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Inhibition of Human Hepatitis B Virus Replication by AT-61, a Phenylpropenamide Derivative, Alone and in Combination with (−)β-l-2′,3′-Dideoxy-3′-Thiacytidine

King, Robert W.; Ladner, Stephanie K.; Miller, Thomas J.; Zaifert, Katie; Perni, Robert B.; Conway, Sameul C.; Otto, Michael J.
Fonte: American Society for Microbiology Publicador: American Society for Microbiology
Tipo: Artigo de Revista Científica
Publicado em /12/1998 EN
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AT-61, a member of a novel class of phenylpropenamide derivatives, was found to be a highly selective and potent inhibitor of human hepatitis B virus (HBV) replication in four different human hepatoblastoma cell lines which support the replication of HBV (i.e., HepAD38, HepAD79, 2.2.15, and transiently transfected HepG2 cells). This compound was equally effective at inhibiting both the formation of intracellular immature core particles and the release of extracellular virions, with 50% effective concentrations ranging from 0.6 to 5.7 μM. AT-61 (27 μM) was able to reduce the amount of HBV covalently closed circular DNA found in the nuclei of HepAD38 cells by >99%. AT-61 at concentrations of >27 μM had little effect on the amount of viral RNA found within the cytoplasms of induced HepAD38 cells but reduced the number of immature virions which contained pregenomic RNA by >99%. The potency of AT-61 was not affected by one of the mutations responsible for (−)-β-l-2′,3′-dideoxy-3′ thiacytidine (3TC) resistance in HBV, and AT-61 acted synergistic with 3TC to inhibit HBV replication. AT-61 (81 μM) was not cytotoxic or antiproliferative to several cell lines and had no antiviral effect on woodchuck or duck HBV, human immunodeficiency virus type 1...

The transcriptional regulatory proteins encoded by varicella-zoster virus open reading frames (ORFs) 4 and 63, but not ORF 61, are associated with purified virus particles.

Kinchington, P R; Bookey, D; Turse, S E
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /07/1995 EN
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Of the five varicella-zoster virus (VZV) open reading frames (ORFs) known to encode proteins which influence viral transcriptional events, two (ORFs 10 and 62) encode proteins associated with the tegument of virus particles, where they may function during the immediate-early events of infection. In this study, antibodies which recognize the products of the three additional VZV ORFs, ORFs 4, 61, and 63, were made and used to characterize their association with virus particles. ORF 4 encoded a 52-kDa polypeptide, and antibodies to ORF 63 reacted with polypeptides of 47 and 28 kDa. Antibodies to ORF 61 recognized heterogeneous polypeptides of 62 to 66 kDa in cells infected with a vaccinia virus recombinant expressing ORF 61 and in VZV-infected melanoma cells but reacted very weakly with polypeptides of VZV-infected human foreskin fibroblasts, suggesting that cell-specific factors were involved in ORF 61 protein accumulation. Analysis of virus particles purified from melanoma cells indicated that a 52-kDa polypeptide from ORF 4 and the 47-kDa polypeptide from ORF 63, but not any from ORF 61, were associated with virus particles. The virion proteins were likely components of the tegument, as they were not solubilized by treatment of virus with mild detergents and were completely resistant to trypsin digestion unless prior envelope solubilization was performed. The products of ORFs 4 and 63 were not found in purified VZV nucleocapsids. These results suggest that forms of the ORF 4- and ORF 63-encoded transcriptional regulatory proteins are also structural and may also have roles in the immediate-early events of infection.

Analysis of five presumptive protein-coding sequences clustered between the primosome genes, 41 and 61, of bacteriophages T4, T2, and T6.

Selick, H E; Stormo, G D; Dyson, R L; Alberts, B M
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /04/1993 EN
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In bacteriophage T4, there is a strong tendency for genes that encode interacting proteins to be clustered on the chromosome. There is 1.6 kb of DNA between the DNA helicase (gene 41) and the DNA primase (gene 61) genes of this virus. The DNA sequence of this region suggests that it contains five genes, designated as open reading frames (ORFs) 61.1 to 61.5, predicted to encode proteins ranging in size from 5.94 to 22.88 kDa. Are these ORFs actually genes? As one test, we compared the DNA sequence of this region in bacteriophages T2, T4, and T6 and found that ORFs 61.1, 61.3, 61.4, and 61.5 are highly conserved among the three closely related viruses. In contrast, ORF 61.2 is conserved between phages T4 and T6 yet is absent from phage T2, where it is replaced by another ORF, T2 ORF 61.2, which is not found in the T4 and T6 genomes. As a second, independent test for coding sequences, we calculated the codon base position preferences for all ORFs in this region that could encode proteins that contain at least 30 amino acids. Both the T4/T6 and T2 versions of ORF 61.2, as well as the other ORFs, have codon base position preferences that are indistinguishable from those of known T4 genes (coefficients of 0.81 to 0.94); the six other possible ORFs of at least 90 bp in this region are ruled out as genes by this test (coefficients less than zero). Thus...

Conformational effects of substituting amino acids for glutamine-61 on the central transforming region of the P21 proteins.

Pincus, M R; Brandt-Rauf, P W; Carty, R P; Lubowsky, J; Avitable, M; Gibson, K D; Scheraga, H A
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /12/1987 EN
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The low-energy conformations for a series of peptides based on the sequence of the ras P21 protein from position 55 to position 67 have been computed using conformational energy analysis. These sequences differed at position 61 and contained Gln, Pro, Leu, Lys, and Arg at this position. P21 proteins with Gln, Glu, or Pro at this position do not cause cell transformation at normal levels of expression; proteins with substitutions of at least 14 other amino acids at this position (Leu, Lys, and Arg having been found in tumors in place of the normally occurring Gln-61) do cause malignant transformation of cells in culture. We find that the segments of residues 55-67 from the nontransforming proteins (Gln- or Pro-61) adopt a structure that is energetically unfavorable for the same segment with Leu, Lys, or Arg at position 61. The critical feature of this structure is an alpha-helix from residues 62 to 68. Residue 61 (Gln or Pro) adopts an extended conformation. On the other hand, the segment from transforming proteins can adopt two structures, one all alpha-helical from residue 61 to residue 68 and the other a less-regular, higher-energy structure. The segments from the normal protein can adopt the all alpha-helical structure, a finding that can explain the fact that elevated intracellular levels of the normal protein also cause cell transformation. The results of the calculations suggest that specific changes in the structure of this region can account for the oncogenic effect of the proteins in which substitutions occur.

Cloning, Expression, and Cell Surface Localization of Paenibacillus sp. Strain W-61 Xylanase 5, a Multidomain Xylanase

Ito, Yasuko; Tomita, Toshio; Roy, Narayan; Nakano, Akito; Sugawara-Tomita, Noriko; Watanabe, Seiji; Okai, Naoko; Abe, Naoki; Kamio, Yoshiyuki
Fonte: American Society for Microbiology Publicador: American Society for Microbiology
Tipo: Artigo de Revista Científica
Publicado em /12/2003 EN
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We have shown that a xylan-degrading bacterium, W-61, excretes multiple xylanases, including xylanase 5 with a molecular mass of 140 kDa. Here, we emend the previously used classification of the bacterium (i.e., Aeromonas caviae W-61) to Paenibacillus sp. strain W-61 on the basis of the nucleotide sequence of the 16S rRNA gene, and we clone and express the xyn5 gene encoding xylanase 5 (Xyn5) in Escherichia coli and study the subcellular localization of Xyn5. xyn5 encodes 1,326 amino acid residues, including a 27-amino-acid signal sequence. Sequence analysis indicated that Xyn5 comprises two family 22 carbohydrate-binding modules (CBM), a family 10 catalytic domain of glycosyl hydrolases, a family 9 CBM, a domain similar to the lysine-rich region of Clostridium thermocellum SdbA, and three S-layer-homologous (SLH) domains. Recombinant Xyn5 bound to a crystalline cellulose, Avicel PH-101, while an N-terminal 90-kDa fragment of Xyn5, which lacks the C-terminal half of the family 9 CBM, did not bind to Avicel PH-101. Xyn5 was cell bound, and the cell-bound protein was digested by exogenous trypsin to produce immunoreactive and xylanolytic fragments with molecular masses of 80 and 60 kDa. Xyn5 was exclusively distributed in the cell envelope fraction consisting of a peptidoglycan-containing layer and an associated S layer. Thus...

High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India.

Saranath, D.; Chang, S. E.; Bhoite, L. T.; Panchal, R. G.; Kerr, I. B.; Mehta, A. R.; Johnson, N. W.; Deo, M. G.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /04/1991 EN
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57 primary tumour samples from Indian oral cancer patients with a 5-15 year tobacco chewing habit, were examined for mutational activation in codons 12, 13 and 61 of the H-ras, K-ras and N-ras oncogenes. The highly sensitive assay based on specific oligonucleotide hybridisation following in vitro amplification of unique sequences by polymerase chain reaction was employed. Mutations were detected in twenty (35%) of the samples and were restricted to H-ras, codons 12, 13 and 61. Two cases had concurrent mutations in codons 12 and 61. The majority of the mutations were at H-ras 61.2 (Glutamine to Arginine) and H-ras 12.2 (Glycine to Valine). Three of the less frequent mutations are apparently novel. Interestingly, eight of the samples with H-ras mutations also showed loss of wild-type H-ras, as judged by absence of signals for wild-type codons 12 or 61 on dot blots. The specific H-ras mutations in these oral malignancies associated with tobacco chewing, may represent an important example of an environmental carcinogen-induced step, in a pathway leading to malignant transformation.

β-Lactamase-Mediated β-Lactam Resistance in Campylobacter Species: Prevalence of Cj0299 (blaOXA-61) and Evidence for a Novel β-Lactamase in C. jejuni▿

Griggs, Deborah J.; Peake, Leanne; Johnson, Margaret M.; Ghori, Saba; Mott, A.; Piddock, Laura J. V.
Fonte: American Society for Microbiology (ASM) Publicador: American Society for Microbiology (ASM)
Tipo: Artigo de Revista Científica
EN
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Fifty-two percent of 1,288 poultry isolates of campylobacters were ampicillin resistant, and resistance was more common among Campylobacter coli isolates (67.4%) than among Campylobacter jejuni isolates (47.5%). Production of β-lactamase was typically associated with resistance to ampicillin, amoxicillin (amoxicilline), penicillin, and ticarcillin. Regardless of β-lactamase production, all isolates were resistant to piperacillin (MICs ≥ 256 μg/ml), and most were resistant to carbenicillin, cloxacillin, and cephalosporins. Of all ampicillin-resistant campylobacters tested, 91% (347/380) carried the blaOXA-61 gene, and 77% (136/175) of those tested with nitrocefin produced a β-lactamase, presumably OXA-61. The isoelectric point (pI) of OXA-61 was 8.7, and the molecular mass was 31.0 kDa. Insertional inactivation of blaOXA-61 in C. jejuni NCTC 11168 and two ampicillin-resistant isolates resulted in increased susceptibility to ampicillin, co-amoxiclav (amoxicillin and clavulanic acid), penicillin, carbenicillin, oxacillin, and piperacillin, but the effects on MICs of cephalosporins and imipenem were negligible. Some C. jejuni isolates that lacked blaOXA-61 produced a β-lactamase, CjBla2, with a pI of 9.2 and molecular mass of 32.4 kDa. Mass spectrometry confirmed that the most prevalent β-lactamase was the product of blaOXA-61...

H3K9me2/3 Binding of the MBT Domain Protein LIN-61 Is Essential for Caenorhabditis elegans Vulva Development

Koester-Eiserfunke, Nora; Fischle, Wolfgang
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
EN
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MBT domain proteins are involved in developmental processes and tumorigenesis. In vitro binding and mutagenesis studies have shown that individual MBT domains within clustered MBT repeat regions bind mono- and dimethylated histone lysine residues with little to no sequence specificity but discriminate against the tri- and unmethylated states. However, the exact function of promiscuous histone methyl-lysine binding in the biology of MBT domain proteins has not been elucidated. Here, we show that the Caenorhabditis elegans four MBT domain protein LIN-61, in contrast to other MBT repeat factors, specifically interacts with histone H3 when methylated on lysine 9, displaying a strong preference for di- and trimethylated states (H3K9me2/3). Although the fourth MBT repeat is implicated in this interaction, H3K9me2/3 binding minimally requires MBT repeats two to four. Further, mutagenesis of residues conserved with other methyl-lysine binding MBT regions in the fourth MBT repeat does not abolish interaction, implicating a distinct binding mode. In vivo, H3K9me2/3 interaction of LIN-61 is required for C. elegans vulva development within the synMuvB pathway. Mutant LIN-61 proteins deficient in H3K9me2/3 binding fail to rescue lin-61 synMuvB function. Also...

GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft

Fu, Junsheng; Rodova, Mariana; Roy, Sanjit K.; Sharma, Jay; Singh, Karan P.; Srivastava, Rakesh K.; Shankar, Sharmila
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
EN
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Multiple lines of evidence suggest that the Sonic Hedgehog (Shh) signaling pathway is aberrantly reactivated in pancreatic cancer stem cells (CSCs). The objectives of this study were to examine the molecular mechanisms by which GANT-61 (Gli transcription factor inhibitor) regulates stem cell characteristics and tumor growth. Effects of GANT-61 on CSC’s viability, spheroid formation, apoptosis, DNA-binding and transcriptional activities, and epithelial-mesenchymal transition (EMT) were measured. Humanized NOD/SCID/IL2Rgammanull mice were used to examine the effects of GANT-61 on CSC’s tumor growth. GANT-61 inhibited cell viability, spheroid formation, and Gli-DNA binding and transcriptional activities, and induced apoptosis by activation of caspase-3 and cleavage of Poly-ADP ribose Polymerase (PARP). GANT-61 increased the expression of TRAIL-R1/DR4, TRAIL-R2/DR5 and Fas, and decreased expression of PDGFRα and Bcl-2. GANT-61 also suppressed EMT by up-regulating E-cadherin and inhibiting N-cadherin and transcription factors Snail, Slug and Zeb1. In addition, GANT-61 inhibited pluripotency maintaining factors Nanog, Oct4, Sox-2 and cMyc. Suppression of both Gli1 plus Gli2 by shRNA mimicked the changes in cell viability, spheroid formation...

Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review

Imamura, Yu; Lochhead, Paul; Yamauchi, Mai; Kuchiba, Aya; Qian, Zhi Rong; Liao, Xiaoyun; Nishihara, Reiko; Jung, Seungyoun; Wu, Kana; Nosho, Katsuhiko; Wang, Yaoyu E; Peng, Shouyong; Bass, Adam J; Haigis, Kevin M; Meyerhardt, Jeffrey A; Chan, Andrew T; Fu
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
EN_US
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Background: KRAS mutations in codons 12 and 13 are established predictive biomarkers for anti-EGFR therapy in colorectal cancer. Previous studies suggest that KRAS codon 61 and 146 mutations may also predict resistance to anti-EGFR therapy in colorectal cancer. However, clinicopathological, molecular, and prognostic features of colorectal carcinoma with KRAS codon 61 or 146 mutation remain unclear. Methods: We utilized a molecular pathological epidemiology database of 1267 colon and rectal cancers in the Nurse’s Health Study and the Health Professionals Follow-up Study. We examined KRAS mutations in codons 12, 13, 61 and 146 (assessed by pyrosequencing), in relation to clinicopathological features, and tumor molecular markers, including BRAF and PIK3CA mutations, CpG island methylator phenotype (CIMP), LINE-1 methylation, and microsatellite instability (MSI). Survival analyses were performed in 1067 BRAF-wild-type cancers to avoid confounding by BRAF mutation. Cox proportional hazards models were used to compute mortality hazard ratio, adjusting for potential confounders, including disease stage, PIK3CA mutation, CIMP, LINE-1 hypomethylation, and MSI. Results: KRAS codon 61 mutations were detected in 19 cases (1.5%), and codon 146 mutations in 40 cases (3.2%). Overall KRAS mutation prevalence in colorectal cancers was 40% (=505/1267). Of interest...

Motor de auto D.K.W modelo 61

Maxim, Petre
Fonte: Venezuela Publicador: Venezuela
ES
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Motor de auto D.K.W modelo 61

Motor de un auto Mercedes Benz modelo 61

Maxim, Petre
Fonte: Venezuela Publicador: Venezuela
ES
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Motor de un auto Mercedes Benz modelo 61

Afiche del 3er Salón Nacional de Arte Fotográfico celebrado en Caracas del 1 al 15 de Diciembre del 61

Fonte: Caracas; Venezuela; Distrito Federal Publicador: Caracas; Venezuela; Distrito Federal
ES
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Afiche del 3er Salón Nacional de Arte Fotográfico celebrado en Caracas del 1 al 15 de Diciembre del 61

Destabilization of Bacteriophage T4 Mrnas by a Mutation of Gene 61.5

Kai, T.; Selick, H. E.; Yonesaki, T.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /09/1996 EN
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We identified a novel gene of bacteriophage T4, gene 61.5, which appears to be involved in protein synthesis late in infection. Northern blot analysis revealed that a mutant of 61.5 accumulated truncated transcripts of representative late genes. Using a double mutant of genes 61.5 and 55, which prevents transcription of late genes, we demonstrate that even transcripts of middle genes, while full-length when initially expressed, are similarly truncated at later stages of infection. These results indicate that the abnormality in transcript length occurs late in infection, regardless of whether the transcript derives from a middle or a late gene. Primer-extension analysis revealed that the 5' ends of the late gene 23 transcripts that accumulated in gene 61.5 mutant-infected cells were located at internal discrete sites as well as at the expected transcription start site. Moreover, the decay rates of full-length transcripts from genes uvsY or 45 were more than twofold faster in the absence of a functional gene 61.5. These results suggest that mutation of gene 61.5 activates endonucleolytic cleavage of middle and late transcripts, probably by RNase M.

The molecular environment of the Galactic star forming region G19.61–0.23

Testi, L.; Walmsley, C. M.; Schuller, F.; Gregorini, L.; Olmi, L.; Carey, S.; Molinari, S.; Cesaroni, R.; Menten, K. M.; Bronfman Aguiló, Leonardo Jaime; Noriega-Crespo, A.; Santangelo, G.
Fonte: ESO Publicador: ESO
Tipo: Artículo de revista
EN
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Artículo de publicación ISI.; Context. Although current facilities allow the study of Galactic star formation at high angular resolution, our current understanding of the high-mass star-formation process is still very poor. In particular, we still need to characterize the properties of clouds giving birth to high-mass stars in our own Galaxy and use them as templates for our understanding of extragalactic star formation. Aims. We present single-dish (sub)millimeter observations of gas and dust in the Galactic high-mass star-forming region G19.61–0.23, with the aim of studying the large-scale properties and physical conditions of the molecular gas across the region. The final aim is to compare the large-scale (about 100 pc) properties with the small-scale (about 3 pc) properties and to consider possible implications for extragalactic studies. Methods. We have mapped CO isotopologues in the J = 1−0 transition using the FCRAO-14m telescope and the J = 2−1 transition using the IRAM-30m telescope. We have also used APEX 870 μm continuum data from the ATLASGAL survey and FCRAO supplementary observations of the 13CO J = 1−0 line from the BU-FCRAO Galactic Ring Survey, as well as the Spitzer infrared Galactic plane surveys GLIMPSE and MIPSGAL to characterize the star-formation activity within the molecular clouds. Results. We reveal a population of molecular clumps in the 13CO(1–0) emission...

Comparación de parámetros de respuesta sísmica y de diseño para elementos estructurales principales de edificios en altura de hormigón armado, frente a los requerimientos de los decretos supremos 60 y 61

Rojas Bories, José Santiago
Fonte: Universidad de Chile Publicador: Universidad de Chile
Tipo: Tesis
ES
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Ingeniero Civil; El objetivo principal de este trabajo de título es realizar un estudio comparativo de parámetros generales de respuesta sísmica y del diseño de elementos estructurales principales, a través de un análisis modal espectral, de 18 edificios en altura de hormigón armado, identificando las diferencias que resultan de aplicar el nuevo código. Los principales requerimientos relevantes establecidos en los decretos supremos 60 y 61 que fueron considerados en este trabajo son el espectro de diseño que depende de una nueva clasificación de suelos, las limitaciones al corte basal, carga axial en muros menor o igual a 0.35*f'c*Ag, y el confinamiento en muro, sumado a los ya establecido en las normas Nch433 of.1996 y Nch430 of.2008, como limitaciones al esfuerzo de corte en muros y a las deformaciones sísmicas. Una vez recopilada la información de interés del diseño original de un edificio, este se modificó incorporando los nuevos requerimientos de los decretos 60 y 61 para generar un nuevo diseño. Estos dos fueron comparados para así obtener la variación de algunos parámetros de respuesta sísmica, de los volúmenes de hormigón y el tonelaje de acero requerido. De acuerdo a los resultados, el requerimiento de confinamiento normativo es responsable de modificaciones en el 100% de los edificios estudiados tanto por el incremento de acero requerido como en el volumen de muros...

A magnetar-like event from LS I +61 303 and its nature as a gamma-ray binary

Torres, Diego F.; Rea, Nanda; Esposito, Paolo; Li, Jian; Chen, Yupeng; Zhang, Shu
Fonte: Universidade Cornell Publicador: Universidade Cornell
Tipo: Artigo de Revista Científica
Publicado em 23/09/2011
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We report on the Swift-BAT detection of a short burst from the direction of the TeV binary LS I +61 303, resembling those generally labelled as magnetar-like. We show that it is likely that the short burst was indeed originating from LS I +61 303 (although we cannot totally exclude the improbable presence of a far-away line-of-sight magnetar) and that it is a different phenomena with respect to the previously-observed ks-long flares from this system. Accepting as a hypothesis that LS I +61 303 is the first magnetar detected in a binary system, we study which are the implications. We find that a magnetar-composed LS I +61 303-system would most likely be (i.e., for usual magnetar parameters and mass-loss rate) subject to a flip-flop behavior, from a rotational powered regime (in apastron) to a propeller regime (in periastron) along each of the LS I +61 303, eccentric orbital motion. We prove that whereas near apastron an inter-wind shock can lead to the normally observed LS I +61 303behavior, with TeV emission, the periastron propeller is expected to efficiently accelerate particles only to sub-TeV energies. This flip-flop scenario would explain the system's behavior where a recurrent TeV emission was seen appearing near apastron only...

The Surface of 2003 EL_(61) in the Near-Infrared

Trujillo, Chadwick A.; Brown, Michael E.; Barkume, Kristina; Schaller, Emily L.; Rabinowitz, David L.
Fonte: American Astronomical Society Publicador: American Astronomical Society
Tipo: Article; PeerReviewed Formato: application/pdf
Publicado em 01/02/2007
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We report the detection of crystalline water ice on the surface of 2003 EL_(61). Reflectance spectra were collected from the Gemini North telescope in the 1.0 to 2.4 μm wavelength range and from the Keck telescope across the 1.4-2.4 μm wavelength range. The signature of crystalline water ice is obvious in all data collected. Like the surfaces of many outer solar system bodies, the surface of 2003 EL_(61) is rich in crystalline water ice, which is energetically less favored than amorphous water ice at low temperatures, suggesting that resurfacing processes may be taking place. The near-infrared color of the object is much bluer than a pure water ice model. Adding a near-infrared blue component such as hydrogen cyanide or phyllosilicate clays improves the fit considerably, with hydrogen cyanide providing the greatest improvement. The addition of hydrated tholins and bitumens also improves the fit, but is inconsistent with the neutral V - J reflectance of 2003 EL_(61). A small decrease in reflectance beyond 2.3 μm may be attributable to cyanide salts. Overall, the reflected light from 2003 EL_(61) is best fit by a model of 2/3-4/5 pure crystalline water ice and 1/3-1/5 near-infrared blue component such as hydrogen cyanide or kaolinite. The surface of 2003 EL_(61) is unlikely to be covered by significant amounts of dark material such as carbon black...

Underwater Characteristics of Projectile 61.04

Knapp, Robert T.; Peabody, Robert M.
Fonte: California Institute of Technology Publicador: California Institute of Technology
Tipo: Report or Paper; PeerReviewed Formato: application/pdf
Publicado em 26/09/1944
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This report covers the underwater performance characteristics of a torpedo shape of the 61 series, designated as Model 61.04 This shape is a modification of Model 61.01, the original form of the 6i series, the tail fin span being reduced and short runners added to the forward part of the cylindrical section and on the fins. All tests were made on models without propellers. The characteristics of Projectile 61.04 are compared with those of Projectile 61.01, for yaw (or pitch) angles up to i2 degrees, and for rudder settings up to 20 degrees. Tests were made, at neutral rudder only, on Projectile 61.04 with the short runners removed from the body and tail fins, to measure the effect of the runners. These tests were authorized by Dr E H Colpitts, Chief of Section 6.1, NDRC, in his letter of October 8 , 1943.

“O MEDO VAI TER TUDO, QUASE TUDO”. A POESIA INDISCIPLINADA DE ALEXANDRE O´NEILL: APROXIMAÇÕES E DESLOCAMENTOS DA "POESIA 61".; “O MEDO VAI TER TUDO, QUASE TUDO”. A POESIA INDISCIPLINADA DE ALEXANDRE O´NEILL: APROXIMAÇÕES E DESLOCAMENTOS DA "POESIA 61"

Evangelista, Lúcia
Fonte: Universidade de São Paulo. Faculdade de Filosofia, Letras e Ciências Humanas Publicador: Universidade de São Paulo. Faculdade de Filosofia, Letras e Ciências Humanas
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; Formato: application/pdf
Publicado em 10/12/2010 POR
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A  poesia  de  Alexandre  O'Neill,  em  sua  aparente  simplicidade,  desconstrói discursos, zomba do status-quo, subverte a ideia de ordem, de disciplina, de tradição. Mas ele não é o único em que se pode ler uma dimensão política no contexto da década de 60, a que este artigo se detem. Nos novos poetas de 61, em especial, em Luísa Neto Jorge e Gastão Cruz a questão do contrapoder é também uma constante, mas uma constante mais difusa. Enquanto que em O'Neill, a resistência da poesia dá-se na subversão dos discursos, numa espécie de paródia ao estabelecido, nesses outros dois poetas a resistência no poema dá-se sobretudo em sua própria forma.; The poetry of Alexandre O´Neill, in its apparent simplicity, deconstructs discourses, mocks the status-quo, subverts the idea of order, discipline, tradition. However, he is not the only author that can be read in a political dimension within the context of the 60´s, period covered by this article. In the works of the new poets of 61, especially Luísa Neto Jorge and Gastão Cruz, the counter-power issue is also a constant, but rather a more diffuse one. While in O´Neill´s work, the resistance of poetry happens through the subversion of the discourses, in a kind of a parody of the establishment...