Página 8 dos resultados de 8938 itens digitais encontrados em 0.005 segundos

Efeitos do tai chi chuan sobre o equilíbrio corporal em idosas com baixa massa óssea; Effects of Tai Chi Chuan on body balance in elderly women with low bone mass

Silva, Nélida Amorim da
Fonte: Universidade de Brasília Publicador: Universidade de Brasília
Tipo: Dissertação
POR
Relevância na Pesquisa
16.91%
Dissertação (mestrado)—Universidade de Brasília, Faculdade de Educação Física , Programa de Pós-Graduação Strictu-Sensu em Educação Física, 2010.; O equilíbrio corporal é uma das capacidades físicas mais afetadas com o envelhecimento. Objetivo: Avaliar o equilíbrio corporal em idosas com baixa massa óssea residentes em comunidade, antes e após 12 semanas do treino de Tai Chi Chuan (TCC). Materiais e Métodos: Esta pesquisa caracterizou-se como tipo quase experimental. A amostra de conveniência foi composta por 30 mulheres idosas escolhidas do banco de dados do Programa de Prevenção e Diagnóstico da Osteoporose da Secretaria de Estado de Saúde do Distrito Federal da Região Administrativa de São Sebastião, das quais 17 mulheres fizeram parte do grupo TCC e 14 idosas fizeram parte do grupo controle. O treino de TCC realizado foi o estilo Yang de 24 movimentos, com a freqüência de duas vezes por semana, no período da manhã, aulas com duração de 50 minutos, durante 12 semanas. A coleta de dados foi realizada através de quatro instrumentos de análise de equilíbrio corporal: o questionário Escala de Equilíbrio de Berg (EEB), “Timed Up and Go”(TUG), teste de Alcance Funcional (TAF) e a plataforma de força (PLAT) AccuSway Plus da marca AMTI. A análise estatística foi feita através do teste Mann Whitney para diferenças entre grupos e Wilcoxon para diferenças intra-grupo...

Insights into Candida tropicalis virulence factors

Gossi, Melyssa Fernanda Norman Negri
Fonte: Universidade do Minho Publicador: Universidade do Minho
Tipo: Tese de Doutorado
Publicado em 22/07/2011 ENG
Relevância na Pesquisa
16.91%
Tese de doutoramento em Engenharia Biomédica; Candida tropicalis is a common species related to nosocomial infections, namely candidemia and candiduria. Several virulence factors seem to be responsible for C. tropicalis infections, which present high potential for dissemination and mortality. Adhesion to surfaces (medical devices and host cells) and biofilm formation, are considered important factors that contribute to the development of candidosis. Hence, the colonization of indwelling devices like urinary catheters by C. tropicalis poses a critical problem. Further, adhesion and invasion of host cells by C. tropicalis is considered the first step to initiate systemic infections. Once adhered to epithelium, C. tropicalis are able to secrete hydrolytic enzymes that cause damage in host cells membrane integrity, leading to dysfunction or disruption of host structures. Thus, the main aim of this work was to characterize the virulence factors of C. tropicalis as well as to evaluate adhesion to biotic and abiotic surfaces, biofilm formation, expression of hydrolytic enzymes and antifungal susceptibility of C. tropicalis clinical isolates from urine and blood cultures and from central venous catheters. Accordingly...

Clouds and convection in the tropics and subtropics:models, observations, and parameterizations

Cardoso, Sambingo da Silva, 1978-
Fonte: Universidade de Lisboa Publicador: Universidade de Lisboa
Tipo: Tese de Doutorado
Publicado em //2013 ENG
Relevância na Pesquisa
17%
Tese de doutoramento, Ciências Geofísicas e da Geoinformação (Meteorologia), Universidade de Lisboa, Faculdade de Ciências, 2013; The GPCI (GCSS / working group on numerical experimentation Pacific Cross-section Intercomparison) project offers a new approach for the intercomparison of models, by focusing the analysis on a single cross section in the NE Pacific ocean. It is targeted at the stratocumulus, shallow cumulus, and deep convection regimes, as well as the respective transitions. Three-hourly satellite observations and model simulations were prepared for GPCI for the JJA season. The seasonal mean results for variables such as total cloud cover, liquid water path, and outgoing longwave radiation show high scatter among models. Mean vertical velocity, and relative humidity, suggest good, overall, representation of the Hadley circulation. Still, differences exist between models (e.g., in the intensity of the deep convection, or humidity content in the boundary layer). The main cloud types are represented differently (e.g., too low stratocumulus clouds). The transitions between stratocumulus and shallow cumulus show two distinct behaviours (smooth versus abrupt with bimodal nature) reflecting distinct cloud parameterization approaches. None of them reproduces well the observations. Following GEPAT (Grade-based Empirical Pattern Analysis Technique)...

Multiple factor analysis of metachronous upper urinary tract transitional cell carcinoma after radical cystectomy

Wang,P.; Luo,J.D.; Wu,W.F.; Wang,S.; Cai,S.L.; Shen,B.H.; Shi,S.F.; Wei,K.X.; Zhang,Z.G.; Chen,Z.D.
Fonte: Associação Brasileira de Divulgação Científica Publicador: Associação Brasileira de Divulgação Científica
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/07/2007 EN
Relevância na Pesquisa
16.91%
Transitional cell carcinoma (TCC) of the urothelium is often multifocal and subsequent tumors may occur anywhere in the urinary tract after the treatment of a primary carcinoma. Patients initially presenting a bladder cancer are at significant risk of developing metachronous tumors in the upper urinary tract (UUT). We evaluated the prognostic factors of primary invasive bladder cancer that may predict a metachronous UUT TCC after radical cystectomy. The records of 476 patients who underwent radical cystectomy for primary invasive bladder TCC from 1989 to 2001 were reviewed retrospectively. The prognostic factors of UUT TCC were determined by multivariate analysis using the COX proportional hazards regression model. Kaplan-Meier analysis was also used to assess the variable incidence of UUT TCC according to different risk factors. Twenty-two patients (4.6%). developed metachronous UUT TCC. Multiplicity, prostatic urethral involvement by the bladder cancer and the associated carcinoma in situ (CIS) were significant and independent factors affecting the occurrence of metachronous UUT TCC (P = 0.0425, 0.0082, and 0.0006, respectively). These results were supported, to some extent, by analysis of the UUT TCC disease-free rate by the Kaplan-Meier method...

Revisão sistemática para estudar a eficácia de terapia cognitivo-comportamental para crianças e adolescentes abusadas sexualmente com transtorno de estresse pós-traumático

Passarela,Cristiane de Medeiros; Mendes,Deise Daniela; Mari,Jair de Jesus
Fonte: Faculdade de Medicina da Universidade de São Paulo Publicador: Faculdade de Medicina da Universidade de São Paulo
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2010 PT
Relevância na Pesquisa
16.94%
CONTEXTO: O transtorno de estresse pós-traumático (TEPT), uma das possíveis consequências de abuso sexual de crianças e adolescentes, pode ser encontrado em aproximadamente 40% a 50% dos casos. OBJETIVO: Conduzir uma revisão sistemática de estudos investigando o uso de terapia cognitivo-comportamental (TCC) para o tratamento de crianças e adolescentes abusadas sexualmente com TEPT. MÉTODOS: Uma pesquisa por ensaios clínicos randomizados que avaliaram TEPT em crianças e adolescentes de 1980 a 1º de fevereiro de 2006 foi conduzida nas seguintes bases de dados: MedLine, EMBASE, LILACS, PsycLIT, PsycINFO, Cochrane Depression, Anxiety and Neurosis Group Database of Trials, Cochrane Controlled Trials Register, Science Citation Index (SciSearch) e PILOTS. As referências em todos os ensaios clínicos foram localizadas manualmente. RESULTADOS: Dos 43 estudos inicialmente selecionados, apenas três preencheram critérios de inclusão. As seguintes comparações foram encontradas nos estudos: TCC para tratar a criança e membros da família versus não tratamento (lista de espera); TCC para tratar apenas a criança, apenas os pais ou ambos versus Community Care; e TCC focada no trauma versus terapia centrada na criança (CCT). Os resultados para tratamento de TEPT com TCC foram melhores do que não tratamento (lista de espera) (p < 0...

Herpes simplex virus-specific human cytotoxic T-cell colonies expressing either gamma delta or alpha beta T-cell receptor: role of accessory molecules on HLA-unrestricted killing of virus-infected targets.

Maccario, R; Comoli, P; Percivalle, E; Montagna, D; Locatelli, F; Gerna, G
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /05/1995 EN
Relevância na Pesquisa
16.91%
Previous studies have demonstrated that herpes simplex virus-1 (HSV-1)-infected mononuclear cells are able to stimulate autologous peripheral blood mononuclear cells (PBMC) of immune donors and to activate HSV-specific cytotoxic T lymphocytes (CTL) expressing either gamma delta or alpha beta T-cell receptors (TCR). In the present report characterization of 10 gamma delta+ and six alpha beta+ HSV-specific cytotoxic T-cell colonies (TCC) is described. Cytotoxic colonies were derived from HSV-induced cell lines of three donors who, in previous experiments, had shown a prevalence of gamma delta+ or alpha beta+ effector cells. HSV-1 induced cell lines obtained from gamma delta responders included more than 80% of cells expressing V gamma 9/delta 2 TCR V region chains. gamma delta+ TCC also expressed V gamma 9/delta 2 molecules. alpha beta+ TCC all expressed CD8 antigen, while only one of 10 gamma delta+ TCC was CD8+, the others being CD4/CD8-double negative. The cytotoxic response of HSV-specific TCC was HLA-unrestricted; nevertheless CD8+ TCC were dependent on the expression of HLA class I on the surface of target cells to mediate cytolytic activity, while CD8- TCC were not. Blocking experiments with monoclonal antibody (mAb) specific for lymphocyte function-associated antigen-1 (LFA-1)...

Urinary Bladder Transitional Cell Carcinogenesis Is Associated with Down-Regulation of NF1 Tumor Suppressor Gene in Vivo and in Vitro

Aaltonen, Vesa; Boström, Peter J.; Söderström, Karl-Ove; Hirvonen, Outi; Tuukkanen, Juha; Nurmi, Martti; Laato, Matti; Peltonen, Juha
Fonte: American Society for Investigative Pathology Publicador: American Society for Investigative Pathology
Tipo: Artigo de Revista Científica
Publicado em /03/1999 EN
Relevância na Pesquisa
16.91%
The NF1 gene product (neurofibromin) is known to act as a tumor suppressor protein by inactivating ras. The best documented factors involved in urinary bladder transitional cell carcinoma (TCC) are ras proto-oncogene activation and p53 suppressor gene mutations. This is the first study reporting alterations in NF1 gene expression in TCC. We examined NF1 gene expression in a total of 29 surgical urinary bladder TCC specimens representing grades 1 to 3 and in three cell lines, RT4, 5637, and T24 (representing grades 1 to 3, respectively). Decreased NF1 gene expression was observed in 23 of 29 (83%) TCC specimens as estimated by immunohistochemistry, the decrease being more pronounced in high-grade tumors. NF1 mRNA levels were markedly lower in TCC tissue compared with adjacent non-neoplastic urothelium, as studied by in situ hybridization for grade 3 TCC. Immunohistochemistry and Western blotting demonstrated that TCC cell lines expressed NF1 protein at different levels, expression being almost undetectable in T24 (grade 3) cells. Northern blotting for cell lines demonstrated reduced NF1 mRNA levels in grade 3 TCC cells. Reverse transcription polymerase chain reaction for cell lines and selected grade 2 and grade 3 tissue samples demonstrated NF1 type II mRNA isoform predominance in all samples studied. Our results show that both NF1 mRNA and protein levels are decreased in high-grade TCC...

Development of a Novel Proteomic Approach for the Detection of Transitional Cell Carcinoma of the Bladder in Urine

Vlahou, Antonia; Schellhammer, Paul F.; Mendrinos, Savvas; Patel, Keyur; Kondylis, Filippos I.; Gong, Lei; Nasim, Suhail; Wright Jr., George L.
Fonte: American Society for Investigative Pathology Publicador: American Society for Investigative Pathology
Tipo: Artigo de Revista Científica
Publicado em /04/2001 EN
Relevância na Pesquisa
16.91%
Development of noninvasive methods for the diagnosis of transitional cell carcinoma (TCC) of the bladder remains a challenge. A ProteinChip technology (surface enhanced laser desorption/ionization time of flight mass spectrometry) has recently been developed to facilitate protein profiling of biological mixtures. This report describes an exploratory study of this technology as a TCC diagnostic tool. Ninety-four urine samples from patients with TCC, patients with other urogenital diseases, and healthy donors were analyzed. Multiple protein changes were reproducibly detected in the TCC group, including five potential novel TCC biomarkers and seven protein clusters (mass range, 3.3 to 133 kd). One of the TCC biomarkers (3.4 kd) was also detected in bladder cancer cells procured from bladder barbotage and was identified as defensin. The TCC detection rates provided by the individual markers ranged from 43 to 70% and specificities from 70 to 86%. Combination of the protein biomarkers and clusters, increased significantly the sensitivity for detecting TCC to 87% with a specificity of 66%. Interestingly, this combinatorial approach provided sensitivity of 78% for detecting low-grade TCC compared to only 33% of voided urine or bladder-washing cytology. Collectively these results support the potential of this proteomic approach for the development of a highly sensitive urinary TCC diagnostic test.

HIV-induced IL-6/IL-10 dysregulation of CD4 cells is associated with defective B cell help and autoantibody formation against CD4 cells

Weimer, R; Zipperle, S; Daniel, V; Zimmermann, R; Schimpf, K; Opelz, G
Fonte: Blackwell Science Inc Publicador: Blackwell Science Inc
Tipo: Artigo de Revista Científica
Publicado em /01/1998 EN
Relevância na Pesquisa
16.98%
To analyse CD4 cell cytokine secretion and helper/suppressor function at a clonal level we established 446 CD4+ T cell clones (TCC) in four healthy controls, three HIV− haemophilia patients, four CDC II,III and four CDC IV patients. Spontaneous TCC secretion of Th1 cytokines (IL-2, interferon-gamma (IFN-γ)) and Th2 cytokines (IL-4, IL-6, IL-10) was determined by ELISA. TCC helper and suppressor functions were tested in a pokeweed mitogen (PWM)-stimulated allogeneic co-culture system using a reverse haemolytic plaque assay for assessment of B cell responses. There was a significant association of TCC surface marker expression (Leu-8, CD45RA) with TCC IL-6 secretion in healthy controls (P < 0·01), HIV− patients (P ≤ 0·001) and CDC II,III patients (P ≤ 0·01) but not in CDC IV patients. Likewise, TCC expression of Leu-8 and CD45RA was significantly associated with TCC suppressor function in healthy controls (P ≤ 0·0005) but not in HIV-infected patients. A reduced TCC helper frequency (≤ 10% of TCC) and an enhanced TCC suppressor frequency (> 80% of TCC) were detected only in those HIV-infected patients who showed an excessively increased TCC IL-6 secretion (> 70% of TCC) together with a significantly diminished TCC IL-10 secretion (≤ 10% of TCC). CD4 cell autoantibodies also were found only in patients with this type of cytokine dysregulation. These data indicate that CD4 cell surface markers lose their functional relevance in HIV-infected patients. HIV-induced IL-6/IL-10 dysregulation of CD4+ T cells...

Bioaccumulation of Triclocarban in Lumbriculus variegatus

Higgins, Christopher P.; J.Paesani, Zachary; Abbot Chalew, Talia E.; Halden, Rolf U.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
16.99%
The antimicrobial triclocarban (TCC) has been detected in streams and municipal biosolids throughout the United States. In addition, TCC and potential TCC transformation products have been detected at high levels (ppm range) in sediments near major United States cities. Previous work has suggested that TCC is relatively stable in these environments, thereby raising concerns about the potential for bioaccumulation in sediment-dwelling organisms. Bioaccumulation of TCC from sediments was assessed using the freshwater oligochaete, Lumbriculus variegatus. Worms were exposed to TCC in sediment spiked to 22.4 ppm to simulate the upper bound of environmental concentrations. Uptake from laboratory-spiked sediment was examined over 56 days for TCC and 4,4′dichlorocarbanilide (DCC), a chemical impurity in and potential transformation product of TCC. The clearance of TCC from worms placed in clean sediment was also examined over 21 d after an initial 35-d exposure to TCC in laboratory-spiked sediment. Concentrations of TCC and DCC were monitored in the worms, sediment, and the overlying water using liquid chromatography tandem mass spectrometry. Experimental data were fitted using a standard biodynamic model to generate uptake and elimination rate constants for TCC in L. variegatus. These rate constants were used to estimate steady-state lipid and organic-carbon normalized biota-sediment accumulation factors (BSAFs) for TCC and DCC of 2.2 ± 0.2 and 0.3 ± 0.1 goc/glip...

Inhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine model

Liu, Jun-Yan; Qiu, Hong; Morisseau, Christophe; Hwang, Sung Hee; Tsai, Hsing-Ju; Ulu, Arzu; Chiamvimonvat, Nipavan; Hammock, Bruce D
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
16.94%
The increasing use of the anti-microbial triclocarban (TCC) in personal care products (PCPs) has resulted in concern regarding environmental pollution. TCC is a potent inhibitor of soluble epoxide hydrolase (sEH). Inhibitors of sEH (sEHIs) are anti-inflammatory, anti-hypertensive and cardio-protective in multiple animal models. However, the in vivo effects anticipated from a sEHI have not been reported for TCC. Here we demonstrated the anti-inflammatory effects in vivo of TCC in a murine model. TCC was employed in a lipopolysaccharide (LPS)-challenged murine model. Systolic blood pressure, plasma levels of several inflammatory cytokines and chemokine, and metabolomic profile of plasma oxylipins were determined. TCC significantly reversed LPS-induced morbid hypotension in a time-dependent manner. TCC significantly repressed the increased release of inflammatory cytokines and chemokine caused by LPS. Furthermore, TCC significantly shifted the oxylipin profile in vivo in a time-dependent manner towards resolution of inflammation as expected from a sEHI. These results demonstrated that at the doses used TCC is anti-inflammatory in the murine model. This study suggests that TCC may provide some benefits in humans in addition to its antimicrobial activities due to its potent inhibition of sEH. It may be a promising starting point for developing new low volume high value applications of TCC. However these biological effects also caution against the general over use of TCC in PCPs.

In Vitro Glucuronidation of the Antibacterial Triclocarban and Its Oxidative MetabolitesS⃞

Schebb, N. H.; Franze, B.; Maul, R.; Ranganathan, A.; Hammock, B. D.
Fonte: The American Society for Pharmacology and Experimental Therapeutics Publicador: The American Society for Pharmacology and Experimental Therapeutics
Tipo: Artigo de Revista Científica
Publicado em /01/2012 EN
Relevância na Pesquisa
16.93%
Triclocarban (3,4,4′-trichlorocarbanilide; TCC) is widely used as an antibacterial in bar soaps. During use of these soaps, a significant portion of TCC is absorbed by humans. For the elimination from the body, glucuronidation plays a key role in both biliary and renal clearance. To investigate this metabolic pathway, we performed microsomal incubations of TCC and its hydroxylated metabolites 2′-OH-TCC, 3′-OH-TCC, and 6-OH-TCC. Using a new liquid chromatography-UV-mass spectrometry method, we could show a rapid glucuronidation for all OH-TCCs by the uridine-5′-diphosphate-glucuronosyltransferases (UGT) present in liver microsomes of humans (HLM), cynomolgus monkeys (CLM), rats (RLM), and mice (MLM). Among the tested human UGT isoforms, UGT1A7, UGT1A8, and UGT1A9 showed the highest activity for the conjugation of hydroxylated TCC metabolites followed by UGT1A1, UGT1A3, and UGT1A10. Due to this broad pattern of active UGTs, OH-TCCs can be efficiently glucuronidated in various tissues, as shown for microsomes from human kidney (HKM) and intestine (HIM). The major renal metabolites in humans, TCC-N-glucuronide and TCC-N′-glucuronide, were formed at very low conversion rates (<1%) by microsomal incubations. Low amounts of N-glucuronides were generated by HLM...

Triclocarban Mediates Induction of Xenobiotic Metabolism through Activation of the Constitutive Androstane Receptor and the Estrogen Receptor Alpha

Yueh, Mei-Fei; Li, Tao; Evans, Ronald M.; Hammock, Bruce; Tukey, Robert H.
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 15/06/2012 EN
Relevância na Pesquisa
16.97%
Triclocarban (3,4,4′-trichlorocarbanilide, TCC) is used as a broad-based antimicrobial agent that is commonly added to personal hygiene products. Because of its extensive use in the health care industry and resistance to degradation in sewage treatment processes, TCC has become a significant waste product that is found in numerous environmental compartments where humans and wildlife can be exposed. While TCC has been linked to a range of health and environmental effects, few studies have been conducted linking exposure to TCC and induction of xenobiotic metabolism through regulation by environmental sensors such as the nuclear xenobiotic receptors (XenoRs). To identify the ability of TCC to activate xenobiotic sensors, we monitored XenoR activities in response to TCC treatment using luciferase-based reporter assays. Among the XenoRs in the reporter screening assay, TCC promotes both constitutive androstane receptor (CAR) and estrogen receptor alpha (ERα) activities. TCC treatment to hUGT1 mice resulted in induction of the UGT1A genes in liver. This induction was dependent upon the constitutive active/androstane receptor (CAR) because no induction occurred in hUGT1Car−/− mice. Induction of the UGT1A genes by TCC corresponded with induction of Cyp2b10...

Investigation of human exposure to triclocarban after showering, and preliminary evaluation of its biological effects

Schebb, Nils Helge; Inceoglu, Bora; Ahn, Ki Chang; Morisseau, Christophe; Gee, Shirley; Hammock, Bruce D.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
16.93%
The antibacterial soap additive triclocarban (TCC) is widely used in personal care products. TCC has a high environmental persistence. We developed and validated a sensitive online solid phase extraction-LC-MS/MS method to rapidly analyze TCC and its major metabolites in urine and other biological samples to assess human exposure. We measured human urine concentrations 0–72 h after showering with a commercial bar soap containing 0.6% TCC. The major route of renal elimination was excretion as N-glucuronides. The absorption was estimated at 0.6% of the 70±15 mg TCC in the soap used. The TCC N-glucuronide urine concentration varied widely among the subjects and continuous daily use of the soap led to steady state levels of excretion. In order to assess potential biological effects arising from this exposure we screened TCC for the inhibition of human enzymes in vitro. We demonstrate that TCC is a potent inhibitor of the enzyme soluble epoxide hydrolase (sEH), whereas TCC′s major metabolites lack strong inhibitory activity. Topical administration of TCC at similar levels to rats in a preliminary in vivo study however failed to alter plasma biomarkers of sEH activity. Overall the analytical strategy described here revealed that use of TCC soap causes exposure levels that warrant further evaluation.

Biomarkers of Exposure to Triclocarban in Urine and Serum

Ye, Xiaoyun; Zhou, Xiaoliu; Furr, Johnathan; Ahn, Ki Chang; Hammock, Bruce D.; Gray, Earl L.; Calafat, Antonia M.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
16.99%
3, 4, 4’- Trichlorocarbanilide (triclocarban, TCC) is widely used as an antimicrobial agent in a variety of consumer and personal care products. TCC is considered a potential endocrine disruptor, but its potential toxic effects in humans are still largely unknown. Because of its widespread uses, the potential for human exposure to TCC is high. In order to identify adequate exposure biomarkers of TCC, we investigated the metabolic profile of TCC in adult female Sprague Dawley rats after administering TCC once (500 mg/kg body weight) by oral gavage. Urine was collected 0–24 hours before dosing, and 0–24 hours and 24–48 hours after dosing. Serum was collected at necropsy 48 h after dosing. We identified several metabolites of TCC in urine and serum by on-line solid phase extraction-high performance liquid chromatography- mass spectrometry. We unambiguously identified two major oxidative metabolites of TCC, 3’-hydroxy-TCC and 2’-hydroxy-TCC, by comparing their chromatographic behavior and mass spectral fragmentation patterns with those of authentic standards. By contrast, compared to these oxidative metabolites, we detected very low levels of TCC in the urine or serum. Taken together these data suggest that in rats, oxidation of TCC is a major metabolic pathway. We also measured TCC and its oxidative metabolites in 50 urine and 16 serum samples collected from adults in the United States. The results suggest differences in the metabolic profile of TCC in rats and in humans; oxidation appears to be a minor metabolic pathway in humans. Total (free plus conjugated) TCC could serve as a potential biomarker for human exposure to TCC.

Pontes com estrutura mista madeira-betão e seu potencial de aplicação

Rodrigues, João Nuno Amado
Fonte: Universidade de Coimbra Publicador: Universidade de Coimbra
Tipo: Tese de Doutorado
POR
Relevância na Pesquisa
16.93%
A aplicação de estruturas mistas madeira-betão em pontes, nomeadamente no tabuleiro, é uma técnica construtiva que, ao longo dos últimos 20 anos, tem vindo a ser adotada com sucesso em várias regiões do mundo, das quais se destacam a Europa Setentrional e a Europa Ocidental. Nesse sentido, foi decidido avaliar em que circunstâncias as estruturas mistas madeira-betão podem constituir uma opção competitiva e com potencial para o tabuleiro de pontes em Portugal. Entenda-se por estrutura mista, aquela que é constituída por dois ou mais materiais mecanicamente ligados. O programa de investigação consistiu, numa primeira fase, em estabelecer uma amostra de pontes com estrutura mista madeira-betão, amostra essa que se procurou que fosse representativa de todas as regiões do globo onde este tipo de pontes tem sido utilizado. As pontes desta amostra foram sujeitas a uma caracterização e análise detalhadas, tendo-se verificado que há fundamentalmente dois tipos de tabuleiros mistos madeira-betão, os quais foram designados por “soluções-tipo”. Numa fase posterior, (i) identificou-se um conjunto de requisitos construtivos e (ii) definiram--se as diretrizes de dimensionamento para o projeto de pontes com tabuleiro misto madeira-betão...

Les besoins des proches, des intervenants et des personnes ayant un traumatisme craniocérébral: comparaison du Québec et de la France.

Lefebvre, Hélène; Mazaux, Jean-Michel; Azouvi, Jean-Philippe; Weiss, Jean-Jacques; Thierry, Sarraf
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Rapport / Report
FR
Relevância na Pesquisa
16.99%
FAITS SAILLANTS SIMILITUDES ET PARTICULARITÉS FRANCE-QUÉBEC Similitudes dans les besoins d’information Pendant la phase des soins aigus:  Information sur le TCC, le diagnostic, les séquelles possibles, buts des traitements  Information répétée et compréhensible  Mauvais rétention de l’information par les familles  L’instabilité de la situation et l’évolution incertaine du TCC freine également l’information transmise aux proches et amène informations incohérentes  Sources d’information alternatives (internet, littérature, contact, associations Pendant la phase de réadaptation:  Information sur l’avenir et l’autonomie de la personne  Intervenants n’ont souvent pas de réponse aux questions des proches Pendant la phase de post-réadaptation:  Information sur des séquelles et des conséquences à long terme  Information sur les ressources et les services d’aide pour la réinsertion socioprofessionnelle  Information sur leurs droits Concernant l’ensemble du continuum de soins:  Information est manquante à bien des égards tout au long du continuum de soins  Professionnels et médecins œuvrant dans la communauté et grand public peu informés sur les TCC Particularités régionales dans le besoin d’information: France:  Les intervenants ont besoin d’information sur les proches...

A study of sexuality following traumatic brain injury : moving towards the validation of a biopsychosocial model

Moreno, Jhon A.
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Thèse ou Mémoire numérique / Electronic Thesis or Dissertation
EN
Relevância na Pesquisa
16.93%
L’étude de la sexualité dans le contexte des maladies neurologiques est un domaine émergent qui nous permet de mieux comprendre les corrélats cérébraux et neurocomportementaux de divers aspects de la sexualité. Les changements au sujet de la sexualité sont fréquents à la suite de troubles neurologiques tels que les blessures de la moelle épinière, la sclérose en plaques, l’accident vasculaire cérébral, l'épilepsie et les traumatismes craniocérébraux (TCC). Compte tenu de la complexité de la sexualité après un TCC, celle-ci doit être analysée à partir d'une perspective biopsychosociale qui comprend trois facteurs interdépendants : a) les facteurs neuropsychologiques et psychologiques, b) les variables médicales et physiques, et c) les facteurs relationnels. L’objectif de cette thèse était d’étudier certains éléments de la sexualité auprès de personnes ayant subi un TCC afin de fournir des preuves empiriques pour contribuer à la validation d’une perspective biopsychosociale de la sexualité après un TCC. Trois études quantitatives originales ont été effectuées auprès de personnes ayant subi un TCC léger, modéré ou grave et ayant reçu des services de réadaptation post-TCC, et d’un groupe de témoins en bonne santé...

Trabalhos Universitários Ganham Espaço nas Telas

Martins Netto, Carlos Alberto
Fonte: Universidade de São Paulo. Escola de Comunicações e Artes Publicador: Universidade de São Paulo. Escola de Comunicações e Artes
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; Pesquisa laboratorial Formato: application/pdf
Publicado em 07/09/2012 POR
Relevância na Pesquisa
26.33%
A opção dos alunos em escolherem o videodocumentário como produto final de seus trabalhos de conclusão de curso (TCC). Essa demanda pelos produtos audiovisuais é, sem dúvida, uma realidade que surge graças as novas tecnologias que auxiliam no aspecto funcional e pragmático os trabalhos desenvolvidos pelos estudantes de comunicação. As inovações tecnológicas, principalmente no que diz respeito a operacionalização dos equipamentos portáteis, como as câmeras de vídeo digitais e softwares de edição, facilitam o acesso à produção de produtos audiovisuais onde os alunos podem elaborar seu próprio projeto, fazer a captação das imagens e ainda editar todo material no próprio computador. Diante dessa realidade tecnológica, os alunos aprendem a trabalhar com as novas linguagens audiovisuais, combinadas com a discursividade jornalística. 

Revisão sistemática para estudar a eficácia de terapia cognitivo-comportamental para crianças e adolescentes abusadas sexualmente com transtorno de estresse pós-traumático; A systematic review to study the efficacy of cognitive behavioral therapy for sexually abused children and adolescents with posttraumatic stress disorder

Passarela, Cristiane de Medeiros; Mendes, Deise Daniela; Mari, Jair de Jesus
Fonte: Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria Publicador: Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; ; Formato: application/pdf; application/pdf
Publicado em 01/01/2010 POR; ENG
Relevância na Pesquisa
16.94%
CONTEXTO: O transtorno de estresse pós-traumático (TEPT), uma das possíveis consequências de abuso sexual de crianças e adolescentes, pode ser encontrado em aproximadamente 40% a 50% dos casos. OBJETIVO: Conduzir uma revisão sistemática de estudos investigando o uso de terapia cognitivo-comportamental (TCC) para o tratamento de crianças e adolescentes abusadas sexualmente com TEPT. MÉTODOS: Uma pesquisa por ensaios clínicos randomizados que avaliaram TEPT em crianças e adolescentes de 1980 a 1º de fevereiro de 2006 foi conduzida nas seguintes bases de dados: MedLine, EMBASE, LILACS, PsycLIT, PsycINFO, Cochrane Depression, Anxiety and Neurosis Group Database of Trials, Cochrane Controlled Trials Register, Science Citation Index (SciSearch) e PILOTS. As referências em todos os ensaios clínicos foram localizadas manualmente. RESULTADOS: Dos 43 estudos inicialmente selecionados, apenas três preencheram critérios de inclusão. As seguintes comparações foram encontradas nos estudos: TCC para tratar a criança e membros da família versus não tratamento (lista de espera); TCC para tratar apenas a criança, apenas os pais ou ambos versus Community Care; e TCC focada no trauma versus terapia centrada na criança (CCT). Os resultados para tratamento de TEPT com TCC foram melhores do que não tratamento (lista de espera) (p < 0...