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A terminologia da Genética Molecular: aspectos morfológicos e semânticos; The Terminology of the Molecular Genetics: morphologic and semantic aspects

Oliveira, Luciana Pissolato de
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 16/05/2007 PT
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Tendo em vista que as unidades de conhecimento especializado (UCEs) formam parte de um universo dinâmico, no panorama das inovações científico-tecnológicas, e que são fundamentais para a comunicação especializada, o presente trabalho, de viés lingüístico/comunicativo, tem por objetivo a sistematização, organização e estruturação do vocabulário da Genética Molecular. Para o empreendimento de tal tarefa, foram necessárias as seguintes etapas: elaboração de um corpus de pesquisa, formado por materiais autênticos que refletissem a área com maior correção; extração das unidades terminológicas representativas do domínio, baseada em critérios lingüísticos, pragmáticos e tipográficos como: caráter morfológico (com significado especializado no campo de conhecimento), condicionamentos sintagmáticos (coocorrência e comutação), grau de coesão e fixação sintática, proximidade de glosas explicativas, grau de lexicalização do termo, relação unívoca com o conceito especializado que designam (monossemia), artifícios tipográficos, análise contextual, seleção dos tipos de documentação adequados e também verificação das particularidades estilísticas dos diferentes níveis de linguagem; análise da constituição morfossintática das unidades elencadas...

Genetics in eating disorders: extending the boundaries of research

Pinheiro,Andréa Poyastro; Sullivan,Patrick F; Bacaltchuck,Josue; Prado-Lima,Pedro Antonio Schmidt do; Bulik,Cynthia M
Fonte: Associação Brasileira de Psiquiatria - ABP Publicador: Associação Brasileira de Psiquiatria - ABP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/2006 EN
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OBJECTIVE: To review the recent literature relevant to genetic research in eating disorders and to discuss unique issues which are crucial for the development of a genetic research project in eating disorders in Brazil. METHOD: A computer literature review was conducted in the Medline database between 1984 and may 2005 with the search terms "eating disorders", "anorexia nervosa", "bulimia nervosa", "binge eating disorder", "family", "twin" and "molecular genetic" studies. RESULTS: Current research findings suggest a substantial influence of genetic factors on the liability to anorexia nervosa and bulimia nervosa. Genetic research with admixed populations should take into consideration sample size, density of genotyping and population stratification. Through admixture mapping it is possible to study the genetic structure of admixed human populations to localize genes that underlie ethnic variation in diseases or traits of interest. CONCLUSIONS: The development of a major collaborative genetics initiative of eating disorders in Brazil and South America would represent a realistic possibility of studying the genetics of eating disorders in the context of inter ethnic groups, and also integrate a new perspective on the biological etiology of eating disorders.

The Ising Model in Physics and Statistical Genetics

Majewski, Jacek; Li, Hao; Ott, Jurg
Fonte: The American Society of Human Genetics Publicador: The American Society of Human Genetics
Tipo: Artigo de Revista Científica
EN
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Interdisciplinary communication is becoming a crucial component of the present scientific environment. Theoretical models developed in diverse disciplines often may be successfully employed in solving seemingly unrelated problems that can be reduced to similar mathematical formulation. The Ising model has been proposed in statistical physics as a simplified model for analysis of magnetic interactions and structures of ferromagnetic substances. Here, we present an application of the one-dimensional, linear Ising model to affected-sib-pair (ASP) analysis in genetics. By analyzing simulated genetics data, we show that the simplified Ising model with only nearest-neighbor interactions between genetic markers has statistical properties comparable to much more complex algorithms from genetics analysis, such as those implemented in the Allegro and Mapmaker-Sibs programs. We also adapt the model to include epistatic interactions and to demonstrate its usefulness in detecting modifier loci with weak individual genetic contributions. A reanalysis of data on type 1 diabetes detects several susceptibility loci not previously found by other methods of analysis.

Successful Implementation of Genetic Education for Native Americans Workshops at National Conferences

Dignan, Mark B.; Burhansstipanov, Linda; Bemis, Lynne
Fonte: Genetics Society of America Publicador: Genetics Society of America
Tipo: Artigo de Revista Científica
Publicado em /02/2005 EN
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Genetic Education for Native Americans (GENA) was a National Human Genome Research Institute (NHGRI)/Ethical, Legal, and Social Implications (ELSI)-funded educational intervention designed to provide a unique genetics education program for Native American college and university students. A curriculum was developed and implemented in workshops in geographically diverse settings throughout the United States, primarily in conjunction with regional and national scientific conferences that include substantial numbers of Native American attendees. The original curriculum includes 24 objectives and has been offered in two formats, as a 16-hr “comprehensive” program and in briefer workshops (referred to as “customized” hereafter) that are designed to include objectives for selected audiences. Both formats teach sufficient genetics to allow discussion and understanding of the ELSI and cultural issues related to genetics science. This article describes the evaluation findings from our implementation of both formats of the GENA curriculum.

Systems Genetics of Mineral Metabolism123

Fleet, James C.; Replogle, Rebecca; Salt, David E.
Fonte: American Society for Nutrition Publicador: American Society for Nutrition
Tipo: Artigo de Revista Científica
EN
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Minerals are essential and toxic elements that have an impact on human health. Although we have learned a tremendous amount about the metabolism, biological roles, and health effects of minerals with the tools of biochemistry, cell biology, and molecular genetics, there are gaps in our knowledge of mineral biology that will benefit from new approaches. Forward genetics, whereby variations in phenotypes are mapped to natural genetic variation in the genome, has been successfully used to increase our understanding of many biologically important traits but has not yet been used extensively for mineral metabolism. In addition, the well-appreciated existence of interactions between minerals justifies a broader, systems approach to the study of mineral metabolism, i.e., ionomics. This short review will explain the value of forward genetics and ionomics as tools for exploring mammalian mineral metabolism.

Moving toward System Genetics through Multiple Trait Analysis in Genome-Wide Association Studies

Shriner, Daniel
Fonte: Frontiers Research Foundation Publicador: Frontiers Research Foundation
Tipo: Artigo de Revista Científica
Publicado em 16/01/2012 EN
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Association studies are a staple of genotype–phenotype mapping studies, whether they are based on single markers, haplotypes, candidate genes, genome-wide genotypes, or whole genome sequences. Although genetic epidemiological studies typically contain data collected on multiple traits which themselves are often correlated, most analyses have been performed on single traits. Here, I review several methods that have been developed to perform multiple trait analysis. These methods range from traditional multivariate models for systems of equations to recently developed graphical approaches based on network theory. The application of network theory to genetics is termed systems genetics and has the potential to address long-standing questions in genetics about complex processes such as coordinate regulation, homeostasis, and pleiotropy.

Mammalian Developmental Genetics in the Twentieth Century

Artzt, Karen
Fonte: Genetics Society of America Publicador: Genetics Society of America
Tipo: Artigo de Revista Científica
Publicado em /12/2012 EN
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This Perspectives is a review of the breathtaking history of mammalian genetics in the past century and, in particular, of the ways in which genetic thinking has illuminated aspects of mouse development. To illustrate the power of that thinking, selected hypothesis-driven experiments and technical advances are discussed. Also included in this account are the beginnings of mouse genetics at the Bussey Institute, Columbia University, and The Jackson Laboratory and a retrospective discussion of one of the classic problems in developmental genetics, the T/t complex and its genetic enigmas.

How to Design a Genetic Mating Scheme: A Basic Training Package for Drosophila Genetics

Roote, John; Prokop, Andreas
Fonte: Genetics Society of America Publicador: Genetics Society of America
Tipo: Artigo de Revista Científica
Publicado em 01/02/2013 EN
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Drosophila melanogaster is a powerful model organism for biological research. The essential and common instrument of fly research is genetics, the art of applying Mendelian rules in the specific context of Drosophila with its unique classical genetic tools and the breadth of modern genetic tools and strategies brought in by molecular biology, transgenic technologies and the use of recombinases. Training newcomers to fly genetics is a complex and time-consuming task but too important to be left to chance. Surprisingly, suitable training resources for beginners currently are not available. Here we provide a training package for basic Drosophila genetics, designed to ensure that basic knowledge on all key areas is covered while reducing the time invested by trainers. First, a manual introduces to fly history, rationale for mating schemes, fly handling, Mendelian rules in fly, markers and balancers, mating scheme design, and transgenic technologies. Its self-study is followed by a practical training session on gender and marker selection, introducing real flies under the dissecting microscope. Next, through self-study of a PowerPoint presentation, trainees are guided step-by-step through a mating scheme. Finally, to consolidate knowledge...

Genetics of Adverse Reactions to Haloperidol in a Mouse Diallel: A Drug–Placebo Experiment and Bayesian Causal Analysis

Crowley, James J.; Kim, Yunjung; Lenarcic, Alan B.; Quackenbush, Corey R.; Barrick, Cordelia J.; Adkins, Daniel E.; Shaw, Ginger S.; Miller, Darla R.; de Villena, Fernando Pardo-Manuel; Sullivan, Patrick F.; Valdar, William
Fonte: Genetics Society of America Publicador: Genetics Society of America
Tipo: Artigo de Revista Científica
EN
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Haloperidol is an efficacious antipsychotic drug that has serious, unpredictable motor side effects that limit its utility and cause noncompliance in many patients. Using a drug–placebo diallel of the eight founder strains of the Collaborative Cross and their F1 hybrids, we characterized aggregate effects of genetics, sex, parent of origin, and their combinations on haloperidol response. Treating matched pairs of both sexes with drug or placebo, we measured changes in the following: open field activity, inclined screen rigidity, orofacial movements, prepulse inhibition of the acoustic startle response, plasma and brain drug level measurements, and body weight. To understand the genetic architecture of haloperidol response we introduce new statistical methodology linking heritable variation with causal effect of drug treatment. Our new estimators, “difference of models” and “multiple-impute matched pairs”, are motivated by the Neyman–Rubin potential outcomes framework and extend our existing Bayesian hierarchical model for the diallel (Lenarcic et al. 2012). Drug-induced rigidity after chronic treatment was affected by mainly additive genetics and parent-of-origin effects (accounting for 28% and 14.8% of the variance), with NZO/HILtJ and 129S1/SvlmJ contributions tending to increase this side effect. Locomotor activity after acute treatment...

Genetics and Evolution: An iOS Application to Supplement Introductory Courses in Transmission and Evolutionary Genetics

Myers, Russell B.; Millman, Brandon; Noor, Mohamed A. F.
Fonte: Genetics Society of America Publicador: Genetics Society of America
Tipo: Artigo de Revista Científica
Publicado em 11/04/2014 EN
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Students in college courses struggle to understand many concepts fundamental to transmission and evolutionary genetics, including multilocus inheritance, recombination, Hardy-Weinberg, and genetic drift. These students consistently ask for more demonstrations and more practice problems. With this demand in mind, the “Genetics and Evolution” app was designed to help students (and their instructors) by providing a suite of tools granting them the ability to: (1) simulate genetic crosses with varying numbers of genes and patterns of inheritance, (2) simulate allele frequency changes under natural selection and/ or genetic drift, (3) quiz themselves to reinforce terminology (customizable by any instructor for their whole classroom), *4) solve various problems (recombination fractions, Hardy-Weinberg, heritability, population growth), and (5) generate literally an infinite number of practice problems in all of these areas to try on their own. Although some of these functions are available elsewhere, the alternatives do not have the ability to instantly generate new practice problems or achieve these diverse functions in devices that students carry in their pockets every day.

A Novel Electronic Assessment Strategy to Support Applied Drosophila Genetics Training in University Courses

Fostier, Maggy; Patel, Sanjai; Clarke, Samantha; Prokop, Andreas
Fonte: Genetics Society of America Publicador: Genetics Society of America
Tipo: Artigo de Revista Científica
Publicado em 25/02/2015 EN
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36.3%
The advent of “omic” technologies has revolutionized genetics and created a demand to focus classical genetics on its present-day applications (Redfield, 2012, PLoS Biol 10: e1001356). This demand can be met by training students in Drosophila mating scheme design, which is an important problem-solving skill routinely applied in many modern research laboratories. It promotes a thorough understanding and application of classical genetics rules and introduces to transgenic technologies and the use of model organisms. As we show here, such training can be implemented as a flexible and concise module (~1-day home study, ~8-hour course time) on university courses by using our previously published training package designed for fly researchers (Roote and Prokop, 2013, G3 (Bethesda) 3: 353−358). However, assessing this training to make it an accredited course element is difficult, especially in large courses. Here, we present a powerful assessment strategy based on a novel hybrid concept in which students solve crossing tasks initially on paper and then answer automatically marked questions on the computer (1.5 hours total). This procedure can be used to examine student performance on more complex tasks than conventional e-assessments and is more versatile...

A Quantitative Test of Population Genetics Using Spatio-Genetic Patterns in Bacterial Colonies

Korolev, Kirill; Xavier, Joao; Foster, Kevin; Nelson, David R.
Fonte: University of Chicago Press Publicador: University of Chicago Press
Tipo: Artigo de Revista Científica
EN_US
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36.3%
It is widely accepted that population genetics theory is the cornerstone of evolutionary analyses. Empirical tests of the theory, however, are challenging because of the complex relationships between space, dispersal, and evolution. Critically, we lack quantitative validation of the spatial models of population genetics. Here we combine analytics, on and off-lattice simulations, and experiments with bacteria to perform quantitative tests of the theory. We study two bacterial species, the gut microbe Escherichia coli and the opportunistic pathogen Pseudomonas aeruginosa, and show that spatio-genetic patterns in colony biofilms of both species are accurately described by an extension of the one-dimensional stepping-stone model. We use one empirical measure, genetic diversity at the colony periphery, to parameterize our models and show that we can then accurately predict another key variable: the degree of short-range cell migration along an edge. Moreover, the model allows us to estimate other key parameters including effective population size (density) at the expansion frontier. While our experimental system is a simplification of natural microbial community, we argue it is a proof of principle that the spatial models of population genetics can quantitatively capture organismal evolution.; Physics

Evolution, Genetics and Ecology of Burrowing Behavior in Deer Mice (Genus Peromyscus)

Weber, Jesse
Fonte: Harvard University Publicador: Harvard University
Tipo: Thesis or Dissertation
EN_US
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Behavioral differences among closely related species can result from adaptation via natural selection, and this is especially true of innately expressed behavior that shows evidence of complex design or function. A major goal of biologists is to understand how and why complex, adaptive behavior evolves. To this end, I investigated the evolution, ecology and genetics of innate burrowing differences in deer mice (genus Peromyscus). First, I show that several species of deer mice recapitulate their natural burrowing habits under laboratory conditions. When I compare these behaviors in a phylogenetic context, I find that burrowing is species-specific and the complex burrows of the oldfield mouse (P. polionotus) likely arose from simple behavior similar to that expressed by two closely related species. Second, I examine the influences of soil composition and genetics on the burrowing behavior of oldfield mice. Although burrow length variation is relatively constant in nature, burrow depth is negatively associated with the silt content of soils. To determine the genetic architecture of complex burrowing, I crossed the oldfield mouse and its sister species, the deer mouse (P. maniculatus), which builds a relatively simple burrow. My results suggest that complexity results from the integration of several component behaviors: the lengthening of entrance tunnels and the construction of an escape tunnel. Additionally...

Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway

Li, Gang; Diogo, Dorothee; Wu, Di; Spoonamore, Jim; Dancik, Vlado; Franke, Lude; Kurreeman, Fina; Rossin, Elizabeth Jeffries; Duclos, Grant; Hartland, Cathy; Zhou, Xuezhong; Li, Kejie; Liu, Jun; De Jager, Philip Lawrence; Siminovitch, Katherine A.; Zherna
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
EN_US
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36.3%
Although genetic and non-genetic studies in mouse and human implicate the CD40 pathway in rheumatoid arthritis (RA), there are no approved drugs that inhibit CD40 signaling for clinical care in RA or any other disease. Here, we sought to understand the biological consequences of a CD40 risk variant in RA discovered by a previous genome-wide association study (GWAS) and to perform a high-throughput drug screen for modulators of CD40 signaling based on human genetic findings. First, we fine-map the CD40 risk locus in 7,222 seropositive RA patients and 15,870 controls, together with deep sequencing of CD40 coding exons in 500 RA cases and 650 controls, to identify a single SNP that explains the entire signal of association ((rs4810485, P = 1.4×10^{−9})). Second, we demonstrate that subjects homozygous for the RA risk allele have (sim33\%) more CD40 on the surface of primary human (CD19^+) B lymphocytes than subjects homozygous for the non-risk allele ((P = 10^{−9})), a finding corroborated by expression quantitative trait loci (eQTL) analysis in peripheral blood mononuclear cells from 1,469 healthy control individuals. Third, we use retroviral shRNA infection to perturb the amount of CD40 on the surface of a human B lymphocyte cell line (BL2) and observe a direct correlation between amount of CD40 protein and phosphorylation of RelA (p65)...

Mitochondrial genomics and northwestern Atlantic population genetics of marine annelids

Jennings, Robert M. (Robert Michael)
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 151 p.
ENG
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The overarching goal of this thesis was to investigate marine benthic invertebrate phylogenetics and population genetics, focused on the phylum Annelida. Recent expansions of molecular methods and the increasing diversity of available markers have allowed more complex and fine-scale questions to be asked at a variety of taxonomic levels. At the phylogenetic level, whole mitochondrial genome sequencing of two polychaetes (the deep-sea tubeworm Riftia pachyptila and the intertidal bamboo worm Clymenella torquata) supports the placement of leeches and oligochaetes within the polychaete radiation, in keeping with molecular evidence and morphological reinvestigations. This re-interpretation, first proposed by others, synonomizes "Annelida" and "Polychaeta", and lends further support to the inclusion of echiurids, siboglinids (previously called vestimentiferans) within annelids, and sipunculans as close allies. The complete mt-genome of C. torquata was then rapidly screened to obtain markers useful in short timescale population genetics.; (cont.) Two quickly evolving mitochondrial markers were sequenced from ten populations of C. torquata from the Bay of Fundy to New Jersey to investigate previous hypotheses that the Cape Cod, MA peninsula is a barrier to gene flow in the northwest Atlantic. A barrier to gene flow was found...

Genetics of amyotrophic lateral sclerosis

Belzil, Véronique Valérie
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Thèse ou Mémoire numérique / Electronic Thesis or Dissertation
EN
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La sclérose latérale amyotrophique (SLA) est la maladie des neurones moteurs la plus fréquente, affectant 4-6 individus par 100,000 habitants à l’échelle mondiale. La maladie se caractérise par une faiblesse et une atrophie musculaire suite à la dégénérescence des neurones du cortex moteur, tronc cérébral et moelle épinière. Les personnes atteintes développent les premiers symptômes à l’âge adulte et la maladie progresse sur une période de trois à cinq ans. Il a été répertorié qu’environ 10% des patients ont une histoire familiale de SLA; 90% des gens affectés le sont donc de façon sporadique. La découverte il y a 19 ans de mutations dans le gène zinc/copper superoxide dismutase (SOD1), présentes dans 15-20% des cas familiaux de SLA et environ 2% du total des individus affectés, a été l’événement déclencheur pour la découverte de variations génétiques responsables de la maladie. La recherche sur la génétique de la SLA a connu une progression rapide ces quatre dernières années avec l’identification de mutations dans de nouveaux gènes. Toutefois, même si certains de ces gènes ont été démontrés comme réellement liés à la maladie, la contribution d’autres gènes demeure incertaine puisque les résultats publiés de ceux-ci n’ont pas...

Molecular Population Genetics, Evolutionary Biology and Biological Conservation of Neotropical Carnivores; Molecular Population Genetics, Evolutionary Biology and Biological Conservation of Neotropical Carnivores

Ruiz-Garcia, Manuel; Pinedo Castro, Myreya
Fonte: Nova Science Pub Inc Publicador: Nova Science Pub Inc
Formato: 1-720
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A total of 44 wild jaguarundis were sampled throughout Mexico, Guatemala, Costa Rica, Colombia, Venezuela, Ecuador, Peru, Bolivia and Brazil and sequenced for three mitochondrial genes (ATP8, 16S rRNA, NADH5). This is the first molecular population genetics and phylogenetic study of this species and the most relevant results were as follows: 1- The gene diversity levels for the jaguarundi at the three mitochondrial genes sequenced were very elevated as it was found for other Neotropical wild cats such as the jaguar, ocelot, margay and the Pampas cat; 2- The levels of gene heterogeneity among putative subspecies or among countries was extremely small, although this species has a broad distribution from southern USA to Argentina; 3- Additionally, the phylogenetics trees (genetic distances, maximum likelihood, maximum parsimony and Bayesian) showed that no molecular subspecies were defined in contradiction with the morphological classifications of Allen (1919), Cabrera (1957) and de Oliveira (1998); 4- Bayesian and network procedures showed that the first haplotype divergence process in the jaguarundi began around 2.0-1.6 MYA, with a second haplotype divergence event around 1.1-0.8 MYA, followed by other haplotype splits around 0.75-0.5 MYA...

Craniometric and microsatellite genetic differentiation among putative ocelot subspecies (leopardus pardalis ) throughout latin America; Molecular population genetics, evolutionary biology and biological conservation of neotropical carnivores

Ruiz-Garcia, Manuel; Corrales, Carolina; Pinedo Castro, Myreya
Fonte: Nova Science Pub Inc Publicador: Nova Science Pub Inc
Formato: 1-720
Relevância na Pesquisa
36.3%
Several taxonomic classifications have been proposed for the ocelot, but almost all of them were based on non-molecular genetics studies. Herein, we analyzed 294 ocelots from Guatemala, Costa Rica, Colombia, Venezuela, French Guiana, Ecuador, Peru, Bolivia, Brazil and Paraguay for 10 microsatellite loci as well as 118 skulls for biometrics analyses. Our genetics and craniometrical data results did not support the three classificatory schemes we analyzed and tested (Allen, 1919; Murray and Gardner, 1997; Eizirik et al., 1998). It seems clear that the albescens form from Southern Texas and northern Mexico is a defined subspecies as is pardalis in Central America. However, our molecular analyses did not determine important levels of genetic heterogeneity among a large fraction of the putative ocelot subspecies in South America. Therefore, previously defined subspecies such as aequatorialis, pseudopardalis, melanura and steinbachi could be assigned to a unique subspecies, pseudopardalis. In contrast, the craniometric analysis differentiated steinbachi from the other South America putative ocelot subspecies. This was mostly likely due to the smaller skull size of the steinbachi individuals analyzed. It’s possible that the southern South America form...

Craniometric and microsatellite genetic differentiation among putative ocelot subspecies (Leopardus pardalis) throughout Latin America; Molecular Population Genetics, Evolutionary Biology, and Biological Conservation of Neotropical Carnivores

Ruiz-García, Manuel; Corrales, Carolina; Pinedo-Castro, Myreya
Fonte: Nova Science Publishers, Inc. Publicador: Nova Science Publishers, Inc.
Relevância na Pesquisa
36.3%
Several taxonomic classifications have been proposed for the ocelot, but almost all of them were based on non-molecular genetics studies. Herein, we analyzed 294 ocelots from Guatemala, Costa Rica, Colombia, Venezuela, French Guiana, Ecuador, Peru, Bolivia, Brazil and Paraguay for 10 microsatellite loci as well as 118 skulls for biometrics analyses. Our genetics and craniometrical data results did not support the three classificatory schemes we analyzed and tested (Allen, 1919; Murray and Gardner, 1997; Eizirik et al., 1998). It seems clear that the albescens form from Southern Texas and northern Mexico is a defined subspecies as is pardalis in Central America. However, our molecular analyses did not determine important levels of genetic heterogeneity among a large fraction of the putative ocelot subspecies in South America. Therefore, previously defined subspecies such as aequatorialis, pseudopardalis, melanura and steinbachi could be assigned to a unique subspecies, pseudopardalis. In contrast, the craniometric analysis differentiated steinbachi from the other South America putative ocelot subspecies. This was mostly likely due to the smaller skull size of the steinbachi individuals analyzed. It’s possible that the southern South America form...

Ejemplares, modelos y principios en la genética clásica; Exemplars, models and principles in classical genetics

Lorenzano, Pablo
Fonte: Universidade de São Paulo. Faculdade de Filosofia, Letras e Ciências Humanas Publicador: Universidade de São Paulo. Faculdade de Filosofia, Letras e Ciências Humanas
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; ; Formato: application/pdf
Publicado em 01/06/2005 SPA
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Tomando como punto de partida el libro de Sinnott y Dunn, Principles of genetics:an elementary text, with problems, que podría ser considerado el primer libro de texto de genética clásica en sentido kuhniano, y el análisis de la estructura de las teorías biológicas y/o biomédicas realizado por Darden y Schaffner, discutiré el problema de la existencia de leyes fundamentales o principios-guía en la biología, a la luz del examen de la genética clásica llevado a cabo en el marco de la concepción estructuralista de las teorías científicas.; Taking as starting point the book of Sinnott and Dunn, Principles of genetics: an elementary text, with problems, that may be considered the first textbook of classical genetics in the Kuhnian sense, and the analyses of the structure of biomedical and/or biological theories carried out by Darden and Schaffner, I will discuss the problem of the existence of fundamental laws or guide-principles in biology, in the light of the examination of classical genetics accomplished with the instruments of the structuralist conception of theories.