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DIABETES AND EXPERIMENTAL PREGNANCY IN RATS - COURSE OF MATERNAL BLOOD-GLUCOSE LEVELS AND ITS REPERCUSSIONS ON THE BLOOD-GLUCOSE LEVELS AND PANCREAS OF NEWBORN PUPS

Rudge, Marilza Vieira Cunha; Calderon, Iracema de Mattos Paranhos; Ramos, M. D.; Rodrigues, MAM
Fonte: Associação Brasileira de Divulgação Científica (ABRADIC) Publicador: Associação Brasileira de Divulgação Científica (ABRADIC)
Tipo: Artigo de Revista Científica Formato: 219-225
ENG
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The objective of the present investigation was to determine the course of maternal blood glucose levels in pregnant rats and its repercussions on the glucose levels and pancreas of their newborn pups. Diabetes was induced by alloxan (42 mg/kg body weight) and streptozotocin (40 mg/kg). Sixty-two pregnant Wistar rats weighing 180 to 250 g were divided into a control group and two groups with moderate (120 to 200 mg/dl glucose) and severe diabetes (greater than 200 mg/dl glucose), respectively. Blood glucose levels were measured in the dams on the 1st, 14th, and 21st days of pregnancy and in the pups at birth. The results were pooled for each litter. The fetal pancreases were removed after cesarian section performed on the 21st day of pregnancy, pooled for each litter and processed for histopathologic examination by light microscopy. Maternal blood glucose levels were significantly increased compared with the first day of pregnancy in both normal and diabetic rats starting on the 14th day of pregnancy. Fetal blood glucose levels correlated with maternal levels. The histopathologic changes characterized by vacuolization and basophilia of the cytoplasm of endocrine pancreas of newborn pups from darns with moderate or severe diabetes suggested pancreatic hyperactivity.

Increased implantation and pregnancy rates obtained by placing the tip of the transfer catheter in the central area of the endometrial cavity

Oliveira, João Batista Alcantara; Martins, A. M V C; Baruffi, R. L R; Mauri, A. L.; Petersen, C. G.; Felipe, V.; Contart, P.; Pontes, A.; Franco, J. G.
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 435-441
ENG
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The influence of endometrial cavity length (ECL) on implantation and pregnancy rates after 400 embryo transfers was studied prospectively in a population with the indication of IVF/intracytoplasmic sperm injection (ICSI). The tip of the transfer catheter was placed above or below the half point of the ECL in a randomized manner. Two analyses were performed: (i) absolute position (AP); embryo transfers were divided into three groups according to the distance between the end of the fundal endometrial surface and the catheter tip (DTC - distance tip catheter): AP 1 (n = 212), 10-15 mm; AP 2 (n = 158), 16-20 mm; and AP 3 (n = 30), ≥21 mm. (ii) relative position (RP) - embryo transfers were divided into four groups according to their RP [RP = (DTC/ECL) × 100]: RP 1 (n = 23), ≤40%; RP 2 (n = 177), 41-50%; RP 3 (n = 117), 51-60%; and RP 4 (n = 83), ≥61%. Analysis based on relative distance revealed significantly higher implantation and pregnancy rates (P < 0.05) in more central areas of the ECL. However, analysis based on absolute position did not reveal any difference. In conclusion, the present results demonstrated that implantation and pregnancy rates are influenced by the site of embryo transfer, with better results being obtained when the catheter tip is positioned close to the middle area of the endometrial cavity. In this respect...

The effect of follicle age on pregnancy rate in beef cows

Abreu, F. M.; Geary, T. W.; Cruppe, L. H.; Madsen, C. A.; Jinks, E. M.; Pohler, K. G.; Vasconcelos, J. L. M.; Day, M. L.
Fonte: Amer Soc Animal Science Publicador: Amer Soc Animal Science
Tipo: Artigo de Revista Científica Formato: 1015-1021
ENG
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The effect of the age of the ovulatory follicle on fertility in beef cows was investigated. Multiparous (n = 171) and primiparous (n = 129) postpartum beef cows in 2 groups (G1 and G2) received estradiol benzoate (EB; 1 mg/500 kg BW, intramuscular [i.m.]) 5.5 d (G1; n = 162) and 6.5 d (G2; n = 138) after the final GnRH of a synchronization program (5d CO-Synch + CIDR) to induce emergence of a new follicular wave (NFW), followed by prostaglandin F2 alpha (PGF2 alpha; 25 mg, i.m.) administration either 5.5 d (young follicle, YF; n = 155) or 9.5 d (mature follicle, MF; n = 145) after EB. Estrous detection coupled with AI 12 h later (estrus-AI) was performed for 60 h (MF) and 84 h (YF) after PGF(2 alpha); cows not detected in estrus within this period received timed AI (TAI) coupled with GnRH at 72 and 96 h, respectively. Within the first 72 h after PGF(2 alpha), more (P < 0.01) cows in the MF (76.3%) than YF treatment (47.7%) exhibited estrus, but through 96 h, the proportion detected in estrus (P < 0.05) and interval from PGF(2 alpha) to estrus (P < 0.01) were greater in the YF than MF treatment (88.6% vs. 76.3%, 78.9 +/- 0.8 vs. 57.5 +/- 1.6 h, respectively). Age of the ovulatory follicle at AI was greater (P < 0.01) in the MF (9.32 +/- 0.04 d) than YF (6.26 +/- 0.02 d) treatment...

Effect of exercise on the maternal outcome in pregnancy of spontaneously hypertensive rats

Rocha, Renato; Peraçoli, José Carlos; Volpato, Gustavo Tadeu; Damasceno, Débora Cristina; Campos, Kleber Eduardo De
Fonte: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia Publicador: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Tipo: Artigo de Revista Científica Formato: 553-559
ENG
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); PURPOSE:To evaluate the effect of exercise (swimming) on pregnancy in spontaneously hypertensive rats (SHR). METHODS:Thirty three pregnant female SHR were distributed into three groups (n=11 animals/group): SHR Control=non-exercised (sedentary); SHR Ex0 = exercised from day zero to day 20 of pregnancy; and SHR Ex7 = exercised from day 7 to 20 of pregnancy. Body weight and systolic blood pressure were indirectly measured during pregnancy. On gestational day 21, the rats were anaesthetized and uterine content was withdrawn for analysis of maternal reproductive outcome parameters and fetal development. RESULTS:The reduced blood pressure percentage was higher in SHR Ex0 and SHR Ex7 compared to SHR Control group. Weight gain was present in all pregnancy periods, but it was lower in SHR Ex7 than in SHR Control dams. The exercise increased the pre-implantation loss rate. The post-implantation loss rate was lower in SHR Ex0 group. SHR Ex7 group showed a significantly higher percentage of fetuses classified as small for gestational age as compared to others groups. CONCLUSION:The exercise contributed to lowering gestational blood pressure in SHR rats...

Expressão de proteinas de choque termico 70 (HSP70) nas celulas uNK de camundongos na gestação normal e sob estresse induzido pela lesão embrionaria; Heat shock protein 70 (HSP70) expression in the mouse uNK cells in normal pregnancy and under stress induced by embryon injury

Patricia Daniele Azevedo Lima
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 29/02/2008 PT
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Durante a gestação em animais que possuem placentação hemocorial, a hipóxia no primeiro terço da prenhez é um dos fatores cruciais para indução da angiogênese e o adequado desenvolvimento da placenta. Contudo, esta hipóxia se contrapõe à intensa atividade das células que requerem elevado metabolismo, gerando um estresse fisiológico para estas células presentes na interface materno-fetal. Presume-se que estas células necessitem de mecanismos apropriados de citoproteção para sua sobrevida enquanto comprometidos ativamente no suporte funcional do útero gestante. Neste sentido, o presente trabalho teve como objetivo investigar a expressão e a distribuição da proteína de choque térmico 70 (HSP70) na interface materno-fetal durante a gestação normal em camundongos e a sua possível variação em condição de estresse adicional induzido experimentalmente através da lesão embrionária. Sítios de desenvolvimento embrionário/fetal de camundongos prenhes do dia de gestação (dg) 6 ao 17 e, após 30 minutos, 1, 6 e 12 h dos animais submetidos à lesão cirúrgida do embrião (LCE) no dg 9 foram coletados para: - processamento histotécnico convencional de embebição em parafina destinados às análises citoquímicas (lectina DBA e reação de TUNEL) e imunocitoquímicas (anti-HSP72/73...

O efeito da reeducação postural global no tratamento da lombalgia durantes a gestação; Effect of global postural reeducation treatment of lumbar pain during pregnancy

Vinicius Fernandes Barrionuevo Gil
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 09/02/2009 PT
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A dor lombar é considerada distúrbio comum na população em geral e é queixa frequente durante a gestação. Estudos recentes mostram que aproximadamente 80% das gestantes relatam dores nas regiões lombar e pélvica, sendo que 51% apresentam dor que interfere significativamente em suas atividades físicas e qualidade de vida. Objetivo: Avaliar o efeito da Reeducação Postural Global (RPG) no tratamento da lombalgia durante a gravidez e sua associação com as limitações funcionais das gestantes. Sujeitos e Métodos: Foi realizado um estudo clínico comparativo, de caráter exploratório, em três centros de saúde e um hospital privado na cidade de Campinas, com 34 gestantes nulíparas que apresentavam queixa de dor lombar. As participantes foram alocadas em dois grupos: um deles submetido a sessões de RPG durante oito semanas consecutivas, e o outro seguiu apenas as orientações médicas no pré-natal para controle da dor lombar. A cada sessão de RPG foi avaliada a intensidade da dor através da escala análogo-visual da dor, antes e depois dos procedimentos fisioterapêuticos, e registrada a existência de algum outro tipo de tratamento para a dor lombar. O grupo de controle foi acompanhado pelo mesmo período, com três avaliações (admissão...

Dieta de cafeteria induz obesidade, resistência periférica a insulina, e reduz a secreção deste hormônio por ilhotas de ratas : restauração do processo secretório, mas não da sensibilidade à insulina durante a prenhez; Cafeteria diet induces obesity, peripheral insulin resistance, and reduces insulin secretion in isolated from rats : restoration of the secretory process but not of the insulin sensibility during pregnancy

Emerielle Cristine Vanzela
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 31/03/2010 PT
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A obesidade atingiu proporções alarmantes constituindo-se num fator de risco para o desenvolvimento de várias doenças. O aumento da resistência periférica à insulina acompanha esta patologia e a incapacidade da célula beta pancreática em suprir a maior necessidade por insulina leva ao desenvolvimento de intolerância à glicose, hiperglicemia e diabetes. Por esta razão, é importante investigar mecanismos que tornem a célula beta capaz de aumentar sua capacidade secretória. A exemplo da obesidade, resistência periférica à insulina é também observada durante a prenhez. No entanto, neste caso, a célula beta é capaz de aumentar a produção e secreção do hormônio, mantendo a tolerância à glicose em condições adequadas. Diante disso,decidimos investigar a sensibilidade à insulina e a consequente resposta das células beta pancreáticas durante a prenhez em ratas obesas. Observamos que a alimentação com a dieta de cafeteria aumentou o ganho de peso, bem como os depósitos de gordura das ratas. Ratas obesas não-prenhes (Caf) e prenhes (CafP) apresentaram tolerância à glicose diminuída, associada a um aumento da insulina plasmática em resposta à sobrecarga de glicose no grupo CafP. Apesar disso, as glicemias de jejum e pós-prandial foram normais nos dois grupos. No entanto...

Ausência de pré-natal e gravidez na adolescência : um estudo ecológico no Estado de São Paulo; Lack of prenatal care and teenage pregnancy : ecological study in São Paulo

Maria Silvia Bergo Guerra
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 18/07/2014 PT
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O pré-natal inadequado e a gestação durante a adolescência são alguns dos fatores que, conhecidamente, interferem na saúde materno-infantil. Modelos conceituais defendem as condições contextuais e os modelos de atenção em saúde como determinantes nesse processo. Essa dissertação produziu dois artigos, que foram divididos capítulos e que tiveram como objetivos verificar como as variáveis contextuais e do modelo de atenção em saúde interferem: a.) na ausência de pré-natal (capítulo 1); e, b.) na gestação durante a adolescência (capítulo 2). Através de um estudo ecológico, em todos os 645 municípios do Estado de São Paulo, durante os anos de 1998 a 2008, pesquisou-se a tendência da ausência de pré-natal e da gravidez na adolescência, bem como possíveis variáveis contextuais e de modelo de atenção podem impactá-las. Para avaliar a ausência de pré natal, a variável dependente foi o coeficiente de nascidos vivos de mães que não fizeram pré-natal (zero consultas); e para avaliar a gestação na adolescência, utilizou-se como variável dependente o coeficiente de nascidos vivos de mães adolescentes (menores de 20 anos). Foram consideradas como características contextuais o PIB per capta e o número de habitantes...

Pregnancy outcome in juvenile systemic lupus erythematosus: A Brazilian multicenter cohort study

SILVA, Clovis A. A.; HILARIO, Maria O.; FEBRONIO, Marilia V.; OLIVEIRA, Sheila K.; ALMEIDA, Rozana G.; FONSECA, Adriana R.; YAMASHITA, Edson M.; RONCHEZEL, Marcos V.; CAMPOS, Luciene L.; APPENZELLER, Simone; QUINTERO, Maria V.; SANTOS, Ana B.; MEDEIROS, A
Fonte: J RHEUMATOL PUBL CO Publicador: J RHEUMATOL PUBL CO
Tipo: Artigo de Revista Científica
ENG
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Objective. To determine pregnancy outcome and fetal loss risk factors in patients with juvenile systemic lupus erythematosus (JSLE). Methods. A total of 315 female patients with JSLE followed in 12 Brazilian pediatric rheumatology centers were consecutively selected. Menarche was observed in 298 (94.6%) patients. Patients` medical records were reviewed for pregnancy outcomes and demographic, clinical, and therapeutic data. Results. A total of 24 unplanned pregnancies occurred in 298 (8%) patients. The outcomes were 5 (21%) early fetal losses (prior to 16 wks gestation), 18 (75%) live births, and 1 (4%) death due to preeclampsia and premature birth. The frequencies of active diffuse proliferative glomerulonephritis, proteinuria >= 0.5 g/day, and arterial hypertension at the beginning of pregnancy were higher in pregnancies resulting in fetal losses than in live births [60% vs 5% (p = 0.02), 60% vs 5% (p = 0.02), 60% vs 5% (p = 0.02), respectively]. JSLE pregnancies with fetal losses had a significantly higher mean SLE Disease Activity Index 2000 (SLEDAI-2K) at the start of pregnancy compared with those with live births (9.40 +/- 7.47 vs 3.94 +/- 6.00; p = 0.049). Four pregnancies were inadvertently exposed to intravenous cyclophosphamide therapy for renal involvement despite contraceptive prescriptions...

Biomechanics of Gait during Pregnancy: a review

Branco, Marco; Santos-Rocha, Rita; Vieira, Filomena
Fonte: Hindawi Publishing Corporation Publicador: Hindawi Publishing Corporation
Tipo: Artigo de Revista Científica
Publicado em 22/12/2014 ENG
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During pregnancy women experience several changes in the body’s physiology, morphology, and hormonal system. These changes may affect the balance and body stability and can cause discomfort and pain. The adaptations of the musculoskeletal system due to morphological changes during pregnancy are not fully understood. Few studies clarify the biomechanical changes of gait that occur during pregnancy and in postpartum period.Purposes. The purpose of this review was to analyze the available evidence on the biomechanical adaptations of gait that occur throughout pregnancy and in postpartum period, specifically with regard to the temporal, spatial, kinematic, and kinetic parameters of gait.Methods. Three databases were searched and 9 studies with a follow-up design were retrieved for analysis.Results. Most studies performed temporal, spatial, and kinematic analysis. Only three studies performed kinetic analysis.Conclusion. The adaptation strategies to the anatomical and physiological changes throughout pregnancy are still unclear, particularly in a longitudinal perspective and regarding kinetic parameters.

Pregnancy and peripartum cardiomyopathy: a comparative and prospective study

Avila,Walkiria Samuel; Carvalho,Maria Elisa Carneiro de; Tschaen,Cleide K.; Rossi,Eduardo Giusti; Grinberg,Max; Mady,Charles; Ramires,José Antonio Franchini
Fonte: Sociedade Brasileira de Cardiologia - SBC Publicador: Sociedade Brasileira de Cardiologia - SBC
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/11/2002 EN
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OBJECTIVE: To assess pregnancy outcome in women with peripartum cardiomyopathy and to compare it with idiopathic cardiomyopathy. METHODS: Twenty-six pregnant women, aged 28.4±6.1 years, with dilated cardiomyopathy were followed. Eighteen patients had peripartum cardiomyopathy [11 with persistent left ventricular systolic dysfunction (EF=45.2±2) and 7 with recovered ventricular function (EF=62.3±3.6)]. The 8 remaining patients had idiopathic cardiomyopathy (EF= 43.5±4.1). During the prenatal period, limited physical activity and a low-sodium diet were recommended, and hospitalization was recommended when complications occurred. RESULTS: Of the 26 patients, 11 (42.3%) had a normal delivery; 9(35.5%) had cardiac complications, 6 (22.2%) had obstetric complications. Two patients (7.7%) died. Two preterm pregnancies occurred, with 26 health newborns (2 sets of twins). Two miscarriages took place. The cardiac complication rate during pregnancy was lower (p<0.009) in the peripartum cardiomyopathy group without ventricular dysfunction and greater (p=0.01) in the idiopathic group when compared with the peripartum group with ventricular dysfunction. Changes in left ventricular ejection fraction were not observed (p<0.05) in the postpartum period...

Do socioeconomic factors explain why maternal smoking during pregnancy is more frequent in a more developed city of Brazil?

Ribeiro,V.S.; Figueiredo,F.P.; Silva,A.A.M.; Batista,R.L.F.; Barbieri,M.A.; Lamy Filho,F.; Alves,M.T.S.S.B.; Santos,A.M.; Bettiol,H.
Fonte: Associação Brasileira de Divulgação Científica Publicador: Associação Brasileira de Divulgação Científica
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/2007 EN
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The prevalence of smoking during pregnancy in Ribeirão Preto, a rich Brazilian city, was significantly higher (21.4%) than in São Luís (5.9%), a less developed city. To assess which variables explain the difference in prevalence of smoking during pregnancy, data from two birth cohorts were used, including 2846 puerperae from Ribeirão Preto, in 1994, and 2443 puerperae from São Luís, in 1997/98. In multivariable analysis, risk of maternal smoking during pregnancy was higher in São Luís for mothers living in a household with five or more persons (OR = 1.72, 95%CI = 1.12-2.64), aged 35 years or older (OR = 1.98, 95%CI = 0.99-3.96), who had five or more children (OR = 2.10, 95%CI = 1.16-3.81), and whose companion smoked (OR = 2.20, 95%CI = 1.52-3.18). Age of less than 20 years was a protective factor (OR = 0.55, 95%CI = 0.33-0.92). In Ribeirão Preto there was association with maternal low educational level (OR = 2.18, 95%CI = 1.30-3.65) and with a smoking companion (OR = 3.25, 95%CI = 2.52-4.18). Receiving prenatal care was a protective factor (OR = 0.24, 95%CI = 0.11-0.49). Mothers from Ribeirão Preto who worked outside the home were at a higher risk and those aged 35 years or older or who attended five or more prenatal care visits were at lower risk of smoking during pregnancy as compared to mothers from São Luís. Smoking by the companion reduced the difference between smoking rates in the two cities by 10%. The socioeconomic variables in the model did not explain the higher prevalence of smoking during pregnancy in the more developed city.

Periodontal infection and adverse pregnancy outcomes: a systematic review of epidemiological studies

Vettore,Mario Vianna; Lamarca,Gabriela de Almeida; Leão,Anna Thereza Thomé; Thomaz,Filipe Brand; Sheiham,Aubrey; Leal,Maria do Carmo
Fonte: Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz Publicador: Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2006 EN
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The objective of this systematic review was to evaluate analytical studies on periodontal disease as a possible risk factor for adverse pregnancy outcomes. A literature search of the MEDLINE, SciELO, and LILACS bibliographic databases and CAPES thesis database was conducted up to December 2005, covering epidemiological studies of periodontal disease and adverse pregnancy outcomes. Of the 964 papers identified, 36 analytical studies met the inclusion criteria. Twenty-six epidemiological studies reported associations between periodontal disease and adverse pregnancy outcomes. There was a clear heterogeneity between studies concerning measurement of periodontal disease and selection of type of adverse pregnancy outcome. Therefore no meta-analysis was performed. Most studies did not control for confounders, thus raising serious doubts about their conclusions. The methodological limitations of most studies did not allow conclusions concerning the effects of periodontal disease on adverse pregnancy outcomes. Larger and methodologically rigorous analytical studies using reliable outcomes and exposure measures are recommended.

Depression during pregnancy: prevalence and risk factors among women attending a public health clinic in Rio de Janeiro, Brazil

Pereira,Priscila Krauss; Lovisi,Giovanni Marcos; Pilowsky,Daniel L.; Lima,Lúcia Abelha; Legay,Leticia Fortes
Fonte: Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz Publicador: Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2009 EN
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36.45%
Depression is the most prevalent psychiatric disorder during pregnancy and is associated with psychosocial and clinical obstetric factors. Despite being an important public health issue, there are few studies about this issue in Brazil. A cross-sectional study was carried out, involving 331 pregnant women attending a public primary health service over a one-year period in Rio de Janeiro city, Brazil. Participants were interviewed about their socio-demographic status, obstetric/medical conditions, life events and violence during pregnancy. Depression was assessed using the Composite International Development Interview. The prevalence of depression during pregnancy was 14.2% (95%CI: 10.7-18.5) and associated factors included: previous history of depression and any psychiatric treatment, unplanned pregnancy, serious physical illness and casual jobs. These data emphasize the need for screening for depression and its risk factors during pregnancy in settings where care is available. Psychosocial interventions and social policies need to be devised for this population.

Effect of exercise on the maternal outcome in pregnancy of spontaneously hypertensive rats

Rocha,Renato; Peraçoli,José Carlos; Volpato,Gustavo Tadeu; Damasceno,Débora Cristina; Campos,Kleber Eduardo de
Fonte: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia Publicador: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/2014 EN
Relevância na Pesquisa
36.45%
PURPOSE: To evaluate the effect of exercise (swimming) on pregnancy in spontaneously hypertensive rats (SHR). METHODS: Thirty three pregnant female SHR were distributed into three groups (n=11 animals/group): SHR Control=non-exercised (sedentary); SHR Ex0 = exercised from day zero to day 20 of pregnancy; and SHR Ex7 = exercised from day 7 to 20 of pregnancy. Body weight and systolic blood pressure were indirectly measured during pregnancy. On gestational day 21, the rats were anaesthetized and uterine content was withdrawn for analysis of maternal reproductive outcome parameters and fetal development. RESULTS: The reduced blood pressure percentage was higher in SHR Ex0 and SHR Ex7 compared to SHR Control group. Weight gain was present in all pregnancy periods, but it was lower in SHR Ex7 than in SHR Control dams. The exercise increased the pre-implantation loss rate. The post-implantation loss rate was lower in SHR Ex0 group. SHR Ex7 group showed a significantly higher percentage of fetuses classified as small for gestational age as compared to others groups. CONCLUSION: The exercise contributed to lowering gestational blood pressure in SHR rats, but had a negative impact on the developing embryo.

Serum markers in the diagnosis of tubal pregnancy

Cabar,Fabio Roberto; Fettback,Paula Beatriz; Pereira,Pedro Paulo; Zugaib,Marcelo
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2008 EN
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The introduction of highly sensitive methods, such as transvaginal sonography and measurement of serum b-human chorionic gonadotropin, has dramatically improved ectopic pregnancy diagnosis in recent years. Early diagnosis is the key to successful and conservative management of women with ectopic pregnancy; however, approximately 50 percent of such women are initially misdiagnosed, resulting in significant morbidity and mortality. In order to improve diagnosis, several serum markers are being investigated including progesterone, CA 125, pregnancy-associated plasma protein-A, vascular endothelial growth factor, and maternal creatine kinase. Measurement of serum vascular endothelial growth factor, alone or together with other markers, could be a promising method for earlier and more accurate differential diagnosis. However, the clinical applicability of these findings remains to be evaluated in larger prospective studies.

Effect of dietary factors in pregnancy on risk of pregnancy complications: results from the Norwegian Mother and Child Cohort Study1234

Meltzer, Helle Margrete; Brantsæter, Anne Lise; Nilsen, Roy M; Magnus, Per; Alexander, Jan; Haugen, Margareta
Fonte: American Society for Nutrition Publicador: American Society for Nutrition
Tipo: Artigo de Revista Científica
EN
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There has been a thrilling development , as well as profound changes, in our understanding of the effect of fetal nutrition on the development and health of the child. The Norwegian Mother and Child Cohort Study (MoBa) is an ongoing nationwide population-based pregnancy cohort study that between 1999 and 2008 recruited 90,723 women with 106,981 pregnancies and 108,487 children. The objective of MoBa is to test specific etiologic hypotheses by estimating the association between exposures and diseases with a special focus on disorders that may originate in early life. An important aspect in this regard is maternal diet and nutritional status during pregnancy. Nutritional factors have long been considered to be important determinants of maternal and fetal health, and dietary information is currently being collected in a number of pregnancy cohorts in Europe and the United States. Thus far, pregnancy complications studied in MoBa are preterm birth, preeclampsia, and fetal growth; and the aim of this article is to report results of recently published studies of dietary factors in relation to these outcomes. Numerous studies are planned using MoBa data, and the aim is to add to the knowledge of the interplay between dietary factors, nonnutrients...

Evidence for a Novel Multipotent Mammary Progenitor with Pregnancy-Specific Activity

Kaanta, Alice
Fonte: Harvard University Publicador: Harvard University
Tipo: Thesis or Dissertation
EN_US
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The mouse mammary gland has emerged as a model system for studying processes involved in the development of epithelial tissues. Current evidence suggests the existence of a differentiation hierarchy in the mammary gland, consisting of a stem cell capable of reconstituting the tissue, progenitors with the capacity to produce specific functional cell types, and differentiated cells with limited or no repopulation potential. Although markers for mammary stem cells and progenitors have been identified, these populations have not been isolated to purity and our understanding of how they function in different stages of mammary development remains incomplete. Many adult stem cells are mitotically quiescent and can therefore retain a DNA or histone label significantly longer than differentiated cells. In an attempt to identify mammary stem cells/progenitors by histone label retention, I crossed a mouse carrying the tetracycline-inducible histone 2b/eGFP (H2BGFP) gene with tetracycline transactivator strains expected to induce H2BGFP in the mammary gland. H2BGFP expression was induced in the mammary gland until puberty and then chased for 6-8 weeks; (H2BGFP^+) label retaining cells were isolated and assayed. Transplantation experiments comparing MMTVrtTA/H2BGFP MECs isolated after induction to MMTVrtTA/H2BGFP MECs retaining label post-chase failed to prove that label retention enriches for stem cells/progenitors in the MMTVrtTA/H2BGFP system. During the course of these experiments...

Motherhood or abortion: pregnancy resolution decisions of Australian teenagers

Evans, Ann
Fonte: Universidade Nacional da Austrália Publicador: Universidade Nacional da Austrália
Tipo: Thesis (PhD); Doctor of Philosophy (PhD)
EN
Relevância na Pesquisa
36.45%
Australia has a lower teenage fertility rate than other industrialised English-speaking countries. However, with over 11,000 births and 12,000 abortions to teenagers each year, the resolution of teenage pregnancy is an issue faced by many young Australian women. ¶ This research seeks to explore the factors that discriminate between those who terminate and those who continue a teenage pregnancy. To achieve this aim a survey was conducted on young ever-pregnant women throughout New South Wales and the Australian Capital Territory. The survey sought information on young women’s characteristics on three different levels: individual; institutional; and societal or cultural. ¶ The findings suggest that, at each of the three levels proposed, there are factors that discriminate between young women who choose abortion and those who choose motherhood. At the individual level, attitudes to abortion and career aspirations were found to affect pregnancy resolution. At the institutional level factors relating to education, family, relationships and religion were found to discriminate between the two groups. Finally, at the cultural level, ethnicity and area of residence were found to be associated with pregnancy resolution, in addition to modifying the effect of characteristics at other levels.; yes

The impact of rubella immunisation on the incidence of rubella, congenital rubella syndrome and rubella-related terminations of pregnancy in South Australia

Cheffins, T.; Chan, A.; Keane, R.; Haan, E.; Hall, R.
Fonte: Blackwell Science Publishers Publicador: Blackwell Science Publishers
Tipo: Artigo de Revista Científica
Publicado em //1998 EN
Relevância na Pesquisa
36.45%
Objectives To describe the impact of rubella immunisation on the incidence of rubella, congenital rubella syndrome and rubella-related terminations of pregnancy in South Australia, and to identify factors associated with a re-emerging problem. Design and Methods A population-based descriptive study using data from South Australian notifications of disease, births and terminations of pregnancy, the rubella immunisation programme, antenatal rubella antibody screening and paediatric hospital case records. Setting South Australia (population 1.48 million people; 20,000 births per year). Main outcome measures Incidence of rubella (age-sex specific), congenital rubella syndrome and rubella-related terminations of pregnancy; antenatal rubella sero-positive rates; rubella immunisation uptake rates. Results Rubella notification rates in 1990–1996 were significantly higher for males than females for ages 15–34 years. There were five cases of congenital rubella syndrome notified in 1980–1996 compared with at least 20 confirmed or compatible cases in 1965–1979. Rubella-related terminations of pregnancy are now rare, with the last termination for maternal rubella being in 1993. The antenatal rubella sero-positive rate in 1995 was 96.7%...