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Electronic Structure and Spectro-Structural Correlations of Fe(III)Zn(II) Biomimetics for Purple Acid Phosphatases: Relevance to DNA Cleavage and Cytotoxic Activity

PERALTA, Rosely A.; BORTOLUZZI, Adailton J.; SOUZA, Bernardo de; JOVITO, Rafael; XAVIER, Fernando R.; COUTO, Ricardo A. A.; CASELLATO, Annelise; NOME, Faruk; DICK, Andrew; GAHAN, Lawrence. R.; SCHENK, Gerhard; HANSON, Graeme R.; PAULA, Flavia C. S. de; PE
Fonte: AMER CHEMICAL SOC Publicador: AMER CHEMICAL SOC
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
27.15%
Purple acid phosphatases (PAPs) are a group of metallohydrolases that contain a dinuclear Fe(II)M(II) center (M(II) = Fe, Mn, Zn) in the active site and are able to catalyze the hydrolysis of a variety of phosphoric acid esters. The dinuclear complex [(H(2)O)Fe(III)(mu-OH)Zn(II)(L-H)](CIO(4))(2) (2) with the ligand 2-[N-bis(2-pyridylmethyl)aminomethyl]-4-methyl-6-[N-(2-pyridylmethyl)(2-hydroxybenzyl) aminomethyl]phenol (H(2)L-H) has recently been prepared and is found to closely mimic the coordination environment of the Fe(III)Zn(II) active site found in red kidney bean PAP (Neves et al. J. Am. Chem. Soc. 2007, 129, 7486). The biomimetic shows significant catalytic activity in hydrolytic reactions. By using a variety of structural, spectroscopic, and computational techniques the electronic structure of the Fe(III) center of this biomimetic complex was determined. In the solid state the electronic ground state reflects the rhombically distorted Fe(III)N(2)O(4) octahedron with a dominant tetragonal compression align ad along the mu-OH-Fe-O(phenolate) direction. To probe the role of the Fe-O(phenolate) bond, the phenolate moiety was modified to contain electron-donating or -withdrawing groups (-CH(3), -H, -Br, -NO(2)) in the 5-position. Tie effects of the substituents on the electronic properties of the biomimetic complexes were studied with a range of experimental and computational techniques. This study establishes benchmarks against accurate crystallographic struck ral information using spectroscopic techniques that are not restricted to single crystals. Kinetic studies on the hydrolysis reaction revealed that the phosphodiesterase activity increases in the order -NO(2)<- Br <- H <- CH(3) when 2...

A biomimética como método criativo para o projeto de produto; Biomimetics as a creative method for product design

Detanico, Flora Bittencourt; Teixeira, Fabio Goncalves; Silva, Tania Luisa Koltermann da
Fonte: Universidade Federal do Rio Grande do Sul Publicador: Universidade Federal do Rio Grande do Sul
Tipo: Artigo de Revista Científica Formato: application/pdf
POR
Relevância na Pesquisa
37.65%
E possível inferir o vasto campo de investigação do conhecimento existente na natureza. O presente trabalho delimita-se quanto ao uso da biomimética como ferramenta para a geração de alternativas, durante a fase de projeto conceitual. Foi realizada a identificação de alguns princípios de solução da natureza, matemáticos/geométricos e/ou funcionais, que possam ser devidamente reconhecidos através dos padrões existentes, visando sua aplicabilidade no desenvolvimento de produtos. Como fundamentação teórica necessária para o desenvolvimento do presente trabalho, há dois principais focos de pesquisa. O primeiro deles está relacionado a metodologia de projeto de produto, mais precisamente a fase conceitual, na qual ocorre o processo criativo ou a geração de soluções alternativas. O segundo ponto abordado se refere ao biomimetismo e ao conhecimento dos principios de solução da natureza como um todo, contemplando simultaneamente seus padrões geométricos, matemáticos e funcionais.; It is possible to infer the broad field of inquiry known in nature. This study is delimited to the use of biomimetics as a tool for the generation of alternatives during the conceptual design phase. It was performed to identify some principles of a settlement of nature...

Estudio de métodos de aproximación y el uso de analogías con el desarrollo de textiles biomiméticos

Fangueiro, Raúl; Lacerda, C.; Vila, Nívea Taís
Fonte: Universidade do Minho Publicador: Universidade do Minho
Tipo: Conferência ou Objeto de Conferência
Publicado em 23/12/2011 SPA
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La biomimética es una rama de la ciencia dedicada al estudio de la naturaleza y aprender de ella objetivar utilizar este conocimiento en diferentes áreas. El término proviene del griego "bios" que significa vida y "mimesis", que significa imitación. Por lo tanto, la imitación biomiméticos media de la vida y es una ciencia que trata de encontrar soluciones a los más variados campos de la inspiración de la ingeniería de los sistemas de la naturaleza y biológicos que tienen millones de años y siempre están evolucionando. Y bajo la inspiración en los modelos y procesos de la naturaleza, la industria textil ha sido la aplicación de los conocimientos de la biomimética y ha logrado un éxito ya que las soluciones se encontraron varios y diversos productos que fueron creados. En este sentido, este trabajo presenta una revisión de la evolución del sector textil obtenida mediante técnicas de mímica y presentar las similitudes de enfoque y los métodos utilizados en la investigación y el desarrollo de textiles biomiméticos.; Biomimetics is a branch of science devoted to study nature and learn from it to use this knowledge in different areas. The term comes from the Greek "bios" meaning life and "mimesis," which means imitation. Therefore...

Biotecnologia e biomimetismo: contributos inovadores para a eco-eficiência da indústria da construção; Biotechnology and biomimicry: innovative contributions to an eco-efficient construction industry

Costa, João José Soares
Fonte: Universidade do Minho Publicador: Universidade do Minho
Tipo: Trabalho de Conclusão de Curso
Publicado em //2014 POR
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27.46%
Dissertação de mestrado integrado em Engenharia Civil (área de especialização em Perfil de Construções); Os desafios ambientais com que o Planeta se depara exigem uma resposta urgente para garantir um desenvolvimento sustentável e as necessidades das gerações futuras. A indústria da construção é um dos principais contribuidores para o actual modelo de desenvolvimento insustentável devido aos seus enormes impactos ambientais. O campo da biotecnologia e também da biomimética apresentam potencial para oferecer soluções inovadoras que podem contribuir para uma maior eco-eficiência da indústria da construção. O objectivo desta dissertação foi a recolha de conteúdos inovadores nas áreas da biotecnologia e do biomimetismo. Nomeadamente os relacionados com a utilização da biotecnologia para aumentar a durabilidade do betão, as aplicações da biotecnologia na estabilização de solos, materiais compósitos bioinspirados, adesivos e materiais de revestimento bioinspirados e materiais com capacidade de auto-limpeza. No decorrer da presente dissertação são apresentados os desenvolvimentos recentes da utilização de microorganismos capazes de induzir a precipitação de carbonato de cálcio para aumentar a durabilidade do betão e a sua capacidade de prover uma melhoria das propriedades do solo. São ainda apresentados diversos materiais compósitos inspirados em estruturas biológicas com propriedades excepcionais que podem encontrar aplicações na área da construção. Também são abordados adesivos sintéticos inspirados na capacidade de adesão de diversos organismos biológicos e materiais com capacidade de auto-limpeza e a sua aplicação no fabrico de superfícies multifuncionais. Apesar do elevado esforço de investigação já levado a cabo nas áreas a que respeita a presente dissertação constata-se que há ainda muitos aspectos a necessitar de mais estudos. Tendo em conta a importância do material betão para a indústria construção...

Earth construction: bird teaching

Silva, B.; Correia, J.; Nunes, F.; Tavares, P.; Varum, H.; Pinto, J.
Fonte: WSEAS Press Publicador: WSEAS Press
Tipo: Conferência ou Objeto de Conferência
ENG
Relevância na Pesquisa
27.15%
The paradigm of earth being a traditional and a modern building material has been related to the fact that it is natural, ecological, recycled, abundant and economic. Among the traditional Portuguese building techniques, earth construction was always one very common. The construction built with these techniques must be preserved. In this context, the main objective of this research work is to give a contribution on the material properties characterization and, in particular, for the development of adequate rehabilitation and strengthening techniques for this type of construction, based upon a biomimetics study focused on the andorinha-dos-beirais nest. A structural numerical model of a nest using a finite element computer analysis program was done in order to understand the structural behavior of this kind of natural structures. In order to identify a possible occurrence of a certain agglutination phenomenon during the building process of the nest by the birds, an experimental identification/characterization study of nest’s material using samples taken in Vila Real area was carried out. The identification of the elementary chemical and the mineralogical compositions of the material were done by the scanning electron microscopy/energy dispersive spectroscopy (SEM/EDS) and by the X-ray diffraction analysis...

Biomimetics: its practice and theory

Vincent, Julian F.V; Bogatyreva, Olga A; Bogatyrev, Nikolaj R; Bowyer, Adrian; Pahl, Anja-Karina
Fonte: The Royal Society Publicador: The Royal Society
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
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Biomimetics, a name coined by Otto Schmitt in the 1950s for the transfer of ideas and analogues from biology to technology, has produced some significant and successful devices and concepts in the past 50 years, but is still empirical. We show that TRIZ, the Russian system of problem solving, can be adapted to illuminate and manipulate this process of transfer. Analysis using TRIZ shows that there is only 12% similarity between biology and technology in the principles which solutions to problems illustrate, and while technology solves problems largely by manipulating usage of energy, biology uses information and structure, two factors largely ignored by technology.

Biomimetics inspired surfaces for drag reduction and oleophobicity/philicity

Bhushan, Bharat
Fonte: Beilstein-Institut Publicador: Beilstein-Institut
Tipo: Artigo de Revista Científica
Publicado em 01/02/2011 EN
Relevância na Pesquisa
27.15%
The emerging field of biomimetics allows one to mimic biology or nature to develop nanomaterials, nanodevices, and processes which provide desirable properties. Hierarchical structures with dimensions of features ranging from the macroscale to the nanoscale are extremely common in nature and possess properties of interest. There are a large number of objects including bacteria, plants, land and aquatic animals, and seashells with properties of commercial interest. Certain plant leaves, such as lotus (Nelumbo nucifera) leaves, are known to be superhydrophobic and self-cleaning due to the hierarchical surface roughness and presence of a wax layer. In addition to a self-cleaning effect, these surfaces with a high contact angle and low contact angle hysteresis also exhibit low adhesion and drag reduction for fluid flow. An aquatic animal, such as a shark, is another model from nature for the reduction of drag in fluid flow. The artificial surfaces inspired from the shark skin and lotus leaf have been created, and in this article the influence of structure on drag reduction efficiency is reviewed. Biomimetic-inspired oleophobic surfaces can be used to prevent contamination of the underwater parts of ships by biological and organic contaminants...

Nanocrystal Core Lipoprotein Biomimetics for Imaging of Lipoproteins and Associated Diseases

Fay, Francois; Sanchez-Gaytan, Brenda L.; Cormode, David P.; Skajaa, Torjus; Fisher, Edward A.; Fayad, Zahi A.; Mulder, Willem J. M.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
27.15%
Lipoproteins are natural nanoparticles composed of phospholipids and apolipoproteins that transport lipids throughout the body. As key effectors of lipid homeostasis, the functions of lipoproteins have been demonstrated to be crucial during the development of cardiovascular diseases. Therefore various strategies have been used to study their biology and detect them in vivo. A recent approach has been the production of lipoprotein biomimetic particles loaded with diagnostically active nanocrystals in their core. These include, but are not limited to: quantum dots, iron oxide or gold nanocrystals. Inclusion of these nanocrystals enables the utilization of lipoproteins as probes for a variety of imaging modalities (computed tomography, magnetic resonance imaging, fluorescence) while preserving their biological activity. Furthermore as some lipoproteins naturally accumulate in atherosclerotic plaque or specific tumor tissues, nanocrystal core lipoprotein biomimetics have been developed as contrast agents for early diagnosis of these diseases.

A simple contact mapping algorithm for identifying potential peptide mimetics in protein–protein interaction partners

Krall, Alex; Brunn, Jonathan; Kankanala, Spandana; Peters, Michael H
Fonte: BlackWell Publishing Ltd Publicador: BlackWell Publishing Ltd
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
17.46%
A simple, static contact mapping algorithm has been developed as a first step at identifying potential peptide biomimetics from protein interaction partner structure files. This rapid and simple mapping algorithm, “OpenContact” provides screened or parsed protein interaction files based on specified criteria for interatomic separation distances and interatomic potential interactions. The algorithm, which uses all-atom Amber03 force field models, was blindly tested on several unrelated cases from the literature where potential peptide mimetics have been experimentally developed to varying degrees of success. In all cases, the screening algorithm efficiently predicted proposed or potential peptide biomimetics, or close variations thereof, and provided complete atom-atom interaction data necessary for further detailed analysis and drug development. In addition, we used the static parsing/mapping method to develop a peptide mimetic to the cancer protein target, epidermal growth factor receptor. In this case, secondary, loop structure for the peptide was indicated from the intra-protein mapping, and the peptide was subsequently synthesized and shown to exhibit successful binding to the target protein. The case studies, which all involved experimental peptide drug advancement...

Biomimetics: forecasting the future of science, engineering, and medicine

Hwang, Jangsun; Jeong, Yoon; Park, Jeong Min; Lee, Kwan Hong; Hong, Jong Wook; Choi, Jonghoon
Fonte: Dove Medical Press Publicador: Dove Medical Press
Tipo: Artigo de Revista Científica
Publicado em 08/09/2015 EN
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Biomimetics is the study of nature and natural phenomena to understand the principles of underlying mechanisms, to obtain ideas from nature, and to apply concepts that may benefit science, engineering, and medicine. Examples of biomimetic studies include fluid-drag reduction swimsuits inspired by the structure of shark’s skin, velcro fasteners modeled on burrs, shape of airplanes developed from the look of birds, and stable building structures copied from the backbone of turban shells. In this article, we focus on the current research topics in biomimetics and discuss the potential of biomimetics in science, engineering, and medicine. Our report proposes to become a blueprint for accomplishments that can stem from biomimetics in the next 5 years as well as providing insight into their unseen limitations.

Biomimetics: From Bioinformatics to Rational Design of Dendrimers as Gene Carriers

Márquez-Miranda, Valeria; Camarada, María Belén; Araya-Durán, Ingrid; Varas-Concha, Ignacio; Almonacid, Daniel Eduardo; González-Nilo, Fernando Danilo
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 18/09/2015 EN
Relevância na Pesquisa
27.15%
Biomimetics, or the use of principles of Nature for developing new materials, is a paradigm that could help Nanomedicine tremendously. One of the current challenges in Nanomedicine is the rational design of new efficient and safer gene carriers. Poly(amidoamine) (PAMAM) dendrimers are a well-known class of nanoparticles, extensively used as non-viral nucleic acid carriers, due to their positively charged end-groups. Yet, there are still several aspects that can be improved for their successful application in in vitro and in vivo systems, including their affinity for nucleic acids as well as lowering their cytotoxicity. In the search of new functional groups that could be used as new dendrimer-reactive groups, we followed a biomimetic approach to determine the amino acids with highest prevalence in protein-DNA interactions. Then we introduced them individually as terminal groups of dendrimers, generating a new class of nanoparticles. Molecular dynamics studies of two systems: PAMAM-Arg and PAMAM-Lys were also performed in order to describe the formation of complexes with DNA. Results confirmed that the introduction of amino acids as terminal groups in a dendrimer increases their affinity for DNA and the interactions in the complexes were characterized at atomic level. We end up by briefly discussing additional modifications that can be made to PAMAM dendrimers to turned them into promising new gene carriers.

Biomimetics through nanoelectronics: development of three-dimensional macroporous nanoelectronics for building smart materials, cyborg tissues and injectable biomedical electronics.

Liu, Jia
Fonte: Harvard University Publicador: Harvard University
Tipo: Thesis or Dissertation
EN_US
Relevância na Pesquisa
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Nanoscale materials enable unique opportunities at the interface between physical and life sciences. The interface between nanoelectronic devices and biological systems makes possible communication between these two diverse systems at the length scale relevant to biological functions. The development of a bottom-up paradigm allows the nanoelectronic units to be synthesized and patterned on unconventional substrates. In this thesis, I will focus on the development of three-dimensional (3D) nanoelectronics, which mimics the structure of porous biomaterials to explore new methods for seamless integration of electronics with other materials, with a special focus on biological tissue.; Chemistry and Chemical Biology

Framework para incorporação da biomimética e propriedades da visão do produto como estratégia de inovação; Framework for incorporation of biomimetics and product vision properties as innovation strategy

Neves, Júlio César Legramanti
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 25/08/2015 PT
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27.65%
Além do objetivo de disponibilizar uma ferramenta adequada para a construção de tecnologias e produtos inovadores esse trabalho também apresenta um caráter pioneiro e prático da transposição de conhecimentos da área da biomimética1 aplicados às diversas áreas, tais como: engenharia, arquitetura, design, ciências, biologia, medicina entre outras. Nesse trabalho é proposto um framework referencial utilizando a biomimética para a construção da visão do produto e que compreende as seguintes características: um procedimento com a descrição dos passos para o uso da biomimética, um conjunto de ferramentas como formulários e templates para apoiadores do procedimento, a disponibilização um checklist de aderência das propriedades da visão do produto e a descrição de um caso real no qual todo o processo foi utilizado. Um dos fatores determinantes para o sucesso da utilização dessa ferramenta no desenvolvimento de novas soluções é a necessidade da participação de um grupo multidisciplinar, como interfaces complementares para a estruturação deste processo inovador. Através da condução de uma pesquisa-ação, a proposta do framework foi aplicada e aperfeiçoada à medida que os ciclos da pesquisa-ação foram conduzidos. Este trabalho de pesquisa ocorreu em uma empresa do setor de higiene pessoal...

Proteoliposomes as matrix vesicles' biomimetics to study the initiation of skeletal mineralization

SIMÃO, A.M.S.; YADAV, M.C.; CIANCAGLINI, P.; MILLÁN, J.L.
Fonte: Associação Brasileira de Divulgação Científica Publicador: Associação Brasileira de Divulgação Científica
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
27.15%
During the process of endochondral bone formation, chondrocytes and osteoblasts mineralize their extracellular matrix by promoting the formation of hydroxyapatite (HA) seed crystals in the sheltered interior of membrane-limited matrix vesicles (MVs). Ion transporters control the availability of phosphate and calcium needed for HA deposition. The lipidic microenvironment in which MV-associated enzymes and transporters function plays a crucial physiological role and must be taken into account when attempting to elucidate their interplay during the initiation of biomineralization. In this short mini-review, we discuss the potential use of proteoliposome systems as chondrocyte- and osteoblast-derived MVs biomimetics, as a means of reconstituting a phospholipid microenvironment in a manner that recapitulates the native functional MV microenvironment. Such a system can be used to elucidate the interplay of MV enzymes during catalysis of biomineralization substrates and in modulating in vitro calcification. As such, the enzymatic defects associated with disease-causing mutations in MV enzymes could be studied in an artificial vesicular environment that better mimics their in vivo biological milieu. These artificial systems could also be used for the screening of small molecule compounds able to modulate the activity of MV enzymes for potential therapeutic uses. Such a nanovesicular system could also prove useful for the repair/treatment of craniofacial and other skeletal defects and to facilitate the mineralization of titanium-based tooth implants.

3.A24 Freshman Seminar: The Engineering of Trees, Spring 2003; Freshman Seminar: The Engineering of Trees

Gibson, Lorna J.
Fonte: MIT - Massachusetts Institute of Technology Publicador: MIT - Massachusetts Institute of Technology
EN-US
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Why are things in nature shaped the way they are? Why can't trees grow taller than they are? Why is grass skinny and hollow? Why are some leaves full of holes? These are the types of questions Dr. Lorna Gibson's freshman seminar at MIT has been investigating. We invite you to explore with us. Questions such as these are the subject of biomimetic research. When engineers copy the shapes found in nature we call it Biomimetics. the word biomimic comes from bio, as in biology and mimetic, which means to copy. Join us as we explore and look for answers to why similar shapes occur in so many natural things and how physics change the shape of nature.

3.A24 Freshman Seminar: The Engineering of Birds, Fall 2004; Freshman Seminar: The Engineering of Birds

Gibson, Lorna J.
Fonte: MIT - Massachusetts Institute of Technology Publicador: MIT - Massachusetts Institute of Technology
EN-US
Relevância na Pesquisa
27.15%
Why are things in nature shaped the way they are? How do birds fly? Why do bird nests look the way they do? How do woodpeckers peck? These are the types of questions Dr. Lorna Gibson's freshman seminar at MIT has been investigating. We invite you to explore with us. Questions such as these are the subject of biomimetic research. When engineers copy the shapes found in nature we call it Biomimetics. The word biomimic comes from bio, as in biology and mimetic, which means to copy. Join us as we explore and look for answers to why similar shapes occur in so many natural things and how physics change the shape of nature.

Proteoliposomes as matrix vesicles' biomimetics to study the initiation of skeletal mineralization

Simão,A.M.S.; Yadav,M.C.; Ciancaglini,P.; Millán,J.L.
Fonte: Associação Brasileira de Divulgação Científica Publicador: Associação Brasileira de Divulgação Científica
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2010 EN
Relevância na Pesquisa
27.15%
During the process of endochondral bone formation, chondrocytes and osteoblasts mineralize their extracellular matrix by promoting the formation of hydroxyapatite (HA) seed crystals in the sheltered interior of membrane-limited matrix vesicles (MVs). Ion transporters control the availability of phosphate and calcium needed for HA deposition. The lipidic microenvironment in which MV-associated enzymes and transporters function plays a crucial physiological role and must be taken into account when attempting to elucidate their interplay during the initiation of biomineralization. In this short mini-review, we discuss the potential use of proteoliposome systems as chondrocyte- and osteoblast-derived MVs biomimetics, as a means of reconstituting a phospholipid microenvironment in a manner that recapitulates the native functional MV microenvironment. Such a system can be used to elucidate the interplay of MV enzymes during catalysis of biomineralization substrates and in modulating in vitro calcification. As such, the enzymatic defects associated with disease-causing mutations in MV enzymes could be studied in an artificial vesicular environment that better mimics their in vivo biological milieu. These artificial systems could also be used for the screening of small molecule compounds able to modulate the activity of MV enzymes for potential therapeutic uses. Such a nanovesicular system could also prove useful for the repair/treatment of craniofacial and other skeletal defects and to facilitate the mineralization of titanium-based tooth implants.

Modelització molecular de complexos dels metalls de transició amb el mètode híbrid imomm de l'organometàl·lica a la bioinorgànica /

Barea García, Guadalupe
Fonte: Bellaterra : Universitat Autònoma de Barcelona, Publicador: Bellaterra : Universitat Autònoma de Barcelona,
Tipo: Tesis i dissertacions electròniques; info:eu-repo/semantics/doctoralThesis Formato: application/pdf; application/pdf; application/pdf
Publicado em //2003 CAT; CAT
Relevância na Pesquisa
17.65%
Consultable des del TDX; Títol obtingut de la portada digitalitzada; Els mètodes híbrids MQ/MM poden ser de gran utilitat en l'estudi de complexos de metalls de transició d'elevada grandària. Tanmateix, la seva aplicació és encara recent i requereix una avaluació inicial de les seves limitacions. L'objectiu fonamental d'aquesta tesi és explorar la validesa del mètode híbrid IMOMM en la correcta representació química dels sistemes dels metalls de transició i aplicar-ho a problemes químics d'interès. En primer lloc s'ha dut a terme l'estudi d'una sèrie de compostos organometàl·lics. Una de les característiques computacionalment més costoses de representar correctament en complexos dels metalls de transicó de certa grandària la constitueixen els efectes estèrics, a causa que per tal de reproduir-los adequadament és necessari incloure al complex model tots els àtoms que el constitueixen, cosa que, sovint, fa impracticable el seu estudi amb mètodes ab initio purs. En aquest sentit, els mètodes híbrids i, en concret, el mètode IMOMM, poden ser de gran utilitat. Cal demostrar, però, la seva validesa en la representació de la geometria i energia dels sistemes estudiats de manera que la preferència conformacional d'un complex pugui ser expressada en termes de repulsions estèriques i energies relatives. És aquest un primer punt important que resoldrem en base a contrastacions amb dades experimentals i que ens permetrà l'extrapol·lació metodològica a complexos en què aquestes dades manquin. Es poden trobar compostos organometàl·lics en què l'efecte dels substituents en els lligands és d'una naturalesa clarament estèrica. Aquest tipus de compostos són ideals per a l'avaluació de les prestacions del mètode IMOMM i per aquest motiu se n'han estudiat dos en detall. Per tal que l'atribució a una determinada preferència conformacional sigui útil en el disseny de nous compostos amb les propietats desitjades és útil...

BioMEMS and molecular processing: Engineering biomimetics in design of MEMS and processing platforms

Lyshevski, Marina; Lyshevski, Sergey
Fonte: IEEE Publicador: IEEE
Tipo: Proceedings
EN_US
Relevância na Pesquisa
37.46%
The fundamentals, operation and functionality of MEMS and their components can be envisioned to be devised and prototyped through biomimetics. Examining actuation, sensing, processing and other key functions, we focus on the pilot studies of efficient hardware and software which are inherently possessed and exhibited by living biosystems. There are a great number of unsolved fundamental and technological problems. To some extent, a number of problems can be attacked by examining and attempting to utilize different biomolecular-centered actuation, sensing and processing solutions. BioMEMS and processing platforms are examined due to their superior performance and unprecedented capabilities. However, non-comprehended cellular phenomena and mechanisms in biosystems are emphasized. This paper documents novel MEMS devices and systems which can be designed utilizing some phenomena and effects observed in biosystems. The performance estimates are reported.; Copyright 2007 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.; MEMSTECH'2007...

Nanoelectromechanical systems and nanomachines: biomimicking and prototyping

Lyshevski, Sergey; Lyshevski, Marina
Fonte: IEEE Publicador: IEEE
Tipo: Proceedings
EN_US
Relevância na Pesquisa
27.15%
Complex nanoelectromechanical systems (NEMS) exist in nature in enormous variety and sophistication. These NEMS are built from various nanoscale structures, devices and subsystems. Complex nanodevices can be devised and designed through biomimetics. Living organisms and systems, which consist of atoms, molecules, molecular structures and molecular systems can be examined and prototyped using the corresponding theories. The ability of organisms to function in a particular way depends on the presence, absence, concentration, location, interaction, and architectures of integrated structures, components and systems. Bioelectromechanics and bioelectronics are the synergy of science, engineering and technology to compliment and enhance fundamental research and applied developments in complex nano- and microscale systems. For example, one can apply complex biological patents and processes to devise and fabricate nanomachines. Biomimicking can be performed in researching structures, architectures and biological materials of biomolecules, cells, tissues, membranes, biomotors, biosystems, etc. This paper aims to provide a focused study of bioelectromechanics, which is a far-reaching frontier of modern science and engineering. The results are illustrated by devising high-performance transducers (actuators and sensors) via synthesis of novel topologies which are discovered when prototyping bionanomotors.; Copyright 2002 IEEE. Personal use of this material is permitted. However...