Página 1 dos resultados de 1573 itens digitais encontrados em 0.010 segundos

DEON, Keila Cristiane; SANTOS, Danielle Maria de Souza Sério dos; REIS, Roberta Alvarenga; FEGADOLLI, Claudia; BULLINGER, Monika; SANTOS, Claudia Benedita dos
Tipo: Artigo de Revista Científica
POR
Relevância na Pesquisa
27.23%

## Concordância e confiabilidade de dois métodos não-invasivos para a avaliação da amplitude de movimento cervical em adultos jovens; Agreement and reliability of two non-invasive methods for assessing cervical range of motion among young adults

FLORÊNCIO, Lidiane L.; PEREIRA, Patrícia A.; SILVA, Elaine R. T.; PEGORETTI, Kátia S.; GONÇALVES, Maria C.; BEVILAQUA-GROSSI, Débora
Fonte: Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia Publicador: Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia
Tipo: Artigo de Revista Científica
POR
Relevância na Pesquisa
27.06%

Deon, Keila Cristiane; Santos, Danielle Maria de Souza Sério dos; Reis, Roberta Alvarenga; Fegadolli, Claudia; Bullinger, Monika; Santos, Cláudia Benedita dos
Tipo: Artigo de Revista Científica Formato: application/pdf
POR
Relevância na Pesquisa
27.23%

## Avaliação goniométrica da amplitude de movimento do ombro de crianças praticantes de beisebol

Miyasava, Hugo Yudi; Navega, Marcelo Tavella
Tipo: Artigo de Revista Científica Formato: 114-120
POR
Relevância na Pesquisa
27.06%
Introduction: Baseball is a Sport disputed by two teams composed at least by nine players which compete between themselves in a game of six innings in the amateur game, for children up to 10 years old. Objective: The objective is to compare the movement degrees of the shoulder joint between the dominant and the non dominant shoulder. Methods: Eleven male subjects were assessed (8,63 ± 0,67 years old) whom practiced baseball at the Nikkey Club of the city of Marília – SP. All of the subjects were assessed by the same examiner, whom measured the range of motion (ROM) of both glenohumeral joint. The Student t test was used for the comparison of the shoulders, with level of significance of 5% (p≤0,05). Results: The subjects presented significant differences on the external rotation movement (p= 0,014) between the dominant shoulder (63,63 ± 12,92°) and the non dominant shoulder (55,45 ± 16,27°), and in the internal rotation movement (p= 0,001) between the dominant shoulder (32,90 ± 5,68°) and the non dominant shoulder (40,72 ± 5,74°). Conclusion: The results obtained in this study, on the experimental conditions utilized, allow us to conclude that the practice of baseball influence the range of motion of external rotation and internal rotation of the dominant shoulder...

Souza,Susane Petinelli
Fonte: Fundação Getulio Vargas, Escola de Administração de Empresas de S.Paulo Publicador: Fundação Getulio Vargas, Escola de Administração de Empresas de S.Paulo
Tipo: Artigo de Revista Científica Formato: text/html
Relevância na Pesquisa
36.91%

## ADM-1, a protein with metalloprotease- and disintegrin-like domains, is expressed in syncytial organs, sperm, and sheath cells of sensory organs in Caenorhabditis elegans.

Podbilewicz, B
Tipo: Artigo de Revista Científica
Relevância na Pesquisa
27.33%
A search was carried out for homologues of possible fusogenic proteins to study their function in a genetically tractable animal. The isolation, molecular, and cellular characterization of the Caenorhabditis elegans adm-1 gene (a disintegrin and metalloprotease domain) are described. A glycoprotein analogous to viral fusion proteins has been identified on the surface of guinea pig sperm (PH-30/fertilin) and is implicated in sperm-egg fusion. adm-1 is the first reported invertebrate gene related to PH-30 and a family of proteins containing snake venom disintegrin- and metalloprotease-like domains. ADM-1 shows a domain organization identical to PH-30. It contains prepro, metalloprotease, disintegrin, cysteine rich with putative fusion peptide, epidermal growth factor-like repeat, transmembrane, and cytoplasmic domains. Antibodies which recognize ADM-1 protein in immunoblots were generated. Using immunofluorescence and in situ hybridization, the products of adm-1 have been detected in specific cells during different stages of development. The localization of ADM-1 to the plasma membrane of embryonic cells and to the sheath cells of sensory organs suggests a function in cell adhesion. ADM-1 expression in the hypodermis, pharynx, vulva...

## Evidence for Functional Redundancy Between C. elegans ADAM Proteins SUP-17/Kuzbanian and ADM-4/TACE

Jarriault, Sophie; Greenwald, Iva
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
27.29%
The ectodomain of LIN-12/Notch proteins is cleaved and shed upon ligand binding. In C. elegans, genetic evidence has implicated SUP-17, the ortholog of Drosophila Kuzbanian and mammalian ADAM10, as the protease that mediates this event. In mammals, however, biochemical evidence has implicated TACE, a different ADAM protein. We have investigated potential functional redundancy of sup-17 and the C. elegans ortholog of TACE, adm-4, by exploring their roles in cell fate decisions mediated by lin-12/Notch genes. We found that reduced adm-4 activity, like reduced sup-17 activity, suppresses an allele of glp-1 that encodes a constitutively active receptor. Furthermore, concomitant reduction of adm-4 and sup-17 activity causes the production of two anchor cells in the hermaphrodite gonad, instead of one--a phenotype associated with loss of lin-12 activity. We also identified a novel fertility defect in the somatic gonad when both sup-17 and adm-4 are depleted. Expression of a truncated form of LIN-12 that mimics the product of ectodomain shedding rescues this fertility defect...

## CdTe quantum dots with daunorubicin induce apoptosis of multidrug-resistant human hepatoma HepG2/ADM cells: in vitro and in vivo evaluation

Zhang, Gen; Shi, Lixin; Selke, Matthias; Wang, Xuemei
Tipo: Artigo de Revista Científica
Relevância na Pesquisa
27.23%
Cadmium telluride quantum dots (Cdte QDs) have received significant attention in biomedical research because of their potential in disease diagnosis and drug delivery. In this study, we have investigated the interaction mechanism and synergistic effect of 3-mercaptopropionic acid-capped Cdte QDs with the anti-cancer drug daunorubicin (DNR) on the induction of apoptosis using drug-resistant human hepatoma HepG2/ADM cells. Electrochemical assay revealed that Cdte QDs readily facilitated the uptake of the DNR into HepG2/ADM cells. Apoptotic staining, DNA fragmentation, and flow cytometry analysis further demonstrated that compared with Cdte QDs or DNR treatment alone, the apoptosis rate increased after the treatment of Cdte QDs together with DNR in HepG2/ADM cells. We observed that Cdte QDs treatment could reduce the effect of P-glycoprotein while the treatment of Cdte QDs together with DNR can clearly activate apoptosis-related caspases protein expression in HepG2/ADM cells. Moreover, our in vivo study indicated that the treatment of Cdte QDs together with DNR effectively inhibited the human hepatoma HepG2/ADM nude mice tumor growth. The increased cell apoptosis rate was closely correlated with the enhanced inhibition of tumor growth in the studied animals. Thus...

## Esthetic Outcomes of ADM-Assisted Expander-Implant Breast Reconstruction

Nguyen, Khang T.; Mioton, Lauren M.; Smetona, John T.; Seth, Akhil K.; Kim, John Y.
Fonte: Open Science Company, LLC Publicador: Open Science Company, LLC
Tipo: Artigo de Revista Científica
Relevância na Pesquisa
27.29%
Objective: Adjunct acellular dermal matrices (ADM) are thought to improve esthetic outcomes of breast reconstruction but the existing evidence is largely anecdotal. In this study, we provide comparative data on esthetic outcomes of expander-implant breast reconstruction with and without ADM. Methods: Chart review was performed on a consecutive series of expander-implant reconstructions by the senior author. Demographic, oncologic, surgical, and photographic data were obtained for each patient. Photographic data were scored using a 3-point (0-1-2) breast-specific esthetic scale by 3 blinded, independent reviewers not involved in patient care. Results: ADM-assisted breast reconstructions had significantly higher scores than the non-ADM reconstructions for breast mound volume (1.38 vs 1.11; P = .0102), breast mound placement (1.57 vs 1.39; P = .0217), and the inframammary fold (1.39 vs 1.23; P = .0458). Conclusions: ADM may improve breast volume, placement, and inframammary fold definition. These specific findings may help plastic surgeons better utilize ADM to improve outcomes for breast reconstruction.

## Sex-Specific Effects of NLRP6/AVR and ADM Loci on Susceptibility to Essential Hypertension in a Sardinian Population

Glorioso, Nicola; Herrera, Victoria L.; Didishvili, Tamara; Ortu, Maria F.; Zaninello, Roberta; Fresu, Giovanni; Argiolas, Guiseppe; Troffa, Chiara; Ruiz-Opazo, Nelson
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Relevância na Pesquisa
27.23%
Coronary artery disease, heart failure, fatal arrhythmias, stroke, and renal disease are the most common causes of mortality for humans, and essential hypertension remains a major risk factor. Elucidation of susceptibility loci for essential hypertension has been difficult because of its complex, multifactorial nature involving genetic, environmental, and sex- and age-dependent nature. We investigated whether the 11p15.5 region syntenic to rat chromosome 1 region containing multiple blood pressure quantitative trait loci (QTL) detected in Dahl rat intercrosses harbors polymorphisms that contribute to susceptibility/resistance to essential hypertension in a Sardinian population. Initial testing performed using microsatellite markers spanning 18 Mb of 11p15.5 detected a strong association between D11S1318 (at 2.1 Mb, P = 0.004) and D11S1346 (at 10.6 Mb, P = 0.00000004), suggesting that loci in close proximity to these markers may contribute to susceptibility in our Sardinian cohort. NLR family, pyrin domain containing 6/angiotensin-vasopressin receptor (NLRP6/AVR), and adrenomedullin (ADM) are in close proximity to D11S1318 and D11S1346, respectively; thus we tested single nucleotide polymorphisms (SNPs) within NLRP6/AVR and ADM for their association with hypertension in our Sardinian cohort. Upon sex stratification...

## The effect of porcine ADM to improve the burn wound healing

Chen, Xiaodong; Shi, Yan; Shu, Bin; Xie, Xiaoxia; Yang, Ronghua; Zhang, Lijun; Ruan, Shubin; Lin, Yan; Lin, Zepeng; Shen, Rui; Zhang, Fenggang; Feng, Xiangsheng; Xie, Julin
Fonte: e-Century Publishing Corporation Publicador: e-Century Publishing Corporation
Tipo: Artigo de Revista Científica
Relevância na Pesquisa
27.16%
To study the effect of porcine acellular dermal matrix (ADM) on the burn wound healing. Seventy healthy Wistar rats were inflicted with 2 cm second degree burn and divided into 2 groups; one group was treated with porcine ADM and the other with Povidone Iodine Cream. Biopsies were taken on day 1, 3, 5, 7, 10, 14, 21 for histopathological and biochemical analysis to test PCNA, K19, Integrin-β1, PDGF, EGF and FGF. The results revealed relatively better and faster regeneration after treatment of porcine ADM, along with greatly increased synthesis in collagen in the experimental group. PCNA, K19, Integrin-β1 had an increase and then tapered down, and were stronger in the experimental group than in the contrast group during 21 days after burns. PDGF, EGF and FGF levels increased on day 3, peaked on day 5 and then started to decrease, while significantly enhanced expression of relevant growth factors were observed in the experimental group. Porcine ADM stimulate collagen synthesis, stem cells proliferation and differentiation, and the expression of relevant growth factors and ultimately improve the burn wound healing.

## Induction of apoptosis and reversal of permeability glycoprotein-mediated multidrug resistance of MCF-7/ADM by ginsenoside Rh2

Zhang, Hui; Gong, Jian; Zhang, Huilai; Kong, Di
Fonte: e-Century Publishing Corporation Publicador: e-Century Publishing Corporation
Tipo: Artigo de Revista Científica
Relevância na Pesquisa
27.16%
Multidrug resistance is a phenomenon that cancer cells develop a cross-resistant phenotype against several unrelated drugs, and permeability glycoprotein derived from the overexpression of multidrug resistance gene 1 has been taken as the most significant cause of multidrug resistance. In the present study, ginsenoside Rh2 was used to reverse permeability glycoprotein-mediated multidrug resistance of MCF-7/ADM cell line. Effects of ginsenoside Rh2 on the apoptotic process and caspase-3 activity of MCF-7 and MCF-7/ADM cell lines were determined using flow cytometry and microplate reader. Methyl thiazolyl tetrazolium test was conducted to assess the IC50 values of ginsenoside Rh2 and adriamycin on MCF-7 and MCF-7/ADM cultures; Rhodamin 123 assay was used to assess the retention of permeability glycoprotein after ginsenoside Rh2 treatment; flow cytometry and real time polymerase chain reaction were used to determine the expression levels of permeability glycoprotein and multidrug resistance gene 1 in drug-resistant cells and their parental cells after exposure to ginsenoside Rh2. The results showed that ginsenoside Rh2, except for inducing apoptosis, had the ability to reverse multidrug resistance in MCF-7/ADM cell line without changing the expression levels of permeability glycoprotein and multidrug resistance gene 1. Our findings provided some valuable information for the application of ginsenoside Rh2 in cancer therapy...

## Relatório de Estágio Curricular - ADM Estrela – Associação de Desenvolvimento e Melhoramentos

Nunes, Pedro
Fonte: Escola Superior de Tecnologia e Gestão Publicador: Escola Superior de Tecnologia e Gestão
Tipo: Relatório
POR
Relevância na Pesquisa
37.06%
O Curso de Especialização Tecnológica de Desenvolvimento de Produtos Multimédia apenas fica concluído após frequentar um estágio de três meses numa organização e apresentar um relatório de estágio. O estágio foi realizado na instituição ADM Estrela, mais precisamente no Centro de Formação Estrela. Neste estágio pretendeu-se criar um cd promocional com o objectivo de divulgar a instituição ADM Estrela, em feiras, exposições, entre outros.

## On the relation between ADM and Bondi energy-momenta

Zhang, Xiao
Tipo: Artigo de Revista Científica
Relevância na Pesquisa
27.23%
When a spacetime takes Bondi radiating metric, and is vacuum and asymptotically flat at spatial infinity which ensures the positive mass theorem, we prove that the standard ADM energy-momentum is the past limit of the Bondi energy-momentum. We also derive a formula relating the ADM energy-momentum of any asymptotically flat spacelike hypersurface to the Bondi energy-momentum of any null hypersurface. The formula indicates that the Bondi mass is always less than the ADM total energy if the system has {\it news}. The assumed asymptotic flatness precludes gravitational radiation. We therefore study further the relation between the ADM total energy and the Bondi mass when gravitational radiation emits. We find that in this case the ADM total energy is no longer the past limit of the Bondi mass. They differ by certain quantity relating to the {\it news} of the system.; Comment: 21 pages, final version

## ADM-CLE approach for detecting slow variables in continuous time Markov chains and dynamic data

Tipo: Artigo de Revista Científica
Relevância na Pesquisa
27.29%
A method for detecting intrinsic slow variables in high-dimensional stochastic chemical reaction networks is developed and analyzed. It combines anisotropic diffusion maps (ADM) with approximations based on the chemical Langevin equation (CLE). The resulting approach, called ADM-CLE, has the potential of being more efficient than the ADM method for a large class of chemical reaction systems, because it replaces the computationally most expensive step of ADM (running local short bursts of simulations) by using an approximation based on the CLE. The ADM-CLE approach can be used to estimate the stationary distribution of the detected slow variable, without any a-priori knowledge of it. If the conditional distribution of the fast variables can be obtained analytically, then the resulting ADM-CLE approach does not make any use of Monte Carlo simulations to estimate the distributions of both slow and fast variables.; Comment: 18 pages

## A construction principle for ADM-type theories in maximal slicing gauge

Gomes, Henrique
Tipo: Artigo de Revista Científica
Relevância na Pesquisa
27.33%
The differing concepts of time in general relativity and quantum mechanics are widely accused as the main culprits in our persistent failure in finding a complete theory of quantum gravity. Here we address this issue by constructing ADM-type theories \emph{in a particular time gauge} directly from first principles. The principles are expressed as conditions on phase space constraints: we search for two sets of spatially covariant constraints, which generate symmetries (are first class) and gauge-fix each other leaving two propagating degrees of freedom. One of the sets is the Weyl generator tr$(\pi)$, and the other is a one-parameter family containing the ADM scalar constraint $\lambda R- \beta(\pi^{ab}\pi_{ab}+(\mbox{tr}(\pi))^2/2))$. The two sets of constraints can be seen as defining ADM-type theories with a maximal slicing gauge-fixing. This work provides an independent, first principles derivation of ADM gravity. The principles above are motivated by a heuristic argument relying in the relation between symmetry doubling and exact renormalization arguments for quantum gravity, aside from compatibility with the spatial diffeomorphisms. As a by-product, these results address one of the most popular criticisms of Shape Dynamics: its construction starts off from the ADM Hamiltonian formulation. The present work severs this dependence: the set of constraints yield reduced phase space theories that can be naturally represented by either Shape Dynamics or ADM. More precisely...

Lehner, Luis; Huq, Mijan; Garrison, David
Tipo: Artigo de Revista Científica
Relevância na Pesquisa
27.23%
Causal differencing has shown to be one of the promising and successful approaches towards excising curvature singularities from numerical simulations of black hole spacetimes. So far it has only been actively implemented in the ADM and Einstein-Bianchi 3+1 formulations of the Einstein equations. Recently, an approach closely related to the ADM one, commonly referred to as as conformal ADM'' (CADM) has shown excellent results when modeling waves on flat spacetimes and black hole spacetimes where singularity avoiding slices are used to deal with the singularity. In these cases, the use of CADM has yielded longer evolutions and better outer boundary dependence than those obtained with the ADM one. If this success translates to the case where excision is implemented, then the CADM formulation will likely be a prime candidate for modeling generic black hole spacetimes. In the present work we investigate the applicability of causal differencing to CADM, presenting the equations in a convenient way for such a goal and compare its application with the ADM approach in 1D.; Comment: 11 pages, 6 figures. These notes illustrate how excision techniques already developed for ADM (in the form usually used in numerical relativity) codes can be straightforwardly applied in the so called `conformal ADM'. A comparison of the solutions obtained with both formulations is carried out highlighting when either formulation can yield better behaved evolutions

## Positivity Bounds for the Y-ADM Mass Density

Kastor, David; Shiromizu, Tetsuya; Tomizawa, Shinya; Traschen, Jennie
Tipo: Artigo de Revista Científica
Relevância na Pesquisa
27.29%
Killing-Yano tensors are natural generalizations of Killing vectors to arbitrary rank anti-symmetric tensor fields. It was recently shown that Killing-Yano tensors lead to conserved gravitational charges, called Y-ADM charges. These new charges are interesting because they measure, for example, the mass density of a p-brane, rather than the total ADM mass which may be infinite. In this paper, we show that the spinorial techniques used by Witten, in his proof of the positive energy theorem, may be straightforwardly extended to study the positivity properties of the Y-ADM mass density for p-brane spacetimes. Although the resulting formalism is quite similar to the ADM case, we show that establishing a positivity bound in the higher rank Y-ADM case requires imposing a condition on the Weyl tensor in addition to an energy condition. We find appropriate energy conditions for spacetimes that are conformally flat or algebraically special, and for spacetimes that have an exact Killing vector along the brane. Finally we discuss our expression for the Y-ADM mass density from the Hamiltonian point of view.; Comment: 8 pages

## Utilization of modified agglutination test and indirect immunofluorescent antibody test for the detection of Toxoplasma gondii antibodies in naturally exposed horses; Utilização do método de aglutinação direta e da reação de imunofluorescência indireta na detecção de anticorpos para Toxoplasma gondii em cavalos naturalmente infectados

Langoni, Helio; Silva, Aristeu Vieira da; Pezerico, Sandia Bergamaschi; Lima, Vanessa Yuri de
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; ; Formato: application/pdf