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## Análise da associação da fadiga com variáveis clínicas e psicológicas em uma série de 371 pacientes brasileiros com artrite reumatoide

Bianchi,Washington A.; Elias,Fernanda R.; Pinheiro,Geraldo da Rocha Castelar; Gayer,Carlos Roberto Machado; Carneiro,Claudio; Grynzpan,Rachel; Hamdan,Paulo; Carneiro,Sueli
Tipo: Artigo de Revista Científica Formato: text/html
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Objetivos: A fadiga é um sintoma altamente subjetivo e extremamente comum em pacientes com artrite reumatoide, embora seja difícil de caracterizar e definir. O objetivo desse estudo foi avaliar a fadiga em uma coorte de pacientes brasileiros e analisar a relação entre fadiga e variáveis específicas da doença. Métodos: Foram prospectivamente investigados 371 pacientes brasileiros diagnosticados com artrite reumatoide, de acordo com os critérios de classificação do Colégio Americano de Reumatologia de 1987. Dados demográficos, clínicos e laboratoriais foram obtidos dos registros clínicos. Foram registrados o número de articulações dolorosas, índice de massa corporal, duração da doença, qualidade de vida, capacidade funcional, ansiedade e depressão. A fadiga foi avaliada com o uso da subescala específica da escala Fatigue Assessment of Chronic Illness Therapy (FACIT-FATIGUE). Resultados: O escore mediano para fadiga foi 42 (10), negativamente correlacionado com a capacidade funcional (-0,507; p < 0,001), ansiedade e depressão (-0,542 e -0,545; p < 0,001, respectivamente) e predominantemente com o domínio físico do questionário Short Form-36 para qualidade de vida (SF-36P: 0...

## Association of a Thr-371 Substitution in a Conserved Amino Acid Motif of Penicillin-Binding Protein 1A with Penicillin Resistance of Streptococcus pneumoniae

Asahi, Yasuko; Ubukata, Kimiko
Fonte: American Society for Microbiology Publicador: American Society for Microbiology
Tipo: Artigo de Revista Científica
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We determined the nucleotide sequence between 1,903 and 3,097 bp of pbp1a, which encodes the transpeptidase domain of PBP 1A, from clinical isolates of penicillin-resistant Streptococcus pneumoniae (PRSP) serotypes 19 (n = 8), 6 (n = 9), 23 (n = 6), and 14 (n = 2) and two penicillin-susceptible S. pneumoniae (PSSP) isolates. These serotyped PRSP strains were isolated predominantly in Japan from 1993 through 1997. The 25 resistant strains were classified into five groups on the basis of the extent of sequence differences. Strains in groups I (n = 5; serotype 6), II (n = 3; serotype 19), and III (n = 12; different serotypes) had sequences highly homologous to the sequence of pbp1a of PRSP strains from South Africa, Spain, and the United States. The group IV strain (n = 1; serotype 14) had unique deletions from or insertions in the sequences. The sequences of group V strains (n = 4; serotypes 6 and 23) had relatively few differences from the sequences of the PSSP strains. For strains (n = 18) for which the threonine at codon 371 (Thr-371) in a conserved STMK motif of PBP 1A was substituted with an alanine or a serine (in addition to having altered pbp2x and pbp2b genes), penicillin MICs were ≧1.0 μg/ml. The PBPs 1A of these strains showed decreased affinities for [3H]benzylpenicillin and slightly faster mobilities on sodium dodecyl sulfate-polyacrylamide gels. In contrast...

## Anchoring 9,371 Maize Expressed Sequence Tagged Unigenes to the Bacterial Artificial Chromosome Contig Map by Two-Dimensional Overgo Hybridization1

Gardiner, Jack; Schroeder, Steven; Polacco, Mary L.; Sanchez-Villeda, Hector; Fang, Zhiwei; Morgante, Michele; Landewe, Tim; Fengler, Kevin; Useche, Francisco; Hanafey, Michael; Tingey, Scott; Chou, Hugh; Wing, Rod; Soderlund, Carol; Coe, Edward H.
Fonte: American Society of Plant Biologists Publicador: American Society of Plant Biologists
Tipo: Artigo de Revista Científica
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Our goal is to construct a robust physical map for maize (Zea mays) comprehensively integrated with the genetic map. We have used a two-dimensional 24 × 24 overgo pooling strategy to anchor maize expressed sequence tagged (EST) unigenes to 165,888 bacterial artificial chromosomes (BACs) on high-density filters. A set of 70,716 public maize ESTs seeded derivation of 10,723 EST unigene assemblies. From these assemblies, 10,642 overgo sequences of 40 bp were applied as hybridization probes. BAC addresses were obtained for 9,371 overgo probes, representing an 88% success rate. More than 96% of the successful overgo probes identified two or more BACs, while 5% identified more than 50 BACs. The majority of BACs identified (79%) were hybridized with one or two overgos. A small number of BACs hybridized with eight or more overgos, suggesting that these BACs must be gene rich. Approximately 5,670 overgos identified BACs assembled within one contig, indicating that these probes are highly locus specific. A total of 1,795 megabases (Mb; 87%) of the total 2,050 Mb in BAC contigs were associated with one or more overgos, which are serving as sequence-tagged sites for single nucleotide polymorphism development. Overgo density ranged from less than one overgo per megabase to greater than 20 overgos per megabase. The majority of contigs (52%) hit by overgos contained three to nine overgos per megabase. Analysis of approximately 1...

## Clinical experience with TENS and TENS combined with nitrous oxide-oxygen. Report of 371 patients.

Quarnstrom, F. C.; Milgrom, P.
Fonte: American Dental Society of Anesthesiology Publicador: American Dental Society of Anesthesiology
Tipo: Artigo de Revista Científica
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Transcutaneous electrical nerve stimulation (TENS) alone or TENS combined with nitrous oxide-oxygen (N2O) was administered for restorative dentistry without local anesthesia to 371 adult patients. A total of 55% of TENS alone and 84% of TENS/N2O visits were rated successful. A total of 53% of TENS alone and 82% of TENS/N2O patients reported slight or no pain. In multivariable analyses, pain reports were related to the anesthesia technique and patient fear and unrelated to sex, race, age, tooth, or depth of preparation.

## The Two Stem Cell MicroRNA Gene Clusters C19MC and miR-371-3 Are Activated by Specific Chromosomal Rearrangements in a Subgroup of Thyroid Adenomas

Rippe, Volkhard; Dittberner, Lea; Lorenz, Verena N.; Drieschner, Norbert; Nimzyk, Rolf; Sendt, Wolfgang; Junker, Klaus; Belge, Gazanfer; Bullerdiek, Jörn
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
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Thyroid adenomas are common benign human tumors with a high prevalence of about 5% of the adult population even in iodine sufficient areas. Rearrangements of chromosomal band 19q13.4 represent a frequent clonal cytogenetic deviation in these tumors making them the most frequent non-random chromosomal translocations in human epithelial tumors at all. Two microRNA (miRNA) gene clusters i.e. C19MC and miR-371-3 are located in close proximity to the breakpoint region of these chromosomal rearrangements and have been checked for a possible up-regulation due to the genomic alteration. In 4/5 cell lines established from thyroid adenomas with 19q13.4 rearrangements and 5/5 primary adenomas with that type of rearrangement both the C19MC and miR-371-3 cluster were found to be significantly overexpressed compared to controls lacking that particular chromosome abnormality. In the remaining cell line qRT-PCR revealed overexpression of members of the miR-371-3 cluster only which might be due to a deletion accompanying the chromosomal rearrangement in that case. In depth molecular characterization of the breakpoint in a cell line from one adenoma of this type reveals the existence of large Pol-II mRNA fragments as the most likely source of up-regulation of the C19MC cluster. The up-regulation of the clusters is likely to be causally associated with the pathogenesis of the corresponding tumors. Of note...

## Activation of the two microRNA clusters C19MC and miR-371-3 does not play prominent role in thyroid cancer

Rippe, Volkhard; Flor, Inga; Debler, Johannes Wolfram; Drieschner, Norbert; Rommel, Birgit; Krause, Daniel; Junker, Klaus; Bullerdiek, Jörn
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
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Chromosomal rearrangements of band 19q13.4 are frequent cytogenetic alterations in benign thyroid adenomas. Apparently, these alterations lead to the upregulation of genes encoding microRNAs of two clusters mapping to the breakpoint region, i.e. miR-371-3 and C19MC. Since members of both clusters have been associated with neoplastic growth in other tumor entities the question arises whether or not their upregulation predisposes to malignant transformation of follicular cells of the thyroid. To address this question we have quantified the expression of miR-372 and miR-520c-3p in samples of 114 thyroid cancers including eight anaplastic thyroid carcinomas, 25 follicular thyroid carcinomas, 78 papillary thyroid carcinomas (including 13 follicular variants thereof), two medullary thyroid carcinomas and one oncocytic thyroid carcinoma. Additionally, we quantified miR-371a-3p and miR-519a-3p in selected samples. While in neither of the cases miR-520c-3p and miR-519a-3p were found to be upregulated, one papillary and one anaplastic thyroid carcinoma, respectively, showed upregulation of miR-372 and miR-371a-3p. However, in these cases fluorescence in situ hybridization did not reveal rearrangements of the common breakpoint region as affected in adenomas. Thus...

## Evolution of the miR-290–295/miR-371–373 Cluster Family Seed Repertoire

Wu, Shuang; Aksoy, Munevver; Shi, Jianting; Houbaviy, Hristo Botev
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
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Expression of the mouse miR-290–295 cluster and its miR-371–373 homolog in human is restricted to early embryos, primordial germ cells, the germ line stem cell compartment of the adult testis and to stem cell lines derived from the early embryonic lineages. Sequencing data suggest considerable seed diversification between the seven homologous pre-miRNAs of miR-290–295 but it is not clear if all of the implied miR-290–295 seeds are also conserved in the human miR-371–373 cluster, which consists of only three homologous pre-miRNAs. By employing miRNA target reporters we show that most, if not all, seeds in miR-290–295 are represented in miR-371–373. In the mouse, pre-miR-290, pre-miR-292 and pre-miR-293 express subsets of the miRNA isoforms processed from the single human pre-miR-371. Comparison of the possible miR-290–295/miR-371–373 seed repertoires in placental mammals suggests a model for the evolution of this miRNA cluster family, which would be otherwise difficult to deduce based solely on pre-miRNA sequence comparisons. The conservation of co-expressed seeds that is characteristic of miR-290–295/miR-371–373 should be taken into account in models of the corresponding miRNA-target interaction networks.

## The SOX17/miR-371-5p/SOX2 axis inhibits EMT, stem cell properties and metastasis in colorectal cancer

Li, Yuling; Lv, Zhenbing; He, Guoyang; Wang, Jianmei; Zhang, Xiaojing; Lu, Guifeng; Ren, Xiaoli; Wang, Feifei; Zhu, Xiaohui; Ding, Yi; Liao, Wenting; Ding, Yanqing; Liang, Li
Fonte: Impact Journals LLC Publicador: Impact Journals LLC
Tipo: Artigo de Revista Científica
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Cancer stem cells (CSCs) and EMT-type cells, which share molecular characteristics with CSCs, have been believed to play critical roles in tumor metastasis. Although much progress has been garnered in elucidating the molecular pathways that trigger EMT, stemness and metastasis, a number of key mechanistic gaps remain elusive. In the study, miR-371-5p was obviously down-regulated in primary CRC tissues compared with matched adjacent normal mucosa and correlated significantly with differentiation, tumor size, lymphatic and liver metastases. MiR-371-5p could attenuate proliferation, invasion in vitro and metastasis in vivo in CRC cells. It also suppressed EMT by regulating Wnt/β-catenin signaling and strongly decreased the CRC stemness phenotypes. Moreover, demethylation of SOX17 induced miR-371-5p expression and consequently suppressed its direct target SOX2 in CRC cells. MiR-371-5p was necessary for SOX17 mediated cancer-related traits and SOX2 was a functional target of miR-371-5p. A positive relationship between SOX17 and miR-371-5p expression and a negative one between miR-371-5p and SOX2 expression were observed in CRC cell lines and tissues. In conclusion, we identified miR-371-5p as an important “oncosuppressor” in CRC progression and elucidated a novel mechanism of the SOX17/miR-371-5p/SOX2 axis in the regulation of EMT...

## A 371-nucleotide region between the herpes simplex virus type 1 (HSV-1) LAT promoter and the 2-kilobase LAT is not essential for efficient spontaneous reactivation of latent HSV-1.

Perng, G C; Slanina, S M; Ghiasi, H; Nesburn, A B; Wechsler, S L
Tipo: Artigo de Revista Científica
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The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is essential for efficient spontaneous reactivation of HSV-1 from latency. However, neither the mechanism by which LAT carries out this function nor the region of LAT responsible for this function in known. LAT is transcribed as an unstable 8.3-kb RNA that gives rise to a very stable 2-kb LAT RNA that is readily detected in latently infected sensory neurons. We show here that 371 of the 662 nucleotides located between the start of LAT transcription and the 5' end of the 2-kb LAT RNA do not appear to be essential for wild-type levels of spontaneous reactivation in the rabbit ocular model of HSV-1 latency. We deleted LAT nucleotides 76 to 447 from both copies of the LAT gene (one in each viral long repeat) to produce the mutant dLAT371. Rabbits were ocularly infected with dLAT371, and spontaneous reactivation was measured in comparison with the marker-rescued virus dLAT371R. Both dLAT371 and dLAT371R had spontaneous reactivation rates of approximately 13 to 14%. This was consistent with the parental McKrae wild-type virus (11.7%; P = 0.49) and significantly higher than the LAT transcription-negative mutant dLAT2903 (2.4%; P < 0.0001). Southern analysis confirmed that the spontaneously reactivated dLAT371 virus retained the deletion in both copies of LAT. Therefore...

## Discovery of an Optical Jet in the BL Lac Object 3C 371

Nilsson, K.; Heidt, J.; Pursimo, T.; Takalo, L. O.; Sillanpaeae, A.; Jaeger, K.
Tipo: Artigo de Revista Científica
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We have detected an optical jet in the BL Lac object 3C 371 that coincides with the radio jet in this object in the central few kpc. The most notable feature is a bright optical knot 3 arcsec (4 kpc) from the nucleus that occurs at the location where the jet apparently changes its direction by ~30 degrees. The radio, near-infrared and optical observations of this knot are consistent with a single power-law spectrum with a radio-optical spectral index alpha = -0.81. One possible scenario for the observed turn is that the jet is interacting with the material in the bridge connecting 3C 371 to nearby galaxies and the pressure gradient is deflecting the jet significantly.; Comment: 11 pages, LaTeX, 4 figures (1 eps, 3 gifs), accepted for publication in ApJ Letters

## Broad-band BeppoSAX observation of the low-mass X-ray binary X1822-371

Parmar, A. N.; Oosterbroek, T.; Del Sordo, S.; Segreto, A.; Santangelo, A.; Fiume, D. Dal; Orlandini, M.
Tipo: Artigo de Revista Científica
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Results of a 1997 September 9-10 BeppoSAX observation of the 5.57 hr low-mass X-ray binary (LMXRB) X1822-371 are presented. The 0.3-40 keV spectrum is unusually complex and cannot be fit by any of the standard models applied to other LMXRB. At least two components are required. One component has a shape consistent with that expected from the Comptonization of an input soft (Wein) spectrum while the other, contributing ~40% of the 1-10 keV flux, is consistent with being a blackbody. In addition, there is a dip'' in the spectrum which can be modeled by a 1.33 +0.05 -0.11 keV absorption edge with an optical depth, tau, of 0.28 +/- 0.06. If the same model is fit to ASCA Solid-State Imaging Spectrometer spectra obtained in 1993 and 1996, then reasonable fits are also obtained, with a similar absorption feature required. The nature of this feature is highly uncertain; its energy corresponds to the K-edges of highly ionized Ne x and neutral Mg, or to an L-edge of moderately ionized Fe. Surprisingly, no strong (tau > 0.05) Fe-K or (tau > 0.18) O-K edges are visible. The folded lightcurve of X1822-371 is similar to previous observations, except that no strong softening is seen near the eclipse. An updated orbital ephemeris is provided.; Comment: 7 pages. To appear in A&A

## The Flared Disc Project: RXTE and ASCA Observations of X 1822-371

Heinz, S.; Nowak, M. A.
Tipo: Artigo de Revista Científica
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We present archival RXTE and simultaneous ASCA data of the eclipsing low mass X-ray binary (LMXB) X 1822-371. Our spectral analysis shows that a variety of simple models can fit the spectra relatively well. Of these models, we explore two in detail through phase resolved fits. These two models represent the case of a very optically thick and a very optically thin corona. While systematic residuals remain at high energies, the overall spectral shape is well-approximated. The same two basic models are fit to the X-ray light curve, which shows sinusoidal modulations interpreted as absorption by an opaque disc rim of varying height. The geometry we infer from these fits is consistent with previous studies: the disc rim reaches out to the tidal truncation radius, while the radius of the corona (approximated as spherical) is very close to the circularization radius. Timing analysis of the RXTE data shows a time lag from hard to soft consistent with the coronal size inferred from the fits. Neither the spectra nor the light curve fits allow us to rule out either model, leaving a key ingredient of the X 1822-371 puzzle unsolved. Furthermore, while previous studies were consistent with the central object being a 1.4 Msol neutron star, which has been adopted as the best guess scenario for this system...

## The Structure of the Accretion Disk in the ADC X-Ray Binary 4U 1822-371 at Optical and Ultraviolet Wavelengths

Bayless, Amanda J.; Robinson, Edward L.; Hynes, Robert I.; Ashcraft, Teresa A.; Cornell, Mark E.
Tipo: Artigo de Revista Científica
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The eclipsing low-mass X-ray binary 4U 1822-371 is the prototypical accretion disk corona (ADC) system. We have obtained new time-resolved UV spectroscopy of 4U 1822-371 with the Advanced Camera for Surveys/Solar Blind Channel (ACS/SBC) on the Hubble Space Telescope (HST) and new V- and J-band photometry with the 1.3-m SMARTS telescope at CTIO. We use the new data to construct its UV/optical spectral energy distribution and its orbital light curve in the UV, V, and J bands. We derive an improved ephemeris for the optical eclipses and confirm that the orbital period is changing rapidly, indicating extremely high rates of mass flow in the system; and we show that the accretion disk in the system has a strong wind with projected velocities up to 4000 km/s. We show that the disk has a vertically-extended, optically-thick component at optical wavelengths.This component extends almost to the edge of the disk and has a height equal to ~0.5 of the disk radius. As it has a low brightness temperature, we identify it as the optically-thick base of a disk wind, not as the optical counterpart of the ADC. Like previous models of 4U 1822-371, ours needs a tall obscuring wall near the edge of the accretion disk, but we interpret the wall as a layer of cooler material at the base of the disk wind...

## Phase-resolved optical and X-ray spectroscopy of low-mass X-ray binary X1822-371

Somero, A.; Hakala, P.; Muhli, P.; Charles, P.; Vilhu, O.
Tipo: Artigo de Revista Científica
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(Abridged) X1822-371 is the prototypical accretion disc corona X-ray source, a low-mass X-ray binary viewed at very high inclination, thereby allowing the disc structure and extended disc coronal regions to be visible. We study the structure of the accretion disc in X1822-371 by modelling the phase-resolved spectra both in optical and X-ray regime. We analyse high time resolution optical ESO/VLT spectra of X1822-371 to study the variability in the emission line profiles. In addition, we use data from XMM-Newton space observatory to study phase-resolved as well as high resolution X-ray spectra. We apply the Doppler tomography technique to reconstruct a map of the optical emission distribution in the system. We fit multi-component models to the X-ray spectra. We find that our results from both the optical and X-ray analysis can be explained with a model where the accretion disc has a thick rim in the region where the accretion stream impacts the disc. The behaviour of the H_beta line complex implies that some of the accreting matter creates an outburst around the accretion stream impact location and that the resulting outflow of matter moves both away from the accretion disc and towards the centre of the disc. Such behaviour can be explained by an almost isotropic outflow of matter from the accretion stream impact region. The optical emission lines of HeII 4686 and 5411 show double peaked profiles...

## Deep Chandra and multicolor HST observations of the jets of 3C 371 and PKS 2201+044

Sambruna, R. M.; Donato, D.; Tavecchio, F.; Maraschi, L.; Cheung, C. C.; Urry, C. M.
Tipo: Artigo de Revista Científica
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This paper presents multiwavelength imaging and broad-band spectroscopy of the relativistic jets in the two nearby radio galaxies 3C 371 and PKS 2201+044, acquired with Chandra, HST, VLA, and Merlin. Radio polarization images are also available. The two sources stand out as "intermediate'' between FRIs and FRIIs; their cores are classified as BL Lacs, although broad and narrow optical emission lines were detected at times. The multiwavelength images show jet morphologies with the X-ray emission peaking closer to the nucleus than the longer wavelengths. The jets are resolved at all wavelengths in a direction perpendicular to the jet axis. The jets SEDs are consistent with a single spectral component from radio to X-rays, interpreted as synchrotron emission. The SEDs show a progressive softening from the inner to the outer regions of the jet, indicating that the electron break energy moves to lower energies with distance from the core. Overall, the X-ray and multiwavelength properties of the jets of 3C 371 and PKS 2201+044 appear intermediate between those of FRIs and FRIIs.; Comment: Accepted for publication in ApJ; 28 pages (emulateapj5), 17 figures

## X-ray spectroscopy of the ADC source X1822-371 with Chandra and XMM-Newton

Iaria, R.; Di Salvo, T.; D'Aì, A.; Burderi, L.; Mineo, T.; Riggio, A.; Papitto, A.; Robba, N. R.
Tipo: Artigo de Revista Científica
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The eclipsing low-mass X-ray binary X1822-371 is the prototype of the accretion disc corona (ADC) sources. We analyse two Chandra observations and one XMM-Newton observation to study the discrete features and their variation as a function of the orbital phase, deriving constraints on the temperature, density, and location of the plasma responsible for emission lines. The HETGS and XMM/Epic-pn observed X1822-371 for 140 and 50 ks, respectively. We extracted an averaged spectrum and five spectra from five selected orbital-phase intervals that are 0.04-0.25, 0.25-0.50, 0.50-0.75, 0.75-0.95, and, finally, 0.95-1.04; the orbital phase zero corresponds to the eclipse time. All spectra cover the energy band between 0.35 and 12 keV. We confirm the presence of local neutral matter that partially covers the X-ray emitting region; the equivalent hydrogen column is $5 \times 10^{22}$ cm$^{-2}$ and the covered fraction is about 60-65%. We identify emission lines from highly ionised elements, and a prominent fluorescence iron line associated with a blending of FeI-FeXV resonant transitions. The transitions of He-like ions show that the intercombination dominates over the forbidden and resonance lines. The line fluxes are the highest during the orbital phases between 0.04 and 0.75. We discuss the presence of an extended...

## Partially Absorbed Comptonization Spectrum from the Nearly Edge-on Source X 1822-371

Iaria, R.; Di Salvo, T.; Burderi, L.; Robba, N. R.
Tipo: Artigo de Revista Científica
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We report the results of a spectral analysis over the range 0.1-200 keV performed on the dipping source X 1822-371 observed by BeppoSAX. We find the best fit to the continuum using a partially covered Comptonization model, due to scattering off soft seed photons by electrons at a temperature of ~4.8 keV, without the presence of any soft blackbody emission. The equivalent hydrogen column obtained for the absorbed component is ~4.5 10^{22} cm^{-2}, an order of magnitude larger than the Galactic absorption for this source, and the covering fraction is ~71%. Because the inclination angle of X 1822-371 to the line of sight is ~85^\circ, this model gives a reasonable scenario for the source: the Comptonized spectrum could come from an extended accretion disk corona (ADC), probably the only region that can be directly observed due to the high inclination. The excess of matter producing the partial covering could be close to the equatorial plane of the system, above the outer disk, occulting the emission from the inner disk and the inner part of the ADC. An iron emission line is also present at ~6.5 keV with an equivalent width of ~150 eV. We argue that this strong iron line cannot be explained as reflection of the Comptonized spectrum by the accretion disk. It is probably produced in the ADC. An emission line at ~1.9 keV (with an equivalent width of ~54 eV) and an absorption edge at \~8.7 keV (with an optical depth of ~0.1) are also required to fit this spectrum. These features are probably produced by highly ionized iron (Fe XXIV) present in the outer part of the ADC...

## Implications of X-Ray Line Variations for 4U1822-371

Ji, Li; Schulz, Norbert S.; Nowak, Michael A.; Canizares, Claude R.
Tipo: Artigo de Revista Científica
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4U 1822-371 is one of the proto-type accretion disk coronal sources with an orbital period of about 5.6 hours. The binary is viewed almost edge-on at a high inclination angle of 83 degrees, which makes it a unique candidate to study binary orbital and accretion disk dynamics in high powered X-ray sources. We observed the X-ray source in 4U 1822-371 with the Chandra High Energy Transmission Grating Spectrometer (HETGS) for almost nine binary orbits. X-ray eclipse times provide an update of the orbital ephemeris. We find that our result follows the quadratic function implied by previous observations; however, it suggests a flatter trend. Detailed line dynamics also confirm a previous suggestion that the observed photo-ionized line emission originates from a confined region in the outer edge of the accretion disk near the hot spot. Line properties allow us to impose limits on the size of accretion disk, the central corona, and the emission region. The photo-ionized plasma is consistent with ionization parameters of log(xi) > 2, and when combined with disk size and reasonable assumptions for the plasma density, this suggests illuminating disk luminosities which are over an order of magnitude higher than what is actually observed. That is...

## A possible cyclotron resonance scattering feature near 0.7 keV in X1822-371

Iaria, R.; Di Salvo, T.; Matranga, M.; Galiano, C. G.; D'Aì, A.; Riggio, A.; Burderi, L.; Sanna, A.; Ferrigno, C.; Del Santo, M.; Pintore, F.; Robba, N. R.
Tipo: Artigo de Revista Científica
We analyse all available X-ray observations of X1822-371 made with XMM-Newton, Chandra, Suzaku and INTEGRAL satellites. The observations were not simultaneous. The Suzaku and INTEGRAL broad band energy coverage allows us to constrain the spectral shape of the continuum emission well. We use the model already proposed for this source, consisting of a Comptonised component absorbed by interstellar matter and partially absorbed by local neutral matter, and we added a Gaussian feature in absorption at $\sim 0.7$ keV. This addition significantly improves the fit and flattens the residuals between 0.6 and 0.8 keV. We interpret the Gaussian feature in absorption as a cyclotron resonant scattering feature (CRSF) produced close to the neutron star surface and derive the magnetic field strength at the surface of the neutron star, $(8.8 \pm 0.3) \times 10^{10}$ G for a radius of 10 km. We derive the pulse period in the EPIC-pn data to be 0.5928850(6) s and estimate that the spin period derivative of X1822-371 is $(-2.55 \pm 0.03) \times 10^{-12}$ s/s using all available pulse period measurements. Assuming that the intrinsic luminosity of X1822-371is at the Eddington limit and using the values of spin period and spin period derivative of the source...