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A review of low-level air pollution and adverse effects on human health: implications for epidemiological studies and public policy

OLMO, Neide Regina Simoes; SALDIVA, Paulo Hilário do Nascimento; BRAGA, Alfésio Luís Ferreira; LIN, Chin An; SANTOS, Ubiratan de Paula; PEREIRA, Luiz Alberto Amador
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
66.04%
The aim of this study was to review original scientific articles describing the relationship between atmospheric pollution and damage to human health. We also aimed to determine which of these studies mentioned public policy issues. Original articles relating to atmospheric pollution and human health published between 1995 and 2009 were retrieved from the PubMed database and analyzed. This study included only articles dealing with atmospheric pollutants resulting primarily from vehicle emissions. Three researchers were involved in the final selection of the studies, and the chosen articles were approved by at least two of the three researchers. Of the 84 non-Brazilian studies analyzed, 80 showed an association between atmospheric pollution and adverse effects on human health. Moreover, 66 showed evidence of adverse effects on human health, even at levels below the permitted emission standards. Three studies mentioned public policies aimed at changing emission standards. Similarly, the 29 selected Brazilian studies reported adverse associations with human health, and 27 showed evidence of adverse effects even at levels below the legally permitted emission standards. Of these studies, 16 mentioned public policies aimed at changing emission standards. Based on the Brazilian and non-Brazilian scientific studies that have been conducted...

Association of a probiotic to a Helicobacter pylori eradication regimen does not increase efficacy or decreases the adverse effects of the treatment: a prospective, randomized, double-blind, placebo-controlled study

Navarro-Rodriguez, Tomás ; Silva, Fernando Marcuz ; Barbuti, Ricardo Correa ; Mattar, Rejane ; Moraes Filho, Joaquim Prado Pinto de; Oliveira, Marice Nogueira de; Bogsan, Cristina Stewart Bittencourt; Chinzon, Décio ; Eisig, Jaime Natan 
Fonte: London Publicador: London
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
66.1%
Abstract Background The treatment for the eradication of Helicobacter pylori (H. pylori) is complex; full effectiveness is rarely achieved and it has many adverse effects. In developing countries, increased resistance to antibiotics and its cost make eradication more difficult. Probiotics can reduce adverse effects and improve the infection treatment efficacy. If the first-line therapy fails a second-line treatment using tetracycline, furazolidone and proton-pump inhibitors has been effective and low cost in Brazil; however it implies in a lot of adverse effects. The aim of this study was to minimize the adverse effects and increase the eradication rate applying the association of a probiotic compound to second-line therapy regimen. Methods Patients with peptic ulcer or functional dyspepsia infected by H. pylori were randomized to treatment with the furazolidone, tetracycline and lansoprazole regimen, twice a day for 7 days. In a double-blind study, patients received placebo or a probiotic compound (Lactobacillus acidophilus...

Efeitos adversos na saúde de cirurgiões-dentistas e suas correlações com o uso de equipamentos motores; Adverse effects on dental surgeons? health and its correlations with motor equipment use

Sebastião, Bárbara Aparecida
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 13/04/2007 PT
Relevância na Pesquisa
66%
O objetivo desta pesquisa foi identificar os efeitos adversos relatados por cirurgiões-dentistas (CD) e correlacioná-los com o uso de equipamentos motores. Trata-se de um estudo seccional, não experimental com análise quantitativa dos dados. O estudo foi realizado com 247 CD de Ribeirão Preto-SP. Na coleta dos dados, foi utilizado um questionário auto-aplicável composto por questões agrupadas em: questões sócio-demográficas, relativas a efeitos adversos (musculoesqueléticos, nervosos e vasculares), prática profissional e questões sobre o uso de equipamentos motores. Os dados foram analisados por meio de medidas de distribuição (freqüência), análise bivariada (Teste qui-quadrado e Exato de Fisher) e análise multivariável (Regressão logística). Os efeitos indesejáveis relatados pelos sujeitos e considerados mais intoleráveis foram: dor (67,65%), limitação de amplitude de movimento (7,84%) e parestesia / formigamento (6,86%). As regiões do corpo mais acometidas foram: pescoço, ombros e membros superiores direitos, perfazendo 76,8% das queixas. Os preditores estatisticamente significativos para os efeitos indesejáveis relatados em mãos foram sexo (RC = 0,513, p = 0,056) e pausa entre os atendimentos (RC = 0...

Evaluation of the adverse effects of subcutaneous carprofen over six days in healthy cats

Steagall, P. V. M.; Moutinho, Flavio Quaresma; Mantovani, F. B.; Passarelli, D.; Thomassian, A.
Fonte: Elsevier B.V. Publicador: Elsevier B.V.
Tipo: Artigo de Revista Científica Formato: 115-120
ENG
Relevância na Pesquisa
65.97%
This study evaluated the adverse effects of carprofen in seven healthy cats. Values for CBC, biochemical profiles and platelet aggregation were measured before and at seven days after SID treatment with subcutaneous carprofen: 4 mg/kg (day 1), 2 mg/kg (day 2 and 3) and 1 mg/kg (day 4 and 6) (CG) or 0.35 ml of saline (SG) for six days in a randomized, blinded, cross-over study with a four-week washout period. No treatment was given on day 5. Endoscopy of the GI tract was performed pre-treatment and on day 7 post-treatment. There were no significant changes in hematological profiles, biochemical profiles and endoscopy grading scores within nor between groups, except for lower albumin values at baseline than on day 7 (CG), and globulin and ALP values were higher at baseline than on day 7 in CG and SG. SC administration of carprofen over six days did not cause any adverse effects on gastrointestinal, hematological, or serum biochemical variables. (c) 2008 Elsevier Ltd. All rights reserved.

Ocular surface adverse effects of ambient levels of air pollution

Torricelli,André Augusto Miranda; Novaes,Priscila; Matsuda,Monique; Alves,Milton Ruiz; Monteiro,Mário Luiz Ribeiro
Fonte: Conselho Brasileiro de Oftalmologia Publicador: Conselho Brasileiro de Oftalmologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2011 EN
Relevância na Pesquisa
66.01%
It is widely recognized today that outdoor air pollution can affect human health. Various chemical components that are present in ambient pollution may have an irritant effect on the mucous membranes of the body, particularly those of the respiratory tract. Much less attention has been focused on the adverse effect on the ocular surface, despite the fact that this structure is even more exposed to air pollution than the respiratory mucosa since only a very thin tear film separates the corneal and conjunctival epithelia from the air pollutants. So far, clinical data are the more widespread tools used by ophthalmologists for assessing possible aggression to the ocular surface; however, clinical findings alone appears not to correlate properly with the complaints presented by the patients pointing out the need for further clinical and laboratory studies on the subject. The purpose of this study is to review signs and symptoms associated with chronic long-term exposure to environmental air pollutants on the ocular structures currently defined as the ocular surface and to review clinical and laboratory tests used to investigate the adverse effects of air pollutants on such structures. We also review previous studies that investigated the adverse effects of air pollution on the ocular surface and discuss the need for further investigation on the subject.

Comparative evaluation of adverse effects in the use of powder trivalent antivenom and liquid antivenoms in Bothrops snake bites

Silva,Iran Mendonça da; Tavares,Antônio Magela
Fonte: Sociedade Brasileira de Medicina Tropical - SBMT Publicador: Sociedade Brasileira de Medicina Tropical - SBMT
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2012 EN
Relevância na Pesquisa
65.97%
INTRODUCTION: Snake bite, a problem in public health, generally occurs where there is no electric power. METHODS: A comparative clinical study was conducted with 102 victims of Bothrops snake bite, from the state of Amazonas, Brazil; 58 victims were treated with liofilizated trivalent antivenom serum (SATL) and 44 victims treated with liquid bivalent and monovalent antivenom serum (SAMBL). RESULTS: 17% (10/58) of patients presented adverse effects with the SATL and 25% (11/44) with the SAMBL. CONCLUSIONS: There was no statistic difference in number of adverse effects between the two types of snake bite antivenom.

Intradermal vaccination of adults with three low doses (2 µg) of recombinant hepatitis B vaccine. I. Seroconversion rate and adverse effects

Baldy,José Luís da S; Elisbão,Maria do Carmo M; Anzai,Edson T; Pontello,Rubens; Reiche,Edna Maria V; Zaha-Inouye,Marta M; Matsuo,Tiemi; Tonani,Pedro CF; Ferelle,Antônio; Henriques,João N; Neves,Jayme
Fonte: Instituto Oswaldo Cruz, Ministério da Saúde Publicador: Instituto Oswaldo Cruz, Ministério da Saúde
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2003 EN
Relevância na Pesquisa
65.97%
A total of 250 dentists (53.6% men and 46.4% women), with a mean age of 35.1 ± 9.8 years, were submitted to serological tests for the diagnosis of hepatitis B (HB) - HBsAg, anti-HBs, anti-HBc, HBeAg, and anti-HBe - using a radioimmunoassay. One or more of these markers were detected in 78 individuals (31.2%) who were excluded from the group to be vaccinated. Of the 172 HB-susceptible individuals, 135 (78.5%) responded to the call and were intradermally injected with three 2 µg doses of the Belgian HB recombinant vaccine, applied at an interval of one month between the 1st and 2nd dose and of five months between the 2nd and 3rd dose. A new determination of HB markers carried out 50 days after the 3rd dose showed that 110 (81.5%) individuals had become anti-HBs positive (65.5% good responders and 34.5% poor responders). Mean serum anti-HBs titer of these 110 dentists was 42.4 U S/N, similar in both sexes. The adverse effects analyzed in 106 dentists were: (a) local: pain (12.3%), burning sensation (14.1%), pruritus (25.5%), erythema (28.3%), local heat (18.9%), and a hypochromic spot (32.1%); (b) systemic (4.7%): discomfort in two patients, and fever, anorexia, and asthenia in one patient each. Intradermal administration of a fourth 2 µg vaccine dose to 39 dentists (poor or non-responders) increased the total number of anti-HBs-positive individuals from 110 (81.5%) to 114 (84.4%)...

Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects

Gonçalves,Heitor de Sá; Pontes,Maria Araci de Andrade; Bührer-Sékula,Samira; Cruz,Rossilene; Almeida,Paulo Cesar; Moraes,Maria Elisabete Amaral de; Penna,Gerson Oliveira
Fonte: Instituto Oswaldo Cruz, Ministério da Saúde Publicador: Instituto Oswaldo Cruz, Ministério da Saúde
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2012 EN
Relevância na Pesquisa
65.99%
This study sought to verify the correlation between leprosy types and the adverse effects of treatment drugs. This quantitative, prospective, nested study was developed at the Dona Libânia Dermatology Centre in Fortaleza, Brazil. Data were collected from November 2007-November 2008. During this period, 818 leprosy patients were diagnosed and began treatment. Forty patients with tuberculoid leprosy (TT) were selected. Twenty patients followed a standard therapy of dapsone and rifampicin and 20 were administered dapsone, rifampicin and clofazimine (U-MDT). Twenty patients with borderline lepromatous (BL) and lepromatous leprosy (LL) were also selected and treated with U-MDT. All of the subjects received six doses. With the exception of haemolytic anaemia, there was a low incidence of adverse effects in all the groups. We did not observe any differences in the incidence of haemolytic anaemia or other side effects across groups of patients with TT, BL or LL treated with U-MDT.

Adverse effects of vancomycin in children: a review of 22 cases

Reis,Amélia Gorete Afonso da Costa; Grisi,Sandra Josefina Ferraz Ellero
Fonte: Associação Paulista de Medicina - APM Publicador: Associação Paulista de Medicina - APM
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/1997 EN
Relevância na Pesquisa
65.97%
Vancomycin has been frequently recommended for the treatment of multi-resistant infections.Twenty-two children undergoing vancomycin treatment were observed. Nine adverse effects were registered in 6 children: eosinophilia in 5 cases, skin rash in 2 cases, and an increase in plasma creatinine in 2 cases. All adverse effects remitted with withdrawal of the drug.

Adherence to treatment in patients with juvenile myoclonic epilepsy: correlation with quality of life and adverse effects of medication

Martins,Heloise Helena; Alonso,Neide Barreira; Guilhoto,Laura Maria F. Ferreira; Guaranha,Mirian S. Bittar; Yacubian,Elza Márcia Targas
Fonte: Liga Brasileira de Epilepsia (LBE) Publicador: Liga Brasileira de Epilepsia (LBE)
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2009 EN
Relevância na Pesquisa
66.07%
PURPOSE: To study the adherence to clinical treatment in patients with Juvenile Myoclonic Epilepsy (JME) and its correlation to Quality of Life (QOL) scores, and antiepileptic drugs (AEDs) adverse effects. METHODS: Forty-three JME (ILAE,1989) outpatients in regular treatment were evaluated by clinical anamnesis and EEG/video-EEG at Hospital São Paulo, UNIFESP, Brazil. They answered a self-report questionnaire assessing adherence to treatment (scores 0 to 100), with higher scores meaning poorer adherence; Quality of Life in Epilepsy-31 (QOLIE-31) Brazilian validated version (scores 0 to 100), and the Adverse Events Profile (AEP), scores 19 to 76, in which scores ≥45 indicate toxicity; values less than 0.05 were considered statistically significant. RESULTS: Sixteen patients (37,2%) were on monotherapy, while 26 (60.4%) on polytherapy. Twenty-two (48%) had experienced a seizure in the preceding three months of the survey. Mean adherence to treatment score was 68.5. AEP scores ≤45 were observed in 38 (88.3%), and 29 (67.4%) reported spontaneous adverse effects with AEDs. The most common adverse effects were sleepiness in 11(13.8%), and restlessness in 7(8.8%).QOLIE-31 highest mean score was 79.0 (Social Function), and the lowest 33.0 (Seizure Worry). Adherence to treatment presented good correlation to better QOL scores (Pearson<0.05)...

Influence of total face, facial and nasal masks on short-term adverse effects during noninvasive ventilation

Holanda,Marcelo Alcantara; Reis,Ricardo Coelho; Winkeler,Georgia Freire Paiva; Fortaleza,Simone Castelo Branco; Lima,José Wellington de Oliveira; Pereira,Eanes Delgado Barros
Fonte: Sociedade Brasileira de Pneumologia e Tisiologia Publicador: Sociedade Brasileira de Pneumologia e Tisiologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/02/2009 EN
Relevância na Pesquisa
66.08%
OBJECTIVE: Failure of noninvasive ventilation (NIV) has been associated with short-term adverse effects related to the use of masks. The aim of this study was to compare the incidence, type and intensity of adverse effects, as well as the comfort, of total face masks (TFMs), facial masks (FMs) and nasal masks (NMs) during NIV. METHODS: This was a randomized crossover trial involving 24 healthy volunteers submitted to six sessions of NIV in bilevel positive airway pressure mode using the TFM, FM and NM masks at low and moderate-to-high pressure levels. A written questionnaire was applied in order to evaluate eleven specific adverse effects related to the use of the masks. Comfort was assessed using a visual analog scale. The CO2 exhaled into the ventilator circuit was measured between the mask and the exhalation port. RESULTS: The performance of the TFM was similar to that of the NM and FM in terms of comfort scores. Higher pressure levels reduced comfort and increased adverse effects, regardless of the mask type. When the TFM was used, there were fewer air leaks and less pain at the nose bridge, although there was greater oronasal dryness and claustrophobia. Air leaks were most pronounced when the FM was used. The partial pressure of exhaled CO2 entering the ventilator circuit was zero for the TFM. CONCLUSIONS: The short-term adverse effects caused by NIV interfaces are related to mask type and pressure settings. The TFM is a reliable alternative to the NM and FM. Rebreathing of CO2 from the circuit is less likely to occur when a TFM is used.

A review of low-level air pollution and adverse effects on human health: implications for epidemiological studies and public policy

Olmo,Neide Regina Simoes; Saldiva,Paulo Hilário do Nascimento; Braga,Alfésio Luís Ferreira; Lin,Chin An; Santos,Ubiratan de Paula; Pereira,Luiz Alberto Amador
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2011 EN
Relevância na Pesquisa
66.04%
The aim of this study was to review original scientific articles describing the relationship between atmospheric pollution and damage to human health. We also aimed to determine which of these studies mentioned public policy issues. Original articles relating to atmospheric pollution and human health published between 1995 and 2009 were retrieved from the PubMed database and analyzed. This study included only articles dealing with atmospheric pollutants resulting primarily from vehicle emissions. Three researchers were involved in the final selection of the studies, and the chosen articles were approved by at least two of the three researchers. Of the 84 non-Brazilian studies analyzed, 80 showed an association between atmospheric pollution and adverse effects on human health. Moreover, 66 showed evidence of adverse effects on human health, even at levels below the permitted emission standards. Three studies mentioned public policies aimed at changing emission standards. Similarly, the 29 selected Brazilian studies reported adverse associations with human health, and 27 showed evidence of adverse effects even at levels below the legally permitted emission standards. Of these studies, 16 mentioned public policies aimed at changing emission standards. Based on the Brazilian and non-Brazilian scientific studies that have been conducted...

Beta-carotene: functions, health benefits, adverse effects and applications.

CARVALHO, L. M. J.; ORTIZ, D.-G.; RIBEIRO, E. M. G.; SMIDERLE, L.; PEREIRA, E. J.; CARVALHO, J. L. V.
Fonte: In: LEFEVRE, M. (Ed.). Beta-carotene: functions, health benefits and adverse effects. New York: Nova Biomedical, 2013. cap. 3, p. 59-79. Publicador: In: LEFEVRE, M. (Ed.). Beta-carotene: functions, health benefits and adverse effects. New York: Nova Biomedical, 2013. cap. 3, p. 59-79.
Tipo: Capítulo em livro técnico-científico (ALICE)
EN
Relevância na Pesquisa
65.9%
The purpose of this chapter is to review the main functions, benefits and possible adverse effects of beta-carotene on human health and its applications in food.; 2013

Adverse effects of small-volume red blood cell transfusions in the neonatal population

Keir, A.; Pal, S.; Trivella, M.; Lieberman, L.; Callum, J.; Shehata, N.; Stanworth, S.
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Publicado em //2014 EN
Relevância na Pesquisa
66.06%
BACKGROUND: Adverse transfusion reactions in the neonatal population are poorly understood and defined. The incidence and pattern of adverse effects due to red blood cell (RBC) transfusion are not well known, and there has been no systematic review of published adverse events. RBC transfusions continue to be linked to the development of morbidities unique to neonates, including chronic lung disease, retinopathy of prematurity, intraventricular haemorrhage and necrotising enterocolitis. Uncertainties about the exact nature of risks alongside benefits of RBC transfusion may contribute to evidence of widespread variation in neonatal RBC transfusion practice.Our review aims to describe clinical adverse effects attributed to small-volume (10-20 mL/kg) RBC transfusions and, where possible, their incidence rates in the neonatal population through the systematic identification of all relevant studies. METHODS: A comprehensive search of the following bibliographic databases will be performed: MEDLINE (PubMed/OVID which includes the Cochrane Library) and EMBASE (OVID). The intervention of interest is small-volume (10-20 mL/kg) RBC transfusions in the neonatal population.We will undertake a narrative synthesis of the evidence. If clinical similarity and data quantity and quality permit...

Untersuchung zu unerwünschten Arzneimittelwirkungen von Metoprolol in Abhängigkeit vom CYP2D6-Genotyp bei ambulanten Patienten; Impact of CYP2D6 genotype on adverse effects during treatment with metoprolol: A prospective clinical trial

Pröhmer, Anne Marie Theres
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
DE_DE
Relevância na Pesquisa
66.07%
Diese prospektive klinische Studie wurde mit dem Ziel durchgeführt, den Einfluss des polymorph exprimierten Cytochrom P450 (CYP) 2D6 auf erwünschte und unerwünschte Wirkungen von Metoprolol in einem ambulanten Setting zu untersuchen. Die mittels eines Tagebuchs abgefragten unerwünschten Arzneimittelwirkungen (UAW) umfassten zentralnervöse und kardiovaskuläre Beschwerden, die sexuelle Funktion und Lebensqualität des Patienten, sowie zusätzlich bei den Patienten mit diagnostizierter Psoriasis vulgaris den Krankheitsverlauf unter der Metoprolol-Therapie. In diese sechswöchige Multicenterstudie wurden Patienten eingeschlossen, bei denen erstmalig die Indikation zur Durchführung einer Therapie mit Metoprolol gestellt wurde. Die Dosierung von Metoprolol war durch den behandelnden Arzt nach Indikation und Schweregrad der Symptomatik frei wählbar. In über 90 % der Fälle war eine arterielle Hypertonie die Indikation zur Therapie mit Metoprolol. Vor und während der Metoprolol-Behandlung wurden Blutdruck und Ruheherzfrequenz gemessen. Einmalig während der Behandlung wurde die Plasmakonzentration von Metoprolol und alpha-Hydroxymetoprolol bestimmt. Mögliche unerwünschte Arzneimittelwirkungen wurden systematisch anhand von standardisierten Fragebögen über den Zeitraum von sechs Wochen erfasst. Die CYP2D6-Genotypisierung umfasste die Bestimmung der Allele *3 bis *10 und *41 sowie der Genduplikationen. Die Studienpopulation setzte sich aus 121 Kaukasiern beiderlei Geschlechts zusammen. Darunter befanden sich 5 Ultrarapid Metabolizer (UM...

CYP2B6∗6 allele and age substantially reduce steady-state ketamine clearance in chronic pain patients: impact on adverse effects

Li, Y.; Jackson, K.A.; Slon, B.; Hardy, J.R.; Franco, M.; William, L.; Poon, P.; Coller, J.K.; Hutchinson, M.R.; Currow, D.C.; Somogyi, A.A.
Fonte: Wiley Publicador: Wiley
Tipo: Artigo de Revista Científica
Publicado em //2015 EN
Relevância na Pesquisa
66.02%
AIMS: Ketamine analgesia is limited by low intrinsic efficacy compounded by large interindividual variability in drug responses, possibly due to the heterogeneity in drug concentration. The CYP2B6*6 allele is associated with substantially reduced ketamine metabolism in vitro and, therefore, may affect ketamine clearance. Our aims were to examine the impact of the CYP2B6*6 allele on ketamine plasma clearance and on adverse effects in chronic pain patients. METHODS: CYP2B6 genotypes were identified in 49 chronic pain patients who received 24 h continuous subcutaneous infusions of ketamine. Steady-state plasma concentrations of ketamine (Css,k ) and norketamine (Css,nk ) were determined using HPLC. RESULTS: The median plasma clearance of ketamine after 100 mg 24 h(-1) dose was significantly lower in patients with the CYP2B6*6/*6 (21.6 l h(-1) ) and CYP2B6*1/*6 (40.6 l h(-1) ) genotypes compared with patients with the CYP2B6*1/*1 genotype (68.1 l h(-1) , P < 0.001). The ketamine : norketamine plasma metabolic ratio was significantly higher in patients with the CYP2B6*6/*6 genotype than in those with the CYP2B6*1/*6 and the CYP2B6*1/*1 genotypes (P < 0.001). Patients who experienced adverse effects had lower plasma clearance (45.6 l h(-1) ) than those who did not (52.6 l h(-1) ...

Maternal adverse effects of different antenatal magnesium sulphate regimens for improving maternal and infant outcomes: a systematic review

Bain, E.; Middleton, P.; Crowther, C.
Fonte: BioMed Central Ltd. Publicador: BioMed Central Ltd.
Tipo: Artigo de Revista Científica
Publicado em //2013 EN
Relevância na Pesquisa
56.16%
Background: Antenatal magnesium sulphate, widely used in obstetrics to improve maternal and infant outcomes, may be associated with adverse effects for the mother sufficient for treatment cessation. This systematic review aimed to quantify maternal adverse effects attributed to treatment, assess how adverse effects vary according to different regimens, and explore women’s experiences with this treatment. Methods: Bibliographic databases were searched from their inceptions to July 2012 for studies of any design that reported on maternal adverse effects associated with antenatal magnesium sulphate given to improve maternal or infant outcomes. Primary outcomes were life-threatening adverse effects of treatment (death, cardiac arrest, respiratory arrest). For randomised controlled trials, data were meta-analysed, and risk ratios (RR) pooled using fixed-effects or random-effects models. For non-randomised studies, data were tabulated by design, and presented as RR, odds ratios or percentages, and summarised narratively. Results: A total of 143 publications were included (21 randomised trials, 15 non-randomised comparative studies, 32 case series and 75 reports of individual cases), of mixed methodological quality. Compared with placebo or no treatment...

Efeitos adversos associados à aplicação de toxina botulínica na face: revisão sistemática com meta-análise; Adverse effects associated with facial application of botulinum toxin: a systematic review with meta-analysis

ZAGUI, Roberta Melissa Benetti; MATAYOSHI, Suzana; MOURA, Frederico Castelo
Fonte: Conselho Brasileiro de Oftalmologia Publicador: Conselho Brasileiro de Oftalmologia
Tipo: Artigo de Revista Científica
POR
Relevância na Pesquisa
66.12%
OBJETIVO: Verificar a ocorrência dos efeitos adversos relacionados ao uso da toxina botulínica na face, por meio de revisão sistemática, usando meta-análise. MÉTODOS: Foi realizada pesquisa eletrônica de artigos publicados no MEDLINE e Cochrane Library até setembro de 2007. A ocorrência dos efeitos adversos foi verificada pela freqüência relativa para os relatos de casos e do risco relativo para os estudos randomizados. A heterogeneidade foi avaliada pelo teste Q e pelo índice I². Foi utilizado o teste de significância de Egger para identificar viés de publicação e a análise de sensibilidade para verificar o efeito dos viéses de publicação. RESULTADOS: Oito estudos randomizados e treze relatos de casos preencheram os critérios de inclusão. Na revisão sistemática dos relatos de casos, 1.003 pacientes foram estudados, dos quais 182 (18,14%) apresentaram efeitos adversos. O efeito adverso mais freqüente foi a ptose palpebral ocorrendo em 34 (3,39%) pacientes dos relatos de casos. Na meta-análise dos estudos randomizados, o risco relativo global para os efeitos adversos como cefaléia, ptose palpebral, reação local e infecção foi 1,07, 3,25, 0,99 e 0,94, respectivamente. Para todas as comparações, o valor de P foi maior que 0...

A review of low-level air pollution and adverse effects on human health: implications for epidemiological studies and public policy

Olmo, Neide Regina Simoes; Saldiva, Paulo Hilário do Nascimento; Braga, Alfésio Luís Ferreira; Lin, Chin An; Santos, Ubiratan de Paula; Pereira, Luiz Alberto Amador
Fonte: Universidade de São Paulo. Faculdade de Medicina Publicador: Universidade de São Paulo. Faculdade de Medicina
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; Formato: application/pdf
Publicado em 01/01/2011 ENG
Relevância na Pesquisa
66.04%
The aim of this study was to review original scientific articles describing the relationship between atmospheric pollution and damage to human health. We also aimed to determine which of these studies mentioned public policy issues. Original articles relating to atmospheric pollution and human health published between 1995 and 2009 were retrieved from the PubMed database and analyzed. This study included only articles dealing with atmospheric pollutants resulting primarily from vehicle emissions. Three researchers were involved in the final selection of the studies, and the chosen articles were approved by at least two of the three researchers. Of the 84 non-Brazilian studies analyzed, 80 showed an association between atmospheric pollution and adverse effects on human health. Moreover, 66 showed evidence of adverse effects on human health, even at levels below the permitted emission standards. Three studies mentioned public policies aimed at changing emission standards. Similarly, the 29 selected Brazilian studies reported adverse associations with human health, and 27 showed evidence of adverse effects even at levels below the legally permitted emission standards. Of these studies, 16 mentioned public policies aimed at changing emission standards. Based on the Brazilian and non-Brazilian scientific studies that have been conducted...

Supplementation prevalence and adverse effects in physical exercise practitioners

Valeriano da Silva,Walkiria; Andrade Gomes Silva,Maria Irene de; Tavares Toscano,Luciana; Dantas de Oliveira,Klébya Hellen; Mateus de Lacerda,Lavoisiana; Sérgio Silva,Alexandre
Fonte: Nutrición Hospitalaria Publicador: Nutrición Hospitalaria
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/01/2014 ENG
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Introduction: The use of nutritional supplements is prevalent among physical exercise practitioners and some adverse effects have been reported, however not sufficiently substantial, because they originate from isolated cases. Objectives: Investigate nutritional supplements consumption prevalence and adverse effects of the use of such products. Methods: An epidemiological, representative and transversal study, with 180 physical exercise practitioners in gyms, who answered questionnaires about sports supplementation, associated factors and self-perceived adverse effects. In a subsample of 86 individuals, blood pressure was measured and blood was collected for the evaluation of lipid profile markers, hepatic and renal function. Results: The supplementation prevalence level was 58.3%, whereas the physicians and nutritionists indicated only 21.9%. The reported adverse effects were observed only by supplement users (acne, insomnia, aggressiveness, headaches and tachycardia). Systolic blood pressure was higher in the supplemented group when compared to the control group (p = 0.04), as in the subgroup of thermogenic users (p < 0.0001) and among those who had consumed any type of supplementation for over 2 years (p = 0.005). Serum creatinine levels were higher only in the subgroup of carbohydrates when compared to the control group (p = 0.03). Diastolic blood pressure...