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Transplant-Associated and Blood Transfusion-Associated Tropical and Parasitic Infections

Machado, Clarisse Martins; Levi, José Eduardo
Fonte: W B SAUNDERS CO-ELSEVIER INC; PHILADELPHIA Publicador: W B SAUNDERS CO-ELSEVIER INC; PHILADELPHIA
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
66.31%
Blood transfusion and transplantation may represent efficient mechanisms of spreading infectious agents to naive populations. In the developed countries, as a consequence of globalization, several factors such as international commerce, tourism, and immigration have acted as important features for the emergence or reemergence of infectious diseases previously referred to as tropical. This article reviews the relevant bacterial, protozoan and viral infections that are more frequently associated with blood transfusion and/or solid organ or marrow transplantation and may affect susceptible populations worldwide.

Bioética e crença religiosa: estudo da relação médico-paciente Testemunha de Jeová com potencial risco de transfusão de sangue; Bioethics and religious belief: a study on the physician-Jehovah's Witness patient at potential risk of blood transfusion

Chehaibar, Graziela Zlotnik
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 13/07/2010 PT
Relevância na Pesquisa
66.46%
As Testemunhas de Jeová têm preceitos religiosos que sustentam a recusa da transfusão de sangue e, frequentemente, vivenciam situações nas quais essa recusa pode ser sustentada por aspectos científicos, legais e bioéticos. Este estudo teve como objetivo analisar a relação médico-paciente Testemunha de Jeová, sob a potencial recomendação de transfusão de sangue durante a internação hospitalar. Além disso, também buscou investigar o momento e a forma da identificação do paciente Testemunha de Jeová; analisar a conduta dos médicos frente a um eventual impasse na relação com os pacientes e analisar as escolhas dos pacientes na relação com os médicos; verificar as condutas realizadas após o processo de tomada de decisão entre médico e seu paciente; e verificar se os médicos conhecem o parecer n.º 007/2004 - "Orientação sobre Recusa de Transfusão de Sangue da Testemunha de Jeová", da Comissão de Bioética (CoBi) do Hospital das Clínicas da FMUSP. A pesquisa foi realizada no Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP) no período de fevereiro de 2007 a maio de 2009. Foram selecionados 46 pacientes e 48 médicos, buscando-se entrevistar o paciente e seu respectivo médico. Trata-se de um estudo de caso exploratório...

Responsabilidade civil e a transfusão de sangue; Civil responsibility and blood transfusion

Nunes, Helena Ferreira
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 04/08/2010 PT
Relevância na Pesquisa
66.52%
O legislador ao normatizar a hemoterapia provocou uma integração da Medicina e do Direito. Com a facilitação do acesso à justiça, inúmeras ações judiciais foram propostas em face das instituições hospitalares e dos profissionais envolvidos nas transfusões de sangue para reparação de prejuízos decorrentes da atividade. De um lado estão os profissionais da saúde, que em alguns casos desconhecem total ou parcialmente suas obrigações, e de outro está o Direito que deve buscar a reparação do dano causado à vitima. Portanto, para que haja o adequado desenvolvimento dos papéis das duas áreas faz-se necessário o apontamento de suas interconexões e conseqüências. Esse trabalho tem por objetivo a análise dos impactos e interfaces da atividade hemoterápica e de suas correspondentes implicações jurídicas ligadas ao instituto da responsabilidade civil previstos no ordenamento jurídico brasileiro vigente. Para realização desse trabalho foram analisadas: a legislação brasileira vigente aplicável ao procedimento de transfusão sangüínea; a literatura médica específica sobre hemoterapia; os estatutos e os códigos de ética dos profissionais da saúde que estão diretamente ligados ao processo da transfusão de sangue; anuários...

A transfusão sanguínea no perioperatório e a ocorrência da infecção de sítio cirúrgico; Perioperative blood transfusion and the occurrence of surgical site infection.

Mantoani, Camila Cristina
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 24/08/2012 PT
Relevância na Pesquisa
66.54%
Trata-se de uma revisão integrativa da literatura com objetivo de identificar e analisar as evidências oriundas de estudos primários que abordaram a relação entre a transfusão sanguínea e a ocorrência da infecção de sítio cirúrgico, em pacientes adultos submetidos à cirurgia eletiva. A busca foi realizada em abril de 2012 nas bases de dados PUBMED/ MEDLINE, CINAHL, LILACS e Biblioteca Cochrane e utilizou-se o limite dos estudos indexados nos últimos 10 anos. Para a busca nas bases de dados eletrônicas foram utilizadas combinações entre os descritores controlados transfusão sanguínea, transfusão de componentes sanguíneos, cirurgia eletiva e infecção de ferida cirúrgica e os não-controlados infusão sanguínea, procedimento cirúrgico eletivo, cirurgia de não urgência e infecção de sítio cirúrgico, as quais resultaram na identificação de 2195 referências, dentre essas, 2112 foram excluídas devido a ausência em relação ao tema a partir da leitura de título e resumo. Assim, 73 estudos mostraram-se elegíveis e foram lidos na íntegra, dentre os quais, 50 estudos não foram selecionados e cita-se como motivo de exclusão para cinco estudos, que não analisavam a relação da infecção de sítio cirúrgico e a transfusão sanguínea...

Validação de um modelo experimental de transfusão de glóbulos vermelhos estocados homólogos em suínos e avaliação de seus efeitos cardiorrespiratórios e inflamatórios na hemorragia aguda; Validation of homologous stored red blood cell transfusion in swine and evaluation of cardiorespiratory and inflammatory effects in acute hemorrhage

Biagini, Silvana
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 25/05/2015 PT
Relevância na Pesquisa
56.51%
Objetivos: Transfusão de sangue é fundamental para a sobrevida de pacientes selecionados, porém é associada a complicações. A literatura é controversa em relação aos efeitos pulmonares, hemodinâmicos e inflamatórios da transfusão de glóbulos vermelhos (GV). Este estudo teve dois objetivos principais: 1- validar um modelo de transfusão homologa de GV estocados em suínos com hipovolemia aguda por hemorragia controlada; 2- avaliar os efeitos agudos da transfusão de GV nas trocas gasosas, mecânica respiratória, hemodinâmica e na resposta inflamatória pulmonar e sistêmica. Métodos: Este estudo foi dividido em duas etapas: 1.Coleta, processamento e estocagem por 14 dias de GV provenientes de um suino Agroceres®, avaliado antes (in vitro) e após (in vivo - marcação com cromato de sódio radioativo) à sua transfusão em suínos sadios , um autólogo e quatro homologos (n=cinco); 2. Outro grupo de suínos foi submetido à hemorragia aguda controlada (25% de sua volemia) e então dividido em dois grupos: grupo transfusão (n= oito) recebeu duas unidades de GV e solução de ringer lactato (RL) para restabelecer a volemia; grupo controle (n=oito) que recebeu somente RL. Ambos os grupos foram seguidos até 6horas após o final da ressuscitação volêmica. Dados hemodinâmicos e respiratórios foram coletados a cada hora após o inicio do estudo. Mediadores inflamatórios e expressão de RNAmensageiro(RNAm) foram medidos no plasma e no tecido pulmonar. Resultados: Houve recuperação de 97...

Transfusion of RHD negative patients with RHD positive red cells concentrates: the HPFF, EPE Blood Department experience (2002-2010)

Barra, A; Barradas, A; Cardoso, E; Costa, C; Fontes, A; Gil, A; Oliveira, C; Pereira, F; Rebelo, S
Fonte: International Society for Blood Transfusion Publicador: International Society for Blood Transfusion
Tipo: Conferência ou Objeto de Conferência
Publicado em //2011 ENG
Relevância na Pesquisa
66.35%
Background: In transfusion practice we should respect the ABO group and the Rh phenotype. The lack of availability of red cells concentrates [RCC] RhD negative in the quantities desired, do nol always make it possible to satisfy that requirement, especially in urgency. In our practice we never transfuse RhD in some groups of patients RhD negative, like women of childbearing age, children, newborns, patients with disease likely to need multiple transfusions [eg oncologic patients]. Alms: The purpose of this study was to assess possible alloimmunization in RhD negative receivers who were transfused with RhD positive RCC and try to interpret some findings. Methods: We included in this study all patients RhD negatives who received RhD positive RCC in our department from 2002 to 2010, all of them have been made an antibody screening by IAT and Enzyme before transfusing. We used for antibody screening the Card-ID “LISS/Coombs”, with the test cell reagents ID-Diacell I-II-III and the Card-ID “NaCl, enzyme test and cold agglutinins” with the test cell reagents Diacell I-II-III P. In case of positive results in the tests we used for antibody identification the ID-Cards “LIDSS/Coombs” with the ID-Panel and/or the “NaCl, enzyme test and cold agglutinins” with the ID-Panel P. When we had doubts in antibody indentification with the ID-Panel we tried resolve Them using the ID-Dia-Panel plus 6 (All the reagents and cards are DiaMed). The results for negative antibody screening were considered only if this was confirmed 72 hours after the transfusion with RhD positive RCC. Results: From 2002 to 2010 in our department...

Transfusion therapy and sickle cell disease

Barra, A; Barradas, A; Cardoso, E; Costa, C; Ferreira, R; Fontes, A; Mota, M; Moura, H; Oliveira, C; Pereira, F; Rebelo, S; Rodrigues, T; Santos, L; Silva, A; Silva, I; Simões, A; Soares, F; Venâncio, B
Fonte: International Society for Blood Transfusion Publicador: International Society for Blood Transfusion
Tipo: Conferência ou Objeto de Conferência
Publicado em //2011 ENG
Relevância na Pesquisa
66.44%
Background: Sickle cell disease is a very common hemoglobinopathy. The main goal of transfusion therapy in sickle cell disease is to prevent thrombotic events, improve tissue oxygenation and treat anaemia complications. However the risk of all immunization is well known. Since 2001 our service has been doing a tight surveillance work in sickle cell patients, creating a database of about 15,000 studied blood donors. Aims: We want to share our experience in transfusion of sickle cell patients and highlight the importance to have a computer database with compatible donors in order to reduce all immunization in these patients. Methods: We have studied the above described donors for the following blood group systems ABO, Rh, Kell, Duffy, Kidd, MNSs, Lutheran, P (P1) and haemoglobin S. For each transfusion demand for these patients we research in our computer data base the more likely compatible donor. From January 2007 to January 2011 we studied 64 patients. To transfuse these patients we followed the protocol described above. We transfused these patients with red cells of compatible donors pre investigated. We perform pre transfusion tests in all patients. Results : Have been studied 64 patients who needed red cells transfusion...

Predictors of transfusion of packed red blood cells in coronary artery bypass grafting surgery

Sá,Michel Pompeu Barros de Oliveira; Soares,Evelyn Figueira; Santos,Cecília Andrade; Figueiredo,Omar Jacobina; Lima,Renato Oliveira Albuquerque; Rueda,Fábio Gonçalves de; Escobar,Rodrigo Renda de; Soares,Alexandre Magno Macário Nunes; Lima,Ricardo de
Fonte: Sociedade Brasileira de Cirurgia Cardiovascular Publicador: Sociedade Brasileira de Cirurgia Cardiovascular
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2011 EN
Relevância na Pesquisa
56.47%
OBJECTIVES: Finding predictors of blood transfusion may facilitate the most efficient approach for the use of blood bank services in coronary artery bypass grafting procedures. The aim of this retrospective study is to identify preoperative and intraoperative patient characteristics predicting the need for blood transfusion during or after CABG in our local cardiac surgical service. METHODS: 435 patients undergoing isolated first-time CABG were reviewed for their preoperative and intraoperative variables and analyzed postoperative data. Patients were 255 males and 180 females, with mean age 62.01 ± 10.13 years. Regression logistic analysis was used for identifying the strongest perioperative predictors of blood transfusion. RESULTS: Blood transfusion was used in 263 patients (60.5%). The mean number of transfused blood products units per patient was 2.27 ± 3.07 (0-23) units. The total number of transfused units of blood products was 983. Univariate analysis identified age >65 years, weight <70 Kg, body mass index <25 Kg/m2, hemoglobin <13mg/dL, hematocrit < 40% and ejection fraction <50%, use of cardiopulmonary bypass (CPB), not using an internal thoracic artery as a bypass, and multiple bypasses as significant predictors. The strongest predictors using multivariate analysis were hematocrit < 40% (OR 2.58; CI 1.62-4.15; P<0.001)...

Impact of autologous blood transfusion on the use of pack of red blood cells in coronary artery bypass grafting surgery

Silva,Leonardo Leiria de Moura da; Andres,Anna Júlia de Borba; Senger,Roberta; Stuermer,Ralf; Godoy,Maria Celoni de Mello de; Correa,Eduardo Francisco Mafassioli; Cóser,Virgínia Maria
Fonte: Sociedade Brasileira de Cirurgia Cardiovascular Publicador: Sociedade Brasileira de Cirurgia Cardiovascular
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2013 EN
Relevância na Pesquisa
66.39%
OBJECTIVE: To evaluate the impact of Cell Saver autologous blood transfusion system (CS) on the use of packed red blood cells (pRBC) in coronary artery bypass grafting (CABG) surgery. METHODS: We carried out a retrospective cross-sectional study in 87 patients undergoing primary elective CABG with miniaturized cardiopulmonary bypass (miniCPB), divided in two groups: 44 without-CS and 43 with-CS. We investigated the necessity of absolute use and the volume of packed red blood cells (pRBC) in each group, as well as cardiovascular risk factors, presurgical variables and intraoperative surgical parameters. All data were collected from medical records and there was no randomization or intervention on group selection. Statistical analysis was performed with Student t-test, Mann-Whitney U-test and χ² test, with a 5% significance level. RESULTS: There were no significant differences between the two groups in terms of cardiovascular risk factors and pre and intraoperative variables. Evaluating the absolute use of pRBC during surgery, there was a statistically significant difference (P=0.00008) between the groups without-CS (21/44 cases; 47.7%) and with-CS (4/43 cases; 9.3%). There was also a statistically significant difference (P=0.000117) in the volumes of pRBC between the groups without-CS (198.651258.65ml) and with-CS (35.061125.67ml). On the other hand...

Analysis of immediate transfusion incidents reported in a regional blood bank

Sousa Neto,Adriana Lemos de; Barbosa,Maria Helena
Fonte: Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular Publicador: Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2011 EN
Relevância na Pesquisa
56.53%
BACKGROUND: Blood transfusion is imperative when treating certain patients; however, it is not risk free. In addition to the possible transmission of contagious infectious diseases, incidents can occur immediately after transfusion and at a later time. AIMS: This study aimed to examine the immediate transfusion incidents reported in a regional blood bank in the state of Minas Gerais between December 2006 and December 2009. A retrospective quantitative epidemiological study was conducted. Data were obtained from 202 transfusion incident reports of 42 health institutions served by the blood bank. Data processing and analysis were carried out using the Statistical Package for the Social Sciences (SPSS) software. RESULTS: The rate of immediate transfusion incidents reported in the period was 0.24%; febrile non-hemolytic reactions were the most common type of incident (56.4%). The most frequent clinical manifestations listed in transfusion incident reports were chills (26.9%) and fever (21.6%). There was a statistically significant association (p-value < 0.05) between the infusion of platelet concentrates and febrile non-hemolytic reactions and between fresh frozen plasma and febrile non-hemolytic reaction. The majority (73.3%) of transfused patients who suffered immediate transfusion incidents had already been transfused and 36.5% of the cases had previous transfusion incident reports. CONCLUSIONS: Data from the present study corroborate the implementation of new professional training programs aimed at blood transfusion surveillance. These measures should emphasize prevention...

Transfusion practices committee of a public blood bank network in Minas Gerais, Brazil

Carvalho,Ricardo Vilas Freire de; Brener,Stela; Ferreira,Angela Melgaço; Valle,Marcele Cunha Ribeiro do; Moraes-Souza,Helio
Fonte: Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular Publicador: Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2012 EN
Relevância na Pesquisa
56.55%
OBJECTIVE: This study aimed to verify the performance of blood transfusion committees in transfusion services linked to the public blood bank network of the state of Minas Gerais. METHODS: A cross-sectional observational study was conducted between 2007 and 2008 using questionnaires and proficiency tests to evaluate the reporting and investigation of transfusion reactions comparing transfusion services with and without transfusion committees in the public transfusion services of the state of Minas Gerais. RESULTS: Nineteen of Hemominas own transfusion services and 207 that contracted the services of the foundation located in 178 municipalities were visited between 2007 and 2008. Established transfusion committees were present in 63.4% of the services visited. Transfusion incidents were reported by 53 (36.8%) transfusion services with transfusion committees and by eight (9.6%) without transfusion committees (p < 0.001) with 543 (97.5%) and 14 (2.5%) notifications, respectively. Of the reported transfusion incidents, 40 (75.5%) transfusion services with transfusion committees and only two (25%) of those without transfusion committees investigated the causes. CONCLUSION: The incidence of notification and investigation of the causes of transfusion reactions was higher in transfusion services where a transfusion committee was present. Despite these results...

Teaching transfusion medicine: current situation and proposals for proper medical training

Flausino,Gustavo de Freitas; Nunes,Flávio Ferreira; Cioffi,Júnia Guimarães Mourão; Proietti,Anna Bárbara de Freitas Carneiro
Fonte: Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular Publicador: Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/02/2015 EN
Relevância na Pesquisa
56.53%
The current curricula in medical schools and hospital residence worldwide lack exposure to blood transfusion medicine, and require the reformulation of academic programs. In many countries, training in blood transfusion is not currently offered to medical students or during residency. Clinical evidence indicates that blood transfusions occur more frequently than recommended, contributing to increased risk due to this procedure. Therefore, the rational use of blood and its components is essential, due to the frequent undesirable reactions, to the increasing demand of blood products and the cost of the process. Significant improvements in knowledge of and skills in transfusion medicine are needed by both students and residents. Improvements are needed in both background knowledge and the practical application of this knowledge to improve safety. Studies prove that hemovigilance has an impact on transfusion safety and helps to prevent the occurrence of transfusion-related adverse effects. To ensure that all these aspects of blood transfusion are being properly addressed, many countries have instituted hospital transfusion committees. From this perspective, the interventions performed during the formation of medical students and residents...

Screening for HIV I through the regional blood transfusion service in southwest Uganda: the Mbarara experience

Rukundo, H; Tumwesigye, N; Wakwe, V.C
Fonte: Health Transition Centre, National Centre for Epidemiology and Population Health, The Australian National University Publicador: Health Transition Centre, National Centre for Epidemiology and Population Health, The Australian National University
Tipo: Artigo de Revista Científica Formato: 20489 bytes; application/pdf
EN_AU
Relevância na Pesquisa
66.32%
Antibody screening for HIV has reduced transmission of AIDS by blood transfusion. Of the 12,768 units of blood donated to the Mbarara Regional Blood Bank between January 1992 and December 1994, 577 were found to be HIV I-positive using the ELISA technique. Percentage of positivity decreased from 5.4 in 1992 to 3.9 in 1994. Replacement donors had a higher positivity rate than volunteer donors. The females had more positives than the males. Distribution of the blood groups O and AB was similar between the Ugandan and English samples. There were differences in the blood groups A and B. The AB blood group which was only 4 per cent of the total had a higher percentage of HIV I positives. This preliminary finding should be confirmed by a more organized study.; no

Techniques of intrauterine fetal transfusion for women with red-cell isoimmunisation for improving health outcomes.

Dodd, J.; Windrim, R.; vanKamp, I.
Fonte: Update Software Ltd Publicador: Update Software Ltd
Tipo: Artigo de Revista Científica
Publicado em //2012 EN
Relevância na Pesquisa
56.51%
BACKGROUND Red-cell alloimmunisation can occur when there are incompatibilities between a woman's blood type and that of her unborn baby. This can cause the baby to become anaemic (low red blood cell count), which may require treatment during the pregnancy by blood transfusion while the baby remains within the uterus (called an intrauterine blood transfusion). OBJECTIVES To compare, using the best available evidence, the benefits and harms of different techniques of intrauterine fetal blood transfusion for women with red-cell alloimmunisation. SEARCH METHODS We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (13 June 2012). SELECTION CRITERIA We considered randomised controlled trials comparing different techniques of intrauterine fetal blood transfusion (either alone or in combination with another technique) for inclusion. DATA COLLECTION AND ANALYSIS Two authors evaluated trials under consideration for appropriateness for inclusion and methodological quality, without consideration of their results according to the prestated eligibility criteria. We planned to use a fixed-effect meta-analysis for combining study data if we judged the trials to be sufficiently similar. We planned to investigate statistical heterogeneity using the I² statistic; if this indicated a high degree of statistical heterogeneity...

Bartonella spp. e o risco potencial de transmissão por transfusão sanguínea = : Bartonella spp. and the potential risk of transmission by blood transfusion; Bartonella spp. and the potential risk of transmission by blood transfusion

Luiza Helena Urso Pitassi
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 23/05/2013 PT
Relevância na Pesquisa
66.53%
O gênero Bartonella constitui um grupo de patógenos zoonóticos re-emergentes e negligenciados que têm sido associados a um amplo espectro de doenças humanas graves. As Bartonella spp. são bacilos gram-negativos que infectam hemácias e células endoteliais, que podem causar infecção crônica ou mesmo fatal. As bartoneloses humanas mais conhecidas são a doença de Carrión, febre das trincheiras, doença da arranhadura do gato e angiomatose bacilar. Como existem espécies de Bartonella intraeritrocitárias e que podem causar infecção persistente e assintomática em humanos, objetivou-se avaliar o risco potencial de transmissão de Bartonella spp. por transfusão sanguínea. No primeiro estudo, os eritrócitos humanos foram infectados com B. henselae em 30 min e 1, 5, 10, e 72 h para a avaliação ultraestrutural por microscopia eletrônica de transmissão (ME). A B. henselae foi vista aderida a eritrócitos humanos 10 h após a inoculação e no interior de eritrócitos após 72 h. A localização intraeritrocitária de B. henselae havia sido mostrada em eritrócitos de gatos, mas nunca antes identificada em eritrócitos humanos. Foi realizado um segundo estudo para determinar as características ultraestruturais da Bartonella spp. nas células do sangue...

Risk factors for indications of intraoperative blood transfusion among patients undergoing surgical treatment for colorectal adenocarcinoma

Gonçalves,Iara; Linhares,Marcelo; Bordin,Jose; Matos,Delcio
Fonte: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED Publicador: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/2009 EN
Relevância na Pesquisa
66.33%
CONTEXT: Identification of risk factors for requiring transfusions during surgery for colorectal cancer may lead to preventive actions or alternative measures, towards decreasing the use of blood components in these procedures, and also rationalization of resources use in hemotherapy services. This was a retrospective case-control study using data from 383 patients who were treated surgically for colorectal adenocarcinoma at "Fundação Pio XII", in Barretos-SP, Brazil, between 1999 and 2003. OBJECTIVE: To recognize significant risk factors for requiring intraoperative blood transfusion in colorectal cancer surgical procedures. METHODS: Univariate analyses were performed using Fisher's exact test or the chi-squared test for dichotomous variables and Student's t test for continuous variables, followed by multivariate analysis using multiple logistic regression. RESULTS: In the univariate analyses, height (P = 0.06), glycemia (P = 0.05), previous abdominal or pelvic surgery (P = 0.031), abdominoperineal surgery (P<0,001), extended surgery (P<0.001) and intervention with radical intent (P<0.001) were considered significant. In the multivariate analysis using logistic regression, intervention with radical intent (OR = 10.249, P<0.001, 95% CI = 3.071-34.212) and abdominoperineal amputation (OR = 3.096...

Whole blood transfusion in small animals: indications and effects

Godinho-Cunha,Luís F; Ferreira,Rui M. R. F; Silvestre-Ferreira,Ana C
Fonte: Academia Brasileira de Ciências Publicador: Academia Brasileira de Ciências
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2011 EN
Relevância na Pesquisa
66.52%
Transfusion therapy is a major resource that can improve the patient's capability to overcome the underlying disease. However, the effects of whole blood infusion, and how they affect the patient's outcome, are not yet clear. For this study, a protocol was developed in order to monitor a group of 15 animals (9 dogs, 6 cats) that received a total of 19 transfusions; 3 animals received more than one transfusion each. The most common indications for blood transfusion included acute blood loss (47%), coagulopathy (33%) and other anaemias (20%). The mean pre-transfusion packed cell volume (PCV) of animals with acute blood loss (18%) was higher than in the group of coagulopathy (15%) or other anaemias (15%). The survival rates at 6 days after transfusion were greater in the coagulopathy (80.0%) and other anaemias (66.7%) than in the group of acute blood loss (42.9%). After transfusion, pulse rate ( p <0.01) and platelet count ( p <0.05) decreased significantly, and there was a significant increase in body temperature of the animals that suffered from hypothermia before the transfusion ( p <0.05). Overall survival was predictable based upon posttransfusion body temperature, observed PCV change, the difference between the obtained and the calculated PCV...

Ethical dilemmas in blood transfusion in Jehovah's Witnesses: a legal-bioethical analysis

França,Inacia Sátiro Xavier de; Baptista,Rosilene Santos; Brito,Virgínia Rosana de Sousa
Fonte: Escola Paulista de Enfermagem, Universidade Federal de São Paulo Publicador: Escola Paulista de Enfermagem, Universidade Federal de São Paulo
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2008 EN
Relevância na Pesquisa
66.5%
OBJECTIVE: To identify knowledge production by healthcare professionals about blood transfusion in Jehovah's Witnesses (JW), listing the therapeutic alternatives for blood transfusion in these individuals and citing the legal, ethical and bioethical standards regarding blood transfusion in JWs. METHODS: Data were collected in the LILACS and SciELO databases, Nursing journals and on http://www.google.com.br. Articles focusing on blood transfusion in JWs were included, and texts that were repeated or did not approach this theme were excluded. Content analysis was used. RESULTS: The thematic categories show that the JWs accept self-transfusion and are opposed to the medical practice of blood transfusion, even if it represents the continuity of life. CONCLUSION: Healthcare professionals experience ethical dilemmas when they need to perform blood transfusion in JWs due to the fact that religious freedom is not an absolute value, and the apparent collision of fundamental rights demands that a decision be made, centered on legal standards and bioethical principles.

Blood use in neurosurgical cases at the University Hospital of the West Indies

Crawford-Sykes,A; Ehikhametalor,K; Tennant,I; Scarlett,M; Augier,R; Williamson,L; Wharfe,G; Harding-Goldson,H
Fonte: West Indian Medical Journal Publicador: West Indian Medical Journal
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2014 EN
Relevância na Pesquisa
56.49%
OBJECTIVE: Many neurosurgical cases are done without the need for blood transfusion, yet blood is unnecessarily cross-matched, resulting in wasted resources. This study was undertaken to document and compare the number of units of blood components requested, cross-matched and transfused in neurosurgical cases at the University Hospital of the West Indies (UHWI). METHODS: A prospective, observational study was undertaken over one year. Data collected for each patient included demographic information, relevant perioperative data, and blood banking data including blood components requested, cross-matched and transfused. Data were analysed using SPSS version 16. RESULTS: Data were analysed on 152 patients, 71 females (46.7%) and 81 males (53.3%). The mean age was 48.7 ± 19.6 years and 100 of the procedures were done electively (65.8%). Blood components were ordered in 114 (75%) cases, red cells more commonly in 113 (74.3%) patients, and plasma in 19 (12.5%) patients. Overall, 20 patients (13.2%) were transfused. Most patients (90.9%) needed one to two units of blood. Of the 236 units of blood components that were cross-matched or prepared, only 62 were transfused. The cross-match/preparation to transfusion ratio (CTR/PTR) was 6.00 for red cells and 1.31 for plasma. Preoperative haemoglobin < 10.0 g/dL (p = 0.001)...

Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial

Williams-Johnson,JA; McDonald,AH; Strachan,G Gordon; Williams,EW
Fonte: West Indian Medical Journal Publicador: West Indian Medical Journal
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2010 EN
Relevância na Pesquisa
66.22%
BACKGROUND: Tranexamic acid can reduce bleeding in patients undergoing elective surgery. We assessed the effects of early administration of a short course of tranexamic acid on death, vascular occlusive events, and the receipt of blood transfusion in trauma patients. METHODS: This randomised controlled trial was undertaken in 274 hospitals in 40 countries. 20 211 adult trauma patients with, or at risk of, significant bleeding were randomly assigned within 8 h of injury to either tranexamic acid (loading dose 1 g over 10 min then infusion of 1 g over 8 h) or matching placebo. Randomisation was balanced by centre, with an allocation sequence based on a block size of eight, generated with a computer random number generator. Both participants and study staff (site investigators and trial coordinating centre staff) were masked to treatment allocation. The primary outcome was death in hospital within 4 weeks of injury, and was described with the following categories: bleeding, vascular occlusion (myocardial infarction, stroke and pulmonary embolism), multiorgan failure, head injury, and other. All analyses were by intention to treat. This study is registered as ISRCTN86750102, Clinicaltrials.gov NCT00375258, and South African Clinical Trial Register DOH-27-0607-1919. RESULTS: 10 096patients were allocated to tranexamic acid and 10 115 to placebo...