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Alterações Genéticas e Epigenéticas dos Genes do Complexo de Destruição de β-Catenina e Perfil Transcricional dos Componentes da Via de Sinalização Wnt no Câncer de Mama; Genetics and Epigenetics Disturbances of β-Catenin Destruction Complex and Transcriptional Profile of Wnt Signaling Components in Breast Cancer

Aristizábal Pachón, Andrés Felipe
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 22/05/2015 PT
Relevância na Pesquisa
66.16%
O câncer de mama é a neoplasia responsável pelo maior número de mortes em mulheres no Brasil, portanto, é importante encontrar novos marcadores específicos e de diagnóstico precoce, utilizando procedimentos simples e rápidos. A via de sinalização Wnt regula importantes funções celulares como proliferação, sobrevida e adesão. Esta via está associada com os processos de iniciação e progressão em muitos tipos tumorais, como câncer de cólon familiar, melanoma e pulmão; sendo que mutações em β-Catenina (CTNNb1) explicam só 30% dos casos de sinalização aberrante encontrada no câncer de mama, indicando que existem outros componentes e/ou reguladores da via que possam estar envolvidos. O objetivo deste trabalho foi avaliar as variantes genéticas e epigenéticas nos genes do complexo de degradação de β-Catenina num grupo de pacientes com câncer de mama e num grupo controle; e determinar os perfis de transcrição dos componentes da via de sinalização Wnt e da molécula de expressão exclusiva do epitélio mamário, a Mamaglobina Humana (MGA), assim como associar estes resultados com as características clínicas, histológicas e patológicas do tumor. Para atingir este objetivo foram coletadas amostras de sangue periférico de 102 mulheres com câncer de mama e 102 mulheres sadias como grupo controle. A avaliação das variantes rs465899 do gene APC...

As praticas preventivas para o cancer de mama e do colo do utero pelas mulheres de 40 anos ou mais de idade no municipio de Campinas, SP; Preventive practices for cervical and breast cancer for women 40 years old and over in the city of Campinas, SP

Vivian Mae Schmidt Lima Amorim
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em //2005 PT
Relevância na Pesquisa
66.15%
Justificativa: O câncer de mama e do colo de útero são neoplasias com altas taxas de incidência e mortalidade no Brasil e que dispõem de métodos eficazes de rastreamento para detecção precoce, oferecidos pelo Sistema Único de Saúde. Existe a necessidade de se identificar os subgrupos de mulheres que não realizam as práticas preventivas para esses agravos, como forma de se desenvolver estratégias, nas três esferas de governo, que venham minimizar as desigualdades ainda existentes em relação ao acesso aos serviços de saúde, a oferta de cuidados básicos, ao diagnóstico, tratamento e reabilitação nas questões relativas à saúde da mulher. Objetivos: Analisar as práticas de detecção precoce para o câncer de mama e do colo uterino, segundo características sociodemográficas, morbidade e comportamentos relacionados à saúde. Material e Métodos: Estudo do tipo transversal, de base populacional, tendo como população de estudo todos os indivíduos do sexo feminino com idade igual ou superior a 40 anos, não institucionalizados, residentes na área urbana de Campinas. Para a obtenção da amostra, os setores censitários do município de Campinas, foram agrupados em três estratos, segundo o percentual de chefes de família com nível universitário. Foram sorteados 10 setores censitários de cada estrato...

Aspectos histológicos e imuno-histoquímicos de mamas radiologicamente densas em pacientes com câncer de mama; Histological and immunohistochemical features of mammographic dense tissue in breast cancer patients

Priscila Silva Marshall
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 10/02/2012 PT
Relevância na Pesquisa
66.15%
Introdução: A densidade mamográfica, uma medida da extensão do tecido fibroglandular radiodenso da mama, é um fator de risco independente para o câncer de mama. Fatores de risco já estabelecidos para o câncer de mama como idade ao primeiro parto, paridade e uso hormonal na pós-menopausa, também estão associados com a densidade mamária. Contudo, a base biológica da associação da densidade mamográfica ao risco de câncer de mama ainda não foi determinada. A literatura conhecida sugere que ela esteja associada à presença de proliferação epitelial ou estromal, com uma delas podendo ser a responsável pela associação da densidade com o risco de câncer de mama. Objetivos: Avaliar a composição histológica e imunohistoquímica de áreas densa e não densa de mamas de mulheres submetidas à mastectomia por câncer de mama. Sujeitos e métodos: Foi realizado estudo de corte transversal em 18 mulheres com mamas de padrão P1, P2 ou Dy (Wolfe) com carcinoma mamário estádio clínico I ou II ou carcinoma in situ com indicação de mastectomia. Suas mamografias foram digitalizadas, sendo localizadas as áreas mais densa, menos densa e tumoral. Cada sujeito também teve sua mama fotografada em 4 posições. Foi utilizada uma técnica de localização baseada em um método de aproximação linear com interpolação das imagens mamográficas e as fotos da mama. Durante a mastectomia...

The Basic Facts of Korean Breast Cancer in 2011: Results of a Nationwide Survey and Breast Cancer Registry Database

Kim, Zisun; Min, Sun Young; Yoon, Chan Seok; Lee, Hun Jae; Lee, Jung Sun; Youn, Hyun Jo; Park, Heung Kyu; Noh, Dong-Young; Hur, Min Hee;
Fonte: Korean Breast Cancer Society Publicador: Korean Breast Cancer Society
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
66.16%
Breast cancer is the second most frequent malignancy in Korean women, with a continuously increasing incidence. The Korean Breast Cancer Society has constructed a nationwide breast cancer database through an online registration program. The aim of the present study was to report the fundamental facts on Korean breast cancer in 2011, and to analyze the changing patterns in clinical characteristics and breast cancer management in Korea over the last 10 years. Data on newly diagnosed breast cancer patients, including the total number of cases, age, stage, and type of surgery, for the year 2011 were collected from 84 hospitals and clinics nationwide using a questionnaire survey. Additional data relating to the changing patterns of breast cancer in Korea were collected from the online breast cancer registry database and analyzed. According to nationwide survey data, a total of 16,967 patients were newly diagnosed with breast cancer in 2011. The crude incidence of female breast cancer, including invasive cancer and in situ cancer, was 67 cases per 100,000 women. Analysis of the survey and registry data gave equivalent results in terms of age distribution, stage, and type of surgery. The median age at diagnosis was 50 years, and the proportion of postmenopausal women (51.3%) was higher than that of premenopausal women (48.7%) with breast cancer. The incidence of stage 0 and stage I breast cancer increased continuously over the last 10 years (56.3% in 2011)...

The Basic Facts of Korean Breast Cancer in 2012: Results from a Nationwide Survey and Breast Cancer Registry Database

Kim, Zisun; Min, Sun Young; Yoon, Chan Seok; Jung, Kyu-Won; Ko, Beom Seok; Kang, Eunyoung; Nam, Seok Jin; Lee, Seokwon; Hur, Min Hee;
Fonte: Korean Breast Cancer Society Publicador: Korean Breast Cancer Society
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
66.15%
The Korean Breast Cancer Society has constructed a nationwide breast cancer database through utilization of an online registration program. We have reported the basic facts about breast cancer in Korea in 2012, and analyzed the changing patterns in the clinical characteristics and management of breast cancer in Korea over the last 10 years. Data on patients newly diagnosed with breast cancer were collected for the year 2012 from 97 hospitals and clinics nationwide using a questionnaire survey, and from the online registry database. A total of 17,792 patients were newly diagnosed with breast cancer in 2012. The crude incidence rate of female breast cancer, including invasive cancer and in situ cancer, was 70.7 cases per 100,000 women. The median age at diagnosis was 51 years, and the proportion of postmenopausal women was higher than that of premenopausal women among those diagnosed with breast cancer. The proportion of cases of early breast cancer increased continuously, and breast-conserving surgery was performed in more cases than total mastectomy in that same year. The total number of breast reconstruction surgeries increased approximately 3-fold over last 10 years. The 5-year overall survival rate for all stages of breast cancer patients was extremely high. The clinical characteristics of breast cancer have changed in ways that resulted in high overall survival over the past 10 years in Korea...

Fatores de risco e de proteção para câncer de mama: revisão sistemática e estudo caso-controle; Risk and protective factors for breast cancer:systematic review and case-control study

INUMARU, Lívia Emi
Fonte: Universidade Federal de Goiás; BR; UFG; Mestrado em Nutricao e Saude; Ciencias da Saude Publicador: Universidade Federal de Goiás; BR; UFG; Mestrado em Nutricao e Saude; Ciencias da Saude
Tipo: Dissertação Formato: application/pdf
POR
Relevância na Pesquisa
66.16%
Breast cancer is an important health concern, being the neoplasm that most affects women. The aims of this study were to elaborate a systematic review on risk and protective factors for breast cancer, and to investigate these factors in women who received health care in two public hospitals of Goiânia, Goiás. In the systematic review, we surveyed the following variables: breastfeeding, physical activity, body composition and alcoholic drink consumption. In the first half of 2010, we performed a review on cohort and case-control studies corresponding to the years 2007 to 2010, through PubMed, Lilacs and Scielo databases. The analytical study was a case-control of outpatient basis. Cases were interviewed at Araújo Jorge Hospital (public hospital of Goiânia specialized in cancer) and at the breast service of Clinical Hospital from Federal University of Goiás (HC/UFG), and controls were selected among users of the Gynecology and Obstetrics Clinic at the HC/UFG. Investigated variables included: socioeconomic data, family history of cancer, hormonal variables, breastfeeding, anthropometric measures, alcoholic drink consumption, physical activity and smoking habit. Data were analyzed through Statistical Software for Professional, version 8.0. According to the systematic review...

Bilateral breast cancer incidence and survival

McCaul, Kieran Anthony
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado Formato: 2208415 bytes; 37168 bytes; application/pdf; application/pdf
Publicado em //2006 EN
Relevância na Pesquisa
66.19%
Introduction - This study re - examined the epidemiology of bilateral breast cancer with regard to the age at diagnosis and histology of the first breast cancer, and examined the effect of bilateral breast cancer on breast cancer survival. Methods - A cohort of US women with breast cancer was identified using cancer registry data for the period 1973 to 2000 obtained from the Surveillance, Epidemiology, and End Results ( SEER ) Program. In this cohort, incidence cases of bilateral breast cancer were identified and rates calculated per 1,000 person - years and the effect on survival of a diagnosis of a bilateral breast cancer was determined using time - dependent proportional hazard regression. Results - The overall incidence of bilateral breast cancer was 5.5 per 1,000 person - years and, apart from an elevation in incidence in the first year, was constant over time. In age - cohorts of young women, age - specific rates of bilateral breast cancer were found to decline as these women aged, approaching the incidence observed in older age cohorts. In older age - cohorts, age - specific rates were comparatively constant until age 75 - 79 years, after which age - specific rates began to decline regardless of age at first diagnosis.Differences in the crude incidence of bilateral breast cancer in sub - cohorts of women with lobular carcinoma ( 6.56 per 1...

A polymorphism in the TC21 promoter associates with an unfavorable tamoxifen treatment outcome in breast cancer

Rokavec, M.; Schroth, W.; Amaral, S.; Fritz, P.; Antoniadou, L.; Glavac, D.; Simon, W.; Schwab, M.; Eichelbaum, M.; Brauch, H.
Fonte: American Association for Cancer Research Publicador: American Association for Cancer Research
Tipo: Artigo de Revista Científica
Publicado em //2008 EN
Relevância na Pesquisa
76.03%
Tamoxifen therapy is a standard in the treatment of estrogen receptor (ER)-positive breast cancer; however, its efficacy varies widely among patients. In addition to interpatient differences in the tamoxifen-metabolizing capacity, there is growing evidence that crosstalk between ER and growth factor signaling contributes to tamoxifen resistance. We focused on TC21, a member of the Ras superfamily, to investigate the influence of the TC21 –582C>T promoter polymorphism on TC21 expression and treatment outcome. Immunohistochemical analyses of breast tumors revealed a higher TC21 expression in ER-negative compared with ER-positive tumors. Expression in ER-positive tumors was higher in carriers of the T allele in an allele dose–dependent manner. Quantitative real-time PCR analyses showed that TC21 mRNA expression is decreased after transfection of ER in ER-negative breast cancer cells MDA-MB-231, UACC893, and BT-20. In MCF7 ER-positive cells, TC21 expression decreased with 17β-estradiol treatment and increased after treatment with tamoxifen metabolites, 4-OH-tamoxifen, or endoxifen. In patients treated with adjuvant mono tamoxifen, high cytoplasmic TC21 tumor expression or the carriership of the –582T allele conferred increased recurrence rates [n = 45: hazard ratio (HR)...

Circulating steroid hormone levels and risk of breast cancer for postmenopausal women

Baglietto, L.; Severi, G.; English, D.; Krishnan, K.; Hopper, J.; McLean, C.; Morris, H.; Tilley, W.; Giles, G.
Fonte: Amer Assoc Cancer Research Publicador: Amer Assoc Cancer Research
Tipo: Artigo de Revista Científica
Publicado em //2010 EN
Relevância na Pesquisa
76.05%
Epidemiologic studies have consistently reported that endogenous steroid hormone levels are associated with postmenopausal breast cancer risk, but little is known on the associations by tumor grade, hormone receptor status, or age at diagnosis. We performed a case-cohort study of naturally postmenopausal women within the Melbourne Collaborative Cohort Study that included a random sample of 857 women and 197 breast cancer cases diagnosed during a mean of 9.2 years of follow-up. Concentrations of total estradiol, estrone sulfate, testosterone, DHEA sulfate, androstenedione, and sex hormone binding globulin were measured in plasma collected at baseline before diagnosis; free estradiol plasma concentration was calculated. Cox regression was used to estimate associations adjusted for known and potential confounders. The HR for breast cancer comparing fourth and first quartiles was 1.44 [95% confidence interval (95% CI), 0.89-2.35] for total estradiol, 1.75 (95% CI, 1.06, 2.89) for free estradiol, 2.05 (95% CI, 1.24-3.37) for estrone sulfate, 1.25 (95% CI, 0.78-2.01) for testosterone, 1.41 (95% CI, 0.88-2.27) for DHEA sulfate, 1.49 (95% CI, 0.91-2.44) for androstenedione, and 0.33 (95% CI, 0.19-0.55) for sex hormone binding globulin. These associations did not differ by tumor grade and estrogen receptor/progesterone receptor status (all test for heterogeneity...

Breast screening and breast cancer survival in Aboriginal and Torres Strait Islander women of Australia

Roder, D.; Webster, F.; Zorbas, H.; Sinclair, S.; Aitken, J.; Culjak, G.; Elston, J.; Epping, Y.; Farrugia, H.; Grayson, N.; Guthridge, S.; Halliday, L.; Muller, J.; Pridmore, V.; Threlfall, T.; Tyzack, C.; Venn, A.; Ward, G.; Williamson, L.; Wylie, L.
Fonte: Asian Pacific Organization for Cancer Prevention Publicador: Asian Pacific Organization for Cancer Prevention
Tipo: Artigo de Revista Científica
Publicado em //2012 EN
Relevância na Pesquisa
76.13%
Aboriginal and Torres Strait Islander people comprise about 2.5% of the Australian population. Cancer registry data indicate that their breast cancer survivals are lower than for other women but the completeness and accuracy of Indigenous descriptors on registries are uncertain. We followed women receiving mammography screening in BreastScreen to determine differences in screening experiences and survivals from breast cancer by Aboriginal and Torres Strait Islander status, as recorded by BreastScreen. This status is self-reported and used in BreastScreen accreditation, and is considered to be more accurate. The study included breast cancers diagnosed during the period of screening and after leaving the screening program. Design: Least square regression models were used to compare screening experiences and outcomes adjusted for age, geographic remoteness, socio-economic disadvantage, screening period and round during 1996-2005. Survival of breast cancer patients from all causes and from breast cancer specifically was compared for the 1991-2006 diagnostic period using linked cancer-registry data. Cox proportional hazards regression was used to adjust for socio-demographic differences, screening period, and where available, tumour size...

Survival from synchronous bilateral breast cancer: The experience of surgeons participating in the breast audit of the Society of Breast Surgeons of Australia and New Zealand

Roder, D.; De Silva, P.; Zorbas, H.; Kollias, J.; Malycha, P.; Pyke, C.; Campbell, I.; Webster, F.
Fonte: Asian Pacific Organization for Cancer Prevention Publicador: Asian Pacific Organization for Cancer Prevention
Tipo: Artigo de Revista Científica
Publicado em //2012 EN
Relevância na Pesquisa
76.1%
Background: Previous studies generally indicate that synchronous bilateral breast cancers (SBBC) have an equivalent or moderately poorer survival compared with unilateral cases. The prognostic characteristics of SBBC would be relevant when planning adjuvant therapies and follow-up medical surveillance. The frequency of SBBC among early breast cancers in clinical settings in Australia and New Zealand was investigated, plus their prognostic significance, using the Breast Cancer Audit Database of the Society of Breast Surgeons of Australia and New Zealand, which covered an estimated 60% of early invasive lesions in those countries. Design: Rate ratios (95% confidence limits) of SBBC were investigated among 35,370 female breast cancer cases by age of woman, histology type, grade, tumour diameter, nodal status, lymphatic/vascular invasion and oestrogen receptor status. Univariate and multivariable disease-specific survival analyses were undertaken. Results: 2.3% of cases were found to be SBBC (i.e., diagnoses occurring within 3 months). The figure increased from 1.4% in women less than 40 years to 4.1% in those aged 80 years or more. Disease-specific survivals did not vary by SBBC status (p=0.206). After adjusting for age, histology type...

Risk factors for poorer breast cancer outcomes in residents of remote areas of Australia

Roder, D.; Zorbas, H.; Kollias, J.; Pyke, C.; Walters, D.; Campbell, I.; Taylor, C.; Webster, F.
Fonte: Asian Pacific Organization for Cancer Prevention Publicador: Asian Pacific Organization for Cancer Prevention
Tipo: Artigo de Revista Científica
Publicado em //2013 EN
Relevância na Pesquisa
76.07%
To investigate patient, cancer and treatment characteristics in females with breast cancer from more remote areas of Australia, to better understand reasons for their poorer outcomes, bi-variable and multivariable analyses were undertaken using the National Breast Cancer Audit database of the Society of Breast Surgeons of Australia and New Zealand. Results indicated that patients from more remote areas were more likely to be of lower socio-economic status and be treated in earlier diagnostic epochs and at inner regional and remote rather than major city centres. They were also more likely to be treated by low case load surgeons, although this finding was only of marginal statistical significance in multivariable analysis (p=0.074). Patients from more remote areas were less likely than those from major cities to be treated by breast conserving surgery, as opposed to mastectomy, and less likely to have adjuvant radiotherapy when having breast conserving surgery. They had a higher rate of adjuvant chemotherapy. Further monitoring will be important to determine whether breast conserving surgery and adjuvant radiotherapy utilization increase in rural patients following the introduction of regional cancer centres recently funded to improve service access in these areas.; David Roder...

Steroid receptor crosstalk in breast cancer cells.

Swinstead, Erin Elizabeth
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado
Publicado em //2014
Relevância na Pesquisa
66.19%
Breast cancer is the leading cause of cancer related death in women, and approximately 1 in 11 women will develop breast cancer before the age of 75. In 2003, breast cancer was responsible for 16% of cancer related deaths in Australian women. This demonstrates that throughout the life span of the female, this organ has a high risk of developing cancer. The growth and survival of normal breast epithelial cells and breast cancer cells is promoted by estrogens and progesterone and both estrogen receptor (ER) and progesterone receptor (PR) have been shown to play prominent roles in breast cancer progression. It has also been demonstrated that co-treatment of breast cancer cells with corticosteroids and 17β-estadiol (E2) can have opposing effects on the proliferation of breast cancer cells compared with the single treatment. In addition, glucocorticoid receptor (GR) levels have been shown to have clinical implications for breast cancer cell survival. This suggests a possible role for activated GR in breast cancer development. Forkhead box protein 1 (FoxA1), a member of the forkhead class of DNA-binding proteins, has also been shown to be an important factor in breast cancer development. FoxA1 has been shown to dictate ER binding in breast cancer cells and has been deemed responsible for the rapid reprogramming of ER signalling seen in breast cancers with poor outcomes and treatment resistance. However...

What sort of follow-up services would Australian breast cancer survivors prefer if we could no longer offer long-term specialist-based care? A discrete choice experiment

Bessen, T.; Chen, G.; Street, J.; Eliott, J.; Karnon, J.; Keefe, D.; Ratcliffe, J.
Fonte: Cancer Research UK Publicador: Cancer Research UK
Tipo: Artigo de Revista Científica
Publicado em //2014 EN
Relevância na Pesquisa
76.12%
Background: Early diagnosis and improved treatment outcomes have increased breast cancer survival rates that, in turn, have led to increased numbers of women undergoing follow-up after completion of primary treatment. The current workload growth is unsustainable for breast cancer specialists who also provide care for women newly diagnosed or with a recurrence. Appropriate and acceptable follow-up care is important; yet, currently we know little about patient preferences. The aim of this study was to explore the preferences of Australian breast cancer survivors for alternative modes of delivery of follow-up services. Methods: A self-administered questionnaire (online or paper) was developed. The questionnaire contained a discrete choice experiment (DCE) designed to explore patient preferences with respect to provider, location, frequency and method of delivery of routine follow-up care in years 3, 4 and 5 after diagnosis, as well as the perceived value of ‘drop-in’ clinics providing additional support. Participants were recruited throughout Australia over a 6-month period from May to October 2012. Preference scores and choice probabilities were used to rank the top 10 most preferred follow-up scenarios for respondents. Results: A total of 836 women participated in the study...

Influence of mammographic screening on breast cancer incidence trends in South Australia

Beckmann, K.R.; Roder, D.M.; Hiller, J.E.; Farshid, G.; Lynch, J.W.
Fonte: National Cancer Center, Korea Publicador: National Cancer Center, Korea
Tipo: Artigo de Revista Científica
Publicado em //2014 EN
Relevância na Pesquisa
75.91%
PURPOSE: To examine breast cancer (BC) incidence trends in relation to mammographic screening and risk factor prevalence in South Australia (SA). MATERIALS AND METHODS: Trends in annual BC incidence rates were calculated using direct standardisation and compared with projected incidence derived from Poisson regression analysis of pre-screening rates. Annual percentage change and change time points were estimated using Joinpoint software. Biennial mammography screening participation rates were calculated using data from BreastScreen SA. Trends in overweight/obesity, alcohol use and hormone replacement therapy (HRT) use were examined using 1991-2009 Health Omnibus Survey data. Trends in total fertility were examined using data from the Australian Bureau of Statistics. RESULTS: BC incidence increased around the time BreastScreen commenced and then stabilised in the mid-1990s. However rates have remained higher than projected, even though the proportion and age distribution of first time screening attendees stabilised around 1998. A decrease in BC incidence was observed among women aged 50-59yrs from the late-1990's but not among older women. Obesity and alcohol use have increased steadily in all age groups, while HRT use declined sharply from the late-1990s. CONCLUSIONS: BC incidence has remained higher than projected since mammography screening began. The sustained elevation is likely to be due to lead time effects...

Adherence to recommended treatments for early invasive breast cancer: decisions of women attending surgeons in the Breast Cancer Audit of Australia and New Zealand

Roder, D.; De Silva, P.; Zorbas, H.; Webster, F.; Kollias, J.; Pyke, C.; Campbell, I.
Fonte: Asian Pacific Organization for Cancer Prevention Publicador: Asian Pacific Organization for Cancer Prevention
Tipo: Artigo de Revista Científica
Publicado em //2012 EN
Relevância na Pesquisa
76.07%
AIM: The study aim was to determine the frequency with which women decline clinicians' treatment recommendations and variations in this frequency by age, cancer and service descriptors. DESIGN: The study included 36,775 women diagnosed with early invasive breast cancer in 1998-2005 and attending Australian and New Zealand breast surgeons. Rate ratios for declining treatment were examined by descriptor, using bilateral and multiple logistic regression analyses. Proportional hazards regression was used in exploratory analyses of associations with breast cancer death. RESULTS: 3.4% of women declined a recommended treatment of some type, ranging from 2.6% for women under 40 years to 5.8% for those aged 80 years or more, and with parallel increases by age presenting for declining radiotherapy (p<0.001) and axillary surgery (p=0.006). Multiple regression confirmed that common predictors of declining various treatments included low surgeon case load, treatment outside major city centres, and older age. Histological features suggesing a favourable prognosis were often predictive of declining various treatments, although reverse findings also applied with women with positive nodal status being more likely to decline a mastectomy and those with larger tumours more likely to decline chemotherapy. While survival anlsysi lacked statistical power due to small numbers...

Recent developments in the ability to predict and modify breast cancer risk

Andrades Cvitanic, Patricio Ricardo; Parada, Francisco; Prado, Arturo
Fonte: ELSEVIER Publicador: ELSEVIER
Tipo: Artículo de revista
EN
Relevância na Pesquisa
66.18%
The identification of women at higher risk for breast cancer is a matter of public health and anyone who participates in any treatment modality of this condition (this includes the plastic surgeon) should be aware of the tools and predictive models of breast cancer. Screening for breast cancer in the community, and probably during the daily plastic surgery consultation, until recently, was limited to decisions about when to initiate a mammography study. New developments that predict and modify breast cancer risk must be clearly understood by our specialty through identification of women at higher risk for breast cancer and be familiar with the current issues related to screening and risk-reduction measures. In this review, we discuss current knowledge regarding the recent data of breast cancer risk, screening strategies for high-risk women and medical and surgical approaches to reduce breast cancer risk. Patients with breast cancer belong to one of three groups: a. Sporadic breast cancer (75%)-patients without family history or those who have a breast biopsy with proliferative changes. b. Genetic mutation breast cancer (5%)-women who have a genetic predisposition, and most of these are attributable to mutations in the breast cancer susceptibility gene 1 (BRCA1) and breast cancer susceptibility gene 2 (BRCA2). c. Cluster family breast cancer (20%)-seen in women with a relevant history of breast cancer in the family and breast biopsy with proliferative breast changes with no association with mutations. Those at high risk for breast cancer should investigate the family history with genetic testing consideration...

Annexin A1 expression in breast cancer: tumor subtypes and prognosis

Sobral-Leite, Marcelo; Wesseling, Jelle; Smit, Vincent T. H. B. M.; Nevanlinna, Heli; van Miltenburg, Martine H.; Sanders, Joyce; Hofland, Ingrid; Blows, Fiona M.; Coulson, Penny; Patrycja, Gazinska; Schellens, Jan H. M.; Fagerholm, Rainer; Heikkil?, P?iv
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Article; published version
EN
Relevância na Pesquisa
66.16%
This is the final published version. It first appeared at http://www.biomedcentral.com/1741-7015/13/156.; Background Annexin A1 (ANXA1) is a protein related with the carcinogenesis process and metastasis formation in many tumors. However, little is known about the prognostic value of ANXA1 in breast cancer. The purpose of this study is to evaluate the association between ANXA1 expression, BRCA1/2 germline carriership, specific tumor subtypes, and survival in breast cancer patients. Methods Clinical-pathological information and follow-up data were collected from nine breast cancer studies from the Breast Cancer Association Consortium (BCAC) (n = 5,752) and from one study of familial breast cancer patients with BRCA1/2 mutations (n = 107). ANXA1 expression was scored based on the percentage of immunohistochemical staining in tumor cells. Survival analyses were performed using a Cox-multivariable model. Results The frequency of ANXA1 positive tumors was higher in familial breast cancer patients with BRCA1/2 mutations than in the BCAC patients, 48.6% versus 12.4% respectively; p < 0.0001. ANXA1 was also highly expressed in BCAC tumors that were poorly differentiated, triple negative, EGFR-CK5/6 positive, or had developed in patients at young age. In the first 5 years of follow-up...

Role of the released forms of L1-CAM in breast cancer cell motility

Chilukuri, Kalyani
Fonte: University of Delaware Publicador: University of Delaware
Tipo: Tese de Doutorado
Relevância na Pesquisa
66.16%
Deni S. Galileo; L1-CAM (L1) is a neural cell adhesion protein which plays a major role in neural development. Recently, L1 is found to be abnormally expressed in several cancers and has been shown to be a biomarker indicating poor outcome and bad prognosis of the cancer. L1 is a transmembrane protein which is abnormally shed in cancer cells to release the cleaved ectodomain. The L1 ectodomain stimulates cell motility and migratory ability of ovarian, colon and other cancerous cells. L1 is also released by the cancer cells in the form of exosomes. Expression of L1 was found in few breast cancer cell lines and was also associated with aggressive nature of the breast cancer disease. However, the molecular mechanisms of L1 in breast cancer are not known. Breast cancer metastasis to the brain leads to very quick death. The extracellular environment in the brain contains L1 protein and the dissemination and metastasis of breast cancer cells in the brain could depend on the L1 expressed by the breast cancer cells. In order to understand the role of L1, I have characterized the presence of L1 in three breast cancer cell lines MDA-MB-231, MDA-MB-435 and MDA-MB- 468. The amount of L1 expressed by the cell lines was correlated with their known metastatic potential. Having found L1 in breast cancer cells...

Breast cancer metastasis to bone: a study of the effect of bone cell conditioned media on triple negative breast cancer cells in bone microenvironment

Adeleye, Regina
Fonte: University of Delaware Publicador: University of Delaware
Tipo: Tese de Doutorado
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Higginson, Jill S.; Nohe, Anja; Breast cancer is the second leading cause of death in women- behind lung cancer. Statistics have shown that 1 in 36 women in the United States die from the pandemic. Triple negative breast cancer, TNBC, which accounts for 10-20% of all breast cancer subtypes, is classified as aggressive in growth and invasiveness and is associated with poorer short-term prognosis. Due to their independence from hormone receptors, these cancer cells lack effective therapeutics and treatment of patients is limited to chemotherapy. Death occurrence from breast cancer is prevalent in patients with metastatic breast cancer. In the United States, approximately 200,000 cases of metastatic breast cancer and 50,000 cases of non-invasive breast cancer are estimated to be diagnosed annually. Breast cancer is frequently associated with skeletal metastases. Over 70% of breast cancer metastasis occurs in bone. Bone metastasis causes bone pain, fracture, hypercalcemia, and paralysis. This is because tumor-bone interaction in the bone microenvironment creates a vicious cycle that upsurges bone resorption. While the effect of triple negative breast cancer tumor cells on bone are widely known, the effect of bone cells on metastatic triple negative breast cancer cells is not fully understood. The present study was designed to investigate the effect of bone-conditioned medium on TNBC using conditioned medium from different lineages of cells within the bone marrow. Conditioned media harvested from new born mice Calvaria...