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Estudo da correlação entre posicionamento do disco articular, cabeça da mandíbula, estalo e dor à palpação em pacientes portadores de disfunção temporomandibular avaliados clinicamente e pela ressonância magnética; Study of correlation between articular disc position, condyle, clicking and pain on palpation in patients with temporomandibular disorders assessed clinically and by magnetic resonance imaging

Nunes, Thaís Borguezan
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 11/03/2013 PT
Relevância na Pesquisa
36.43%
A Disfunção Temporomandibular (DTM) se refere a várias doenças que envolvem os músculos da mastigação e/ou a articulação temporomandibular (ATM). Ao longo da história, o desenvolvimento de técnicas de imagem possibilitou a avaliação das disfunções intra-articulares. A Ressonância Magnética (RM) é considerada o melhor método de avaliação de imagem para diagnosticar doenças da ATM e o exame mais preciso para detectar a posição do disco articular e visualizar estruturas ósseas, como a cabeça da mandíbula e a fossa mandibular, complementando o exame clínico. A associação entre sinais e sintomas de DTM e achados na RM é controversa na literatura e a correlação entre a posição da cabeça da mandíbula dentro da fossa mandibular e a sintomatologia de pacientes diagnosticados com DTM foi pouco elucidada pelos autores. O objetivo do estudo foi analisar os achados imaginológicos da ressonância magnética quanto à posição da cabeça da mandíbula e quanto à posição do disco articular, verificando sua correlação com os sinais clínicos de estalo e de dor à palpação muscular e articular relatados pelo paciente. Foram analisados 163 prontuários contendo ficha clínica e exame de RM de pacientes com DTM. As fichas clínicas forneceram dados referentes a sinais e sintomas dos pacientes...

Aspectos afetivos na percepção da dor pediátrica, estresse e qualidade de vida de crianças hospitalizadas; Affective aspects of pain perception in pediatric, distress and quality of life of hospitalized children

Castro, Ana Cláudia Matsuda
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 18/09/2013 PT
Relevância na Pesquisa
36.43%
O presente estudo teve por objetivo examinar a relação entre dor em crianças enfermas e hospitalizadas e a percepção materna sobre a dor, a qualidade de vida da criança e indicadores psicológicos da mãe e da criança. A amostra foi composta por 30 crianças de seis a 12 anos internadas na Enfermaria Pediátrica e suas mães. Os instrumentos utilizados foram: Escala de Faces Revisada e Escala de Stress Infantil com as crianças e Escala de Faces Revisada, Inventário de Sintomas de Stress para Adultos de Lipp, Escala de Modos de Enfrentamento de Problemas e Questionário de Qualidade de Vida relacionado à Saúde com as mães, Roteiros de Caracterização da Criança e Socioeconômica. Os dados foram submetidos à análise de estatística descritiva, à análise de relação entre variáveis por meio do teste de correlação de Pearson, do teste de Qui-quadrado e do teste de Mann-Whitney. Foram examinados os modelos de predição por meio da análise de regressão linear múltipla, tendo a variável predita qualidade de vida da criança e as variáveis preditoras estresse infantil e enfrentamento de problemas materno. Em relação à dor, quanto maior a intensidade de dor avaliada pela criança, maior era o estresse e as reações fisiológicas e psicológicas das crianças. Em relação ao estresse materno...

Dor neuropática: implicações na qualidade de vida de pessoas com lesão medular; Central neuropathic pain: implications of spinal cord lesion for the quality of life

Aquarone, Rita Lacerda
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 16/12/2013 PT
Relevância na Pesquisa
36.43%
A dor é uma das consequências da lesão medular, somada às disfunções miccional e intestinal, à manutenção da integridade da pele, alterações na sexualidade e na reprodução, às questões sociais e familiares. Conhecer a dor e a interferência na qualidade de vida faz com que o profissional que assiste ao paciente, consiga seguir o caminho mais adequado e conjugar modalidades para o controle da dor neuropática. Neste estudo objetivou-se conhecer as implicações da dor neuropática na qualidade de vida de indivíduos com lesão medular traumática. Trata-se de uma pesquisa de abordagem quantitativa, do tipo transversal, exploratória, descritiva e comparativa. Os dados foram coletados pela propria pesquisadora. A coleta incluiu entrevista com os pacientes, aplicando Escala de Avaliação da Dor de McGill, uma escala analógica de avaliação da intensidade da dor e a Escala WHOQOL-brief, versão abreviada do WHOQOL-100. Os pacientes participantes da pesquisa foram em sua maioria do sexo masculino, com idade entre 30 e 49 anos, casados, aposentados, com ensino médio, lesao medular causada por queda, paraplegicos com lesao incompleta, entre um e cinco anos de lesao. As implicações dos pacientes com dor neuropática e qualidade de vida mostram que pacientes que referiram maior intensidade de dor...

Eficácia do bloqueio simpático torácico no tratamento da síndrome complexa de dor regional do membro superior; Efficacy of the thoracic sympathetic block for treatment of the complex regional pain syndrome of the upper limb

Rocha, Roberto de Oliveira
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 24/06/2014 PT
Relevância na Pesquisa
36.43%
INTRODUÇÃO: Há poucos estudos bem estruturados sobre a eficácia do bloqueio anestésico do gânglio estrelado (BGE) e do bloqueio simpático torácico (BST) para o tratamento da síndrome complexa de dor regional (SCDR) do membro superior. Há evidências anatômicas e clínicas de que o BGE frequentemente não interrompe a atividade neurovegetativa simpática do membro superior. OBJETIVOS: Avaliar-se a eficácia do BST para tratar a SCDR do membro superior. CASUÍSTICA E MÉTODOS: De acordo com estudo controlado com amostra aleatória e duplamente encoberto, doentes com SCDR, com duração maior que seis meses, foram aleatoriamente submetidos ao método padronizado de tratamento (polifarmacoterapia e terapia física) associadamente aos procedimentos BST ou ao bloqueio controle. Foram comparados os aspectos demográficos, a apresentação clínica, a intensidade da dor, as alterações do humor, a qualidade de vida, a função do membro acometido e os eventos adversos dos procedimentos até um ano após sua realização. Foram utilizadas entrevistas estruturadas, o Inventário Breve de Dor (IBD), o Questionário de Dor McGill (QDM), o Questionário para Diagnóstico de Dor Neuropática (DN4), o Inventário de Sintomas de Dor Neuropática (NPSI)...

Comparison of pain threshold and duration of pain perception in men and women of different ages

Nazaré, Marília Soares Leonel De; Silva, José Adolfo Menezes Garcia; Navega, Marcelo Tavella; Fagnello-navega, Flávia Roberta
Fonte: Pontifícia Universidade Católica do Paraná Publicador: Pontifícia Universidade Católica do Paraná
Tipo: Artigo de Revista Científica Formato: 77-84
ENG
Relevância na Pesquisa
36.43%
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Introduction Pain is a sensory and emotional experience that occurs with the presence of tissue injury, actual or potential. Pain is subjective, and its expression is primarily determined by the perceived intensity of the painful sensation, called the pain threshold. Objective To evaluate whether there are differences in pain threshold (LD) and time to pain perception (TPED) between the gender in different age groups and to analyze the correlation between age and pain threshold in each gender. Methods and procedures Participants were 60 volunteers divided into 6 groups (n = 10 each) according to gender and age (18–33, 34–49, and 50–64 years). The evaluation of perception and pain tolerance was performed by immersing the container with one hand in water at a temperature of 0 °C–2 °C; the latency to withdrawal of the hand from ice water was measured in seconds and was considered a measure of LD. The TPED was reported by each participant as the start time of the painful stimulus. Results We found differences between the LD for G1 (men aged between 18 and 33 years) and G2 (women aged 18 to 33 years) with greater LD for G1 (p = 0.0122) and greater LD for women (p = 0.0094); for other comparisons of LD and TPED...

Evaluation of acupuncture, electroacupuncture and sham acupuncture on the treatment of myofascial pain at the upper trapezius muscle; Avaliação da acupuntura, da eletroacupuntura e da acupuntura sham no tratamento da dor miofascial na parte superior do músculo trapézio

Maria Fernanda Montans Aranha Jorge Ferreira
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 24/02/2014 PT
Relevância na Pesquisa
36.43%
A dor miofascial (DM), proveniente de um ponto gatilho miofascial (Pg), é a principal causa de dor de cabeça e pescoço. A sua presença é associada à rigidez muscular e estresse e pode influenciar a qualidade de vida de pacientes sintomáticos. Imagens ultrassonográficas do tecido disfuncional têm sido realizadas com o intuito de avaliar objetivamente o Pg. Com o objetivo de avaliar o efeito da acupuntura e da eletroacupuntura no tratamento da DM da parte superior do músculo trapézio, sessenta voluntárias com idade entre 18 e 40 anos, índice de massa corpórea entre 18 e 30 Kg/m2, com pelo menos um ponto gatilho na parte superior do músculo trapézio, dor local ou referida por mais de seis meses foram randomizadas em três grupos: eletroacupuntura (EA), acupuntura (AC) e acupuntura SHAM (SHAM). O avaliador e as voluntárias eram cegos aos tratamentos. Os pontos de acupuntura utilizados foram: VB20, VB21, F3 e IG4, além de no máximo, 2 pontos ashi em cada lado do trapézio superior. A efetividade do tratamento, assim como a manutenção dos resultados até um mês após o final do tratamento, foram avaliada pela intensidade de dor (escala visual analógica: EVA), amplitude de movimento cervical (fleximetria), qualidade de vida (SF-36)...

Therapeutic efficacy of the association of counselling and stabilization splint treatment on chronic pain in myofascial pain = : Eficácia terapêutica da associação do aconselhamento e do aparelho estabilizador plano sobre a dor crônica presente na dor miofascial; Eficácia terapêutica da associação do aconselhamento e do aparelho estabilizador plano sobre a dor crônica presente na dor miofascial

Giancarlo Canales De La Torre
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 23/02/2015 PT
Relevância na Pesquisa
36.43%
Disfunção temporomandibular (DTM) ou desordem craniomandibular são termos genéricos que abrangem um grupo amplo de problemas clínicos relacionados ao sistema estomatognático (SEG). A etiologia das DTM pode ser considerada multifatorial. Em função da similaridade com outras disfunções musculoesqueléticas, sobre as quais se desconhece o curso natural, terapias conservadoras estão indicadas como tratamento de primeira eleição. Dentre elas, cita-se a conscientização e a educação do paciente, as quais são intervenções rápidas, simples, sem riscos, e que podem obter sucesso sem custo adicional. Da mesma forma, os aparelhos interoclusais planos (AIP) são utilizados com frequência no controle da dor em portadores de DTM. Por tanto, o objetivo no presente trabalho foi avaliar o efeito da associação dessas duas terapias conservadoras (aconselhamento e aparelho interoclusal plano) sobre a dor crônica presente na dor miofascial. Ainda, buscou-se investigar o status psicológico e comprometimento psicossocial presentes nesta disfunção. Foram selecionadas 20 voluntárias com dor miofascial (RDC/TMD Ia e Ib), as quais foram submetidas a uma sessão de aconselhamento para DTM e uma semana após essa sessão AIP foram instalados. O efeito dos tratamentos foi avaliado através das variáveis: Escala Visual Analógica (EVA)...

Pain evaluation and control after routine interventions in cattle

Stilwell, George Thomas
Fonte: Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária Publicador: Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária
Tipo: Tese de Doutorado
Publicado em 21/09/2009 ENG
Relevância na Pesquisa
36.43%
Tese de Doutoramento em Ciências Veterinária; Disbudding and castration are two routine interventions in cattle practice. Both can cause severe pain and cause poor welfare. Through plasma cortisol levels and behaviour evaluation we measured pain caused by different disbudding and castration methods. We also studied the efficacy of several anaesthesia and analgesia protocols. The main conclusions are: - Cortisol together with behaviour assessment is very useful in detecting calves in pain. - Certain behaviours are only shown by very young calves. - Vocalization should not be used as a sign of pain in calves. - Scoop disbudding causes long term pain and local anaesthesia is not efficient. - Hot-iron disbudding causes severe pain during the procedure but does not differ from paste disbudding in the next hours. Local anaesthesia plus analgesia does reduce pain cause by these methods. - Xylazine causes an increase in cortisol even if pain is not induced. - Pain caused by clamp-castration lasts for at least 48 hours and is only controlled by long acting analgesics. - Surgical castration causes intense pain but shorter if two incisions are made instead of just one.; RESUMO - Avaliação e controlo da dor causada por intervenções de rotina em bovinos - A descorna e a castração de bovinos jovens são duas intervenções de rotina nas explorações. Ambas intervenções têm o potencial de causar dor e...

Relationship of inflammatory markers and pain in patients with head and neck cancer prior to anticancer therapy

Oliveira,K.G.; von Zeidler,S.V.; Lamas,A.Z.; de Podestá,J.R.V.; Sena,A.; Souza,E.D.; Lenzi,J.; Lemos,E.M.; Gouvea,S.A.; Bissoli,N.S.
Fonte: Associação Brasileira de Divulgação Científica Publicador: Associação Brasileira de Divulgação Científica
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/07/2014 EN
Relevância na Pesquisa
36.43%
Pain is a common symptom in patients with cancer, including those with head and neck cancer (HNC). While studies suggest an association between chronic inflammation and pain, levels of inflammatory cytokines, such as C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α), have not been correlated with pain in HNC patients who are not currently undergoing anticancer treatment. The purpose of this study was to examine the relationship between these inflammatory markers and perceived pain in HNC patients prior to anticancer therapy. The study group consisted of 127 HNC patients and 9 healthy controls. Pain was assessed using the Brief Pain Inventory (BPI), and serum levels of CRP and TNF-α were determined using the particle-enhanced turbidimetric immunoassay (PETIA) and ELISA techniques, respectively. Patients experiencing pain had significantly higher levels of CRP (P<0.01) and TNF-α (P<0.05) compared with controls and with patients reporting no pain. There were significantly positive associations between pain, CRP level, and tumor stage. This is the first study to report a positive association between perceived pain and CRP in HNC patients at the time of diagnosis. The current findings suggest important associations between pain and inflammatory processes in HNC patients...

Comparison of pain threshold and duration of pain perception in men and women of different ages

Nazaré,Marília Soares Leonel de; Silva,José Adolfo Menezes Garcia; Navega,Marcelo Tavella; Fagnello-Navega,Flávia Roberta
Fonte: Pontifícia Universidade Católica do Paraná Publicador: Pontifícia Universidade Católica do Paraná
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2014 EN
Relevância na Pesquisa
36.43%
Introduction Pain is a sensory and emotional experience that occurs with the presence of tissue injury, actual or potential. Pain is subjective, and its expression is primarily determined by the perceived intensity of the painful sensation, called the pain threshold. Objective To evaluate whether there are differences in pain threshold (LD) and time to pain perception (TPED) between the gender in different age groups and to analyze the correlation between age and pain threshold in each gender. Methods and procedures Participants were 60 volunteers divided into 6 groups (n = 10 each) according to gender and age (18–33, 34–49, and 50–64 years). The evaluation of perception and pain tolerance was performed by immersing the container with one hand in water at a temperature of 0 °C–2 °C; the latency to withdrawal of the hand from ice water was measured in seconds and was considered a measure of LD. The TPED was reported by each participant as the start time of the painful stimulus. Results We found differences between the LD for G1 (men aged between 18 and 33 years) and G2 (women aged 18 to 33 years) with greater LD for G1 (p = 0.0122) and greater LD for women (p = 0.0094); for other comparisons of LD and TPED...

Evaluation and measurement of pain in the aging process

Pelegrin,Andressa K.A.P.; Siqueira,Hilze B.O. Moura; Garbi,Márcia O.S.S.; Saltareli,Simone; Sousa,Fátima Faleiros
Fonte: Pontificia Universidade Católica do Rio de Janeiro; Universidade de Brasília; Universidade de São Paulo Publicador: Pontificia Universidade Católica do Rio de Janeiro; Universidade de Brasília; Universidade de São Paulo
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2014 EN
Relevância na Pesquisa
36.43%
The purpose of the present study was to evaluate pain in the aging process in long-term care institutions. The study included 46 elderly subjects of both genders and with chronic pain. Descriptors of chronic pain were analyzed using psychophysical category estimation methods, and the thematic content of semi-structured interviews was analyzed. Chronic pain was perceived in 33.33% of the elderly subjects. For the descriptors of pain, the results showed higher scores for "painful." In the interview, the thematic units were time, start of symptoms, coping, pain-related causes, current situation, and other perceptions about pain. Pain was related to physical, emotional, and cognitive factors. The present results shed light on "pain" and "aging" phenomena and may contribute to improving the management of pain symptoms in long-term institution residents.

Muscleskeletal pain in dysphonic women

Silverio,Kelly Cristina Alves; Siqueira,Larissa Thaís Donalonso; Lauris,José Roberto Pereira; Brasolotto,Alcione Ghedini
Fonte: Sociedade Brasileira de Fonoaudiologia Publicador: Sociedade Brasileira de Fonoaudiologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2014 EN
Relevância na Pesquisa
36.43%
Objective: To investigate the location, frequency and intensity of muscle pain in dysphonic functional/organofunctional women in comparison to women with healthy voices. Methods: Sixty women, ranging in age from 18 to 45 years, divided into two groups: Dysphonic Group (DG) – 30 women with functional or organofunctional dysphonia; Non-Dysphonic Group (NDG) – 30 women without vocal complaints, and with adapted voices. All answered a protocol, marking the localization, frequency and intensity symptoms of pain on the temporal area, masseters, submandibular areas, larynx/pharynx, front and back of the neck, shoulders, upper back, lower back, elbows, fists/hands/fingers, hip/this, knees and ankles/feet. The volunteer should report the frequency in which pain was present in the last 12 months: no, rarely, frequently or always. The intensity of pain was measured by visual-analogue scales. The DG and NDG groups were compared using the Mann-Whitney test (p<0.05). Results: The women of the DG reported significantly greater frequency of submandibular area (p=0.008), laryngeal pain (p<0.001), front of the neck (p=0.015), back of the neck (p=0.001), shoulder pain (p=0.027), upper back (p=0.027) and also reported significant greater intensity of pain in the larynx/pharynx (p=0.022) and back of the neck (p=0.003). Conclusion: The frequency and intensity of musculoskeletal pain was more frequent and more intense in dysphonic women than in women without vocal complaints...

Neonatal Pain in Very Preterm Infants: Long-Term Effects on Brain, Neurodevelopment and Pain Reactivity

Grunau, Ruth Eckstein
Fonte: Rambam Health Care Campus Publicador: Rambam Health Care Campus
Tipo: Artigo de Revista Científica
Publicado em 29/10/2013 EN
Relevância na Pesquisa
36.43%
Effects of early life psychosocial adversity have received a great deal of attention, such as maternal separation in experimental animal models and abuse/neglect in young humans. More recently, long-term effects of the physical stress of repetitive procedural pain have begun to be addressed in infants hospitalized in neonatal intensive care. Preterm infants are more sensitive to pain and stress, which cannot be distinguished in neonates. The focus of this review is clinical studies of long-term effects of repeated procedural pain-related stress in the neonatal intensive care unit (NICU) in relation to brain development, neurodevelopment, programming of stress systems, and later pain sensitivity in infants born very preterm (24–32 weeks’ gestational age). Neonatal pain exposure has been quantified as the number of invasive and/or skin-breaking procedures during hospitalization in the NICU. Emerging studies provide convincing clinical evidence for an adverse impact of neonatal pain/stress in infants at a time of physiological immaturity, rapidly developing brain microstructure and networks, as well as programming of the hypothalamic-pituitary-adrenal axis. Currently it appears that early pain/stress may influence the developing brain and thereby neurodevelopment and stress-sensitive behaviors...

NGF – the TrkA to successful pain treatment

Kumar, Vinayak; Mahal, Brandon
Fonte: Dove Medical Press Publicador: Dove Medical Press
Tipo: Artigo de Revista Científica
EN_US
Relevância na Pesquisa
36.43%
Chronic pain arising from various pathological conditions such as osteoarthritis, low back or spinal injuries, cancer, and urological chronic pelvic pain syndromes presents significant challenges in diagnosis and treatment. Specifically, since the underlying cause of these pain syndromes is unknown or heterogeneous, physicians diagnose and treat patients based on the symptoms presented. Nerve growth factor (NGF) has been recognized as an important mediator of chronic pain in many pathological conditions, and has been shown to be upregulated in a subset of individuals suffering from such pain syndromes. These findings have led to the development of anti-NGF monoclonal antibodies such as tanezumab as potentially effective therapeutics for chronic pain. Although tanezumab has reached Phase II and III clinical trials, the trials of anti-NGF antibodies were halted due to safety concerns. Some of these trials of anti-NGF treatment have had statistically significant decreases in pain, while others have yielded inconclusive results. These findings are suggestive of, though do not prove, target (NGF) neutralization in chronic pain syndromes. A biomarker-driven anti-NGF clinical study layout is proposed that incorporates NGF measurements in the relevant samples before and after treatment...

Pain hypersensitivity in juvenile idiopathic arthritis: a quantitative sensory testing study

Cornelissen, Laura; Donado, Carolina; Kim, Joseph; Chiel, Laura; Zurakowski, David; Logan, Deirdre E; Meier, Petra; Sethna, Navil F; Blankenburg, Markus; Zernikow, Boris; Sundel, Robert P; Berde, Charles B
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
EN_US
Relevância na Pesquisa
36.43%
Background: Juvenile Idiopathic Arthritis (JIA) is the most common cause of non-infectious joint inflammation in children. Synovial inflammation results in pain, swelling and stiffness. Animal and adult human studies indicate that localized joint-associated inflammation may produce generalized changes in pain sensitivity. The aim was to characterize pain sensitivity in children with JIA to mechanical and thermal stimulus modalities using quantitative sensory testing (QST) at an affected inflamed joint, and compare to children in clinical remission. Generalized hypersensitivity was evaluated by comparing QST measures at the thenar eminence between JIA and healthy control children. Methods: 60 children aged 7–17 years with JIA participated. QST assessed sensory detection threshold and pain threshold at two sites: (1) affected joint (clinically active or inactive), (2) contralateral thenar eminence. Joint site included finger, wrist, knee and ankle. Clinical status was measured using objective and subjective markers of disease severity. Questionnaires assessed pain intensity and frequency, functional disability, anxiety, pain catastrophization and fatigue. QST data collected from joints were compared within JIA patients: active vs. inactive inflammation; and data from the contralateral thenar eminence were compared between JIA and healthy control cohorts in Europe [EU...

Prenatal endotoxin exposure alters behavioural pain responses to lipopolysaccharide in adult offspring

Hodyl, N.; Walker, F.; Krivanek, K.; Clifton, V.; Hodgson, D.
Fonte: Pergamon-Elsevier Science Ltd Publicador: Pergamon-Elsevier Science Ltd
Tipo: Artigo de Revista Científica
Publicado em //2010 EN
Relevância na Pesquisa
36.43%
Evidence suggests that exposure to bacterial endotoxin in early life can alter the production of pro-inflammatory cytokines in later life. This phenomenon may have significant consequences for pain and pain related behaviours as pro-inflammatory cytokines heighten pain sensitivity. This association has yet to be examined. As such, the aim of the present study was to characterize pain behaviours in adult rat offspring following prenatal endotoxin (PE) exposure. Pregnant F344 rats received endotoxin (200 µg/kg, s.c.) or saline on gestational days 16, 18 and 20. Pain thresholds were assessed in the adult PE offspring (n = 23) and control offspring (n = 24) prior to and 4 h following administration of lipopolysaccharide (LPS; 100 µg/kg, s.c.). Three assays of pain were employed — the hot plate, tail immersion and von Frey tests. Results demonstrated sex-specific effects of prenatal endotoxin on the offspring, with PE males displaying unaltered pain thresholds on the von Frey test post-LPS administration (p < 0.01), while male control offspring (n = 24) displayed the expected hyperalgesia. Male PE offspring also displayed increased pain thresholds on the tail immersion test (p < 0.01), while no change in pain sensitivity was observed in control males following LPS exposure. No difference in response was observed between the female PE and control offspring on the von Frey test...

Effect of mental stress on cold pain in chronic tension-type headache sufferers

Cathcart, S.; Winefield, A.; Lushington, K.; Rolan, P.
Fonte: Springer Italia Srl Publicador: Springer Italia Srl
Tipo: Artigo de Revista Científica
Publicado em //2009 EN
Relevância na Pesquisa
36.43%
Mental stress is a noted contributing factor in chronic tension-type headache (CTH), however the mechanisms underlying this are not clearly understood. One proposition is that stress aggravates already increased pain sensitivity in CTH sufferers. This hypothesis could be partially tested by examining effects of mental stress on threshold and supra-threshold experimental pain processing in CTH sufferers. Such studies have not been reported to date. The present study measured pain detection and tolerance thresholds and ratings of supra-threshold pain stimulation from cold pressor test in CTH sufferers (CTH-S) and healthy Control (CNT) subjects exposed to a 60-min stressful mental task, and in CTH sufferers exposed to a 60-min neutral condition (CTH-N). Headache sufferers had lower pain tolerance thresholds and increased pain intensity ratings compared to controls. Pain detection and tolerance thresholds decreased and pain intensity ratings increased during the stress task, with a greater reduction in pain detection threshold and increase in pain intensity ratings in the CTH-S compared to CNT group. The results support the hypothesis that mental stress contributes to CTH through aggravating already increased pain sensitivity in CTH sufferers.; Stuart Cathcart...

Age and gender differences in disabling foot pain using different definitions of the manchester foot pain and disability index

Menz, H.; Gill, T.; Taylor, A.; Hill, C.
Fonte: BioMed Central Ltd. Publicador: BioMed Central Ltd.
Tipo: Artigo de Revista Científica
Publicado em //2011 EN
Relevância na Pesquisa
36.43%
Background: The Manchester Foot Pain and Disability Index (MFPDI) has been used to determine the prevalence of disabling foot pain in several studies, however there is some debate as to which case definition is most appropriate. The objective of this study was to explore age and gender differences in the proportion of people with disabling foot pain using three different case definitions of the MFPDI and for each individual MFPDI item. Methods: A random sample of 223 participants aged 27 to 90 years (88 males and 135 females) from the North West Adelaide Health Study, who reported having pain, aching or stiffness in either of their feet on most days in the last month, completed the MFPDI by telephone interview. The proportion of people with disabling foot pain was determined using three definitions: (i) Definition A-at least one of the 17 items documented on at least some days in the last month; (ii) Definition B-at least one of the 17 items documented on most/every day(s) in the last month, and; (iii) Definition C-at least one of the ten functional limitation items documented on most/every day(s) in the last month. Cross-tabulations and chi-squared statistics were used to explore differences in responses to the MFPDI items according to age and gender. Results: The proportion of people with disabling foot pain according to each definition was as follows: Definition A (100%)...

Socio-demographic and behavioural inequalities in the impact of dental pain among adults: a population-based study

Constante, H.; Bastos, J.; Glazer De Anselmo Peres, K.; De Anselmo Peres, M.
Fonte: Blackwell Munksgaard Publicador: Blackwell Munksgaard
Tipo: Artigo de Revista Científica
Publicado em //2012 EN
Relevância na Pesquisa
36.43%
OBJECTIVES: To assess socio-demographic and behavioural inequalities in the impact of dental pain on daily activities, as well as to estimate the prevalence and intensity of dental pain. METHODS: A populationbased cross-sectional study was carried out in Florianopolis, Southern Brazil, with 1720 adults aged 20–59 years in 2009–2010. Interviews were performed at adults’ households, which included socio-demographics and behavioural characteristics, such as smoking status and alcohol abuse, along with mental health, self-reported health, number of retained teeth, dental pain occurrence (including its intensity and its impact on daily life). The association between the impact of dental pain and the covariates was tested using multinomial logistic regression. Results: The global prevalence of dental pain was 14.8% (95% CI, 12.9–16.7). Adjusted analysis showed that women, those who self-classified as dark-skinned Blacks, those with low family income, current smokers and those with common mental disorders reported a higher impact of dental pain than their counterparts. Among subjects reporting dental pain, 12.7% indicated the maximum intensity, whereas 6.0% had some daily activity disrupted by it, such as difficulties in chewing certain foods (38.0%)...

Opioid analgesics for rheumatoid arthritis pain

Whittle, S.; Richards, B.; Buchbinder, R.
Fonte: American Medical Association (AMA) Publicador: American Medical Association (AMA)
Tipo: Artigo de Revista Científica
Publicado em //2013 EN
Relevância na Pesquisa
36.43%
Clinical Question: Do the benefits of opioid analgesics outweigh the risks in patients with persistent pain due to rheumatoid arthritis? Bottom Line: Weak opioids (such as codeine, dextropropoxyphene, and tramadol) may be effective in the short-term management of rheumatoid arthritis pain, but adverse effects are common and may outweigh the benefits; alternative analgesics should be considered first. The role of opioid analgesics is clearly established in acute pain and chronic cancer pain, but their long-term use in chronic noncancer pain is controversial.¹ The recent increase in the rate of opioid prescriptions for chronic noncancer pain has not seen a parallel growth in the evidence base. Pain management remains a major challenge in rheumatoid arthritis (RA) despite the major advances in RA treatment strategies over the last 2 decades. Patients with RA report pain management as their highest priority.² Pain in RA may occur when disease-modifying antirheumatic drugs (DMARDs) are ineffective or yet to achieve their full effect, when irreversible joint damage has occurred, or when noninflammatory mechanisms of pain generation (such as central sensitization) are activated. Opioids are often prescribed in these circumstances,³ but existing guidelines for treating RA have provided little direction to prescribers. This article summarizes the results of a recent Cochrane review of opioids for RA pain.⁴; Samuel L. Whittle...