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Role of the spinal cord NO/cGMP pathway in the control of arterial pressure and heart rate

SABINO, Joao Paulo J.; BOMBARDA, Gabriela; SILVA, Carlos Alberto A. da; FAZAN JR., Rubens; SALGADO, Maria Cristina O.; SALGADO, Helio C.
Fonte: SPRINGER Publicador: SPRINGER
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
56.31%
The modulatory effect of nitric oxide/cyclic guanosine monophosphate (NO/cGMP) pathway on sympathetic preganglionic neurons still deserves further investigation. The present study was designed to examine the role of the spinal cord NO/cGMP pathway in controlling mean arterial pressure and heart rate. We observed that intrathecal administration of the NO synthase inhibitor N omega-Nitro-L-arginine methyl ester hydrochloride (L-NAME) causes an increase in mean arterial pressure but does not affect heart rate. Intrathecal administration of the soluble guanylyl cyclase inhibitor 1H-[1,2,4] Oxadiazolo[4,3-a] quinoxalin-1-one (ODQ) does not change mean arterial pressure and heart rate. The precursor for NO synthesis, L-arginine, reduces both mean arterial pressure and heart rate while administration of ODQ before L-arginine impaired decreases in mean arterial pressure and heart rate. Administration of the N-methyl-D-aspartate (NMDA) receptor antagonist DL-2-amino-5-phosphonopentanoic acid (AP5) after L-NAME does not affect increases in mean arterial pressure promoted by NO synthase inhibition. Although the hypotensive and bradycardic responses induced by intrathecal administration of L-arginine depend on cGMP, our results indicate that NO acts to tonically inhibit SPNs...

Avaliação eletrocardiográfica e da pressão arterial na indução anestésica com propofol e na manutenção com isofluorano ou infusão contínua de propofol em cães; Electrocardiography and arterial pressure evaluation of propofol in anesthesia induction and in anesthesia maintenance with isofluorane or continuous infusion of propofol in dogs

Fragata, Fernanda da Silva
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 24/09/2004 PT
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56.39%
Nos últimos 15 anos, o uso do propofol vem se popularizando na prática clínica como anestésico intravenoso para indução e manutenção da anestesia em cães e gatos. O objetivo deste estudo foi avaliar os efeitos do propofol na pressão arterial, freqüência e ritmo cardíacos, quando empregado na indução e na manutenção anestésica de cães, verificar a correlação entre os valores de freqüência cardíaca e pressão arterial média, obtidos durante a indução e a manutenção anestésica e avaliar a incidência de efeitos colaterais deste fármaco. Foram utilizados 53 cães, 15 machos e 38 fêmeas, clinicamente sadios, com idades entre 1 e 12 anos, peso entre 2 e 44 kg, de diferentes raças, categoria de risco ASA 1 ? 2. Após avaliação clinica, foi administrada a medicação pré-anestésica (T0) constituída de acepromazina (0,05mg/kg) e meperidina (3mg/kg) pela via intramuscular. A indução da anestesia foi realizada em dois momentos, no primeiro momento infundiu-se metade da dose de propofol calculada (T1), no segundo momento procedeu-se o término da administração da dose total de indução da anestesia (T2), o terceiro momento correspondeu a intubação orotraqueal (T3). Durante a manutenção da anestesia...

Efeito da dieta, estatina e ácidos graxos ômega-3 sobre a pressão arterial e a lipidemia em humanos; Effect of the diet, statin and ω-3 fatty acid on the arterial pressure and lipidemia in humans

Denardi, Daniela Cristiane Ferrari
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 03/10/2007 PT
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66.3%
As doenças cardiovasculares (DCV) são responsáveis pelas principais causas (dislipidemias e hipertensão arterial) de morte, sendo que o tratamento convencional é feito com estatina. Hoje alguns componentes presentes em alimentos tem sido apontados como alternativas ou coadjuvantes no tratamento. O objetivo deste trabalho foi avaliar as concentrações séricas de colesterol e suas frações, triglicérides e pressão arterial em humanos. O estudo foi conduzido em três tratamentos (placebo, estatina e ω-3) com dieta de 1200 calorias por dia. Os grupos com oito pacientes cada tratamento, foram avaliados no tempo zero e 30 dias. Nos três tratamentos houveram reduções no peso, porém não houve mudanças significativas no IMC. A circunferência de cintura (CC) diminuiu aproximadamente 3 cm em todos os tratamentos. Para a circunferência do quadril (CQ) maior diminuição foi no tratamento estatina (redução de 2,44 cm). Não houve diferença em nenhum dos tratamentos para relação circunferência cintura-quadril (CCQ). As concentrações de colesterol total diminuiu 41%; 11,38% e 5% para os tratamentos estatina, dieta e ω-3, respectivamente. Para o HDL-C o tratamento estatina aumentou 10,09%, dieta diminuiu 9,65% e ω-3 não promoveu mudança nos valores. Para LDL-C os tratamentos estatina e ω-3 reduziram 49% e 3...

Sobrecarga salinas cronica em ratos Wistar eleva a pressão arterial e aumenta o metabolismo da glicose, sem modificar a sensibilidade a insulina; Sobrecarga salina cronica em ratos wistar eleva a pressao arterial e aumenta o metabolismo da glicose, sem modificar a sensibilidade a insulina

Lima, Nereida Kilza da Costa
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 20/12/1995 PT
Relevância na Pesquisa
56.37%
Durante o processo de envelhecimento humano, há aumento da pressão arterial e da prevalência de distúrbios do metabolismo de carboidratos, tais como: resistência à ação da insulina na captação de glicose, intolerância à glicose e diabetes mellitus tipo II. Questiona-se a existência de uma associação de causaefeito entre hipertensão arterial e resistência à insulina ou se apenas há concomitância eventual entre os dois fenômenos, com potencial ação amplificadora de um sobre o outro. Por outro lado, sabendo-se que o sal participa do aumento pressórico com a idade, torna-se importante o conhecimento de seu papel na sensibilidade à insulina durante o envelhecimento. O objetivo deste estudo, portanto, foi avaliar o papel do sal na pressão arterial, metabolismo da glicose e resistência à insulina durante o envelhecimento de ratos. Utilizaram-se ratos Wistar machos que foram submetidos, logo após o desmame, à dieta hipossódica (0,15% de NaCl) ou hipersódica (7,94% de NaCl) mantidas até 72 semanas de idade. Em um subgrupo de animais em cada dieta, procedeu-se à inversão das mesmas após 48 semanas de vida. Em animais jovens e idosos, procedeu-se à medida da pressão arterial, peso, massa renal e ventricular esquerda...

Nitric oxide of the supraoptic nucleus influences the salivary secretion, sodium renal excretion, urinary volume and arterial blood pressure induced by pilocarpine

Saad, W. A.; Gutierrez, L. I.; Guarda, I. F. M. S.; Camargo, L. A. D.; Santos, T. A. F. B. dos; Simoes, S.; Guarda, R. S.
Fonte: Elsevier B.V. Publicador: Elsevier B.V.
Tipo: Artigo de Revista Científica Formato: 1593-1603
ENG
Relevância na Pesquisa
56.17%
Male Holtzman rats weighting 200-250 g were anesthetized with zoletil 50 mg/Kg (tiletamine chloridrate 125.0 mg and zolazepan chloridrate 125.0 mg) into quadriceps muscle and stainless steel cannulas were implanted into their supraoptic nucleus (SON). We investigated the effects of the injection into the supraoptic nucleus (SON) of FK 409, a nitric oxide donor, and N(W-)nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor (NOS), on the salivary secretion, arterial blood pressure, sodium excretion and urinary volume induced by pilocarpine, which was injected into SON. The drugs were injected in 0.5 mul volume over 30-60 s. Controls was injected with a similar volume of 0.15 M NaCl. FK 409 and L-NAME were injected at doses of 20 mug/0.5 mul and 40 mug/0.5 mul. respectively. The amount of saliva secretion was studied over a five-minute period after injection of pilocarpine into SON. Injection of pilocarpine (10, 20, 40, 80, 160 mug/mul) into SON produced a dose-dependent increase in salivary secretion. L-NAME was injected into SON prior to the injection of pilocarpine into SON, producing an increase in salivary secretion due to the effect of pilocarpine. FK 409 injected into SON attenuating the increase in salivary secretion induced by pilocarpine. Mean arterial pressure (MAP) increase after injections of pilocarpine into the SON. L-NAME injected into the SON prior to injection of pilocarpine into SON increased the MAP. FK 409 injected into the SON prior to pilocarpine attenuated the effect of pilocarpine on MAP. Pilocarpine (0.5 mumol/0.5 mul) injected into the SON induced an increase in sodium and urinary excretion. L-NAME injected prior to pilocarpine into the SON increased the urinary sodium excretion and urinary volume induced by pilocarpine. FK 409 injected prior to pilocarpine into the SON decreased the sodium excretion and urinary volume induced by pilocarpine. All these roles of pilocarpine depend on the release of nitric oxide into the SON. In summary the present results show: a) SON is involved in pilocarpine-induced salivation; b) that mechanism involves increase in MAP...

Vasopressin and angiotensin receptors of the medial septal area in the control of mean arterial pressure induced by vasopressin

Pavan de Arruda Camargo, Gabriela Maria; Saad, Wilson Abrao; de Arruda Camargo, Luiz Antonio
Fonte: Sage Publications Ltd Publicador: Sage Publications Ltd
Tipo: Artigo de Revista Científica Formato: 133-138
ENG
Relevância na Pesquisa
66.08%
Introduction. Brain arginine(8)-vasopressin (AVP), through the V-1a- and V-2-receptors, is essential for the maintenance of mean arterial pressure (MAP). Central AVP interacts with the components of the renin-angiotensin system, which participate in MAP regulation. This study all to determine the effects of V-1a-, V-2- and V-1a/V-2-AVP selective antagonists and AT(1)- and AT(2)-angiotensin II (Ang II) selective antagonists on the MAP induced by AVP injected into the medial septal area (MSA) of the brain.Materials and methods. Male Holtzman rats with stainless steel cannulae implanted into the MSA were used in experiments. Direct MAP was recorded in Conscious rats.Results. AVP administration into the MSA caused a prompt and potent pressor response in a dose-dependent fashion. Pretreatment with the V-1a- and V-2-antagonists reduced, whereas prior injection of the V-1a/V-2-antagonist induced a decrease in the MAP that remained below the baseline. Both AT(1)- and AT(2)-antagonists elicited a decrease, While simultaneous injections of two antagonists were more effective in decreasing the MAP induced AVP.Conclusion. These results indicate there is a synergism bell the V-1a- and V-2-AVP, and AT(1)- AT, and AT(2)-Ang II receptors in the MSA in the regulation of MAP.

LESION OF THE ANTEROVENTRAL 3RD VENTRICLE REGION IMPAIRS THE RECOVERY OF ARTERIAL-PRESSURE INDUCED BY HYPERTONIC SALINE IN RATS SUBMITTED TO HEMORRHAGIC-SHOCK

Barbosa, S. P.; Camargo, LAD; Saad, W. A.; Renzi, A.; Deluca, L. A.; Menani, Jose Vanderlei
Fonte: Elsevier B.V. Publicador: Elsevier B.V.
Tipo: Artigo de Revista Científica Formato: 109-114
ENG
Relevância na Pesquisa
66.12%
The effect of intravenous infusion of hypertonic saline (HS, 7.5% NaCl) on the recovery of mean arteria pressure (MAP) after hemorrhage was studied in sham-operated rats and in rats with electrolytic lesion of the anteroventral third ventricle (AV3V) region (4 h, 4 and 20 days). Rats anesthetized with thiopental sodium were bled (about 2.8 ml/100 g) until the MAP was stabilized at the level of 60 mmHg for 30 min. In sham-lesioned rats, MAP increased to 90 mmHg and became stable near this level after intravenous infusion of 7.5% NaCl (4 ml/kg b.wt.). In AV3V-lesioned rats, the same infusion induced a smaller increase in MAP (80 mmHg) and the MAP returned to pre-infusion levels within 30 min. These results show that the AV3V region plays an important role in the recovery of arterial pressure induced by hypertonic saline in rats submitted to hemorrhagic shock.

Effects of intracerebroventricular injections of losartan or PD123319 on arterial pressure and heart rate of sodium replete and sodium deplete rats

De Luca Jr., Laurival A.; Barbosa, Silas P.; Sugawara, Alexandre M.; Menani, Jose Vanderlei
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 31-35
ENG
Relevância na Pesquisa
66.12%
Angiotensin II (Ang II) non-peptide antagonists were injected i.c.v. (6.25-200 nmol, n = 5-8 rats/group): In sodium replete rats, losartan (AT1 receptor antagonist) induced an increase in mean arterial pressure (MAP) and in heart rate (HR) by 3rd ventricular (3rdV) injection, and a weaker pressor response and bradycardia by 4th ventricular (4thV) injection. PD123319 (AT2 receptor antagonist) induced an increase in MAP and in HR by 3rdV injection, and an increase in MAP and no alteration in HR by 4thV injection. In sodium deplete (furosemide plus removal of ambient sodium for 24 h) rats, losartan induced an increase in MAP and no alteration in HR by 3rdV injection, and no alteration in MAP and bradycardia by 4thV injection. PD123319 induced an increase in MAP and in HR by 3rdV injection, and an increase in MAP and bradycardia by 4thV injection. Thus, there was no fall in MAP by central injections of Ang II antagonists. Intravenous injection of losartan, but not of PD123319, induced a fall in MAP in both sodium replete and sodium deplete animals. Therefore, losartan and PD123319 can have similar effects on MAP and HR when injected intracerebroventricularly, although some differences are also present. The bradycardia is consistent with an withdrawal of Ang II inhibitory action on baroreflex.

Efeitos do extrato aquoso de cebola (Allium cepa L.) sobre a função renal e a pressão arterial em ratos Wistar

Campos, K. E.; Balbi, A. P C; Alves, M. J Q F
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 24-29
POR
Relevância na Pesquisa
56.22%
The vegetal species, Allium cepa, known as onion, is widely used in the folk medicine as diuretic, besides it has been used on the bronchitis, cough, cardiovascular diseases and hypertension treatment. In this study we evaluate the onion aqueous extract (AE) effect on water flow and electrolytes in anesthetized Wistar rats, besides we also evaluate arterial pressure alterations. Two groups were studied: Group 1 (control) - oral tratment with 1.0 mL of distilled water, and Group 2 (experimental) - oral treatment with 1.0 mL of AE 20%. The rats were anesthetized and we canulate the trachea, left carotide artery (for arterial pressure measurement and blood collecting), jugular vein (to execute inulin perfusion - to register glomerular filtration), and urinary bladder (to collect urine). The Group 1 results had shown that the animals had not presented significant alterations (p>0.05) in the analyzed parameters. The animals of Group 2 had a significant reduction (p<0.05) in the arterial pressure (22.0%). However, there were not significant alterations in renal parameters (p>0.05). These results show that the treatment with the AE lead a hypotensor effect in anesthetized Wistar rats, but not followed by renal parameters alterations.

Efetividade de um programa de exercícios no condicionamento físico, perfil metabólico e pressão arterial de pacientes hipertensos

Monteiro, Henrique L.; Rolim, Lívia M. C.; Squinca, Daniela A.; Silva, Fernando C.; Ticianeli, Carla C. C.; Amaral, Sandra L.
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 107-112
POR; ENG
Relevância na Pesquisa
56.17%
Background and objective: It has been shown that aerobic exercise is useful to reduce arterial pressure, however, the effectiveness of an exercise program is still controversial and not very well analyzed among populations with low-income. The objective of the present study was to set up an individualized physical fitness program - Projeto Hipertensão - focused on hypertensive people, patients from a Health Basic Unit (HBU) and, after that, to investigate the effects of this program on physical fitness, metabolic profile and pressure levels. Methods: Sixteen hypertensive women (56 ± 3yrs) under regular pharmacological treatment underwent 4 months of a supervised aerobic and stretching exercise program (3 sessions/wk, 90 min/session, 60% of V̇O 2 max). Several physical and metabolic variables were compared before and after 4 months of training. Results: Training significantly reduced systolic arterial pressure (SAP, -6%), improved cardio-respiratory fitness (+42% of V̇O2max), flexibility (+11%) and plasma glucose content (-4%). BMI and % fat did not change. Besides modifying metabolic profile, it was found that training presented significant correlations between individual initial values of cholesterol total level (CT), high density lipoprotein (HDL-C) and low density lipoprotein (LDL-C) and its responses after exercise. Conclusions: The study shows that exercise programs can be personalized for hypertensive patients from a HBU and confirms the effectiveness of exercise on AP...

Medição da pressão arterial em canídeos e felinos

Arvela, Sofia Coelho
Fonte: Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária Publicador: Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária
Tipo: Dissertação de Mestrado
Publicado em 31/07/2013 POR
Relevância na Pesquisa
56.38%
Dissertação de Mestrado Integrado em Medicina Veterinária; Neste trabalho realizou-se um estudo sobre as metodologias disponíveis para avaliação da pressão arterial em canídeos e em felinos, focando aquelas metodologias exequíveis na prática clínica de forma a obter a pressão arterial de animais conscientes de uma forma rápida e prática. Realizaram-se 87 medições de pressão arterial em canídeos e felinos, incluindo animais doentes e saudáveis utilizando um aparelho oscilométrico: “PetMAP”. Os valores de pressão arterial sistólica, média e diastólica alcançados para animais saudáveis da espécie canina foram 180,73 (+/- 28,04); 124,03 (+/- 20,13) e 95,59 (+/- 17,63) respetivamente. Para animais saudáveis da espécie felina foram 166,25 (+/- 28,38); 126,36 (+/- 22,82) e 105,45 (+/- 21,04) respetivamente. O estudo da relação da pressão arterial com fatores que a influenciam demonstrou que na espécie canina é o peso que provoca variações no valor da pressão arterial enquanto que na espécie felina é a idade. Conclui-se que apesar deste tipo de aparelhos de medição indireta sobrevalorizarem ou subestimarem o valor real da pressão arterial, constituem uma ferramenta de trabalho importante para a obtenção de dados fiáveis acerca do animal alvo de medição...

Influence of physical exercise and sodium intake on arterial pressure and cardiac hypertrophy in rats

Santos,Bruno Mello Rodrigues dos; Gonçalves,Roberto M.; Silva,Arnaldo Alves da; Petroianu,Andy
Fonte: Faculdade de Medicina / Universidade de São Paulo - FM/USP Publicador: Faculdade de Medicina / Universidade de São Paulo - FM/USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/1999 EN
Relevância na Pesquisa
56.19%
Evidence shows that cardiac hypertrophy (CH) is a risk factor for many cardiovascular diseases. Several stimuli may cause CH-like manifestations and promote volume or pressure overload. Exercise-induced cardiac hypertrophy is an expected adaptation to regular exercise training. Salt intake has been shown to be the most important determinant of blood pressure in different populations. The purpose of the present work was to verify the influence of physical exercise and sodium intake on the blood pressure and myocardium. The study was performed on 36 rats divided into six groups: Group I (diet without salt overload), Group II (diet without salt overload and swimming), Group III (diet with 2.5% NaCl solution and swimming), Group IV (diet with 5% NaCl solution and swimming), Group V (diet with 2.5% NaCl solution without exercise), Group VI (diet with 5% NaCl solution without exercise). The arterial pressure was significantly lower in Group I when compared with Group IV. The ratio of cardiac mass/body mass was increased in Groups III and IV. In conclusion, there was evidence that exercise training and NaCl intake promotes arterial hypertension and cardiac hypertrophy.

Neural reflex regulation of arterial pressure in pathophysiological conditions: interplay among the baroreflex, the cardiopulmonary reflexes and the chemoreflex

Fonte: Associação Brasileira de Divulgação Científica Publicador: Associação Brasileira de Divulgação Científica
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/1997 EN
Relevância na Pesquisa
66.28%
The maintenance of arterial pressure at levels adequate to perfuse the tissues is a basic requirement for the constancy of the internal environment and survival. The objective of the present review was to provide information about the basic reflex mechanisms that are responsible for the moment-to-moment regulation of the cardiovascular system. We demonstrate that this control is largely provided by the action of arterial and non-arterial reflexes that detect and correct changes in arterial pressure (baroreflex), blood volume or chemical composition (mechano- and chemosensitive cardiopulmonary reflexes), and changes in blood-gas composition (chemoreceptor reflex). The importance of the integration of these cardiovascular reflexes is well understood and it is clear that processing mainly occurs in the nucleus tractus solitarii, although the mechanism is poorly understood. There are several indications that the interactions of baroreflex, chemoreflex and Bezold-Jarisch reflex inputs, and the central nervous system control the activity of autonomic preganglionic neurons through parallel afferent and efferent pathways to achieve cardiovascular homeostasis. It is surprising that so little appears in the literature about the integration of these neural reflexes in cardiovascular function. Thus...

Exercise training improves mean arterial pressure in breast cancer survivors

C. Mills,Robert; Nascimento,Marcelo G. B.; Melo,Gislane F. de; Hackney,Anthony C.; Battaglini,Claudio L.
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/2014 EN
Relevância na Pesquisa
66.08%
Currently, many breast cancer survivors worldwide live with treatment-related side effects, including cardiovascular health problems. This study examined effects of a 5-month exercise intervention on non-invasive markers of cardiovascular health in breast cancer survivors. Relationships between these markers and commonly used markers of overall health were also explored. Fifty-two survivors completed the exercise training at a rehabilitation center at the University of North Carolina at Chapel Hill between 2008-2011. A combined aerobic and resistance exercise intervention (3 times/week for 1h) at intensities progressing from low (40%) to moderate (65-70% of VO2max) for aerobic and 8-12 repetitions max for the resistance exercise were implemented. Significant reduction in mean arterial pressure (MAP) was observed from baseline to final assessment. A significant correlation was found between MAP and Body Mass Index (BMI). In conclusion, 5-months combined aerobic and resistance exercise intervention positively improved MAP which was, in part, attributed to changes in BMI.

Femoral-radial arterial pressure gradients in critically ill patients

Galluccio, S.; Chapman, M.; Finnis, M.
Fonte: Australasian Academy of Critical Care Medicine Publicador: Australasian Academy of Critical Care Medicine
Tipo: Artigo de Revista Científica
Publicado em //2009 EN
Relevância na Pesquisa
56.26%
OBJECTIVE: To investigate the presence and determinants of femoral-radial gradients in mean arterial pressure (MAP) in a critically ill population. DESIGN: Prospective observational study. SETTING AND PARTICIPANTS: Critically ill patients who were undergoing simultaneous monitoring of arterial pressure by radial arterial catheterisation and transpulmonary thermodilution (via femoral arterial access) in a Level 3, mixed medical-surgical intensive care unit, December 2007 to May 2008. MAIN OUTCOME MEASURES: Level of agreement between simultaneous measurements of MAP via the femoral and radial arteries, determined by Bland-Altman analysis; haemodynamic and demographic factors associated with a MAP gradient, assessed by multiple linear regression. RESULTS: 131 observations were made in 24 patients. Mean age of patients was 56 (SD, 18) years, and mean APACHE II score was 27 (SD, 8). Overall mean bias between radial and femoral MAP measurements was 4.27 mmHg (limits of agreement, -3.41 to 11.94 mmHg). Fifteen patients (62%) had maximum MAP gradients > 5mmHg, and seven of these (29% of the total) had maximum gradients > 10 mmHg. The largest discrepancy in MAP was 18 mmHg in a patient with septic shock resistant to high-dose catecholamine infusion. Regression analysis failed to identify any statistically significant associations between patient factors and MAP gradient. CONCLUSION: A systematic difference in MAP measured at the radial and femoral sites was demonstrated. In some critically ill patients...

Accuracy of mean arterial pressure and blood pressure measurements in predicting pre-eclampsia: systematic review and meta-analysis

Cnossen, J.; Vollebregt, K.; de Vrieze, N.; ter Riet, G.; Mol, B.; Franx, A.; Khan, K.; van der Post, J.
Fonte: British Medical Association Publicador: British Medical Association
Tipo: Artigo de Revista Científica
Publicado em //2008 EN
Relevância na Pesquisa
56.32%
Objective: To determine the accuracy of using systolic and diastolic blood pressure, mean arterial pressure, and increase of blood pressure to predict pre-eclampsia. Design: Systematic review with meta-analysis of data on test accuracy. Data sources: Medline, Embase, Cochrane Library, Medion, checking reference lists of included articles and reviews, contact with authors. Review methods: Without language restrictions, two reviewers independently selected the articles in which the accuracy of blood pressure measurement during pregnancy was evaluated to predict pre-eclampsia. Data were extracted on study characteristics, quality, and results to construct 2×2 tables. Summary receiver operating characteristic curves and likelihood ratios were generated for the various levels and their thresholds. Results: 34 studies, testing 60 599 women (3341 cases of pre-eclampsia), were included. In women at low risk for pre-eclampsia, the areas under the summary receiver operating characteristic curves for blood pressure measurement in the second trimester were 0.68 (95% confidence interval 0.64 to 0.72) for systolic blood pressure, 0.66 (0.59 to 0.72) for diastolic blood pressure, and 0.76 (0.70 to 0.82) for mean arterial pressure. Findings for the first trimester showed a similar pattern. Second trimester mean arterial pressure of 90 mm Hg or more showed a positive likelihood ratio of 3.5 (95% confidence interval 2.0 to 5.0) and a negative likelihood ratio of 0.46 (0.16 to 0.75). In women deemed to be at high risk...

Presión arterial: ¿esfigmomanómetro manual o digital?; Arterial pressure: manual or digital sphygmomanometer?

Martínez Ramos, S.; Roselló Hervás, M.; Valle Morales, R.; Gámez García, M.J.; Jaen Cervera, R.
Fonte: Murcia : Servicio de Publicaciones de la Universidad de Murcia Publicador: Murcia : Servicio de Publicaciones de la Universidad de Murcia
Tipo: Artigo de Revista Científica Formato: application/pdf
SPA
Relevância na Pesquisa
66.25%
El presente es un estudio prospectivo y comparativo entre la medición de la presión arterial obtenida de manera manual con esfigmomanómetro aneroide y la obtenida mediante monitor automático. El desarrollo de la práctica se realizó sobre un grupo de 100 pacientes hospitalizados en el servicio de Neurocirugía y Otorrinolaringología del Consorcio Hospital General de Valencia durante el primer trimestre del año 2007, mediante mediciones secuenciales y efectuadas por el mismo observador con ambos aparatos bien calibrados. Se observó mediante el método de correlación bivariada de Pearson que no existen diferencias estadísticamente significativas entre las presiones tomadas por ambos aparatos determinando así la fiabilidad del aparato automático utilizado en esta sala para el registro de la tensión arterial.; SUMMARY This is a prospective and comparative work between arterial pressure obtained through manual measurement with aneroid sphygmomanometer and the arterial pressure obtained through automatic monitor. The practice was carried out in a group of 100 inpatients in the Neurosurgery and Otolaryngology Service in the Consortium of the General Hospital of Valencia during the first term of 2007. The development of this hospital training was made on each individual through sequential measurements and executed by the same observer with both well-calibrated machines.

Evidence Linking Alterations in the Moment-to-Moment Pressure-Natriuresis Mechanism to Hypertension and Salt-Sensitivity in Rodents

Komolova, Marina
Fonte: Quens University Publicador: Quens University
Tipo: Tese de Doutorado
EN; EN
Relevância na Pesquisa
56.21%
Hypertension and salt-sensitivity are independent risk factors for cardiovascular disease. Although both conditions are idiopathic, they develop due to a complex interplay between susceptibility genes and environmental factors. Given that the kidney plays an important role in regulating blood pressure, in particular, by maintaining sodium and water balance via pressure-natriuresis, it is not surprising that disturbances in the proper functioning of this intrarenal mechanism have been linked to these conditions. Although direct coupling of changes in renal arterial pressure (RAP) to renal interstitial hydrostatic pressure (RIHP) and consequent sodium excretion is well established, few studies have characterized the moment-to-moment aspects of this process. Thus, the main focus of the research presented herein was to characterize the moment-to-moment RAP-RIHP relationship, and assess the functioning of this intrarenal mechanism in various animal models of genetic and environmentally-induced hypertension and/or salt-sensitivity. In adult normotensive rats, the response time of RIHP to acute changes in RAP was rapid (<2 seconds), and the moment-to-moment RAP-RIHP relationship was linear over a wide range of pressures. Additionally...

Control of arterial pressure in aquatic sea snakes

Lillywhite, H.; Pough, F. Harvey
Fonte: American Physiological Society: American Journal of Physiology – Regulatory, Integrative, and Comparative Physiology Publicador: American Physiological Society: American Journal of Physiology – Regulatory, Integrative, and Comparative Physiology
Tipo: Artigo de Revista Científica Formato: 37531 bytes; application/pdf
EN_US
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Cardiovascular responses to head-up tilt, acutely graded hemorrhage, and pharmacologic stimulation by principal autonomic drugs were studied in four species of marine snakes, principally Aipysurus laevis (family Hydrophiidae). Arterial pressure varied inversely with tilt angle and blood volume deficit in conscious snakes outside of water, indicating that physiological regulation was poor or lacking. Calculated arterial pressures at head level typically diminished to zero in A. laevis tilted to angles greater than or equal to 30 degrees. Arterial pressure (corrected for external water pressure) did not change when these snakes were tilted in seawater. Changes of arterial pressure induced by tilt, blood loss, or autonomic drugs elicited reflex adjustments in heart activity, but the magnitude of these responses was less than that observed in terrestrial species of snake. It is concluded that baroreflexes are present but comparatively ineffective in sea snakes. Snakes tolerated large losses of blood volume, and extravascular fluids were absorbed into the circulation during hemorrhage; both hemorrhage and estimated hemodilution volumes exceeded 100% of the initial blood volume in Acalyptophis peronii. Thus, in marine snakes major fluid shifts between nonvascular and vascular compartments significantly compensate hypovolemia but...

Influência de exercícios físicos e do cloreto de sódio na pressão arterial e hipertrofia cardíaca nos ratos; Influence of physical exercise and sodium intake on arterial pressure and cardiac hypertrophy in rats

Santos, Bruno Mello Rodrigues dos; Gonçalves, Roberto M.; Silva, Arnaldo Alves da; Petroianu, Andy
Fonte: Universidade de São Paulo. Faculdade de Medicina Publicador: Universidade de São Paulo. Faculdade de Medicina
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; Formato: application/pdf
Publicado em 01/08/1999 ENG
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Evidence shows that cardiac hypertrophy (CH) is a risk factor for many cardiovascular diseases. Several stimuli may cause CH-like manifestations and promote volume or pressure overload. Exercise-induced cardiac hypertrophy is an expected adaptation to regular exercise training. Salt intake has been shown to be the most important determinant of blood pressure in different populations. The purpose of the present work was to verify the influence of physical exercise and sodium intake on the blood pressure and myocardium. The study was performed on 36 rats divided into six groups: Group I (diet without salt overload), Group II (diet without salt overload and swimming), Group III (diet with 2.5% NaCl solution and swimming), Group IV (diet with 5% NaCl solution and swimming), Group V (diet with 2.5% NaCl solution without exercise), Group VI (diet with 5% NaCl solution without exercise). The arterial pressure was significantly lower in Group I when compared with Group IV. The ratio of cardiac mass/body mass was increased in Groups III and IV. In conclusion, there was evidence that exercise training and NaCl intake promotes arterial hypertension and cardiac hypertrophy.; Há evidências de que a hipertrofia cardíaca (HC) seja um fator de risco para várias doenças cardiovasculares. Uma variedade de estímulos pode levar à HC...