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Lipodistrofia em crianças e adolescentes com síndrome da imunodeficiência adquirida e sua relação com a terapia antirretroviral empregada; Lipodystrophy in children and adolescents with acquired immunodeficiency syndrome and its relationship with the antiretroviral therapy employed

SARNI, Roseli Oselka Saccardo; SOUZA, Fabíola Isabel Suano de; BATTISTINI, Tânia Regina Beraldo; PITTA, Tassiana Sacchi; FERNANDES, Ana Paula; TARDINI, Priscila Chemiotti; FONSECA, Fernando Luis Affonso; SANTOS, Valter Pinho dos; LOPEZ, Fábio Ancona
Fonte: Sociedade Brasileira de Pediatria Publicador: Sociedade Brasileira de Pediatria
Tipo: Artigo de Revista Científica
POR
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OBJETIVO: Avaliar a presença de lipodistrofia clínica em crianças com síndrome da imunodeficiência adquirida e relacioná-la com o esquema antirretroviral utilizado, alterações do perfil lipídico e resistência insulínica. MÉTODOS: Por meio de estudo transversal, foram avaliadas 30 crianças e adolescentes (mediana de idade = 9,1 anos) com síndrome da imunodeficiência adquirida, no período entre 2004 e 2005. As avaliações clínico-laboratoriais incluíram: classificação da infecção pelo HIV, medidas antropométricas (peso e estatura), glicemia e insulina séricas e perfil lipídico (LDL-c, HDL-c, triglicérides). A lipodistrofia foi definida por parâmetros clínicos. O teste do qui-quadrado foi utilizado na análise estatística. RESULTADOS: Todos os pacientes recebiam terapia antirretroviral regularmente (mediana de tempo de uso = 28,4 meses), 80% utilizavam três drogas em associação (terapia fortemente ativa) e 30% usavam inibidores de protease. Lipodistrofia e dislipidemia foram observadas em 53,3 e 60% dos pacientes, respectivamente. Crianças que utilizavam terapia fortemente ativa com inibidor de protease apresentaram maior percentual de lipodistrofia mista, com diferença estatisticamente significante em relação ao grupo com terapia fortemente ativa sem inibidor de protease e ao grupo sem terapia fortemente ativa (44...

Sarcoma de Kaposi relacionado à síndrome da imunodeficiência adquirida: características do comprometimento hepático na tomografia computadorizada e na ressonância magnética; Kaposi sarcoma related to acquired immunodeficiency syndrome: hepatic findings on computed tomography and magnetic resonance imaging

COSTA, Daniel Nobrega da; VIANA, Publio Cesar Cavalcante; MACIEL, Rosângela Pereira; GEBRIM, Eloisa Maria Mello Santiago; ROCHA, Manoel de Souza
Fonte: Colégio Brasileiro de Radiologia e Diagnóstico por Imagem Publicador: Colégio Brasileiro de Radiologia e Diagnóstico por Imagem
Tipo: Artigo de Revista Científica
POR
Relevância na Pesquisa
96.24%
Sarcoma de Kaposi é uma neoplasia associada a condições de imunossupressão que acomete os vasos linfáticos e sanguíneos. É a neoplasia intra-hepática mais comum na síndrome da imunodeficiência adquirida. A tomografia computadorizada e a ressonância magnética revelam múltiplos pequenos nódulos, proeminência e realce dos planos periportais, devido à presença de tecido neoplásico. Os autores descrevem um caso de paciente masculino, de 47 anos de idade, com síndrome da imunodeficiência adquirida e sarcoma de Kaposi disseminado.; Kaposi sarcoma is a neoplasm associated with immunosuppressive conditions, and involving blood and lymphatic vessels. It is the most frequent intrahepatic neoplasm in patients with acquired immunodeficiency syndrome. Computed tomography and magnetic resonance imaging demonstrate multiple small nodules, prominence and contrast-enhancement of periportal branches due to the presence of the neoplastic tissue. The authors report a case of a 47-year-old male patient with acquired immunodeficiency syndrome presenting disseminated Kaposi sarcoma.

Evolução de parâmetros antropométricos em portadores do vírus da Imunodeficiência Humana ou com Síndrome da Imunodeficiência Adquirida: um estudo prospectivo; Changes in the anthropometric parameters of patients with the Human Immunodeficiency virus or Acquired Immunodeficiency Syndrome: a prospective study

CURTI, Maíra Ladeia Rodrigues; ALMEIDA, Luara Bellinghausen; JAIME, Patrícia Constante
Fonte: Pontifícia Universidade Católica de Campinas Publicador: Pontifícia Universidade Católica de Campinas
Tipo: Artigo de Revista Científica
POR
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OBJETIVO: Avaliar o estado nutricional e a evolução de parâmetros antropométricos para alterações morfológicas em pacientes vivendo com o vírus da Imunodeficiência Humana ou com Síndrome da Imunodeficiência Adquirida em uso de terapia antirretroviral de alta atividade. MÉTODOS: Trata-se de estudo de coorte prospectiva com duração de 12 meses, envolvendo indivíduos adultos, de ambos os sexos, em terapia antirretroviral recém introduzida. Os indicadores antropométricos estudados foram índice de massa corporal, circunferência de cintura, dobras cutâneas subescapular, biciptal e triciptal, avaliados com intervalos de três meses, totalizando 4 medidas do tempo. Variáveis foram descritas segundo mediana e percentis 25 e 75 e analisadas por ANOVA para medidas repetidas. RESULTADOS: A população estudada foi composta por 53 indivíduos, a maioria do sexo masculino (81%), entre 30 e 39 anos. Apenas a dobra cutânea subescapular apresentou significante variação no tempo (T1=13,7 vs T4=16,0; p<0,001), apontando para lipo-hipertrofia dorso-cervical. CONCLUSÃO: Os achados deste estudo, embora limitados, direcionam para a necessidade de vigilância de parâmetros antropométricos associados a alterações morfológicas...

Gastric cryptosporidiosis as a clue for the diagnosis of the acquired immunodeficiency syndrome

CLEMENTE, Cyntia Mendes; CARAMORI, Carlos Antonio; PADULA, Pedro; RODRIGUES, Maria Aparecida Marchesan
Fonte: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE); Colégio Brasileiro de Cirurgia Digestiva (CBCD); Sociedade Brasileira de Motilidade Digestiva (SBMD); Federação Brasileira de Gastroenterologia (FBG); Sociedade Brasileira de Hepatologia (SBH); Sociedade Brasileira de Endoscopia Digestiva (SOBED) Publicador: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE); Colégio Brasileiro de Cirurgia Digestiva (CBCD); Sociedade Brasileira de Motilidade Digestiva (SBMD); Federação Brasileira de Gastroenterologia (FBG); Sociedade Brasileira de Hepatologia (SBH); Sociedade Brasileira de Endoscopia Digestiva (SOBED)
Tipo: Artigo de Revista Científica Formato: 180-182
ENG
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Infecções oportunistas do trato gastrointestinal constituem ameaça à população crescente de portadores de imunossupressão. O comprometimento do estômago por Cryptosporidium é incomum. Quando identificado no exame histopatológico da mucosa gástrica, é mandatória a investigação do estado imunológico do hospedeiro. São apresentados os dados clinicopatológicos e endoscópicos de uma paciente de 64 anos com gastrite erosiva associada à infecção por Cryptosporidium. O encontro deste agente oportunista no exame histopatológico da mucosa gástrica foi fundamental para esclarecer a doença de base da paciente, que era a síndrome da imunodeficiência adquirida.; Cryptosporidium parvum has been detected with increasing frequency in the gastrointestinal tract, but involvement of the stomach is rarely reported. Whenever found in the histologic examination of the gastrointestinal mucosa, it should raise the suspicion of an immunocompromised host. We report a case of Cryptosporidium-associated erosive gastritis in a 64-year-old woman, who was found later to have the acquired immunodeficiency syndrome. Gastroduodenoendoscopy and biopsy of the gastric mucosa played an invaluable role in the diagnosis of cryptosporidiosis and to disclose the underlying immunodeficiency state

Is human immunodeficiency virus/acquired immunodeficiency syndrome decreasing among Brazilian injection drug users? Recent findings and how to interpret them

Bastos, Francisco In??cio Pinkusfeld Monteiro; Bongertz, Vera; Teixeira, Sylvia Lopes Maia; Morgado, Mariza Gon??alves; Hacker, Mariana de Andrea Vilas-Boas
Fonte: Instituto Oswaldo Cruz Publicador: Instituto Oswaldo Cruz
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
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Francisco I Bastos,a, Vera Bongertz*, Sylvia Lopes Teixeira*, Mariza G Morgado*,Mariana A Hacker a Departamento de Informa????o em Sa??de, CICT-Fiocruz, Av. Brasil 4365, 21045-900, Rio de Janeiro, RJ, Brasil *Departamento de Imunologia, IOC-Fiocruz, Rio de Janeiro, RJ, Brasil; We briefly review findings from Brazilian settings where the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) epidemic among injection drug users (IDUs) seems to be decreasing, highlighting recent findings from Rio de Janeiro and discussing methodological alternatives. Former analyses using serologic testing algorithm for recent HIV seroconversion have shown that HIV incidence has been low in IDUs recruited by two different surveys carried out in Rio, where low injection frequencies and infection rates have been found among new injectors. The proportion of AIDS cases among IDUs in Rio has been fairly modest, compared to S??o Paulo and especially to the southernmost states. Notwithstanding, the interpretation of findings from serial surveys constitutes a challenge, magnified in the assessment of HIV spread among IDUs due to the dynamic nature of the drug scenes and limitations of sampling strategies targeting hard-to-reach populations. Assessment of epidemic trends may profit from the triangulation of data...

Human immunodeficiency virus/acquired immunodeficiency syndrome and tropical diseases: a brazilian perspective

Morgado, Mariza Gon??alves; Barcellos, Christovam de Castro; Pina, Maria de F??tima Rodrigues Pereira de; Bastos, Francisco In??cio Pinkusfeld Monteiro
Fonte: Funda????o Oswaldo Cruz Publicador: Funda????o Oswaldo Cruz
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
96.23%
Mariza G Morgado, Christovam Barcellos*, Maria de F??tima Pina*, Francisco In??cio Bastos* Laborat??rio de Aids e Imunologia Molecular, Departamento de Imunologia, Instituto Oswaldo Cruz *Departamento de Informa????es em Sa??de, Centro de Informa????o Cient??fica e Tecnol??gica-Fiocruz, UNAIDS Collaborating Centre, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brasil; The paper summarizes recent findings on the epidemiology and pathogenesis of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/Aids), highlighting the role of co-infections with major tropical diseases. Such co-infections have been studied in the Brazilian context since the beginning of the Aids epidemic and are expected to be more frequent and relevant as the Aids epidemic in Brazil proceeds towards smaller municipalities and the countryside, where tropical diseases are endemic. Unlike opportunistic diseases that affect basically the immunocompromised host, most tropical diseases, as well as tuberculosis, are pathogenic on their own, and can affect subjects with mild or no immunossuppression. In the era of highly active anti-retroviral therapies (HAART), opportunistic diseases seem to be on decrease in Brazil, where such medicines are fully available. Benefiting from HAART in terms of restoration of the immune function...

Gastric cryptosporidiosis as a clue for the diagnosis of the acquired immunodeficiency syndrome

CLEMENTE,Cyntia Mendes; CARAMORI,Carlos Antonio; PADULA,Pedro; RODRIGUES,Maria Aparecida Marchesan
Fonte: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED Publicador: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/07/2000 EN
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Cryptosporidium parvum has been detected with increasing frequency in the gastrointestinal tract, but involvement of the stomach is rarely reported. Whenever found in the histologic examination of the gastrointestinal mucosa, it should raise the suspicion of an immunocompromised host. We report a case of Cryptosporidium-associated erosive gastritis in a 64-year-old woman, who was found later to have the acquired immunodeficiency syndrome. Gastroduodenoendoscopy and biopsy of the gastric mucosa played an invaluable role in the diagnosis of cryptosporidiosis and to disclose the underlying immunodeficiency state

Primary meningeal Burkitt-type lymphoma presenting as the first clinical manifestation of acquired immunodeficiency syndrome

Gobbato,Pedro Luís; Pereira Filho,Arthur de Azambuja; David,Gustavo de; Faria,Mário de Barros; David,Felipe de; Aleixo,Pedro Bandeira; Barra,Marinez Bizarro; Ferreira,Nelson Pires
Fonte: Academia Brasileira de Neurologia - ABNEURO Publicador: Academia Brasileira de Neurologia - ABNEURO
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2006 EN
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The purpose of this study is to report a rare case of primary meningeal high grade Burkitt-type lymphoma presenting as the first clinical manifestation of acquired immunodeficiency syndrome. A 38-year-old Caucasian man, with a negative past medical history, sought treatment after experiencing global headache for five days. CT-Scan revealed a right front-temporo-parietal hyperdense subdural expansive mass. A craniotomy was performed and a hard white subdural was microsurgically dissected. Some hours after the surgery, the patient developed hemispheric cerebral edema and intracranial hypertension syndrome. Decompressive craniotomy was performed and the patient had an excellent recovery. Screening blood tests diagnosed human immunodeficiency virus infection. Further investigation ruled out systemic diseases. Eleven days after the initial surgery, the patient developed an acute respiratory failure and sepsis, dieing on that day. Pathological studies diagnosed Burkitt-type lymphoma.

Cardiac abnormalities in the acquired immunodeficiency syndrome. A prospective study with a clinical-pathological correlation in twenty-one adult patients

Herdy,Gesmar Volga Haddad; Herdy,Artur Haddad; Almeida,Pedro Savio; Carvalho,Roberto de; Azevedo,Fabiano B.; Azevedo,Kátia; Vasconcelos,Márcia Cláudia; Paiva,Raquel; Tchou,Hsu Y.; Nascimento,Pablo; Cosendey,Rachel; Ferrari,Analise; Lopes,Vania S.
Fonte: Sociedade Brasileira de Cardiologia - SBC Publicador: Sociedade Brasileira de Cardiologia - SBC
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/1999 EN
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OBJECTIVE - To evaluate the cardiac abnormalities and their evolution during the course of the acquired immunodeficiency syndrome, as well as to correlate clinical and pathological data. METHODS - Twenty-one patients, admitted to the hospital with the diagnosis of acquired immunodeficiency syndrome, were prospectively studied and followed until their death. Age ranged from 19 to 42 years (17 males). ECG and echocardiogram were also obtained every six months. After death, macro- and microscopic examinations were also performed. RESULTS - The most frequent causes of referral to the hospital were: diarrhea or repeated pneumonias, tuberculosis, toxoplasmosis or Kaposi sarcoma. The most frequent findings were acute or chronic pericarditis (42%) and dilated cardiomyopathy (19%). Four patients died of cardiac problems: infective endocarditis, pericarditis with pericardial effusion, bacterial myocarditis and infection by Toxoplasma gondii. CONCLUSION - Severe cardiac abnormalities were the cause of death in some patients. In the majority of the patients, a good correlation existed between clinical and anatomical-pathological data. Cardiac evaluation was important to detect early manifestations and treat them accordingly, even in asymptomatic patients.

Immunocompromised host: from the early events until the impact of acquired immunodeficiency syndrome

Costa,Sylvio Celso Gonçalves da
Fonte: Instituto Oswaldo Cruz, Ministério da Saúde Publicador: Instituto Oswaldo Cruz, Ministério da Saúde
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2000 EN
Relevância na Pesquisa
96.21%
The concept that microorganisms can modulate the host resistance was historically reviewed in the present article. The importance of African trypanosomiasis in the development of the research on immunosuppression as well as the impact of human immunodeficiency virus infection are discussed. Each day new opportunistic organisms establish a constant challenge for the correct diagnosis of concomitant infections in acquired immunodeficiency syndrome. The importance of parasite infection in the balance of host resistance in the third world was emphasized. Finally, some aspects of Leishmania as opportunistic organisms were presented.

Human immunodeficiency virus/acquired immunodeficiency syndrome and tropical diseases: a Brazilian perspective

Morgado,Mariza G; Barcellos,Christovam; Pina,Maria de Fátima; Bastos,Francisco Inácio
Fonte: Instituto Oswaldo Cruz, Ministério da Saúde Publicador: Instituto Oswaldo Cruz, Ministério da Saúde
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2000 EN
Relevância na Pesquisa
96.23%
The paper summarizes recent findings on the epidemiology and pathogenesis of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/Aids), highlighting the role of co-infections with major tropical diseases. Such co-infections have been studied in the Brazilian context since the beginning of the Aids epidemic and are expected to be more frequent and relevant as the Aids epidemic in Brazil proceeds towards smaller municipalities and the countryside, where tropical diseases are endemic. Unlike opportunistic diseases that affect basically the immunocompromised host, most tropical diseases, as well as tuberculosis, are pathogenic on their own, and can affect subjects with mild or no immunossuppression. In the era of highly active anti-retroviral therapies (HAART), opportunistic diseases seem to be on decrease in Brazil, where such medicines are fully available. Benefiting from HAART in terms of restoration of the immune function, putative milder clinical courses are expected in the future for most co-infections, including tropical diseases. On the other hand, from an ecological perspective, the progressive geographic diffusion of Aids makes tropical diseases and tuberculosis a renewed challenge for Brazilian researchers and practitioners dealing with HIV/Aids in the coming years.

Bloodstream infections in late-stage acquired immunodeficiency syndrome patients evaluated by a lysis centrifugation system

Rosas,RC; Salomão,R; Matta,DA da; Lopes,HV; Pignatari,AC; Colombo,AL
Fonte: Instituto Oswaldo Cruz, Ministério da Saúde Publicador: Instituto Oswaldo Cruz, Ministério da Saúde
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2003 EN
Relevância na Pesquisa
96.18%
Opportunistic infections, which affect acquired immunodeficiency syndrome (Aids) patients, are frequently disseminated and may cause bloodstream infections (BSI). The aim of this study was to evaluate the main causes of BSI in Aids patients with advanced stage of the disease, with special emphasis on the identification of fungemia. During a 21 months period, all patients with Aids (CD4 < 200) and febrile syndrome admitted to 3 university hospitals were systematically evaluated. For each patient presenting fever, a pair of blood cultures was collected and processed by using a commercial lysis-centrifugation system. One hundred and eleven patients (75 males) with a mean age of 36 years (median 33 years) and mean CD4 count of 64 cells/ml were included. Among the 111 patients evaluated we documented 54 episodes of BSI, including 46 patients with truly systemic infections and 8 episodes considered as contaminants. BSI were caused by gram-positive bacteria (43%), fungi (20%), gram-negative bacteria (15%), mycobacteria (15%), and mixed flora (7%). The crude mortality rate of our patients was 39%, being 50% for patients with BSI and 31% for the others. In conclusion, BSI are a common related to systemic infections on Aids patients with advanced stage of disease and is associated with a high rate of mortality.

Is human immunodeficiency virus/acquired immunodeficiency syndrome decreasing among Brazilian injection drug users? Recent findings and how to interpret them

Bastos,Francisco I; Bongertz,Vera; Teixeira,Sylvia Lopes; Morgado,Mariza G; Hacker,Mariana A
Fonte: Instituto Oswaldo Cruz, Ministério da Saúde Publicador: Instituto Oswaldo Cruz, Ministério da Saúde
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/02/2005 EN
Relevância na Pesquisa
96.23%
We briefly review findings from Brazilian settings where the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) epidemic among injection drug users (IDUs) seems to be decreasing, highlighting recent findings from Rio de Janeiro and discussing methodological alternatives. Former analyses using serologic testing algorithm for recent HIV seroconversion have shown that HIV incidence has been low in IDUs recruited by two different surveys carried out in Rio, where low injection frequencies and infection rates have been found among new injectors. The proportion of AIDS cases among IDUs in Rio has been fairly modest, compared to São Paulo and especially to the southernmost states. Notwithstanding, the interpretation of findings from serial surveys constitutes a challenge, magnified in the assessment of HIV spread among IDUs due to the dynamic nature of the drug scenes and limitations of sampling strategies targeting hard-to-reach populations. Assessment of epidemic trends may profit from the triangulation of data, but cannot avert biases associated with sampling errors. Efforts should be made to triangulate data from different sources, besides exploring specific studies from different perspectives. In an attempt to further assess the observed trends...

Trypanosoma cruzi meningoencephalitis and myocarditis in a patient with acquired immunodeficiency syndrome

Rocha,Ademir; Ferreira,Marcelo S.; Nishioka,Sergio A.; Silva,Marcos; Burgarelli,Marcius K. N.; Silva,Arnaldo M.; Moura,Leandro P.; Ugrinovich,Reinaldo; Raffin,César N.
Fonte: Instituto de Medicina Tropical Publicador: Instituto de Medicina Tropical
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/1993 EN
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We report the case of a 52-year-old male heterosexual patient with acquired immunodeficiency syndrome (AIDS) and reactivation of Chagas' disease manifested by meningoencephalitis and myocarditis, diagnosed post-mortem. Unexplained reactivation of Chagas' disease should be included among the diagnostic criteria of AIDS in human immunodeficiency virus positive patients. On the other hand, AIDS should be considered in the differential diagnosis of patients with unexplained reactivation of Chagas' disease.

Detection of Cryptosporidium - specific coproantigen in human immunodeficiency virus/acquired immunodeficiency syndrome patients by using a commercially available immunoenzymatic assay

Silva,Claudio Vieira; Ferreira,Marcelo Simão; Gonçalves-Pires,Maria do Rosário de Fátima; Costa-Cruz,Julia Maria
Fonte: Instituto Oswaldo Cruz, Ministério da Saúde Publicador: Instituto Oswaldo Cruz, Ministério da Saúde
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2003 EN
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The aim of this study was to verify the occurrence of Cryptosporidium infection in 52 human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients (group 1) and 38 clinically healthy individuals (group 2) by using enzyme immunoassay (EIA). All fecal samples collected were submitted to the Baermann, Lutz, and Ritchie methods, the Safranin/Methylene Blue, and Weber's chromotrope modified Trichrome staining techniques, and EIA. In group 1, parasitological staining techniques and EIA were both positive for Cryptosporidium sp. infection in 3/52 (5.8%) samples and both negative in 45/52 (86.5%) samples, while 4/52 (7.7%) samples were positive in EIA and negative in parasitological staining techniques. Concerning group 2, all samples were negative by EIA and microscopy for Cryptosporidium infection. In conclusion, EIA may be an alternative method for detecting Cryptosporidium-specific coproantigen in HIV/AIDS patients.

Reiter's Syndrome associated with the Acquired Immunodeficiency Syndrome: a case report

Malta,J.B.N.S.; Milanelo,D.; Carvalheiro,F.A.R.; Silva,M.V.
Fonte: Brazilian Society of Infectious Diseases Publicador: Brazilian Society of Infectious Diseases
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/02/2002 EN
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The association of Reiter's Syndrome (RS) with the Acquired Immunodeficiency Syndrome (AIDS) is seldom mentioned in the medical literature. This report illustrates this relationship in a 46 years old male patient suffering from AIDS (CD4+ = 240 cells/mm³, CD8+ = 1,301 cells/mm³ and viral load = 330,000 copies/ml), pulmonary tuberculosis (positive catarrhal bacilluscopy), and RS. The diagnosis of RS was based on the combination of dermatological and articular alterations. The patient's cutaneous lesions were characterized by exfoliation and the formation of crusts located on the face, scalp, genitals, hands, and feet; onychodystrophy with opacity; yellowish coloring; and hyperkeratosis of the nails. Articular lesions led to progressive deformity of phalangeal joints of the hands, and intensive arthralgia, mainly of the larger joints (shoulders, elbows, hips and knees). AIDS treatment was administered with anti-retroviral drugs (zidovudine and didanosine); for tuberculosis (isoniazid, rifampicine, and pyrazinamide); and (prednisone and inometacine) for the RS. The patient recovered with the improvement of articular symptoms; however, on the eighth day of treatment, the patient showed significant hemoptysis and hypovolemic shock, and died. The association of RS and HIV infection is reviewed.

Reactivation of Chagas' disease leading to the diagnosis of acquired immunodeficiency syndrome

Santos,Eder de Oliveira; Canela,João dos Reis; Monção,Henry Carlos Gomes; Roque,Mauro José Guedes
Fonte: Brazilian Society of Infectious Diseases Publicador: Brazilian Society of Infectious Diseases
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2002 EN
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Reactivation of chronic Chagas' disease is a rare condition and occurs only in immunosuppressed patients. We report a case of a patient with a rapid and fatal reactivation of Chagas' disease, manifested by meningoencephalitis, which lead to a diagnosis of acquired immunodeficiency syndrome (AIDS). We believe there is sufficient evidence to include the reactivation of Chagas' disease among the diagnostic criteria of AIDS in Human Immunodeficiency Virus (HIV) infection.

SARCOMA DE KAPOSI E SÍNDROME DA IMUNODEFICIÊNCIA ADQUIRIDA: CARACTERÍSTICAS DESTA ASSOCIAÇÃO, INCLUINDO NOVOS CONCEITOS SOBRE PATOGÊNESE E TRATAMENTO; KAPOSI’S SARCOMA AND ACQUIRED IMMUNODEFICIENCY SYNDROME: CHARACTERISTICS OF THIS ASSOCIATION INCLUDING NEW CONCEPTS ON PATHOGENESIS AND TREATMENT

Fonseca, Benedito A. L.; Bollela, Valdes R.; Pires Neto, Roberto da Justa
Fonte: Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto Publicador: Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; Formato: application/pdf
Publicado em 30/03/1999 POR
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No início da década de 80, a síndrome da imunodeficiência adquirida foi reconhecida e descrita em homossexuais jovens, do sexo masculino, previamente saudáveis, acometidos por pneumopatia atípica causada por microorganismo oportunista, identificado como sendo o Pneumocystis carinii, e com lesões cutâneas vinhosas, nodulares, cujo estudo histopatológico revelou tratar-se de Sarcoma de Kaposi. O Sarcoma de Kaposi é a neoplasia mais freqüente em pacientes com infecção pelo vírus da imunodeficiência humana. Apesar de não totalmente esclarecida, sua fisiopatogenia tem sido associada à presença de um herpes vírus, de provável transmissão sexual, que estaria implicado no surgimento da doença. Esta revisão busca atualizar conceitos da fisiopatologia e tratamento desta condição grave e freqüente associada à infecção pelo HIV.; In early 80’s, the acquired immunodeficiency syndrome was initially recognized from the outbreak of Kaposi’s sarcoma and Pneumocystis carinii pneumonia among young, previously healthy homosexual men. Kaposi’s sarcoma is the most frequent neoplasm associated with human immunodeficiency virus (HIV) infection. Although Kaposi’s sarcoma pathogenesis is not clear at all, the disease has been associated with the presence of a sexual transmitted herpes virus. This paper intends to review and update some topics about HIV/Kaposi’s sarcoma pathogenesis and therapeutic aspects.

Meningoencefalite e miocardite por Trypanosoma cruzi em paciente com síndrome da imunodeficiência adquirida; Trypanosoma cruzi meningoencephalitis and myocarditis in a patient with acquired immunodeficiency syndrome

Rocha, Ademir; Ferreira, Marcelo S.; Nishioka, Sergio A.; Silva, Marcos; Burgarelli, Marcius K. N.; Silva, Arnaldo M.; Moura, Leandro P.; Ugrinovich, Reinaldo; Raffin, César N.
Fonte: Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo Publicador: Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; Formato: application/pdf
Publicado em 01/04/1993 ENG
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Relata-se o caso de um paciente de 52 anos, heterossexual, com síndrome da imunodeficiência adquirida e reativação de doença de Chagas, manifestada por meningoencefalite e miocardite diagnosticadas post mortem. Reativação inexplicada de doença de Chagas deveria estar entre os critérios para diagnóstico de AIDS em portadores do vírus da imunodeficiência adquirida. Por outro lado, o diagnóstico de AIDS deveria ser considerado em pacientes com reativação inexplicada de doença de Chagas.; We report the case of a 52-year-old male heterosexual patient with acquired immunodeficiency syndrome (AIDS) and reactivation of Chagas' disease manifested by meningoencephalitis and myocarditis, diagnosed post-mortem. Unexplained reactivation of Chagas' disease should be included among the diagnostic criteria of AIDS in human immunodeficiency virus positive patients. On the other hand, AIDS should be considered in the differential diagnosis of patients with unexplained reactivation of Chagas' disease.

Prevention and treatment of human immunodeficiency virus/acquired immunodeficiency syndrome in resource-limited settings

Hogan,Daniel R.; Salomon,Joshua A.
Fonte: World Health Organization Publicador: World Health Organization
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/02/2005 EN
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Strategies for confronting the epidemic of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) have included a range of different approaches that focus on prevention and treatment. However, debate persists over what levels of emphasis are appropriate for the different components of the global response. This paper presents an overview of this debate and briefly summarizes the evidence on a range of interventions designed to prevent the spread of HIV infection, paying particular attention to voluntary counselling and testing, treatment for sexually transmitted infections and prevention of mother-to-child transmission. We also review the experience with antiretroviral therapy to date in terms of response rates and survival rates, adherence, drug resistance, behavioural change and epidemiological impact. Although various studies have identified strategies with proven effectiveness in reducing the risks of HIV infection and AIDS mortality, considerable uncertainties remain. Successful integration of treatment and prevention of HIV/AIDS will require a balanced approach and rigorous monitoring of the impact of programmes in terms of both individual and population outcomes.