa desordem neurodegenerativa sobre o citoesqueleto de células neurais de ratos. Nesse modelo fatias de córtex cerebral de ratos de diferentes idades, ou culturas de células neurais foram incubados com concentrações variando de 0,1 a 10 mM de cada metabólito. Inicialmente demonstramos que o CIC, CMV e CIV inibiram a captação de glutamato em fatias de córtex cerebral de ratos durante o desenvolvimento. O CIC inibiu a captação de glutamato em ratos de 9...

Doença da urina do xarope do bordo no Brasil : um panorama das duas últimas décadas

Herber, Silvani
Fonte: Universidade Federal do Rio Grande do Sul Publicador: Universidade Federal do Rio Grande do Sul
Tipo: Dissertação Formato: application/pdf
POR
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Introdução: A Doença da Urina do Xarope do Bordo (DXB) é um Erro Inato do Metabolsimo (EIM), causada pela deficiência da atividade do complexo enzimático desidrogenase dos L-cetoácidos de cadeia ramificada (CACR). O programa público brasileiro de triagem neonatal não inclui o diagnóstico e o tratamento da DXB. Objetivo: Caracterizar aspectos relacionados ao diagnóstico e ao tratamento de pacientes brasileiros com DXB. Metodologia: Estudo retrospectivo. Os pacientes foram identificados a partir dos registros de laboratório considerado referência nacional para o diagnóstico de DXB, e de contato com demais serviços nacionais de referência em genética médica. O diagnóstico foi realizado entre 1992-2011. Os dados analisados foram obtidos a partir da revisão de prontuários. Resultados: Oitenta e três pacientes, oriundos de 75 famílias, foram incluídos no estudo (mediana de idade= 3 anos; IQ25- 75= 0,57-7). A mediana da idade de início dos sintomas foi de 10 dias (IQ= 5-30), enquanto que a mediana da idade ao diagnóstico foi de 60 dias (IQ= 29-240, p= 0,001). Apenas três (3,6%) pacientes foram diagnosticados antes de desenvolverem manifestações clínicas. A comparação entre os pacientes com (n=12) e sem (n=71) diagnóstico precoce mostrou que o mesmo associa-se com a presença de história familiar positiva e diminuição da prevalência de manifestações clínicas ao diagnóstico...

Estratigrafia, geoquímica e isótopos de C, o e Sr do Grupo Bambuí a leste da falha de São Domingos, NE Minas Gerais

Santana, Rafael Oliveira
Fonte: Universidade de Brasília Publicador: Universidade de Brasília
Tipo: Dissertação
POR
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Dissertação (mestrado)—Universidade de Brasília, Instituto de Geociências, Programa de Pós-Graduação em Geologia, 2012.; A sedimentação pelito-carbonática do grupo Bambuí a leste da falha de São Domingos (Seção Ribeirão Caldeira - SRC), NE de Minas Gerais é marcada por episódios de inundações, exposições, retrabalhamentos, passíveis de serem correlacionados em escala bacinal. Os estudos realizados nessa dissertação permitiram definir nove fácies nessa porção da bacia, que são: Dolomito Estromatolítico Doe; Calcarenito Laminado Clm; Calcarenito/Dolarenito Oolítico Cao; Dolomito Laminado Dlm; Dic; Pelito Laminado Plm; Pelito com lentes de Arenito Pla; Pelito com lentes de Carbonato Plc e Calcarenito com níveis de Calcirudito Cacr esete associações de fácies - Recife estromatolítico - Laguna Restrita e Aberta - Bancos Oolíticos - Canais de Maré Dominado por Onda - Bancos Carbonáticos - Pelitos de Borda de Plataforma - Pelitos Marinhos, que perfazem a plataforma carbonática em rampa do grupo Bambuí na região. Os dados isotópicos de carbono levantados ao longo da estratigrafia do grupo Bambuí na SRC, apresentam valores 13C(PDB) (ex. - ) na sua base. À medida que o empilhamento estratigráfico vai adentrando o grupo Bambuí...

Tratamento do câncer colorretal em idosos extremos: relato de caso e revisão da literatura

Fonseca,Leonardo Maciel da; Hanan,Bernardo; Neiva,Augusto Motta; Silva,Rodrigo Gomes da
Fonte: Cidade Editora Científica Ltda Publicador: Cidade Editora Científica Ltda
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2010 PT
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Com o envelhecimento da população brasileira, cada vez mais o cirurgião colorretal se defrontará com pacientes chamados de idosos extremos, com idade superior a 75 ou 85 anos e apresentando diagnóstico de câncer colorretal (CaCR). A conduta é controversa diante desses casos. Este trabalho relata a abordagem de uma paciente de 97 anos com diagnóstico de adenocarcinoma de reto alto e faz uma revisão da literatura sobre o assunto. Esta paciente foi submetida à retossigmoidectomia paliativa vídeo-assistida, com incisão suprapúbica transversa para confecção da anastomose colorretal primária e retirada do espécime cirúrgico. Foi incluída no programa de reabilitação multimodal pós-operatória (fast-trac) para cirurgia colorretal, apresentou boa evolução e recebeu alta hospitalar no terceiro dia de pós-operatório. O estudo anatomopatológico da peça mostrou tratar-se de adenocarcinoma moderadamente diferenciado, invasor até a muscular própria e metastático em 2 de 12 linfonodos dissecados. De acordo com a literatura, em pacientes selecionados com mais de 75 anos, a cirurgia colorretal eletiva para CaCR pode ser realizada com taxa de morbimortalidade semelhante àquela de pacientes jovens, obtendo-se sobrevidas geral e livre de doença favoráveis. Comorbidades não definem isoladamente o prognóstico e nem contraindicam o procedimento.

The effect of computer-assisted cognitive rehabilitation and repetitive transcranial magnetic stimulation on cognitive function for stroke patients

Park, In-Seok; Yoon, Jung-Gyu
Fonte: The Society of Physical Therapy Science Publicador: The Society of Physical Therapy Science
Tipo: Artigo de Revista Científica
EN
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[Purpose] This study investigated the effects of computer-assisted cognitive rehabilitation (CACR) and repetitive transcranial magnetic stimulation (rTMS) on cognitive function in patients with stroke. [Subjects and Methods] We enrolled 20 patients and divided them into CACR and rTMS groups. CACR and rTMS were performed thrice a week for 4 weeks. Cognitive function was measured with the Korean Mini-Mental State Examination (K-MMSE) and Lowenstein Occupational Therapy Cognitive Assessment-Geriatric (LOTCA-G) before and after treatment. The independent samples t-test was performed to test the homogeneity of K-MMSE and LOTCA-G before treatment and compare the differences in cognitive improvement between the CACR and rTMS groups. A paired samples t-test was used to compare cognitive function before and after treatment. [Results] Cognitive function of both the groups significantly improved after the intervention based on the K-MMSE and LOTCA-G scores. While the LOTCA-G score improved significantly more in the CACR group than in the rTMS group, no significant difference was seen in the K-MMSE scores. [Conclusion] We showed that CACR is more effective than rTMS in improving cognitive function after stroke.

Effects of computer assisted cognitive rehabilitation on brain wave, memory and attention of stroke patients: a randomized control trial

Cho, Hwi-Young; Kim, Ki-Tae; Jung, Jin-Hwa
Fonte: The Society of Physical Therapy Science Publicador: The Society of Physical Therapy Science
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
18.52%
[Purpose] This study investigated brain wave, memory and attention changes in adult stroke patients using computer assisted cognitive rehabilitation (CACR). [Subjects] Twenty-five stroke patients were randomly allocated to either the CACR group (n=12) or the control group (n=13). [Methods] Two expert therapists provided the CACR group and the control group with traditional rehabilitation therapy in 30-minute sessions, semi-weekly, for 6 weeks. CACR was provided only to the CACR group. The control group received traditional rehabilitation therapy only. Before and after the 6 weeks of intervention, electroencephalography (EEG) and a computerized neurocognitive function test (CNT) were performed, and the results were analyzed. [Results] After the intervention, the CACR group showed significant differences in the frontal lobe (Fp1, Fp2, and F4) and in the parietal lobe (P3 and P4), and also showed significant differences in CNT memory (DST and VST forward/backward test) and attention (VCPT correct responses), but no notable changes were observed in the control group. [Conclusion] These results suggest that CACR is feasible and suitable for individuals with stroke. Detailed and diverse investigations should be performed considering the numbers and characteristics of subjects...

Kinetic Assessment of Breast Tumors Using High Spatial Resolution Signal Enhancement Ratio (SER) Imaging

Li, Ka-Loh; Henry, Roland G.; Wilmes, Lisa J.; Gibbs, Jessica; Zhu, Xiaoping; Lu, Ying; Hylton, Nola M.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /09/2007 EN
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The goal of this study was to investigate the relationship between an empirical contrast kinetic parameter, the signal enhancement ratio (SER), for three-timepoint, high spatial resolution contrast-enhanced (CE) MRI, and a commonly analyzed pharmacokinetic parameter, kep, using dynamic high temporal resolution CE-MRI. Computer simulation was performed to investigate: 1) the relationship between the SER and the contrast agent concentration ratio (CACR) of two postcontrast time-points (tp1 and tp2); 2) the relationship between the CACR and the redistribution rate constant (kep) based on a two-compartment pharmacokinetic model; and 3) the sensitivity of the relationship between the SER and kep to native tissue T1 relaxation time, T10, and to errors in an assumed vascular input function. The relationship between SER and kep was verified experimentally using a mouse model of breast cancer. The results showed that a monotonic mathematical relationship between SER and kep could be established if the acquisition parameters and the two postinjection timepoints of SER, tp1, tp2, were appropriately chosen. The in vivo study demonstrated a close correlation between SER and kep on a pixel-by-pixel basis (Spearman rank correlation coefficient = 0.87 ± 0.03). The SER is easy to calculate and may have a unique role in breast tissue characterization.

Center for Applied Cybersecurity Research: 2015 Annual Report and Strategic Plan (2015-2020); CACR Annual Report and Strategic Plan 2015

Delaney, David G.; Welch, Von; Starzynski Coddens, Amy
Fonte: Universidade de Indiana Publicador: Universidade de Indiana
Tipo: Relatório
EN_US
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Czech Republic : Accounting and Auditing

World Bank
Fonte: Washington, DC Publicador: Washington, DC
Tipo: Economic & Sector Work :: Accounting and Auditing Assessment (ROSC); Economic & Sector Work
ENGLISH; EN_US
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Financial reporting and auditing requirements in the Czech Republic are currently in transition from complying with national standards to complying with International Accounting Standards (IAS), International Standards on Auditing (ISA), and the European Union (EU) Directives. By law, the Czech Republic seeks to attain maximum compliance with the EU Fourth and Seventh Directives and the EU Regulation on the use of IAS, and to create an environment for implementing IAS for the financial statements of public interest entities by 2005. Small- and medium-size enterprises prepare their financial statements in accord with Czech Accounting Standards, which are largely based on the EU Directives and IAS. In practice, compliance with certain complex EU Directives and IAS requirements, including those dealing with consolidation and deferred tax, has been delayed. Presently, compliance with IAS is not effectively enforced. The transition to full IAS compliance for public interest entities will require extensive education in a different style and philosophy of accounting requirements. The transition to full IAS will require a culture shift to reduce the influence of tax accounting on general-purpose financial statements. By law...

Biochemical evaluation of bone turnover in cancer patients with bone metastases: relationship with radiograph appearances and disease extension.

Berruti, A.; Piovesan, A.; Torta, M.; Raucci, C. A.; Gorzegno, G.; Paccotti, P.; Dogliotti, L.; Angeli, A.
Fonte: Nature Publishing Group Publicador: Nature Publishing Group
Tipo: Artigo de Revista Científica
Publicado em /06/1996 EN
Relevância na Pesquisa
17.89%
Serum bone alkaline phosphatase (BALP), serum carboxy-terminal propeptide of type I procollagen (PICP) and serum bone gla protein (BGP) as markers of bone formation, serum carboxy-terminal telopeptide of type I collagen (ICTP) as a marker of collagen resorption and fasting molar ratio of urinary calcium to creatinine (CaCr) and serum parathyroid hormone (PTH) were determined in two groups of cancer patients: 48 with advanced or metastatic disease with negative bone scan and 174 with bone metastases categorised as having lytic, mixed or blastic lesions and with more or fewer than or equal to three sites involved. In patients without apparent bone involvement, bone formation markers were rarely elevated. Conversely, serum ICTP was frequently found to be supranormal, showing it to be a non-specific marker for early detection of bone metastases. As expected, values of bone formation markers progressively increased in patients with lytic, mixed and blastic lesions, but ICTP levels did not show any differences according to the types of bone appearances, confirming previous reports of elevated osteoclast activity also in patients with apparent blastic lesions. Serum PTH increased significantly in patients with lytic compared with patients with mixed and blastic appearances...

Electronic structure and magnetic properties of $\mathrm{CaCr}\mathrm{O}_3$: The interplay between spin- and orbital-orderings

Wu, Wei
Fonte: Universidade Cornell Publicador: Universidade Cornell
Tipo: Artigo de Revista Científica
Relevância na Pesquisa
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The electronic structure and magnetic properties of CaCr$\mathrm{O}_3$ have been calculated by two methods, including hybrid-exchange density-function theory and density-functional theory + $U$. The computed densities of states from both of these methods are in a qualitative agreement with the previous x-ray spectroscopy. On the other hand, the opening of the band gap separates them apart. hybrid-exchange density-functional theory always gives a finite band gap, down to $\sim 1.2$ eV from HSE06 functional, whereas by tuning the Hubbard-$U$ parameter down to $0.5$ eV, a conducting state with AFM-C (defined in the text) spin configuration can be achieved. From hybrid density-functional theory, the computed nearest-neighbouring exchange interaction along the $c$-axis and in the $ab$-plane are $\sim 4$ meV and $\sim 6$ meV (anti-ferromagnetic), respectively, which are qualitatively in agreement with the previous magnetic measurements. These anti-ferromagnetic exchange interaction, together with the in-plane anti-ferro-orbital ordering will induce a spin-orbital frustration, which could play a role for the abnormal electronic properties in CaCrO$_3$. In hybrid-exchange density-functional theory, an abrupt reduction ($\sim 0.2$ eV) of the majority-spin band gap of the ferromagnetic state between 60 K and 100 K has been found as lowering temperature...

Ultracold magnetically tunable interactions without radiative charge transfer losses between Ca$^+$, Sr$^+$, Ba$^+$, and Yb$^+$ ions and Cr atoms

Tomza, Michał
Fonte: Universidade Cornell Publicador: Universidade Cornell
Tipo: Artigo de Revista Científica
Relevância na Pesquisa
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The Ca$^+$, Sr$^+$, Ba$^+$, and Yb$^+$ ions immersed in an ultracold gas of the Cr atoms are proposed as experimentally feasible heteronuclear systems in which ion-atom interactions at ultralow temperatures can be controlled with magnetically tunable Feshbach resonances without charge transfer and radiative losses. \textit{Ab initio} techniques are applied to investigate electronic-ground-state properties of the (CaCr)$^+$, (SrCr)$^+$, (BaCr)$^+$, and (YbCr)$^+$ molecular ions. The potential energy curves, permanent electric dipole moments, and static electric dipole polarizabilities are computed. The spin restricted open-shell coupled cluster method restricted to single, double, and noniterative triple excitations, RCCSD(T), and the multireference configuration interaction method restricted to single and double excitations, MRCISD, are employed. The scalar relativistic effects are included within the small-core energy-consistent pseudopotentials. The leading long-range induction and dispersion interaction coefficients are also reported. Finally, magnetic Feshbach resonances between the Ca$^+$, Sr$^+$, Ba$^+$, and Yb$^+$ ions interacting with the Cr atoms are analyzed. The present proposal opens the way towards robust quantum simulations and computations with ultracold ion-atom systems free of radiative charge transfer losses.; Comment: 10 pages...

The GIOD Project: Globally Interconnected Object Databases

Bunn, Julian J; Holtman, Koen; Newman, Harvey B.; Wilkinson, Richard P.
Fonte: California Institute of Technology Publicador: California Institute of Technology
Tipo: Report or Paper; PeerReviewed Formato: application/pdf
Publicado em 01/01/2000
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The GIOD (Globally Interconnected Object Databases) Project, a joint effort between Caltech and CERN, funded by Hewlett Packard Corporation, has investigated the use of WAN-distributed Object Databases and Mass Storage systems for LHC data. A prototype small-scale LHC data analysis center has been constructed using computing resources at Caltech's Centre for Advanced Computing Research (CACR). These resources include a 256 CPU HP Exemplar of ~4600 SPECfp95, a 600 TByte High Performance Storage System (HPSS), and local/wide area links based on OC3 ATM. Using the Exemplar, a large number of fully simulated CMS events were produced, and used to populate an object database with a complete schema for raw, reconstructed and analysis objects. The reconstruction software used for this task was based on early codes developed in preparation for the current CMS reconstruction program, ORCA. Simple analysis software was then developed in Java, and integrated with SLACs Java Analysis Studio tool. An event viewer was constructed with the Java 3D API. Using this suite of software, tests were made in collaboration with researchers at FNAL and SDSC, that focused on distributed access to the database by numerous clients, and measure-ments of peak bandwidths were made and interpreted. In this paper...

Report on the EU-US Workshop on Large Scientific Databases

Williams, R.; Messina, P.; Gagliardi, F.; Darlington, J.; Aloisio, G.
Fonte: California Institute of Technology Publicador: California Institute of Technology
Tipo: Report or Paper; PeerReviewed Formato: application/pdf
Publicado em 01/01/1999
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This joint workshop was set up under the auspices of the Joint European Commission/National Science Foundation Strategy Group that met in Budapest in September 1998. The meeting derived from a joint collaboration agreement between the EC and NSF, signed by Dr. George Metakides (Director of Information Technologies for the EC) and Prof. Juris Hartmanis (Director of Computer and Information Science and Engineering at the NSF). Some themes that were identified include: digital libraries human-centered computing and virtual environments large scientific databases, and intelligent implants This report expresses the conclusions and recommendations of the Workshop on Large Scientific Databases, held in Annapolis, Maryland, USA in September 1999. The purpose of the workshop was to develop a report to the funding agencies outlining a possible solicitation to the research community, with emphasis on joint European-US work on Large Scientific Databases. Before the workshop, each participant submitted a position paper (these are available at the web site http://www.cacr.caltech.edu/euus). The results of the position papers, presentations, and group discussion are summarized in this report. There were 12 participants from Europe and 12 from the United States...

Analysis, Tracing, Characterization and Performance Modeling of Select ASCI Applications for BlueGene/L Using Parallel Discrete Event Simulation

Upchurch, Ed; Springer, Paul L.; Brodowicz, Maciej; Brunett, Sharon; Gottschalk, T.D.
Fonte: California Institute of Technology Publicador: California Institute of Technology
Tipo: Report or Paper; PeerReviewed Formato: application/pdf
Publicado em 01/01/2003
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Caltech's Jet Propulsion Laboratory (JPL) and Center for Advanced Computer Architecture (CACR) are conducting application and simulation analyses of Blue Gene/L[1] in order to establish a range of effectiveness of the architecture in performing important classes of computations and to determine the design sensitivity of the global interconnect network in support of real world ASCI application execution.

The MeshRouter Architecture

Gottschalk, T.D.
Fonte: Caltech CACR Publicador: Caltech CACR
Tipo: Report or Paper; PeerReviewed Formato: application/pdf
Publicado em /04/2004
Relevância na Pesquisa
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The Joint Forces Command (JFCOM) Experimentation Directorate (J9)'s recent Joint Urban Operations (JUO) experiments have demonstrated the viability of Forces Modeling and Simulation in a distributed environment. The JSAF application suite, combined with the RTI-s communications system, provides the ability to run distributed simulations with sites located across the United States, from Norfolk, Virginia to Maui, Hawaii. Interest-aware routers are essential for communications in the large, distributed environments, and the current RTI-s framework provides such routers connected in a straightforward tree topology. This approach is successful for small to medium sized simulations, but faces a number of significant limitations for very large simulations over high-latency, wide area networks. In particular, traffic is forced through a single site, drastically increasing distances messages must travel to sites not near the top of the tree. Aggregate bandwidth is limited to the bandwidth of the site hosting the top router, and failures in the upper levels of the router tree can result in widespread communications losses throughout the system. To resolve these issues, this work extends the RTI-s software router infrastructure to accommodate more sophisticated...

Pipes and Connections

Gottschalk, Thomas D.; Barrett, Brian R.
Fonte: Caltech CACR Publicador: Caltech CACR
Tipo: Report or Paper; PeerReviewed Formato: application/pdf
Publicado em /08/2004
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This document describes the low-level Pipe and ConnectionManager objects of the Mesh- Router system. The overall MeshRouter framework provides a general scheme for interest- limited communications among a number of client processes. This generality is achieved by a carefully factorized, object-oriented software implementation. Within this framework, the Pipe and ConnectionManager (base) classes dened in this note specify the interfaces for i) ac- tual `bits on the wire' communications and ii) dynamic client insertions during overall system execution. Two specic implementations of the Pipe class are described in detail: a `Memo- ryPipe' linking objects instanced on a single processor and a more general 'rtisPipe' providing inter-processor communications built entirely from the standard RTI-s library used in current JSAF applications. Initialization procedures within the overall MeshRouter system are dis- cussed, with particular attention given to dynamic management of inter-processor connections. Prototype RTI-s router processes are discussed, and simple extensions of the standard system conguration data les are presented.

MeshRouter Primitives: Messages, Interest, and Interpreters

Gottschalk, T.D.
Fonte: Caltech CACR Publicador: Caltech CACR
Tipo: Report or Paper; PeerReviewed Formato: application/pdf
Publicado em /04/2004
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16.84%
The MeshRouter architecture provides a general framework for interest-limited message ex- changes among client processes. There are two general areas in which the MeshRouter im- plementation depends on specics of the associated clients: i) the lowest level inter-processor communications model and ii) the nature/content of exchanged messages and \interest". This note describes the hierarchical object design (C++ sense) used to implement the basic Message and Interest objects of the MeshRouter. Interfaces are dened in terms of abstract base classes, and specific inherited objects appropriate for the RTI-s/JSAF application are presented as concrete examples. The MeshRouter system includes a substantial memory management com- ponent for efficient use of the basic Message objects. This system is summarized and plausible near-term extensions are noted.

A Virtual Observatory Vision based on Publishing and Virtual Data

Williams, Roy; Moore, Reagan; Hanisch, Robert
Fonte: Caltech CACR Publicador: Caltech CACR
Tipo: Report or Paper; PeerReviewed Formato: application/pdf
Publicado em /10/2004
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We would like to propose a vision of the Virtual Observatory where the "killer-app" is seen to be generalizing and extending the idea of "publication" from the narrow meaning of peer-reviewed journals. Here, publication ranges from private temporary storage, to group access, to public access, through to data that supports peer-reviewed Journal papers in perpetuity. The publication model is further extended by the possibility of Virtual Data -- where only the method of computation is stored, not necessarily the data itself. Furthermore, virtual data products may depend on other virtual data products, creating an implicit network of on-demand computation. This computation may take huge resources, or it may be all within a laptop.

Indiana University’s advanced cyberinfrastructure in service of IU strategic goals: Activities of PTI during FY2015

Stewart, Craig A.; Plale, Beth; Welch, Von; Link, Matthew R.; Miller, Therese; Wernert, Eric A.; Boyles, Michael J.; Fulton, Ben; Hancock, David Y.; Henschel, Robert; Michael, Scott A.; Pierce, Marlon; Ping, Robert J.; Gniady, Tassie
Fonte: Universidade de Indiana Publicador: Universidade de Indiana
Tipo: Relatório
EN_US
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16.84%